Lista de obras - Walter Becker - Dominio Público Uruguay

10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.

artículo científico publicado en 2015

A complex interaction pattern of CIS and SOCS2 with the leptin receptor

artículo científico publicado en 2006

A wake-up call to quiescent cancer cells - potential use of DYRK1B inhibitors in cancer therapy

artículo científico publicado en 2017

Activation, regulation, and inhibition of DYRK1A.

artículo científico publicado en 2010

Alternative splicing variants of dual specificity tyrosine phosphorylated and regulated kinase 1B exhibit distinct patterns of expression and functional properties

artículo científico publicado en 2003

Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat.

artículo científico publicado en 2002

Characterization of cyclin L1 as an immobile component of the splicing factor compartment

artículo científico publicado en 2007

Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors

artículo científico publicado en 2004

Characterization of the human DYRK1A promoter and its regulation by the transcription factor E2F1.

artículo científico publicado en 2008

Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases

scientific journal article

Cloning and functional characterization of the ovine malic enzyme promoter

artículo científico publicado en 2008

Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases

artículo científico publicado en 1995

Cloning of a novel member (ARL5) of the ARF-family of Ras-related GTPases

scientific journal article

Comparison of the effects of insulin, PDGF, interleukin-6, and interferon-gamma on glucose transport in 3T3-L1 cells: lack of cross-talk between tyrosine kinase receptors and JAK/STAT pathways

artículo científico publicado en 1996

DYRK protein kinases

artículo científico publicado en 2015

DYRK1 is a co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression.

artículo científico publicado en 2003

DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain

artículo científico publicado en 2017

Development of a sensitive non-radioactive protein kinase assay and its application for detecting DYRK activity in Xenopus laevis oocytes

artículo científico publicado en 2010

Differential hepatic gene expression in a polygenic mouse model with insulin resistance and hyperglycemia: evidence for a combined transcriptional dysregulation of gluconeogenesis and fatty acid synthesis

artículo científico publicado en 2004

Distribution of the mRNA for protein phosphatase T in rat brain

artículo científico publicado en 1996

Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII

scientific journal article

Effect of hyperinsulinemia and type 2 diabetes-like hyperglycemia on expression of hepatic cytochrome p450 and glutathione s-transferase isoforms in a New Zealand obese-derived mouse backcross population

artículo científico publicado en 2002

Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).

artículo científico publicado en 2015

Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control ⬇️

artículo científico publicado el 23 de agosto de 2012

Extracellular ATP activates NFAT-dependent gene expression in neuronal PC12 cells via P2X receptors

artículo científico publicado en 2011

Functional characterization of DYRK1A missense variants associated with a syndromic form of intellectual deficiency and autism

artículo científico publicado en 2018

How to Separate Kinase Inhibition from Undesired Monoamine Oxidase A Inhibition-The Development of the DYRK1A Inhibitor AnnH75 from the Alkaloid Harmine

artículo científico publicado en 2020

Hyperleptinemia and leptin receptor variant Asp600Asn in the obese, hyperinsulinemic KK mouse strain

artículo científico publicado en 1998

Hyperleptinemia, leptin resistance, and polymorphic leptin receptor in the New Zealand obese mouse.

artículo científico publicado en 1997

Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1A

artículo científico publicado en 2001

Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers

artículo científico publicado en 2002

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design.

artículo científico publicado en 2018

Isolation and characterization of a cDNA clone encoding a novel jasmonate-induced protein of barley (Hordeum vulgare L.).

artículo científico publicado en 1992

JIP60, a methyl jasmonate-induced ribosome-inactivating protein involved in plant stress reactions

artículo científico publicado en 1994

Leptin induces inflammation-related genes in RINm5F insulinoma cells

scientific journal article

Long-term and rapid regulation of ob mRNA levels in adipose tissue from normal (Sprague Dawley rats) and obese (db/db mice, fa/fa rats) rodents.

artículo científico publicado en 1996

Mechanism of attenuation of leptin signaling under chronic ligand stimulation

artículo científico publicado en 2010

Mechanism of dual specificity kinase activity of DYRK1A.

artículo científico publicado en 2013

Minibrain/DYRK1A gene: candidate gene for mental retardation in Down's syndrome?

artículo científico publicado en 2000

Mutational analysis of two residues in the DYRK homology box of the protein kinase DYRK1A.

artículo científico publicado en 2018

NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect

artículo científico publicado en 2013

Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines.

artículo científico publicado en 2005

Preparation of recombinant histone H3 as a substrate for protein kinase assays

artículo científico publicado en 1999

STAT3 is enriched in nuclear bodies

artículo científico publicado en 2003

Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors

artículo científico publicado en 2015

Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases

artículo científico publicado en 1998

Specificity determinants of substrate recognition by the protein kinase DYRK1A

scientific article published on 01 January 2000

Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity

artículo científico publicado en 2010

The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4.

artículo científico publicado en 2008

The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation

artículo científico publicado en 2014

The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2

scientific journal article

The identification of leaf thionin as one of the main jasmonate-induced proteins of barley (Hordeum vulgare).

artículo científico publicado en 1992

The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site

artículo científico publicado en 2006

Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling

artículo científico publicado en 2011

Unusual function of the activation loop in the protein kinase DYRK1A.

artículo científico publicado en 2003

cDNA cloning and characterization of rat Clk3, a LAMMER kinase predominately expressed in testis

scientific journal article

Lista de obras de Walter Becker

10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.

A complex interaction pattern of CIS and SOCS2 with the leptin receptor

A wake-up call to quiescent cancer cells - potential use of DYRK1B inhibitors in cancer therapy

Activation, regulation, and inhibition of DYRK1A.

Alternative splicing variants of dual specificity tyrosine phosphorylated and regulated kinase 1B exhibit distinct patterns of expression and functional properties

Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat.

Characterization of cyclin L1 as an immobile component of the splicing factor compartment

Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors

Characterization of the human DYRK1A promoter and its regulation by the transcription factor E2F1.

Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases

Cloning and functional characterization of the ovine malic enzyme promoter

Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases

Cloning of a novel member (ARL5) of the ARF-family of Ras-related GTPases

Comparison of the effects of insulin, PDGF, interleukin-6, and interferon-gamma on glucose transport in 3T3-L1 cells: lack of cross-talk between tyrosine kinase receptors and JAK/STAT pathways

DYRK protein kinases

DYRK1 is a co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression.

DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain

Development of a sensitive non-radioactive protein kinase assay and its application for detecting DYRK activity in Xenopus laevis oocytes

Differential hepatic gene expression in a polygenic mouse model with insulin resistance and hyperglycemia: evidence for a combined transcriptional dysregulation of gluconeogenesis and fatty acid synthesis

Distribution of the mRNA for protein phosphatase T in rat brain

Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII

Effect of hyperinsulinemia and type 2 diabetes-like hyperglycemia on expression of hepatic cytochrome p450 and glutathione s-transferase isoforms in a New Zealand obese-derived mouse backcross population

Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).

Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control ⬇️

Extracellular ATP activates NFAT-dependent gene expression in neuronal PC12 cells via P2X receptors

Functional characterization of DYRK1A missense variants associated with a syndromic form of intellectual deficiency and autism

How to Separate Kinase Inhibition from Undesired Monoamine Oxidase A Inhibition-The Development of the DYRK1A Inhibitor AnnH75 from the Alkaloid Harmine

Hyperleptinemia and leptin receptor variant Asp600Asn in the obese, hyperinsulinemic KK mouse strain

Hyperleptinemia, leptin resistance, and polymorphic leptin receptor in the New Zealand obese mouse.

Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1A

Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design.

Isolation and characterization of a cDNA clone encoding a novel jasmonate-induced protein of barley (Hordeum vulgare L.).

JIP60, a methyl jasmonate-induced ribosome-inactivating protein involved in plant stress reactions

Leptin induces inflammation-related genes in RINm5F insulinoma cells

Long-term and rapid regulation of ob mRNA levels in adipose tissue from normal (Sprague Dawley rats) and obese (db/db mice, fa/fa rats) rodents.

Mechanism of attenuation of leptin signaling under chronic ligand stimulation

Mechanism of dual specificity kinase activity of DYRK1A.

Minibrain/DYRK1A gene: candidate gene for mental retardation in Down's syndrome?

Mutational analysis of two residues in the DYRK homology box of the protein kinase DYRK1A.

NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect

Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines.

Preparation of recombinant histone H3 as a substrate for protein kinase assays

STAT3 is enriched in nuclear bodies

Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors

Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases

Specificity determinants of substrate recognition by the protein kinase DYRK1A

Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity

The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4.

The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation

The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2

The identification of leaf thionin as one of the main jasmonate-induced proteins of barley (Hordeum vulgare).

The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site

Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling

Unusual function of the activation loop in the protein kinase DYRK1A.

cDNA cloning and characterization of rat Clk3, a LAMMER kinase predominately expressed in testis