Lista de obras - Calum Sutherland - Dominio Público Uruguay

5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men.

artículo científico publicado en 2007

A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin

artículo científico publicado en 2012

A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration.

artículo científico publicado en 2005

A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression

article

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

artículo científico publicado en 2005

Activation of the Ras Mitogen-activated Protein Kinase-Ribosomal Protein Kinase Pathway Is Not Required for the Repression of Phosphoenolpyruvate Carboxykinase Gene Transcription by Insulin

scientific article published in Journal of Biological Chemistry

Anaesthesia generates neuronal insulin resistance by inducing hypothermia

artículo científico publicado en 2008

Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3.

artículo científico publicado en 2005

Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin

artículo científico publicado en 1996

Antagonistic effects of phorbol esters on insulin regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) but not glucose-6-phosphatase gene expression

artículo científico publicado en 2001

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

artículo científico publicado en 2010

Bioinformatic prediction and confirmation of beta-adducin as a novel substrate of glycogen synthase kinase 3.

artículo científico publicado en 2011

Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status

artículo científico publicado en 2009

CNP/cGMP signaling regulates axon branching and growth by modulating microtubule polymerization.

artículo científico publicado en 2013

CRMP2 hyperphosphorylation is characteristic of Alzheimer's disease and not a feature common to other neurodegenerative diseases

artículo científico publicado en 2011

Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells

artículo científico publicado en 2007

Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression

artículo científico publicado en 2007

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

artículo científico publicado en 2010

Constitutive activation of GSK3 down-regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells.

artículo científico publicado en 2005

Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

artículo científico publicado en 2005

Different mechanisms are used by insulin to repress three genes that contain a homologous thymine-rich insulin response element

artículo científico publicado en 2003

Differential proteomics analysis of synaptic proteins identifies potential cellular targets and protein mediators of synaptic neuroprotection conferred by the slow Wallerian degeneration (Wlds) gene

artículo científico publicado en 2007

Disordered insulin secretion in the development of insulin resistance and Type 2 diabetes

artículo científico

Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo

artículo científico publicado en 2006

Dominant negative forms of Akt (protein kinase B) and atypical protein kinase Clambda do not prevent insulin inhibition of phosphoenolpyruvate carboxykinase gene transcription

artículo científico publicado en 1999

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3.

artículo científico

Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles.

artículo científico publicado en 2010

Erratum to: A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin

scholarly article published in Diabetologia

Esterification and absorption of cholesterol: in vitro and in vivo observations in the rat

artículo científico publicado en 1989

Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain

artículo científico publicado en 2010

Filaggrin in the frontline: role in skin barrier function and disease

artículo científico publicado en 2009

Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226.

artículo científico publicado en 2006

GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons.

artículo científico publicado en 2004

GSK3 beta regulates myelin-dependent axon outgrowth inhibition through CRMP4.

artículo científico publicado en 2010

Generation, validation and humanisation of a novel insulin resistant cell model.

artículo científico publicado en 2010

Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases

artículo científico publicado en 2016

High fat feeding is associated with stimulation of the hypothalamic-pituitary-adrenal axis and reduced anxiety in the rat.

artículo científico publicado en 2014

High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task

artículo científico publicado en 2010

Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats

artículo científico publicado en 2014

Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP)•collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation

artículo científico publicado en 2011

Identification of insulin-stimulated protein kinase-1 as the rabbit equivalent of rskmo-2. Identification of two threonines phosphorylated during activation by mitogen-activated protein kinase

artículo científico publicado en 1993

Implications of genome wide association studies for the understanding of type 2 diabetes pathophysiology

artículo científico publicado en 2010

Insulin Regulation of Insulin-like Growth Factor-binding Protein-1 Gene Expression Is Dependent on the Mammalian Target of Rapamycin, but Independent of Ribosomal S6 Kinase Activity ⬇️

artículo científico publicado el 9 de enero de 2002

Insulin regulation of hepatic insulin-like growth factor-binding protein-1 (IGFBP-1) gene expression and mammalian target of rapamycin (mTOR) signalling is impaired by the presence of hydrogen peroxide

scientific journal article

Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway

artículo científico publicado en 1996

Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo.

artículo científico publicado en 2009

Insulin resistance in the brain: an old-age or new-age problem?

artículo científico

Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug

artículo científico publicado en 2016

Invited commentary

artículo científico publicado en 2015

Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels

artículo científico publicado en 2009

Measuring GSK3 expression and activity in cells

artículo científico publicado en 2008

Models of dementia: an introductory overview

artículo científico publicado en 2011

Molecular connexions between dementia and diabetes.

artículo científico publicado en 2007

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

artículo científico publicado en 2008

Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2.

artículo científico publicado en 2014

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.

artículo científico publicado en 2012

Obesity-induced insulin resistance in human skeletal muscle is characterised by defective activation of p42/p44 MAP kinase

artículo científico publicado en 2013

Phosphatidylinositol 3-Kinase, but Not p70/p85 Ribosomal S6 Protein Kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression by Insulin

artículo científico publicado en 1995

Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis.

artículo científico publicado en 2015

Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons

artículo científico publicado en 2015

Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation.

artículo científico publicado en 2008

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

artículo científico publicado en 2014

The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1

artículo científico publicado en 2004

The effect of dietary intervention on the metabolic and behavioural impairments generated by short term high fat feeding in the rat.

artículo científico publicado en 2016

The molecular physiology of hepatic nuclear factor 3 in the regulation of gluconeogenesis

artículo científico

The role of ATM in response to metformin treatment and activation of AMPK.

artículo científico publicado en 2012

The α-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro

artículo científico publicado en 1994

Tumour necrosis factor alpha decreases glucose-6-phosphatase gene expression by activation of nuclear factor kappaB.

artículo científico publicado en 2004

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

artículo científico publicado en 2016

What Are the bona fide GSK3 Substrates?

artículo científico publicado en 2011

Lista de obras de Calum Sutherland

5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men.

A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin

A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration.

A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

Activation of the Ras Mitogen-activated Protein Kinase-Ribosomal Protein Kinase Pathway Is Not Required for the Repression of Phosphoenolpyruvate Carboxykinase Gene Transcription by Insulin

Anaesthesia generates neuronal insulin resistance by inducing hypothermia

Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3.

Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin

Antagonistic effects of phorbol esters on insulin regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) but not glucose-6-phosphatase gene expression

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

Bioinformatic prediction and confirmation of beta-adducin as a novel substrate of glycogen synthase kinase 3.

Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status

CNP/cGMP signaling regulates axon branching and growth by modulating microtubule polymerization.

CRMP2 hyperphosphorylation is characteristic of Alzheimer's disease and not a feature common to other neurodegenerative diseases

Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells

Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

Constitutive activation of GSK3 down-regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells.

Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

Different mechanisms are used by insulin to repress three genes that contain a homologous thymine-rich insulin response element

Differential proteomics analysis of synaptic proteins identifies potential cellular targets and protein mediators of synaptic neuroprotection conferred by the slow Wallerian degeneration (Wlds) gene

Disordered insulin secretion in the development of insulin resistance and Type 2 diabetes

Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo

Dominant negative forms of Akt (protein kinase B) and atypical protein kinase Clambda do not prevent insulin inhibition of phosphoenolpyruvate carboxykinase gene transcription

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3.

Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles.

Erratum to: A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin

Esterification and absorption of cholesterol: in vitro and in vivo observations in the rat

Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain

Filaggrin in the frontline: role in skin barrier function and disease

Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226.

GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons.

GSK3 beta regulates myelin-dependent axon outgrowth inhibition through CRMP4.

Generation, validation and humanisation of a novel insulin resistant cell model.

Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases

High fat feeding is associated with stimulation of the hypothalamic-pituitary-adrenal axis and reduced anxiety in the rat.

High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task

Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats

Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP)•collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation

Identification of insulin-stimulated protein kinase-1 as the rabbit equivalent of rskmo-2. Identification of two threonines phosphorylated during activation by mitogen-activated protein kinase

Implications of genome wide association studies for the understanding of type 2 diabetes pathophysiology

Insulin Regulation of Insulin-like Growth Factor-binding Protein-1 Gene Expression Is Dependent on the Mammalian Target of Rapamycin, but Independent of Ribosomal S6 Kinase Activity ⬇️

Insulin regulation of hepatic insulin-like growth factor-binding protein-1 (IGFBP-1) gene expression and mammalian target of rapamycin (mTOR) signalling is impaired by the presence of hydrogen peroxide

Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway

Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo.

Insulin resistance in the brain: an old-age or new-age problem?

Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug

Invited commentary

Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels

Measuring GSK3 expression and activity in cells

Models of dementia: an introductory overview

Molecular connexions between dementia and diabetes.

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2.

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.

Obesity-induced insulin resistance in human skeletal muscle is characterised by defective activation of p42/p44 MAP kinase

Phosphatidylinositol 3-Kinase, but Not p70/p85 Ribosomal S6 Protein Kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression by Insulin

Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis.

Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons

Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation.

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1

The effect of dietary intervention on the metabolic and behavioural impairments generated by short term high fat feeding in the rat.

The molecular physiology of hepatic nuclear factor 3 in the regulation of gluconeogenesis

The role of ATM in response to metformin treatment and activation of AMPK.

The α-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro

Tumour necrosis factor alpha decreases glucose-6-phosphatase gene expression by activation of nuclear factor kappaB.

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

What Are the bona fide GSK3 Substrates?