Lista de obras - Ian D. Kerr - Dominio Público Uruguay

A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma

scientific article published on 16 July 2019

ABC proteins and antibiotic drug resistance: is it all about transport?

artículo científico publicado en 2005

ABC transporter research: going strong 40 years on

artículo científico publicado en 2015

ABCB1 in children's brain tumours.

artículo científico publicado en 2015

ABCG2: does resolving its structure elucidate the mechanism?

scientific article published on 21 November 2018

Alamethicin Pyromellitate: An Ion-Activated Channel-Forming Peptide

artículo científico publicado en 1994

Alamethicin channels - modelling via restrained molecular dynamics simulations

artículo científico publicado en 1997

An atomic detail model for the human ATP binding cassette transporter P‐glycoprotein derived from disulphide cross‐ linking and homology modeling ⬇️

artículo científico publicado el 16 de octubre de 2003

Analysis of the Sam50 translocase of excavate organisms supports evolution of divergent organelles from a common endosymbiotic event

artículo científico publicado en 2013

Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy

artículo científico publicado en 2009

Cation selectivity in ion channels

artículo científico publicado en 1995

Cellular Patterning of Arabidopsis Roots Under Low Phosphate Conditions.

artículo científico publicado en 2018

Communication between the nucleotide binding domains of P-glycoprotein occurs via conformational changes that involve residue 508.

artículo científico publicado en 2003

Cytosolic region of TM6 in P-glycoprotein: topographical analysis and functional perturbation by site directed labeling

artículo científico publicado en 2008

Definition of the domain boundaries is critical to the expression of the nucleotide-binding domains of P-glycoprotein

artículo científico publicado en 2003

Detergent-free purification of ABC (ATP-binding-cassette) transporters.

artículo científico publicado en 2014

Dimerization of ABCG2 analysed by bimolecular fluorescence complementation

artículo científico publicado en 2011

Ferrocenoyl Derivatives of Alamethicin: Redox-Sensitive Ion Channels†

scientific article published on 01 February 1997

Heterologous expression of a membrane-spanning auxin importer: implications for functional analyses of auxin transporters

artículo científico publicado en 2009

Hydrophilic surface maps of channel-forming peptides: analysis of amphipathic helices

scientific article published on 01 January 1993

Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences.

artículo científico publicado en 2015

Improving the stability and function of purified ABCB1 and ABCA4: the influence of membrane lipids.

artículo científico publicado en 2013

Induction of a stress response in Lactococcus lactis is associated with a resistance to ribosomally active antibiotics

article

Influenza virus M2 protein: a molecular modelling study of the ion channel.

artículo científico publicado en 1993

Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids ⬇️

artículo científico publicado en 2013

Ion channel formation by synthetic analogues of staphylococcal δ-toxin

artículo científico publicado en 1995

Ion channel stability and hydrogen bonding. Molecular modelling of channels formed by synthetic alamethicin analogues.

artículo científico publicado en 1997

Ion channels formed by HIV-1 Vpu: a modelling and simulation study

artículo científico publicado en 1997

Ion channels formed by amphipathic helical peptides

artículo científico publicado en 1991

Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?

artículo científico publicado en 2008

Localisation of a family of complex-forming β-barrels in the T. vaginalis hydrogenosomal membrane

artículo científico publicado en 2012

Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein

artículo científico publicado en 2016

Long-term exposure to irinotecan reduces cell migration in glioma cells.

artículo científico publicado en 2016

Mechanistic insight into the role of AUXIN RESISTANCE4 in trafficking of AUXIN1 and LIKE AUX1-2

Modelling membrane proteins using structural restraints

artículo científico publicado en 1995

Modelling the packing of transmembrane helices: application to aquaporin-1

scientific article published on 01 August 1998

Modelling the restoration of wild-type dynamic behaviour in ΔF508-CFTR NBD1 by 8-cyclopentyl-1,3-dipropylxanthine

artículo científico publicado en 2007

Molecular dynamics of ion/channel interactions [1]

article

Multidrug efflux pumps: the structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues.

artículo científico publicado en 2009

Multiple drugbinding sites on the R482G isoform of the ABCG2 transporter.

artículo científico publicado en 2006

New insight into the biochemical mechanisms regulating auxin transport in plants

artículo científico publicado en 2007

Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors

artículo científico publicado en 2015

Overcoming multiple drug resistance mechanisms in medulloblastoma.

artículo científico publicado en 2014

Packing interactions of aib-containing helices: Molecular modeling of parallel dimers of simple hydrophobic helices and of alamethicin

article

Pediatric brain tumor cancer stem cells: cell cycle dynamics, DNA repair, and etoposide extrusion ⬇️

artículo científico publicado en 2010

Picky ABCG5/G8 and promiscuous ABCG2 - a tale of fatty diets and drug toxicity

scientific article published on 26 September 2020

Plasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniques

artículo científico publicado en 2015

Polymorphisms of the multidrug pump ABCG2: a systematic review of their effect on protein expression, function and drug pharmacokinetics

scholarly article by Niall Heyes et al published 28 September 2018 in Drug Metabolism and Disposition

Protein-water-ion interactions in a model of the pore domain of a potassium channel: a simulation study.

artículo científico publicado en 1998

Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2.

artículo científico publicado en 2006

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

artículo científico publicado en 2001

Residue G346 in transmembrane segment six is involved in inter-domain communication in P-glycoprotein

artículo científico publicado en 2007

Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets

artículo científico publicado en 2018

Secondary structure of an isolated P-region from the voltage-gated sodium channel: a molecular modelling/dynamics study

artículo científico publicado en 1997

Sequence analysis of twin ATP binding cassette proteins involved in translational control, antibiotic resistance, and ribonuclease L inhibition

artículo científico publicado en 2004

Seven-helix bundles: molecular modeling via restrained molecular dynamics.

artículo científico publicado en 1995

Simulation studies on bacteriorhodopsin bundle of transmembrane α segments

artículo científico publicado en 2000

Structure and association of ATP-binding cassette transporter nucleotide-binding domains

artículo científico publicado en 2002

Structure-based interpretation of the mutagenesis database for the nucleotide binding domains of P-glycoprotein.

artículo científico publicado en 2007

Structure-function analysis of the presumptive Arabidopsis auxin permease AUX1

article

Studies of the pore-forming domain of a voltage-gated potassium channel protein.

artículo científico publicado en 1994

The ABCG family of membrane-associated transporters: you don't have to be big to be mighty

artículo científico publicado en 2011

The ATP-binding cassette proteins of the deep-branching protozoan parasite Trichomonas vaginalis

artículo científico publicado en 2012

The auxin influx carrier LAX3 promotes lateral root emergence

article

The binding of auxin to the Arabidopsis auxin influx transporter AUX1.

artículo científico publicado en 2008

The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis

artículo científico publicado en 2014

The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment.

artículo científico publicado en 2005

The influenza A virus M2 channel: a molecular modeling and simulation study.

artículo científico publicado en 1997

The multidrug transporter ABCG2: still more questions than answers

artículo científico publicado en 2016

The nucleotide-binding domains of P-glycoprotein. Functional symmetry in the isolated domain demonstrated by N-ethylmaleimide labelling

artículo científico publicado en 2003

The pore-lining region of shaker voltage-gated potassium channels: comparison of beta-barrel and alpha-helix bundle models ⬇️

artículo científico publicado el 1 de agosto de 1997

The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein.

artículo científico publicado en 2004

The translocation mechanism of P-glycoprotein.

artículo científico publicado en 2005

Towards understanding promiscuity in multidrug efflux pumps

artículo científico publicado en 2013

Transmembrane helix 12 modulates progression of the ATP catalytic cycle in ABCB1.

artículo científico publicado en 2009

Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1.

artículo científico publicado en 2010

Unraveling the evolution of auxin signaling

artículo científico publicado en 2010

Water in channel-like cavities: structure and dynamics.

artículo científico publicado en 1996

Lista de obras de Ian D. Kerr

A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma

ABC proteins and antibiotic drug resistance: is it all about transport?

ABC transporter research: going strong 40 years on

ABCB1 in children's brain tumours.

ABCG2: does resolving its structure elucidate the mechanism?

Alamethicin Pyromellitate: An Ion-Activated Channel-Forming Peptide

Alamethicin channels - modelling via restrained molecular dynamics simulations

An atomic detail model for the human ATP binding cassette transporter P‐glycoprotein derived from disulphide cross‐ linking and homology modeling ⬇️

Analysis of the Sam50 translocase of excavate organisms supports evolution of divergent organelles from a common endosymbiotic event

Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy

Cation selectivity in ion channels

Cellular Patterning of Arabidopsis Roots Under Low Phosphate Conditions.

Communication between the nucleotide binding domains of P-glycoprotein occurs via conformational changes that involve residue 508.

Cytosolic region of TM6 in P-glycoprotein: topographical analysis and functional perturbation by site directed labeling

Definition of the domain boundaries is critical to the expression of the nucleotide-binding domains of P-glycoprotein

Detergent-free purification of ABC (ATP-binding-cassette) transporters.

Dimerization of ABCG2 analysed by bimolecular fluorescence complementation

Ferrocenoyl Derivatives of Alamethicin: Redox-Sensitive Ion Channels†

Heterologous expression of a membrane-spanning auxin importer: implications for functional analyses of auxin transporters

Hydrophilic surface maps of channel-forming peptides: analysis of amphipathic helices

Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences.

Improving the stability and function of purified ABCB1 and ABCA4: the influence of membrane lipids.

Induction of a stress response in Lactococcus lactis is associated with a resistance to ribosomally active antibiotics

Influenza virus M2 protein: a molecular modelling study of the ion channel.

Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids ⬇️

Ion channel formation by synthetic analogues of staphylococcal δ-toxin

Ion channel stability and hydrogen bonding. Molecular modelling of channels formed by synthetic alamethicin analogues.

Ion channels formed by HIV-1 Vpu: a modelling and simulation study

Ion channels formed by amphipathic helical peptides

Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?

Localisation of a family of complex-forming β-barrels in the T. vaginalis hydrogenosomal membrane

Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein

Long-term exposure to irinotecan reduces cell migration in glioma cells.

Mechanistic insight into the role of AUXIN RESISTANCE4 in trafficking of AUXIN1 and LIKE AUX1-2

Modelling membrane proteins using structural restraints

Modelling the packing of transmembrane helices: application to aquaporin-1

Modelling the restoration of wild-type dynamic behaviour in ΔF508-CFTR NBD1 by 8-cyclopentyl-1,3-dipropylxanthine

Molecular dynamics of ion/channel interactions [1]

Multidrug efflux pumps: the structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues.

Multiple drugbinding sites on the R482G isoform of the ABCG2 transporter.

New insight into the biochemical mechanisms regulating auxin transport in plants

Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors

Overcoming multiple drug resistance mechanisms in medulloblastoma.

Packing interactions of aib-containing helices: Molecular modeling of parallel dimers of simple hydrophobic helices and of alamethicin

Pediatric brain tumor cancer stem cells: cell cycle dynamics, DNA repair, and etoposide extrusion ⬇️

Picky ABCG5/G8 and promiscuous ABCG2 - a tale of fatty diets and drug toxicity

Plasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniques

Polymorphisms of the multidrug pump ABCG2: a systematic review of their effect on protein expression, function and drug pharmacokinetics

Protein-water-ion interactions in a model of the pore domain of a potassium channel: a simulation study.

Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2.

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

Residue G346 in transmembrane segment six is involved in inter-domain communication in P-glycoprotein

Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets

Secondary structure of an isolated P-region from the voltage-gated sodium channel: a molecular modelling/dynamics study

Sequence analysis of twin ATP binding cassette proteins involved in translational control, antibiotic resistance, and ribonuclease L inhibition

Seven-helix bundles: molecular modeling via restrained molecular dynamics.

Simulation studies on bacteriorhodopsin bundle of transmembrane α segments

Structure and association of ATP-binding cassette transporter nucleotide-binding domains

Structure-based interpretation of the mutagenesis database for the nucleotide binding domains of P-glycoprotein.

Structure-function analysis of the presumptive Arabidopsis auxin permease AUX1

Studies of the pore-forming domain of a voltage-gated potassium channel protein.

The ABCG family of membrane-associated transporters: you don't have to be big to be mighty

The ATP-binding cassette proteins of the deep-branching protozoan parasite Trichomonas vaginalis

The auxin influx carrier LAX3 promotes lateral root emergence

The binding of auxin to the Arabidopsis auxin influx transporter AUX1.

The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis

The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment.

The influenza A virus M2 channel: a molecular modeling and simulation study.

The multidrug transporter ABCG2: still more questions than answers

The nucleotide-binding domains of P-glycoprotein. Functional symmetry in the isolated domain demonstrated by N-ethylmaleimide labelling

The pore-lining region of shaker voltage-gated potassium channels: comparison of beta-barrel and alpha-helix bundle models ⬇️

The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein.

The translocation mechanism of P-glycoprotein.

Towards understanding promiscuity in multidrug efflux pumps

Transmembrane helix 12 modulates progression of the ATP catalytic cycle in ABCB1.

Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1.

Unraveling the evolution of auxin signaling

Water in channel-like cavities: structure and dynamics.