Lista de obras - Anders Nykjaer - Dominio Público Uruguay

A carboxyl-terminal fragment of lipoprotein lipase binds to the low density lipoprotein receptor-related protein and inhibits lipase-mediated uptake of lipoprotein in cells.

artículo científico publicado en 1994

A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney

artículo científico publicado en 2001

APP involvement in retinogenesis of mice

artículo científico publicado en 2010

Alpha 2-macroglobulin receptor mediates binding and cytotoxicity of plant ribosome-inactivating proteins.

artículo científico publicado en 1995

Alpha 2-macroglobulin-proteinase complexes, plasminogen activator inhibitor type-1-plasminogen activator complexes, and receptor-associated protein bind to a region of the alpha 2-macroglobulin receptor containing a cluster of eight complement-type

artículo científico publicado en 1993

Analysis of ligand binding to the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that lipoprotein lipase and the carboxyl-terminal domain of the receptor-associated protein bind to the same site.

artículo científico publicado en 1995

Assessing low-dose gentamicin-induced kidney injury in rats by analysis of urine

artículo científico publicado en 2009

Bioactive human recombinant tumor necrosis factor-alpha: an unstable dimer?

scientific article published on 01 October 1989

Both pro-uPA and uPA: PAI-1 complex bind to the alpha 2-macroglobulin receptor/LDL receptor-related protein. Evidence for multiple independent contacts between the ligands and receptor

scientific article published on 01 September 1994

Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression.

artículo científico publicado en 2009

Cellular targets and receptors for interleukin-6. II. Characterization of IL-6 binding and receptors in peripheral blood cells and macrophages

scientific article published on 01 August 1990

Characterization of a saporin isoform with lower ribosome-inhibiting activity

artículo científico publicado en 1997

Cubilin and megalin co-localize in the neonatal inner ear.

artículo científico publicado en 2009

Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)

artículo científico publicado en 2001

Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head.

artículo científico publicado en 2013

DiDBiT-TMT: A novel method to quantify changes in the proteomic landscape induced by neural plasticity

artículo científico publicado en 2024

Different motifs regulate trafficking of SorCS1 isoforms

artículo científico publicado en 2008

Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation.

artículo científico publicado en 2013

Endocytosis of sex steroids: the hypothesis of free hormones revisited

artículo científico publicado en 2008

Evidence for an essential role of megalin in transepithelial transport of retinol

artículo científico publicado en 1999

Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal development

artículo científico publicado en 1999

Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism.

artículo científico publicado en 2002

From holoprosencephaly to osteopathology: role of multifunctional endocytic receptors in absorptive epithelia.

artículo científico publicado en 2003

Functional organization of the sortilin Vps10p domain

artículo científico publicado en 2004

Gentamicin Binds to the Megalin Receptor as a Competitive Inhibitor Using the Common Ligand Binding Motif of Complement Type Repeats: INSIGHT FROM THE NMR STRUCTURE OF THE 10TH COMPLEMENT TYPE REPEAT DOMAIN ALONE AND IN COMPLEX WITH GENTAMICIN

artículo científico publicado en 2013

Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin

artículo científico publicado en 2010

Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect

artículo científico publicado en 2002

Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin

scientific journal article

Identification and characterization of urokinase receptors in natural killer cells and T-cell-derived lymphokine activated killer cells

artículo científico publicado en 1992

Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding.

artículo científico publicado en 2010

Impaired aldosterone responsiveness in corticosteroid binding globulin deficient mice

artículo científico publicado en 2010

Inhibition of PDGF-BB by Factor VII-activating protease (FSAP) is neutralized by protease nexin-1, and the FSAP-inhibitor complexes are internalized via LRP.

artículo científico publicado en 2007

Lipoprotein receptors: new roles for ancient proteins.

artículo científico publicado en 1999

Loss of BDNF or its receptors in three mouse models has unpredictable consequences for anxiety and fear acquisition

artículo científico publicado en 2013

Mannose 6-Phosphate/Insulin-like Growth Factor–II Receptor Targets the Urokinase Receptor to Lysosomes via a Novel Binding Interaction ⬇️

artículo científico publicado el 4 de mayo de 1998

Mapping of the interaction site between sortilin and the p75 neurotrophin receptor reveals a regulatory role for the sortilin intracellular domain in p75 neurotrophin receptor shedding and apoptosis

artículo científico publicado en 2012

Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus

artículo científico publicado en 2009

Megalin antagonizes activation of the parathyroid hormone receptor.

artículo científico publicado en 1999

Megalin knockout mice as an animal model of low molecular weight proteinuria.

artículo científico publicado en 1999

Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein

artículo científico publicado en 1996

Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography

artículo científico publicado en 1997

Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation.

artículo científico

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

artículo científico publicado en 2005

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.

artículo científico publicado en 2018

Preservation of cortical sortilin protein levels in MCI and Alzheimer's disease.

artículo científico publicado en 2010

Prions amplify through degradation of the VPS10P sorting receptor sortilin

artículo científico publicado en 2017

Pro-neurotrophins, sortilin, and nociception

artículo científico publicado en 2014

ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin.

artículo científico publicado en 2005

ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation ⬇️

artículo científico publicado el 22 de octubre de 2012

Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons

artículo científico publicado en 2011

Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR).

artículo científico publicado en 2011

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes

scientific article published on 01 July 1992

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

artículo científico publicado en 2012

Receptor-mediated endocytosis of plasminogen activators and activator/inhibitor complexes

artículo científico publicado en 1994

Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that the urokinase receptor protects pro-urokinase against

artículo científico publicado en 1994

Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2

scientific article published on 25 October 2018

Role of endocytosis in cellular uptake of sex steroids.

artículo científico publicado en 2005

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury

artículo científico publicado en 2007

SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes

artículo científico publicado en 2013

SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2.

artículo científico publicado en 2010

Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals

artículo científico publicado en 2016

SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology

artículo científico publicado en 2019

SorCS2 is required for BDNF-dependent plasticity in the hippocampus

artículo científico publicado en 2016

SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia

scientific journal article

SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET.

artículo científico publicado en 2013

SorLA regulates the activity of lipoprotein lipase by intracellular trafficking

artículo científico publicado en 2011

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export

artículo científico publicado en 2010

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

artículo científico publicado en 2010

Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway.

artículo científico publicado en 2005

Sortilin is essential for proNGF-induced neuronal cell death

artículo científico publicado en 2004

Sortilin mediates vascular calcification via its recruitment into extracellular vesicles

artículo científico publicado en 2016

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

artículo científico publicado en 2010

Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction

scientific journal article

Sortilin: a receptor to regulate neuronal viability and function

artículo científico publicado en 2012

Sortilins in neurotrophic factor signaling

artículo científico publicado en 2014

Sortilins: new players in lipoprotein metabolism

artículo científico publicado en 2011

Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases.

artículo científico publicado en 2014

Structure of heparin fragments with high affinity for lipoprotein lipase and inhibition of lipoprotein lipase binding to alpha 2-macroglobulin-receptor/low-density-lipoprotein-receptor-related protein by heparin fragments

artículo científico publicado en 1995

Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis.

artículo científico publicado en 2014

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds lipoprotein lipase and beta-migrating very low density lipoprotein associated with the lipase

artículo científico publicado en 1993

The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion

artículo científico publicado en 2014

The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand.

artículo científico publicado en 2004

The multiligand alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein (alpha 2MR/LRP). Binding and endocytosis of fluid phase and membrane-associated ligands.

artículo científico publicado en 1994

The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain

artículo científico publicado en 2013

The proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages.

artículo científico publicado en 2016

The receptor-associated protein (RAP) binds calmodulin and is phosphorylated by calmodulin-dependent kinase II.

artículo científico publicado en 1996

The role of SorLA in neurotrophic activity and complex behavior.

artículo científico publicado en 2013

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

artículo científico publicado en 2001

The sorting receptor SorCS3 is a stronger regulator of glutamate receptor functions compared to GABAergic mechanisms in the hippocampus.

artículo científico publicado en 2016

The spared nerve injury (SNI) model of induced mechanical allodynia in mice

artículo científico publicado en 2011

Transient denervation of viable myocardium after myocardial infarction does not alter arrhythmia susceptibility

artículo científico publicado en 2017

Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members

artículo científico publicado en 2006

Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex

artículo científico publicado en 1998

Up-regulation of sortilin mediated by amyloid-β and p75(NTR): safety lies in the middle course

artículo científico publicado en 2013

Urokinase binds to a plasminogen activator inhibitor type-2-like molecule in placental microvillous membranes

artículo científico publicado en 1989

Urokinase receptors in human monocytes

scientific article published on 01 May 1990

VPS10P-domain receptors - regulators of neuronal viability and function.

artículo científico publicado en 2008

[Complement activation caused by beta-amyloid in Alzheimer's dementia].

artículo científico publicado en 1993

[Transport receptors can signal, too]

artículo científico publicado en 2000

Lista de obras de Anders Nykjaer

A carboxyl-terminal fragment of lipoprotein lipase binds to the low density lipoprotein receptor-related protein and inhibits lipase-mediated uptake of lipoprotein in cells.

A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney

APP involvement in retinogenesis of mice

Alpha 2-macroglobulin receptor mediates binding and cytotoxicity of plant ribosome-inactivating proteins.

Alpha 2-macroglobulin-proteinase complexes, plasminogen activator inhibitor type-1-plasminogen activator complexes, and receptor-associated protein bind to a region of the alpha 2-macroglobulin receptor containing a cluster of eight complement-type

Analysis of ligand binding to the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that lipoprotein lipase and the carboxyl-terminal domain of the receptor-associated protein bind to the same site.

Assessing low-dose gentamicin-induced kidney injury in rats by analysis of urine

Bioactive human recombinant tumor necrosis factor-alpha: an unstable dimer?

Both pro-uPA and uPA: PAI-1 complex bind to the alpha 2-macroglobulin receptor/LDL receptor-related protein. Evidence for multiple independent contacts between the ligands and receptor

Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression.

Cellular targets and receptors for interleukin-6. II. Characterization of IL-6 binding and receptors in peripheral blood cells and macrophages

Characterization of a saporin isoform with lower ribosome-inhibiting activity

Cubilin and megalin co-localize in the neonatal inner ear.

Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)

Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head.

DiDBiT-TMT: A novel method to quantify changes in the proteomic landscape induced by neural plasticity

Different motifs regulate trafficking of SorCS1 isoforms

Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation.

Endocytosis of sex steroids: the hypothesis of free hormones revisited

Evidence for an essential role of megalin in transepithelial transport of retinol

Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal development

Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism.

From holoprosencephaly to osteopathology: role of multifunctional endocytic receptors in absorptive epithelia.

Functional organization of the sortilin Vps10p domain

Gentamicin Binds to the Megalin Receptor as a Competitive Inhibitor Using the Common Ligand Binding Motif of Complement Type Repeats: INSIGHT FROM THE NMR STRUCTURE OF THE 10TH COMPLEMENT TYPE REPEAT DOMAIN ALONE AND IN COMPLEX WITH GENTAMICIN

Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin

Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect

Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin

Identification and characterization of urokinase receptors in natural killer cells and T-cell-derived lymphokine activated killer cells

Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding.

Impaired aldosterone responsiveness in corticosteroid binding globulin deficient mice

Inhibition of PDGF-BB by Factor VII-activating protease (FSAP) is neutralized by protease nexin-1, and the FSAP-inhibitor complexes are internalized via LRP.

Lipoprotein receptors: new roles for ancient proteins.

Loss of BDNF or its receptors in three mouse models has unpredictable consequences for anxiety and fear acquisition

Mannose 6-Phosphate/Insulin-like Growth Factor–II Receptor Targets the Urokinase Receptor to Lysosomes via a Novel Binding Interaction ⬇️

Mapping of the interaction site between sortilin and the p75 neurotrophin receptor reveals a regulatory role for the sortilin intracellular domain in p75 neurotrophin receptor shedding and apoptosis

Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus

Megalin antagonizes activation of the parathyroid hormone receptor.

Megalin knockout mice as an animal model of low molecular weight proteinuria.

Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein

Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography

Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation.

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.

Preservation of cortical sortilin protein levels in MCI and Alzheimer's disease.

Prions amplify through degradation of the VPS10P sorting receptor sortilin

Pro-neurotrophins, sortilin, and nociception

ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin.

ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation ⬇️

Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons

Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR).

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

Receptor-mediated endocytosis of plasminogen activators and activator/inhibitor complexes

Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that the urokinase receptor protects pro-urokinase against

Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2

Role of endocytosis in cellular uptake of sex steroids.

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury

SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes

SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2.

Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals

SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology

SorCS2 is required for BDNF-dependent plasticity in the hippocampus

SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia

SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET.

SorLA regulates the activity of lipoprotein lipase by intracellular trafficking

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway.

Sortilin is essential for proNGF-induced neuronal cell death

Sortilin mediates vascular calcification via its recruitment into extracellular vesicles

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction

Sortilin: a receptor to regulate neuronal viability and function

Sortilins in neurotrophic factor signaling

Sortilins: new players in lipoprotein metabolism

Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases.

Structure of heparin fragments with high affinity for lipoprotein lipase and inhibition of lipoprotein lipase binding to alpha 2-macroglobulin-receptor/low-density-lipoprotein-receptor-related protein by heparin fragments

Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis.