Lista de obras - Andrew J Murphy - Dominio Público Uruguay

"Transactivation" control signals in the promoter of the herpesvirus thymidine kinase gene.

scientific article published on February 1985

A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies

artículo científico publicado en 2020

A novel bispecific antibody platform to direct complement activity for efficient lysis of target cells

scientific article published on 19 August 2019

A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production

artículo científico publicado en 2017

A rapid procedure for isolation of RNA-free genomic DNA from mammalian cells.

artículo científico publicado en 1993

ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.

artículo científico publicado en 2015

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys.

artículo científico publicado en 2015

ANGPTL4-αvβ3 interaction counteracts hypoxia-induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2.

artículo científico publicado en 2016

ANGPTL8/betatrophin does not control pancreatic beta cell expansion

artículo científico publicado en 2014

Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1.

artículo científico publicado en 2010

Absence of central tolerance in Aire-deficient mice synergizes with immune-checkpoint inhibition to enhance antitumor responses

scientific article published on 08 July 2020

Agouti-related protein-deficient mice display an age-related lean phenotype

artículo científico publicado en 2005

Alteration of developmental and pathological retinal angiogenesis in angptl4-deficient mice.

artículo científico publicado en 2011

Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung.

artículo científico publicado en 2009

An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

artículo científico publicado en 2019

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.

artículo científico publicado en 2011

Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis.

artículo científico publicado en 2009

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

artículo científico publicado en 2020

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

artículo científico publicado en 2015

C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice.

artículo científico publicado en 2016

CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors

artículo científico publicado en 2008

CS-21EphA2 PROMOTES INFILTRATIVE INVASION OF GLIOMA STEM CELLS IN VIVO THROUGH CROSSTALK WITH Akt AND REGULATES STEM PROPERTIES

Cell-specified expression of a selectable hybrid gene ⬇️

artículo científico publicado el 1 de agosto de 1984

Chronic allergen exposure drives accumulation of long-lived IgE plasma cells in the bone marrow, giving rise to serological memory

scientific article published on 01 January 2020

Cloning vectors for expression of cDNA libraries in mammalian cells

artículo científico publicado en 1987

Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8+ T cell dysfunction and maintain memory phenotype

artículo científico publicado en 2018

Conditionals by inversion provide a universal method for the generation of conditional alleles

scientific journal article

Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis

artículo científico publicado en 2009

Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis

scientific article published on 01 September 2006

Efficient differentiation and function of human macrophages in humanized CSF-1 mice

artículo científico publicado en 2011

Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination

artículo científico publicado en 2010

EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties.

artículo científico publicado en 2014

Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury

article

From DNA to drugs: the orphan G-protein coupled receptors.

artículo científico publicado en 1998

Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo

scientific journal article

GPR17 gene disruption does not alter food intake or glucose homeostasis in mice.

artículo científico publicado en 2015

Generation of functional multipotent adult stem cells from GPR125+ germline progenitors

artículo científico publicado en 2007

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

artículo científico publicado en 2017

Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis

artículo científico publicado en 2007

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

artículo científico publicado en 2018

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.

artículo científico publicado en 2010

Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys

artículo científico

Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation

artículo científico publicado en 2008

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

artículo científico publicado en 2004

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

artículo científico publicado en 2003

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

artículo científico publicado en 2011

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

artículo científico publicado en 2011

Humanized mouse model supports development, function, and tissue residency of human natural killer cells

artículo científico publicado en 2017

Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis.

artículo científico publicado en 2009

IL-22 promotes fibroblast-mediated wound repair in the skin

artículo científico publicado en 2012

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

scientific journal article

Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast.

artículo científico publicado en 1998

In Vivo Quantitative Microcomputed Tomographic Analysis of Vasculature and Organs in a Normal and Diseased Mouse Model

artículo científico publicado en 2016

In-silico discovery of cancer-specific peptide-HLA complexes for targeted therapy

artículo científico publicado en 2016

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease

artículo científico publicado en 2016

Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease

artículo científico publicado en 2008

Interleukin-19 is a negative regulator of innate immunity and critical for colonic protection

artículo científico publicado en 2010

Interleukin-19 protects mice from innate-mediated colonic inflammation

artículo científico publicado en 2010

Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation

artículo científico publicado en 2007

Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation

artículo científico publicado en 2005

Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus

artículo científico publicado en 2005

Long form of latent TGF- binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling

artículo científico publicado en 2007

Loss of SFRP4 Alters Body Size, Food Intake, and Energy Expenditure in Diet-Induced Obese Male Mice

artículo científico publicado en 2015

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

scientific journal article

Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice

artículo científico publicado en 2016

Mice completely lacking immunoproteasomes show major changes in antigen presentation

artículo científico publicado en 2011

Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses

artículo científico publicado en 2007

Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice

artículo científico publicado en 2014

Mutants deleted in the agnogene of simian virus 40 define a new complementation group ⬇️

artículo científico publicado el 1 de enero de 1983

Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice

artículo científico publicado en 2015

Ongoing Dll4-Notch signaling is required for T-cell homeostasis in the adult thymus

artículo científico publicado en 2011

Peptide YY regulates bone turnover in rodents

artículo científico publicado en 2007

Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina.

artículo científico publicado en 2006

Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis

artículo científico publicado en 2018

Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes.

artículo científico publicado en 2014

Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4.

artículo científico publicado en 2011

Protective effects of angiopoietin-like 4 on cerebrovascular and functional damages in ischaemic stroke

artículo científico publicado en 2013

Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence ⬇️

scientific article published on 26 November 2019

Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections.

artículo científico publicado en 2008

REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters

artículo científico publicado en 2020

RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.

artículo científico publicado en 2008

Regulation of the germinal center response by microRNA-155

artículo científico publicado en 2007

Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5

artículo científico publicado en 2005

Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility

artículo científico publicado en 2006

Ric-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane association

artículo científico publicado en 2011

Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice.

artículo científico publicado en 2010

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

artículo científico publicado en 2006

SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease

artículo científico publicado en 2013

Single-Cell RNAseq Reveals That Pancreatic β-Cells From Very Old Male Mice Have a Young Gene Signature

artículo científico publicado en 2016

Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice

scientific journal article

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

artículo científico publicado en 2020

TLR8 deficiency leads to autoimmunity in mice

artículo científico publicado en 2010

The loss-of-allele assay for ES cell screening and mouse genotyping

artículo científico publicado en 2010

The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis

artículo científico publicado en 2008

Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement.

artículo científico publicado en 2018

Tumor-targeted CD28 bispecific antibodies enhance the antitumor efficacy of PD-1 immunotherapy

scientific article published on 01 June 2020

Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain

scientific article published on 09 December 2007

Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells.

artículo científico publicado en 2016

VEGF-mediated inflammation precedes angiogenesis in adult brain

artículo científico publicado en 2004

Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis

scientific journal article

p lambda Zd39: a new type of cDNA expression vector for low background, high efficiency directional cloning

artículo científico publicado en 1991

Lista de obras de Andrew J Murphy

"Transactivation" control signals in the promoter of the herpesvirus thymidine kinase gene.

A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies

A novel bispecific antibody platform to direct complement activity for efficient lysis of target cells

A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production

A rapid procedure for isolation of RNA-free genomic DNA from mammalian cells.

ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys.

ANGPTL4-αvβ3 interaction counteracts hypoxia-induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2.

ANGPTL8/betatrophin does not control pancreatic beta cell expansion

Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1.

Absence of central tolerance in Aire-deficient mice synergizes with immune-checkpoint inhibition to enhance antitumor responses

Agouti-related protein-deficient mice display an age-related lean phenotype

Alteration of developmental and pathological retinal angiogenesis in angptl4-deficient mice.

Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung.

An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.

Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis.

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice.

CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors

CS-21EphA2 PROMOTES INFILTRATIVE INVASION OF GLIOMA STEM CELLS IN VIVO THROUGH CROSSTALK WITH Akt AND REGULATES STEM PROPERTIES

Cell-specified expression of a selectable hybrid gene ⬇️

Chronic allergen exposure drives accumulation of long-lived IgE plasma cells in the bone marrow, giving rise to serological memory

Cloning vectors for expression of cDNA libraries in mammalian cells

Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8+ T cell dysfunction and maintain memory phenotype

Conditionals by inversion provide a universal method for the generation of conditional alleles

Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis

Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis

Efficient differentiation and function of human macrophages in humanized CSF-1 mice

Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination

EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties.

Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury

From DNA to drugs: the orphan G-protein coupled receptors.

Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo

GPR17 gene disruption does not alter food intake or glucose homeostasis in mice.

Generation of functional multipotent adult stem cells from GPR125+ germline progenitors

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.

Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys

Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

Humanized mouse model supports development, function, and tissue residency of human natural killer cells

Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis.

IL-22 promotes fibroblast-mediated wound repair in the skin

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast.

In Vivo Quantitative Microcomputed Tomographic Analysis of Vasculature and Organs in a Normal and Diseased Mouse Model

In-silico discovery of cancer-specific peptide-HLA complexes for targeted therapy

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease

Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease

Interleukin-19 is a negative regulator of innate immunity and critical for colonic protection

Interleukin-19 protects mice from innate-mediated colonic inflammation

Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation

Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation

Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus

Long form of latent TGF- binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling

Loss of SFRP4 Alters Body Size, Food Intake, and Energy Expenditure in Diet-Induced Obese Male Mice

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice

Mice completely lacking immunoproteasomes show major changes in antigen presentation

Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses

Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice

Mutants deleted in the agnogene of simian virus 40 define a new complementation group ⬇️

Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice

Ongoing Dll4-Notch signaling is required for T-cell homeostasis in the adult thymus

Peptide YY regulates bone turnover in rodents

Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina.

Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis

Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes.

Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4.

Protective effects of angiopoietin-like 4 on cerebrovascular and functional damages in ischaemic stroke

Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence ⬇️

Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections.