Lista de obras - Philippe P. Roux - Dominio Público Uruguay

A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells

artículo científico publicado en 2014

A comprehensive map of the mTOR signaling network

artículo científico publicado en 2010

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

artículo científico publicado en 2017

Actin cortex architecture regulates cell surface tension.

artículo científico publicado en 2017

Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

artículo científico publicado en 2011

Activation of transcription factors NF-kappaB and NF-IL-6 by human immunodeficiency virus type 1 protein R (Vpr) induces interleukin-8 expression

artículo científico publicado en 2000

An ErbB2 splice variant lacking exon 16 drives lung carcinoma

artículo científico publicado en 2020

Casein kinase 1ε promotes cell proliferation by regulating mRNA translation

artículo científico publicado en 2013

CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein.

artículo científico publicado en 2018

Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging.

artículo científico publicado en 2013

Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression ⬇️

artículo científico publicado el 15 de julio de 2013

Cellular control of cortical actin nucleation

artículo científico publicado en 2014

Controversies around the function of LARP1

scientific article published on 01 April 2020

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

scientific article published on 24 July 2020

Defining the role of the RSK isoforms in cancer

artículo científico publicado en 2017

Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly

artículo científico publicado en 2013

EPCR expression marks UM171-expanded CD34+ cord blood stem cells.

artículo científico publicado en 2017

ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).

artículo científico publicado en 2010

ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation

artículo científico publicado en 2019

Effect of the transient pharmacological inhibition of Mapk3/1 pathway on ovulation in mice

artículo científico publicado en 2015

Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt Signaling

artículo científico publicado en 2017

F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis

artículo científico publicado en 2020

F-box proteins elongate translation during stress recovery.

artículo científico publicado en 2012

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

artículo científico publicado en 2017

Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1.

artículo científico publicado en 2013

High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.

artículo científico publicado en 2016

Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities

artículo científico publicado en 2019

Identification of RSK substrates using an analog-sensitive kinase approach

artículo científico publicado en 2024

Insulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism.

artículo científico publicado en 2013

K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK.

artículo científico publicado en 2002

Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling

scientific article published on 09 January 2020

Mechanistic target of rapamycin (MTOR) signaling during ovulation in mice.

artículo científico publicado en 2014

Mind the GAP: Wnt steps onto the mTORC1 train

artículo científico publicado en 2006

Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration

scientific article published on 02 September 2019

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

scientific article published on 01 July 2019

Mutations in DOCK7 in individuals with epileptic encephalopathy and cortical blindness

artículo científico publicado en 2014

NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis

artículo científico publicado en 2000

Paving the way for targeting RSK in cancer.

artículo científico publicado en 2010

Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.

artículo científico publicado en 2014

Phosphorylation of the eukaryotic translation initiation factor 4E-transporter (4E-T) by c-Jun N-terminal kinase promotes stress-dependent P-body assembly.

artículo científico publicado en 2012

Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children

artículo científico publicado en 2019

Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension.

artículo científico publicado en 2004

Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion

scientific article published on 02 November 2019

Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation

artículo científico publicado en 2014

Proteomics Screen Identifies Class I Rab11 Family Interacting Proteins as Key Regulators of Cytokinesis

artículo científico publicado en 2016

Publisher Correction: Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1

artículo científico publicado en 2020

Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

artículo científico publicado en 2005

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

artículo científico publicado en 2007

RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit

artículo científico publicado en 2021

RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma.

artículo científico publicado en 2018

RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation

artículo científico publicado en 2012

RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance

artículo científico publicado en 2012

RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth

artículo científico publicado en 2012

Rapamycin resistance: mTORC1 substrates hold some of the answers

artículo científico publicado en 2013

Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.

artículo científico publicado en 2015

Regulation and function of the RSK family of protein kinases

artículo científico

Regulation of global and specific mRNA translation by the mTOR signaling pathway

artículo científico publicado en 2015

Regulation of karyopherin α1 and nuclear import by mammalian target of rapamycin

artículo científico publicado en 2012

Regulation of mRNA translation by signaling pathways

artículo científico publicado en 2012

Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1

scientific article published on 26 November 2019

SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization

artículo científico publicado en 2020

STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity

scientific article published on 01 November 2020

Signaling pathways involved in the regulation of mRNA translation.

artículo científico publicado en 2018

Targeting copper metabolism to defeat KRAS-driven colorectal cancer

scientific article published on 07 October 2020

The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation.

artículo científico publicado en 2011

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression

artículo científico publicado en 2018

The coming of age of phosphoproteomics--from large data sets to inference of protein functions

artículo científico publicado en 2013

The expanding role of mTOR in cancer cell growth and proliferation

artículo científico publicado en 2015

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

artículo científico publicado en 2006

The p75 neurotrophin receptor (p75NTR) alters tumor necrosis factor-mediated NF-kappaB activity under physiological conditions, but direct p75NTR-mediated NF-kappaB activation requires cell stress

artículo científico publicado en 1999

The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway

artículo científico publicado en 2001

The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling

artículo científico publicado en 2005

Translational control by oncogenic signaling pathways.

artículo científico publicado en 2014

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

artículo científico publicado en 2004

Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells

artículo científico publicado en 2008

mTOR, the mammalian target of rapamycin

artículo científico publicado en 2010

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling

artículo científico publicado en 2009

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

artículo científico publicado en 2010

Lista de obras de Philippe P. Roux

A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells

A comprehensive map of the mTOR signaling network

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

Actin cortex architecture regulates cell surface tension.

Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

Activation of transcription factors NF-kappaB and NF-IL-6 by human immunodeficiency virus type 1 protein R (Vpr) induces interleukin-8 expression

An ErbB2 splice variant lacking exon 16 drives lung carcinoma

Casein kinase 1ε promotes cell proliferation by regulating mRNA translation

CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein.

Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging.

Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression ⬇️

Cellular control of cortical actin nucleation

Controversies around the function of LARP1

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

Defining the role of the RSK isoforms in cancer

Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly

EPCR expression marks UM171-expanded CD34+ cord blood stem cells.

ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).

ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation

Effect of the transient pharmacological inhibition of Mapk3/1 pathway on ovulation in mice

Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt Signaling

F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis

F-box proteins elongate translation during stress recovery.

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1.

High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.

Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities

Identification of RSK substrates using an analog-sensitive kinase approach

Insulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism.

K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK.

Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling

Mechanistic target of rapamycin (MTOR) signaling during ovulation in mice.

Mind the GAP: Wnt steps onto the mTORC1 train

Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

Mutations in DOCK7 in individuals with epileptic encephalopathy and cortical blindness

NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis

Paving the way for targeting RSK in cancer.

Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.

Phosphorylation of the eukaryotic translation initiation factor 4E-transporter (4E-T) by c-Jun N-terminal kinase promotes stress-dependent P-body assembly.

Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children

Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension.

Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion

Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation

Proteomics Screen Identifies Class I Rab11 Family Interacting Proteins as Key Regulators of Cytokinesis

Publisher Correction: Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1

Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit

RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma.

RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation

RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance

RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth

Rapamycin resistance: mTORC1 substrates hold some of the answers

Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.

Regulation and function of the RSK family of protein kinases

Regulation of global and specific mRNA translation by the mTOR signaling pathway

Regulation of karyopherin α1 and nuclear import by mammalian target of rapamycin

Regulation of mRNA translation by signaling pathways

Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1

SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization

STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity

Signaling pathways involved in the regulation of mRNA translation.

Targeting copper metabolism to defeat KRAS-driven colorectal cancer

The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation.

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression

The coming of age of phosphoproteomics--from large data sets to inference of protein functions

The expanding role of mTOR in cancer cell growth and proliferation

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

The p75 neurotrophin receptor (p75NTR) alters tumor necrosis factor-mediated NF-kappaB activity under physiological conditions, but direct p75NTR-mediated NF-kappaB activation requires cell stress

The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway

The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling

Translational control by oncogenic signaling pathways.

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells

mTOR, the mammalian target of rapamycin

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide