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Lista de obras de William G. Kerr

A critical role for Stat3 signaling in immune tolerance

artículo científico publicado en 2003

A rapid and quantitative assay to estimate gene transfer into retrovirally transduced hematopoietic stem/progenitor cells using a 96-well format PCR and fluorescent detection system universal for MMLV-based proviruses

artículo científico publicado en 1996

A role for SHIP in stem cell biology and transplantation.

scientific article published on May 2008

Analysis of apoptosis in hematopoietic stem cells by flow cytometry

artículo científico publicado en 2008

Analysis of lipopolysaccharide-response genes in B-lineage cells demonstrates that they can have differentiation stage-restricted expression and contain SH2 domains.

artículo científico publicado en 1996

Coordinate expansion of murine hematopoietic and mesenchymal stem cell compartments by SHIPi

artículo científico publicado en 2015

Cutting edge: dominance by an MHC-independent inhibitory receptor compromises NK killing of complex targets

artículo científico publicado en 2006

Deregulated expression of LRBA facilitates cancer cell growth

artículo científico publicado en 2004

Detection and isolation of gene-corrected cells in Gaucher disease via a fluorescence-activated cell sorter assay for lysosomal glucocerebrosidase activity.

artículo científico publicado en 1997

Discovery and development of small molecule SHIP phosphatase modulators

artículo científico publicado en 2013

Dual enhancement of T and NK cell function by pulsatile inhibition of SHIP1 improves antitumor immunity and survival.

artículo científico publicado en 2017

Embryonic and hematopoietic stem cells express a novel SH2-containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein

artículo científico publicado en 2001

Expansion of myeloid suppressor cells in SHIP-deficient mice represses allogeneic T cell responses

article

Expression of individual immunoglobulin genes occurs in an unusual system consisting of multiple independent loci

article

Farnesyltransferase inhibitor R115777 (Zarnestra, Tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells.

artículo científico publicado en 2005

Follicular dendritic cell (FDC) precursors in primary lymphoid tissues

artículo científico publicado en 1998

Gene therapy: current status and future prospects

artículo científico publicado en 1994

Genetic modification of the hematolymphoid compartment for therapeutic purposes

artículo científico publicado el 1 de junio de 1998

Identification of a novel lipopolysaccharide-inducible gene with key features of both A kinase anchor proteins and chs1/beige proteins

scientific journal article

Impaired T-cell survival promotes mucosal inflammatory disease in SHIP1-deficient mice

artículo científico publicado en 2014

In situ detection of transcriptionally active chromatin and genetic regulatory elements in individual viable mammalian cells.

artículo científico publicado en 1989

Inappropriate recruitment and activity by the Src homology region 2 domain-containing phosphatase 1 (SHP1) is responsible for receptor dominance in the SHIP-deficient NK cell

artículo científico publicado en 2007

Induced SHIP deficiency expands myeloid regulatory cells and abrogates graft-versus-host disease

artículo científico publicado en 2007

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

artículo científico publicado en 2005

Inhibitor and activator: dual functions for SHIP in immunity and cancer

artículo científico publicado el 13 de diciembre de 2010

Introduction to Inositol Phospholipid Signaling in Physiology and Disease

artículo científico publicado el 1 de marzo de 2013

Lineage extrinsic and intrinsic control of immunoregulatory cell numbers by SHIP.

artículo científico publicado en 2012

Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation

artículo científico publicado en 2016

Ly49Q positively regulates type I IFN production by plasmacytoid dendritic cells in an immunoreceptor tyrosine-based inhibitory motif-dependent manner.

artículo científico publicado en 2013

Major remodelling of the murine stem cell kinome following differentiation in the hematopoietic compartment

artículo científico publicado en 2011

Mouse natural killer cell development and maturation are differentially regulated by SHIP-1.

artículo científico publicado en 2012

Myeloid cell-specific expression of Ship1 regulates IL-12 production and immunity to helminth infection

article

Overexpression of SH2-Containing Inositol Phosphatase Contributes to Chronic Lymphocytic Leukemia Survival

scientific article published on 13 December 2019

Pan-SHIP1/2 inhibitors promote microglia effector functions essential for CNS homeostasis

artículo científico publicado en 2020

Progress towards a new wave of immune-based therapeutics

article

Quorum Sensing Contributes to Activated IgM-Secreting B Cell Homeostasis

artículo científico publicado el 3 de diciembre de 2012

Regulation of IgM and IgD expression in human B-lineage cells

artículo científico publicado en 1991

Relationship between selectin-mediated rolling of hematopoietic stem and progenitor cells and progression in hematopoietic development

artículo científico publicado en 2000

Role of SHIP1 in Invariant NKT Cell Development and Functions

artículo científico publicado en 2015

Role of SHIP1 in bone biology

artículo científico

Role of SHIP1 in cancer and mucosal inflammation

artículo científico publicado en 2013

Role of c-mpl in early hematopoiesis.

artículo científico publicado en 1998

Role of inositol phospholipid signaling in natural killer cell biology.

artículo científico

Role of inositol poly-phosphatases and their targets in T cell biology

artículo científico publicado en 2013

SH2-inositol phosphatase 1 negatively influences early megakaryocyte progenitors

artículo científico publicado en 2008

SHIP deficiency causes Crohn's disease-like ileitis

artículo científico publicado en 2010

SHIP deficiency enhances HSC proliferation and survival but compromises homing and repopulation

artículo científico publicado en 2006

SHIP influences signals from CD48 and MHC class I ligands that regulate NK cell homeostasis, effector function, and repertoire formation

artículo científico publicado en 2010

SHIP is required for a functional hematopoietic stem cell niche.

artículo científico publicado en 2008

SHIP limits immunoregulatory capacity in the T-cell compartment.

artículo científico publicado en 2009

SHIP represses Th2 skewing by inhibiting IL-4 production from basophils

artículo científico publicado en 2010

SHIP-1 Couples to the Dectin-1 hemITAM and Selectively Modulates Reactive Oxygen Species Production in Dendritic Cells in Response to Candida albicans

artículo científico publicado en 2015

SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation

artículo científico publicado en 2014

SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells.

artículo científico publicado en 2010

SHIP1 intrinsically regulates NK cell signaling and education, resulting in tolerance of an MHC class I-mismatched bone marrow graft in mice

artículo científico publicado en 2015

SHIP1 regulates MSC numbers and their osteolineage commitment by limiting induction of the PI3K/Akt/β-catenin/Id2 axis

artículo científico publicado en 2014

SHIP1-expressing mesenchymal stem cells regulate hematopoietic stem cell homeostasis and lineage commitment during aging.

artículo científico publicado en 2015

SHIPi Enhances Autologous and Allogeneic Hematolymphoid Stem Cell Transplantation.

artículo científico publicado en 2015

Small molecule targeting of SHIP1 and SHIP2

artículo científico publicado en 2020

Stage-specific transcription of germline IgH C gamma and C alpha regions during human B cell differentiation

artículo científico publicado en 1991

TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.

artículo científico publicado en 2010

The Next Generation of Immunotherapy for Cancer: Small Molecules Could Make Big Waves

artículo científico publicado en 2019

The mouse that lost its appetite for human

artículo científico publicado en 2013

The thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells.

artículo científico publicado en 2006

Therapeutic potential of SH2 domain-containing inositol-5'-phosphatase 1 (SHIP1) and SHIP2 inhibition in cancer

artículo científico publicado en 2012

Transcriptionally defective retroviruses containing lacZ for the in situ detection of endogenous genes and developmentally regulated chromatin

artículo científico publicado en 1989

Widespread deregulation of phosphorylation-based signaling pathways in multiple myeloma cells: opportunities for therapeutic intervention

artículo científico publicado en 2011

miR-155 Upregulation in Dendritic Cells Is Sufficient To Break Tolerance In Vivo by Negatively Regulating SHIP1.

artículo científico publicado en 2015

s-SHIP associates with receptor complexes essential for pluripotent stem cell growth and survival.

artículo científico publicado en 2006