Lista de obras - James A Irving - Dominio Público Uruguay

A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4

artículo científico publicado en 2013

A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites

artículo científico publicado en 2009

A serpin in the cellulosome of the anaerobic fungus Piromyces sp. strain E2.

artículo científico publicado en 2008

A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity

artículo científico publicado en 2015

Aeropin from the extremophile Pyrobaculum aerophilum bypasses the serpin misfolding trap

artículo científico publicado en 2007

Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerization

artículo científico publicado en 2014

An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein

artículo científico publicado en 2015

An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding

artículo científico publicado en 2015

Characterisation of a type II functionally-deficient variant of alpha-1-antitrypsin discovered in the general population

artículo científico publicado en 2019

Characterisation of serpin polymers in vitro and in vivo.

artículo científico publicado en 2010

Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody

artículo científico publicado en 2014

Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection.

artículo científico publicado en 2003

Computational analysis of evolution and conservation in a protein superfamily

artículo científico publicado en 2004

Conformational change in the chromatin remodelling protein MENT

artículo científico publicado en 2009

Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes

artículo científico publicado en 2021

DNA accelerates the inhibition of human cathepsin V by serpins

artículo científico publicado en 2007

Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization

artículo científico publicado en 2015

Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases

artículo científico publicado en 2002

Functional insights from the distribution and role of homopeptide repeat-containing proteins

artículo científico publicado en 2005

High-resolution ex vivo NMR spectroscopy of human Z α<sub>1</sub>-antitrypsin

artículo científico publicado en 2020

Human Ovalbumin Serpin Evolution: Phylogenic Analysis, Gene Organization, and Identification of New PI8-Related Genes Suggest That Two Interchromosomal and Several Intrachromosomal Duplications Generated the Gene Clusters at 18q21–q23 and 6p25

article

Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis.

artículo científico publicado en 2004

Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis

artículo científico publicado en 2003

Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation

artículo científico publicado en 2002

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum

artículo científico publicado en 2015

MUSTANG-MR structural sieving server: applications in protein structural analysis and crystallography

artículo científico publicado en 2010

Peptide mimotopes selected with HIV-1-blocking monoclonal antibodies against CCR5 represent motifs specific for HIV-1 entry

artículo científico publicado en 2007

Phosphoproteins in stress-induced disease

artículo científico publicado en 2012

Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.

artículo científico publicado en 2000

Probing the folding pathway of a consensus serpin using single tryptophan mutants

artículo científico publicado en 2018

Protein structural alignments and functional genomics

artículo científico publicado en 2001

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

artículo científico publicado en 2013

Requirement of multiple phage displayed peptide libraries for optimal mapping of a conformational antibody epitope on CCR5.

artículo científico publicado en 2005

Role of the alpha-helix 163-170 in factor Xa catalytic activity

scientific article published on 28 August 2007

Sequence, organization, chromosomal localization, and alternative splicing of the human serine protease inhibitor gene hurpin (PI13) which is upregulated in psoriasis

artículo científico publicado en 2001

Serpins in prokaryotes

artículo científico publicado en 2002

Serpins in the Caenorhabditis elegans genome

scientific article published on 01 July 1999

Serpins: finely balanced conformational traps

artículo científico publicado en 2002

Structural mechanisms of inactivation in scabies mite serine protease paralogues

artículo científico publicado en 2009

Structure of granzyme C reveals an unusual mechanism of protease autoinhibition

artículo científico publicado en 2009

Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity

artículo científico publicado en 2013

Targeting serpins in high-throughput and structure-based drug design

artículo científico publicado en 2011

The N terminus of the serpin, tengpin, functions to trap the metastable native state

artículo científico publicado en 2007

The evolution of enzyme specificity in Fasciola spp.

artículo científico publicado en 2003

The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition

artículo científico publicado en 2004

The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix

artículo científico publicado en 2005

The molecular species responsible for α1 -antitrypsin deficiency are suppressed by a small molecule chaperone

scientific article published on 15 October 2020

The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins

artículo científico publicado en 2005

The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization

artículo científico publicado en 2017

The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases

artículo científico publicado en 2002

The serpinopathies studying serpin polymerization in vivo

artículo científico publicado en 2011

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

artículo científico publicado en 2001

The structural basis for Z α1-antitrypsin polymerization in the liver

scientific article published on 21 October 2020

Unravelling the twists and turns of the serpinopathies.

artículo científico publicado en 2011

X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation

artículo científico publicado en 2006

Lista de obras de James A Irving

A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4

A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites

A serpin in the cellulosome of the anaerobic fungus Piromyces sp. strain E2.

A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity

Aeropin from the extremophile Pyrobaculum aerophilum bypasses the serpin misfolding trap

Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerization

An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein

An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding

Characterisation of a type II functionally-deficient variant of alpha-1-antitrypsin discovered in the general population

Characterisation of serpin polymers in vitro and in vivo.

Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody

Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection.

Computational analysis of evolution and conservation in a protein superfamily

Conformational change in the chromatin remodelling protein MENT

Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes

DNA accelerates the inhibition of human cathepsin V by serpins

Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization

Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases

Functional insights from the distribution and role of homopeptide repeat-containing proteins

High-resolution ex vivo NMR spectroscopy of human Z α<sub>1</sub>-antitrypsin

Human Ovalbumin Serpin Evolution: Phylogenic Analysis, Gene Organization, and Identification of New PI8-Related Genes Suggest That Two Interchromosomal and Several Intrachromosomal Duplications Generated the Gene Clusters at 18q21–q23 and 6p25

Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis.

Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis

Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum

MUSTANG-MR structural sieving server: applications in protein structural analysis and crystallography

Peptide mimotopes selected with HIV-1-blocking monoclonal antibodies against CCR5 represent motifs specific for HIV-1 entry

Phosphoproteins in stress-induced disease

Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.

Probing the folding pathway of a consensus serpin using single tryptophan mutants

Protein structural alignments and functional genomics

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

Requirement of multiple phage displayed peptide libraries for optimal mapping of a conformational antibody epitope on CCR5.

Role of the alpha-helix 163-170 in factor Xa catalytic activity

Sequence, organization, chromosomal localization, and alternative splicing of the human serine protease inhibitor gene hurpin (PI13) which is upregulated in psoriasis

Serpins in prokaryotes

Serpins in the Caenorhabditis elegans genome

Serpins: finely balanced conformational traps

Structural mechanisms of inactivation in scabies mite serine protease paralogues

Structure of granzyme C reveals an unusual mechanism of protease autoinhibition

Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity

Targeting serpins in high-throughput and structure-based drug design

The N terminus of the serpin, tengpin, functions to trap the metastable native state

The evolution of enzyme specificity in Fasciola spp.

The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition

The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix

The molecular species responsible for α1 -antitrypsin deficiency are suppressed by a small molecule chaperone

The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins

The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization

The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases

The serpinopathies studying serpin polymerization in vivo

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

The structural basis for Z α1-antitrypsin polymerization in the liver

Unravelling the twists and turns of the serpinopathies.

X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation