Lista de obras - Miguel Medina - Dominio Público Uruguay

A delta-catenin signaling pathway leading to dendritic protrusions

artículo científico publicado en 2008

A longitudinal FDG-PET study of transgenic mice overexpressing GSK- 3β in the brain

artículo científico publicado en 2014

Additional mechanisms conferring genetic susceptibility to Alzheimer's disease

artículo científico publicado en 2015

An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration

scientific article published on 05 July 2018

An Overview on the Clinical Development of Tau-Based Therapeutics

artículo científico publicado en 2018

Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice

artículo científico publicado en 2008

Bi-directional genetic modulation of GSK-3β exacerbates hippocampal neuropathology in experimental status epilepticus

artículo científico publicado en 2018

Bioactive prenylated phenyl derivatives derived from marine natural products: novel scaffolds for the design of BACE inhibitors

article published in 2014

Clinical Relevance of Specific Cognitive Complaints in Determining Mild Cognitive Impairment from Cognitively Normal States in a Study of Healthy Elderly Controls

scientific article published on 04 October 2016

Deconstructing GSK‐3: The Fine Regulation of Its Activity ⬇️

artículo científico publicado el 28 de abril de 2011

Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease

artículo científico publicado en 2005

Detecting Circulating MicroRNAs as Biomarkers in Alzheimer's Disease

artículo científico publicado en 2018

Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.

artículo científico publicado en 2005

Drosophila cathepsin B-like proteinase: a suggested role in yolk degradation

artículo científico publicado en 1988

Dual binding site acetylcholinesterase inhibitors: potential new disease-modifying agents for AD.

artículo científico publicado en 2006

Effects of commonly prescribed drugs on cognition and mild cognitive impairment in healthy elderly people

scientific article published on 26 June 2019

Elevated Plasma microRNA-206 Levels Predict Cognitive Decline and Progression to Dementia from Mild Cognitive Impairment

scientific article published on 13 November 2019

EuroTau: towing scientists to tau without tautology.

artículo científico publicado en 2017

Evidence for a new binding mode to GSK-3: allosteric regulation by the marine compound palinurin.

artículo científico publicado en 2012

Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib

artículo científico publicado en 2012

Expression of presenilin 1 in nervous system during rat development

artículo científico publicado en 1999

Further understanding of tau phosphorylation: implications for therapy.

artículo científico publicado en 2015

Glycogen synthase kinase 3 phosphorylates recombinant human tau protein at serine-262 in the presence of heparin (or tubulin)

scientific article published on 01 September 1995

Glycogen synthase kinase-3 (GSK-3) inhibitors for the treatment of Alzheimer's disease.

artículo científico publicado en 2010

Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease.

artículo científico publicado en 2007

Hemizygosity of delta-catenin (CTNND2) is associated with severe mental retardation in cri-du-chat syndrome

artículo científico publicado en 2000

Identification of protein kinases that modify specific epitopes

scientific article published on 01 November 1994

Is tau a prion-like protein?

artículo científico publicado en 2014

Long runs of homozygosity are associated with Alzheimer's disease

artículo científico publicado en 2021

Longitudinal Assessment of a Transgenic Animal Model of Tauopathy by FDG-PET Imaging

scientific article published on 01 January 2014

Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases ⬇️

artículo científico publicado en 2006

MicroRNAs in Neurodegenerative Diseases.

artículo científico

Modifications of the 5' untranslated region of foot-and-mouth disease virus after prolonged persistence in cell culture

artículo científico publicado en 1992

Modulation of GSK-3 as a Therapeutic Strategy on Tau Pathologies ⬇️

artículo científico publicado el 5 de octubre de 2011

NP7 protects from cell death induced by oxidative stress in neuronal and glial midbrain cultures from parkin null mice

artículo científico publicado en 2008

Neuronal membrane cholesterol loss enhances amyloid peptide generation

artículo científico publicado en 2004

New Features about Tau Function and Dysfunction

artículo científico publicado en 2016

New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors.

artículo científico publicado en 2012

New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease.

artículo científico publicado en 2013

New perspectives on the role of tau in Alzheimer's disease. Implications for therapy.

artículo científico

Overcoming cell death and tau phosphorylation mediated by PI3K-inhibition: a cell assay to measure neuroprotection.

artículo científico publicado en 2011

Potent beta-amyloid modulators.

artículo científico publicado en 2008

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

artículo científico publicado en 1997

Presenilin affects arm/beta-catenin localization and function in Drosophila

artículo científico publicado en 2000

Protein kinases involved in the phosphorylation of human tau protein in transfected COS-1 cells.

artículo científico publicado en 1996

Recent Developments in Tau-Based Therapeutics for Neurodegenerative Diseases ⬇️

artículo científico publicado el 1 de enero de 2011

Recent developments in tau-based therapeutics for Alzheimer's disease and related dementsia

artículo científico publicado en 2015

RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability

artículo científico publicado en 2003

Role of tau N-terminal motif in the secretion of human tau by End Binding proteins

artículo científico publicado en 2019

Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitro

artículo científico publicado en 2018

Specific Features of Subjective Cognitive Decline Predict Faster Conversion to Mild Cognitive Impairment.

artículo científico publicado en 2016

Strong buffering capacity of insect cells. Implications for the baculovirus expression system

artículo científico publicado en 1995

Tau Assembly into Filaments

artículo científico publicado en 2018

Tauopathy Analysis in P301S Mouse Model of Alzheimer Disease Immunized With DNA and MVA Poxvirus-Based Vaccines Expressing Human Full-Length 4R2N or 3RC Tau Proteins

scientific article published on 13 March 2020

The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?

scientific article published on 01 March 2019

The in vitro formation of recombinant tau polymers: effect of phosphorylation and glycation.

artículo científico publicado en 1996

The need for better AD animal models

artículo científico publicado en 2014

The role of extracellular Tau in the spreading of neurofibrillary pathology.

artículo científico publicado en 2014

The role of tau phosphorylation in transfected COS-1 cells

artículo científico publicado en 1995

The two species of the foot-and-mouth disease virus leader protein, expressed individually, exhibit the same activities

artículo científico publicado en 1993

Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation

artículo científico publicado en 2005

Toward common mechanisms for risk factors in Alzheimer's syndrome

artículo científico publicado en 2017

Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: a pilot study.

artículo científico publicado en 2013

Understanding the relationship between GSK-3 and Alzheimer's disease: a focus on how GSK-3 can modulate synaptic plasticity processes

artículo científico

Use of okadaic acid to identify relevant phosphoepitopes in pathology: a focus on neurodegeneration

artículo científico publicado en 2013

Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP.

artículo científico publicado en 2004

delta-catenin is a nervous system-specific adherens junction protein which undergoes dynamic relocalization during development

artículo científico publicado en 2000

Lista de obras de Miguel Medina

A delta-catenin signaling pathway leading to dendritic protrusions

A longitudinal FDG-PET study of transgenic mice overexpressing GSK- 3β in the brain

Additional mechanisms conferring genetic susceptibility to Alzheimer's disease

An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration

An Overview on the Clinical Development of Tau-Based Therapeutics

Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice

Bi-directional genetic modulation of GSK-3β exacerbates hippocampal neuropathology in experimental status epilepticus

Bioactive prenylated phenyl derivatives derived from marine natural products: novel scaffolds for the design of BACE inhibitors

Clinical Relevance of Specific Cognitive Complaints in Determining Mild Cognitive Impairment from Cognitively Normal States in a Study of Healthy Elderly Controls

Deconstructing GSK‐3: The Fine Regulation of Its Activity ⬇️

Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease

Detecting Circulating MicroRNAs as Biomarkers in Alzheimer's Disease

Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.

Drosophila cathepsin B-like proteinase: a suggested role in yolk degradation

Dual binding site acetylcholinesterase inhibitors: potential new disease-modifying agents for AD.

Effects of commonly prescribed drugs on cognition and mild cognitive impairment in healthy elderly people

Elevated Plasma microRNA-206 Levels Predict Cognitive Decline and Progression to Dementia from Mild Cognitive Impairment

EuroTau: towing scientists to tau without tautology.

Evidence for a new binding mode to GSK-3: allosteric regulation by the marine compound palinurin.

Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib

Expression of presenilin 1 in nervous system during rat development

Further understanding of tau phosphorylation: implications for therapy.

Glycogen synthase kinase 3 phosphorylates recombinant human tau protein at serine-262 in the presence of heparin (or tubulin)

Glycogen synthase kinase-3 (GSK-3) inhibitors for the treatment of Alzheimer's disease.

Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease.

Hemizygosity of delta-catenin (CTNND2) is associated with severe mental retardation in cri-du-chat syndrome

Identification of protein kinases that modify specific epitopes

Is tau a prion-like protein?

Long runs of homozygosity are associated with Alzheimer's disease

Longitudinal Assessment of a Transgenic Animal Model of Tauopathy by FDG-PET Imaging

Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases ⬇️

MicroRNAs in Neurodegenerative Diseases.

Modifications of the 5' untranslated region of foot-and-mouth disease virus after prolonged persistence in cell culture

Modulation of GSK-3 as a Therapeutic Strategy on Tau Pathologies ⬇️

NP7 protects from cell death induced by oxidative stress in neuronal and glial midbrain cultures from parkin null mice

Neuronal membrane cholesterol loss enhances amyloid peptide generation

New Features about Tau Function and Dysfunction

New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors.

New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease.

New perspectives on the role of tau in Alzheimer's disease. Implications for therapy.

Overcoming cell death and tau phosphorylation mediated by PI3K-inhibition: a cell assay to measure neuroprotection.

Potent beta-amyloid modulators.

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

Presenilin affects arm/beta-catenin localization and function in Drosophila

Protein kinases involved in the phosphorylation of human tau protein in transfected COS-1 cells.

Recent Developments in Tau-Based Therapeutics for Neurodegenerative Diseases ⬇️

Recent developments in tau-based therapeutics for Alzheimer's disease and related dementsia

RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability

Role of tau N-terminal motif in the secretion of human tau by End Binding proteins

Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitro

Specific Features of Subjective Cognitive Decline Predict Faster Conversion to Mild Cognitive Impairment.

Strong buffering capacity of insect cells. Implications for the baculovirus expression system

Tau Assembly into Filaments

Tauopathy Analysis in P301S Mouse Model of Alzheimer Disease Immunized With DNA and MVA Poxvirus-Based Vaccines Expressing Human Full-Length 4R2N or 3RC Tau Proteins

The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?

The in vitro formation of recombinant tau polymers: effect of phosphorylation and glycation.

The need for better AD animal models

The role of extracellular Tau in the spreading of neurofibrillary pathology.

The role of tau phosphorylation in transfected COS-1 cells

The two species of the foot-and-mouth disease virus leader protein, expressed individually, exhibit the same activities

Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation

Toward common mechanisms for risk factors in Alzheimer's syndrome

Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: a pilot study.

Understanding the relationship between GSK-3 and Alzheimer's disease: a focus on how GSK-3 can modulate synaptic plasticity processes

Use of okadaic acid to identify relevant phosphoepitopes in pathology: a focus on neurodegeneration

Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP.

delta-catenin is a nervous system-specific adherens junction protein which undergoes dynamic relocalization during development