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Lista de obras de Charles G Mullighan

A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor.

artículo científico publicado en 2017

A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults

artículo científico publicado en 2014

A genomic random interval model for statistical analysis of genomic lesion data

artículo científico publicado en 2013

A novel retinoblastoma therapy from genomic and epigenetic analyses

artículo científico publicado en 2012

A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403

scientific article published on 18 January 2019

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

artículo científico publicado en 2013

Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia

artículo científico publicado en 2012

Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia

artículo científico publicado en 2010

Acquired isolated factor VII deficiency associated with severe bleeding and successful treatment with recombinant FVIIa (NovoSeven).

artículo científico publicado en 2004

Acute lymphoblastic leukaemia

artículo científico publicado en 2013

Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group

artículo científico publicado en 2013

Adhesion molecule polymorphisms in chronic renal allograft failure

artículo científico publicado en 1999

Advances in the genetics of high-risk childhood B-progenitor acute lymphoblastic leukemia and juvenile myelomonocytic leukemia: implications for therapy

artículo científico publicado en 2012

Analysis of the Relationship Between Mannose-Binding Lectin (MBL) Genotype, MBL Levels and Function in an Australian Blood Donor Population

article

Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation

artículo científico publicado en 2011

Analysis of the coding genome of diffuse large B-cell lymphoma

artículo científico publicado en 2011

Antileukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia

artículo científico publicado en 2019

Assessment of male CVID patients for mutations in the Btk gene: how many have been misdiagnosed?

article

Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia

artículo científico publicado en 2019

CONSERTING: integrating copy-number analysis with structural-variation detection

artículo científico publicado en 2015

CREBBP mutations in relapsed acute lymphoblastic leukaemia

artículo científico publicado en 2011

CREST maps somatic structural variation in cancer genomes with base-pair resolution.

artículo científico publicado en 2011

Cell of origin strongly influences genetic selection in a mouse model of T-ALL

artículo científico publicado en 2011

Characterization of leukemias with ETV6-ABL1 fusion

artículo científico publicado en 2016

Clinical efficacy of ruxolitinib and chemotherapy in a child with Philadelphia chromosome-like acute lymphoblastic leukemia with GOLGA5-JAK2 fusion and induction failure.

artículo científico publicado en 2018

Clinical interpretation of whole-genome and whole-transcriptome sequencing for precision oncology

scientific article published on 10 July 2021

Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia

artículo científico publicado en 2018

Co-occurrence of CRLF2-rearranged and Ph+ acute lymphoblastic leukemia: a report of four patients

artículo científico publicado en 2017

Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors

artículo científico publicado en 2013

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

artículo científico publicado en 2014

Cyclin C is a haploinsufficient tumour suppressor

artículo científico publicado en 2014

Cytochrome P450 1A2 is a target antigen in hepatitic graft-versus-host disease

article

CytofIn enables integrated analysis of public mass cytometry datasets using generalized anchors

artículo científico publicado en 2022

Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo

artículo científico publicado en 2013

Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia

artículo científico publicado en 2009

Deregulation of DUX4 and ERG in acute lymphoblastic leukemia

artículo científico publicado en 2016

Dominant-negative Ikaros cooperates with BCR-ABL1 to induce human acute myeloid leukemia in xenografts

artículo científico publicado en 2014

Donor Mannose‐Binding Lectin Deficiency Increases the Likelihood of Clinically Significant Infection after Liver Transplantation

article

ETV6-NTRK3 induces aggressive acute lymphoblastic leukemia highly sensitive to selective TRK inhibition

artículo científico publicado en 2018

Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia

artículo científico publicado en 2015

Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia.

artículo científico publicado en 2013

Enhancer Hijacking Drives Oncogenic <i>BCL11B</i> Expression in Lineage-Ambiguous Stem Cell Leukemia

publication published on 08 June 2021

Evaluation of the in vitro and in vivo efficacy of the JAK inhibitor AZD1480 against JAK-mutated acute lymphoblastic leukemia

artículo científico publicado en 2014

Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells.

artículo científico publicado en 2011

Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL.

artículo científico publicado en 2008

Fas gene promoter polymorphisms in primary Sjögren's syndrome

artículo científico publicado en 2004

From trees to the forest: genes to genomics

artículo científico publicado en 2011

GATA3 rs3824662A allele is associated with CRLF2 rearranged B-cell acute lymphoblastic leukemia in adults and adolescents and young adults (AYAs) and is associated with poor prognosis

artículo científico publicado en 2020

Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia

artículo científico publicado en 2009

Genetic Alterations Targeting Lymphoid Development in Acute Lymphoblastic Leukemia

article

Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia

artículo científico publicado en 2012

Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia

scientific article published on 25 June 2018

Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome

artículo científico publicado en 2013

Genetic variation and the risk of acute lymphoblastic leukemia

scientific article published on 09 June 2010

Genome-wide analysis links NFATC2 with asparaginase hypersensitivity

artículo científico publicado en 2015

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

artículo científico publicado en 2007

Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma

artículo científico publicado en 2019

Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions.

artículo científico publicado en 2009

Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11.

artículo científico publicado en 2007

Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia

artículo científico publicado en 2016

Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.

artículo científico publicado en 2008

Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia

scholarly article

Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the Children's Oncology Group

scientific article published on 11 July 2018

Genomic characterization of childhood acute lymphoblastic leukemia

scientific article published on 04 October 2013

Genomic polymorphism and allogeneic hematopoietic transplantation outcome.

artículo científico publicado en 2006

Genomic profiling of B-progenitor acute lymphoblastic leukemia

artículo científico publicado en 2011

Genomic profiling of high-risk acute lymphoblastic leukemia.

artículo científico publicado en 2010

Genomic subtyping and therapeutic targeting of acute erythroleukemia

artículo científico publicado en 2019

Genomics in acute lymphoblastic leukaemia: insights and treatment implications

artículo científico

Germline ETV6 Mutations Confer Susceptibility to Acute Lymphoblastic Leukemia and Thrombocytopenia

artículo científico publicado en 2015

Germline SAMD9 and SAMD9L mutations are associated with extensive genetic evolution and diverse hematologic outcomes

artículo científico publicado en 2018

Germline deletion of in familial acute lymphoblastic leukemia

scientific article published on 01 April 2019

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

artículo científico publicado en 2013

Global genomic characterization of acute lymphoblastic leukemia

artículo científico publicado en 2009

High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults

artículo científico publicado en 2016

Highly sensitive MRD tests for ALL based on the IKZF1 Δ3-6 microdeletion

artículo científico publicado en 2011

How new advances in genetic analysis are influencing the understanding and treatment of childhood acute leukemia

artículo científico publicado en 2011

Human cytomegalovirus infection is not increased in common variable immunodeficiency

artículo científico publicado en 1996

Human gastrointestinal neoplasia-associated myofibroblasts can develop from bone marrow-derived cells following allogeneic stem cell transplantation.

artículo científico publicado en 2009

Hyper-CVAD regimen in combination with ofatumumab as frontline therapy for adults with Philadelphia chromosome-negative B-cell acute lymphoblastic leukaemia: a single-arm, phase 2 trial

artículo científico publicado en 2020

IDH1 and IDH2 mutations in pediatric acute leukemia

artículo científico publicado en 2011

Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk

scientific article published on 25 November 2019

Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome

artículo científico publicado en 2010

Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors.

artículo científico publicado en 2013

Improving outcomes for high-risk ALL: translating new discoveries into clinical care

scientific article published on 15 February 2011

Inactivating mutations of acetyltransferase genes in B-cell lymphoma

artículo científico publicado en 2011

Increased baseline RASGRP1 signals enhance stem cell fitness during native hematopoiesis

artículo científico publicado en 2020

Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse

artículo científico publicado en 2013

Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children

artículo científico publicado en 2015

Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia

artículo científico publicado en 2013

Integrative genomic analysis of B-lymphoblastic lymphoma with intrachromosomal amplification of chromosome 21

artículo científico publicado en 2020

Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential.

artículo científico publicado en 2014

Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia

artículo científico publicado en 2021

Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-β, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth

article

JAK mutations in high-risk childhood acute lymphoblastic leukemia

scholarly article

JAK2—a new player in acute lymphoblastic leukaemia

artículo científico publicado en 2008

Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group

artículo científico publicado en 2011

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways

artículo científico publicado en 2014

LOHAS: loss-of-heterozygosity analysis suite

artículo científico publicado en 2011

Lack of association between mannose-binding lectin gene polymorphisms and primary Sjögren's syndrome

article

Lin28 promotes transformation and is associated with advanced human malignancies

scientific article published on 31 May 2009

Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia

artículo científico publicado en 2013

Loss of p19Arf in a Rag1(-/-) B-cell precursor population initiates acute B-lymphoblastic leukemia

artículo científico publicado en 2011

MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours.

artículo científico publicado en 2015

Mannose Binding Lectin Polymorphisms are Associated With Early Age of Disease Onset and Autoimmunity in Common Variable Immunodeficiency

artículo científico publicado en 2000

Mannose-Binding Lectin and Liver Transplantation

artículo científico publicado en 2005

Mannose-binding lectin and gastric cancer

artículo científico publicado en 2007

Mannose-binding lectin deficiency does not increase the prevalence of Helicobacter pylori seropositivity

artículo científico publicado en 2007

Mannose-binding lectin gene polymorphisms are associated with major infection following allogeneic hemopoietic stem cell transplantation.

artículo científico publicado en 2002

Mannose-binding lectin promoter and structural gene variants in sarcoidosis

artículo científico publicado en 2000

Mannose-binding lectin status is associated with risk of major infection following myeloablative sibling allogeneic hematopoietic stem cell transplantation

artículo científico publicado en 2008

Mannose-binding lectin: biology and clinical implications

artículo científico publicado en 2005

Modeling the evolution of ETV6-RUNX1-induced B-cell precursor acute lymphoblastic leukemia in mice.

artículo científico publicado en 2011

Mutant PRPS1: a new therapeutic target in relapsed acute lymphoblastic leukemia

artículo científico publicado en 2015

Mutations of NOTCH1, FBXW7, and prognosis in T-lineage acute lymphoblastic leukemia

artículo científico publicado en 2009

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells

artículo científico publicado en 2015

Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia

artículo científico publicado en 2021

New Strategies in Acute Lymphoblastic Leukemia: Translating Advances in Genomics into Clinical Practice ⬇️

artículo científico publicado el 13 de diciembre de 2010

New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironment

artículo científico publicado en 2018

Non-HLA immunogenetic polymorphisms and the risk of complications after allogeneic hemopoietic stem-cell transplantation.

artículo científico publicado en 2004

Notch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression.

artículo científico publicado en 2011

Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations

scientific journal article

Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics

artículo científico publicado en 2018

OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL

scientific article published on 23 April 2019

Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study

artículo científico publicado en 2012

Outcomes of children with BCR-ABL1–like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease

artículo científico publicado en 2014

PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia.

artículo científico publicado en 2015

PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia

scientific article published on 14 January 2019

PHF6 mutations in T-lineage acute lymphoblastic leukemia

artículo científico publicado en 2010

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia

artículo científico publicado en 2014

Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias

article

Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8+ T cell responses

scientific article published on 01 June 2019

Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults

artículo científico publicado en 2016

Polymorphisms in immunoregulatory genes and the risk of histologic chorioamnionitis in Caucasoid women: a case control study

artículo científico publicado en 2005

Rare allelic forms of PRDM9 associated with childhood leukemogenesis.

artículo científico publicado en 2012

Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia

scientific article published on 18 October 2009

Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia

artículo científico publicado en 2010

Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors.

artículo científico publicado en 2015

Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine

artículo científico publicado en 2015

Reference alignment of SNP microarray signals for copy number analysis of tumors

artículo científico publicado en 2008

Relapse of BCR-ABL1-like ALL mediated by the ABL1 kinase domain mutation T315I following initial response to dasatinib treatment.

artículo científico publicado en 2014

Relapse-Fated Latent Diagnosis Subclones in Acute B Lineage Leukemia Are Drug Tolerant and Possess Distinct Metabolic Programs

scientific article published on 21 February 2020

Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia.

artículo científico publicado en 2015

Shared acquired genomic changes in zebrafish and human T-ALL.

artículo científico publicado en 2011

Single Nucleotide Polymorphism Microarray Analysis of Genetic Alterations in Cancer ⬇️

artículo científico publicado el 1 de enero de 2011

Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia

artículo científico publicado en 2013

Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells

artículo científico publicado en 2011

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

artículo científico publicado en 2012

St. Jude Cloud-a Pediatric Cancer Genomic Data Sharing Ecosystem

artículo científico publicado en 2021

Subclonal evolution in disease progression from MGUS/SMM to multiple myeloma is characterised by clonal stability

artículo científico publicado en 2018

T-Lineage Lymphoblastic Lymphoma and Leukemia—a MASSive Problem

scientific article published on 01 October 2010

TET2 mutations in myelodysplasia and myeloid malignancies

Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group

artículo científico publicado en 2017

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia

artículo científico publicado en 2014

Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia

artículo científico publicado en 2012

The ASH Agenda for Hematology Research: a roadmap for advancing scientific discovery and cures for hematologic diseases

scientific article published on 01 October 2018

The Biology of B-Progenitor Acute Lymphoblastic Leukemia

scientific article published on 25 October 2019

The Heme-regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics

scientific article published on 07 December 2020

The Role of TET2 in Hematologic Neoplasms

artículo científico publicado en 2011

The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy.

artículo científico publicado en 2012

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

artículo científico publicado en 2012

The genomic landscape of acute lymphoblastic leukemia in children and young adults

artículo científico publicado en 2014

The genomic landscape of core-binding factor acute myeloid leukemias

artículo científico publicado en 2016

The genomic landscape of hypodiploid acute lymphoblastic leukemia

artículo científico publicado en 2013

The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia.

artículo científico publicado en 2017

The genomic landscape of pediatric myelodysplastic syndromes.

artículo científico publicado en 2017

The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

artículo científico publicado en 2015

Therapy of pediatric ALL: from Bowie to Obama

artículo científico publicado en 2013

Tissue plasminogen activator -7351C/T enhancer polymorphism is a risk factor for lacunar stroke.

artículo científico publicado en 2004

Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia

artículo científico publicado en 2016

Tyrosine kinase inhibitor therapy induces remission in a patient with refractory EBF1-PDGFRB-positive acute lymphoblastic leukemia.

artículo científico publicado en 2013

Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project

artículo científico publicado en 2012

VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.

artículo científico publicado en 2013

Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer

artículo científico publicado en 2012

Variation in immune response genes and chronic Q fever. Concepts: preliminary test with post-Q fever fatigue syndrome.

artículo científico publicado en 2003

Vitamin D receptor gene polymorphism: association with Crohn's disease susceptibility.

artículo científico publicado en 2000

Welcoming a new age for gene therapy in hematology

artículo científico publicado en 2016

Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

artículo científico publicado en 2013

YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway

artículo científico publicado en 2015

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