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Lista de obras de Christian Hölscher

7-Nitro indazole, a neuron-specific nitric oxide synthase inhibitor, produces amnesia in the chick

artículo científico publicado en 1994

7-Nitro indazole, a selective neuronal nitric oxide synthase inhibitor in vivo, impairs spatial learning in the rat.

artículo científico publicado en 1996

A GLP-1/GIP/Gcg receptor triagonist improves memory behavior, as well as synaptic transmission, neuronal excitability and Ca2+ homeostasis in 3xTg-AD mice

scientific article published on 05 March 2020

A Novel Bioresorbable Device as a Controlled Release System for Protecting Cells from Oxidative Stress from Alzheimer's Disease.

artículo científico publicado en 2016

A dual GLP-1 and Gcg receptor agonist rescues spatial memory and synaptic plasticity in APP/PS1 transgenic mice

artículo científico publicado en 2019

A novel GLP-1/GIP dual agonist is more effective than liraglutide in reducing inflammation and enhancing GDNF release in the MPTP mouse model of Parkinson's disease

artículo científico publicado en 2017

A novel GLP-1/GIP dual receptor agonist protects from 6-OHDA lesion in a rat model of Parkinson's disease.

artículo científico publicado en 2017

A novel GLP-1/GIP/Gcg triagonist reduces cognitive deficits and pathology in the 3xTg mouse model of Alzheimer's disease.

artículo científico publicado en 2018

A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson's disease by reducing chronic inflammation in the brain

artículo científico publicado en 2016

A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson's disease by increasing expression of BNDF.

artículo científico publicado en 2015

A novel dual GLP-1/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the Alzheimer icv. STZ rat model

artículo científico publicado en 2017

A novel dual-glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonist is neuroprotective in transient focal cerebral ischemia in the rat.

artículo científico publicado en 2015

A novel retro-inverso peptide inhibitor reduces amyloid deposition, oxidation and inflammation and stimulates neurogenesis in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease

artículo científico publicado en 2013

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

artículo científico publicado en 2006

Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet

artículo científico publicado en 2010

Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice.

artículo científico publicado en 2012

Activation of group-II metabotropic glutamate receptors blocks induction of long-term potentiation and depotentiation in area CA1 of the rat in vivo.

artículo científico publicado en 1997

Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease

scientific article published on 14 December 2020

Age-associated changes of brain copper, iron, and zinc in Alzheimer's disease and dementia with Lewy bodies

artículo científico publicado en 2014

Alzheimer's disease-like pathology has transient effects on the brain and blood metabolome

artículo científico publicado en 2015

An inhibitor of nitric oxide synthesis prevents memory formation in the chick

artículo científico publicado en 1992

Anaesthesia generates neuronal insulin resistance by inducing hypothermia

artículo científico publicado en 2008

Are Alzheimer's disease and other neurodegenerative disorders caused by impaired signalling of insulin and other hormones?

artículo científico publicado en 2018

Beta-amyloid induced reduction in synaptic transmission is reversed by inhibitors of nitric oxide synthase

article

Block of HFS-induced LTP in the dentate gyrus by 1S,3S-ACPD: further evidence against LTP as a model for learning.

artículo científico publicado en 1997

Block of theta-burst-induced long-term potentiation by (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid: further evidence against long-term potentiation as a model for learning

artículo científico publicado en 1997

Blockade of long-term potentiation by beta-amyloid peptides in the CA1 region of the rat hippocampus in vivo.

artículo científico publicado en 2001

Brain insulin resistance: role in neurodegenerative disease and potential for targeting

artículo científico publicado en 2020

Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases

artículo científico

Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model

artículo científico publicado en 2013

Coexistences of insulin signaling-related proteins and choline acetyltransferase in neurons.

artículo científico publicado en 2008

Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice

artículo científico publicado en 2014

Consciousness in mind: a correlate for ACh?

scientific article published on 01 December 1999

Correction: A Novel Retro-Inverso Peptide Inhibitor Reduces Amyloid Deposition, Oxidation and Inflammation and Stimulates Neurogenesis in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease

artículo científico publicado en 2013

D-Ala2-GIP-glu-PAL is neuroprotective in a chronic Parkinson's disease mouse model and increases BNDF expression while reducing neuroinflammation and lipid peroxidation

artículo científico publicado en 2016

D-Ala2GIP facilitated synaptic plasticity and reduces plaque load in aged wild type mice and in an Alzheimer's disease mouse model

artículo científico publicado en 2013

D-Ser2-oxyntomodulin ameliorated Aβ31-35-induced circadian rhythm disorder in mice

scientific article published on 14 August 2019

DA-JC1 improves learning and memory by antagonizing Aβ31-35-induced circadian rhythm disorder

scientific article published on 11 February 2019

DA5-CH, a novel GLP-1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease

artículo científico publicado en 2018

Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies.

artículo científico publicado en 2005

Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease ⬇️

artículo científico publicado el 1 de agosto de 2011

Different strains of rats show different sensitivity to block of long-term potentiation by nitric oxide synthase inhibitors.

artículo científico publicado en 2002

Driving GABAergic neurons optogenetically improves learning, reduces amyloid load and enhances autophagy in a mouse model of Alzheimer's disease

scientific article published on 12 March 2020

Drugs developed for treatment of diabetes show protective effects in Alzheimer's and Parkinson's diseases

artículo científico publicado en 2014

Editorial

Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice

artículo científico publicado en 2011

Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain

artículo científico publicado en 2012

Evidence That Parietal Lobe Fatty Acids May Be More Profoundly Affected in Moderate Alzheimer's Disease (AD) Pathology Than in Severe AD Pathology

artículo científico publicado en 2018

First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease

artículo científico publicado en 2014

Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance

artículo científico publicado en 2010

GIP has neuroprotective effects in Alzheimer and Parkinson's disease models

scientific article published on 06 November 2019

GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid

artículo científico publicado en 2008

GLP-1 receptor agonists show neuroprotective effects in animal models of diabetes

artículo científico publicado en 2018

GLP-1/GIP/Gcg receptor Triagonist improves the cognitive behaviors in triple-transgenic mice of Alzheimer's disease

artículo científico publicado en 2017

GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease

artículo científico publicado en 2011

Glucagon like peptide-1 receptor agonists as neuroprotective agents for ischemic stroke: a systematic scoping review

scientific article published on 20 September 2020

Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease

artículo científico publicado en 2009

Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis

artículo científico publicado en 2011

HFS-induced long-term potentiation and LFS-induced depotentiation in area CA1 of the hippocampus are not good models for learning.

artículo científico publicado en 1997

Hepcidin treatment modulates the expression of divalent metal transporter-1, ceruloplasmin, and ferroportin-1 in the rat cerebral cortex and hippocampus

artículo científico publicado en 2011

Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease

artículo científico publicado en 2009

Impairments of hippocampal synaptic plasticity induced by aggregated beta-amyloid (25-35) are dependent on stimulation-protocol and genetic background.

artículo científico publicado en 2006

Increased number of orexin/hypocretin neurons with high and prolonged external stress-induced depression.

artículo científico publicado en 2014

Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease.

artículo científico publicado en 2010

Incretin-based therapy for type 2 diabetes mellitus is promising for treating neurodegenerative diseases

artículo científico publicado en 2016

Inhibiting synthesis of the putative retrograde messenger nitric oxide results in amnesia in a passive avoidance task in the chick

artículo científico publicado en 1993

Inhibitors of Cyclooxygenases produce Amnesia for a Passive Avoidance Task in the Chick ⬇️

artículo científico publicado el 1 de junio de 1995

Inhibitors of PLA2 and NO synthase cooperate in producing amnesia of a spatial task

artículo científico publicado en 1995

Inhibitors of metabotropic glutamate receptors produce amnestic effects in chicks.

artículo científico publicado en 1994

Inhibitors of phospholipase A2 produce amnesia for a passive avoidance task in the chick

artículo científico publicado en 1994

Insulin Signaling Impairment in the Brain as a Risk Factor in Alzheimer's Disease

artículo científico publicado en 2019

Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases

artículo científico

Integrating microRNA and messenger RNA expression profiles in a rat model of deep vein thrombosis.

artículo científico publicado en 2017

Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence

artículo científico publicado en 2013

Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer's disease

artículo científico publicado en 2013

L-AP4 (L-(+)-2-amino-4-phosphonobutyric acid) induced impairment of spatial learning in the rat is antagonized by MAP4 ((S)-2-amino-2-methyl-4-phosphonobutanoic acid).

artículo científico publicado en 1996

Lack of the metabotropic glutamate receptor subtype 7 selectively impairs short-term working memory but not long-term memory

scientific journal article

Lack of the metabotropic glutamate receptor subtype 7 selectively modulates Theta rhythm and working memory

scientific journal article

Learned association of allocentric and egocentric information in the hippocampus

artículo científico publicado en 2004

Levo-tetrahydropalmatine inhibits the acquisition of ketamine-induced conditioned place preference by regulating the expression of ERK and CREB phosphorylation in rats

artículo científico publicado en 2016

Liraglutide and a lipidized analog of prolactin-releasing peptide show neuroprotective effects in a mouse model of β-amyloid pathology

artículo científico publicado en 2018

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease.

artículo científico publicado en 2013

Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice.

artículo científico publicado en 2012

Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats

artículo científico publicado en 2012

Liraglutide restores chronic ER stress, autophagy impairments and apoptotic signalling in SH-SY5Y cells

artículo científico publicado en 2017

Lixisenatide attenuates the detrimental effects of amyloid β protein on spatial working memory and hippocampal neurons in rats

artículo científico publicado en 2016

Lixisenatide rescues spatial memory and synaptic plasticity from amyloid β protein-induced impairments in rats

artículo científico publicado en 2014

Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease

artículo científico publicado en 2014

Magnolol alleviates Alzheimer's disease-like pathology in transgenic C. elegans by promoting microglia phagocytosis and the degradation of beta-amyloid through activation of PPAR-γ

artículo científico publicado en 2020

Metabolomic Profiling of Bile Acids in Clinical and Experimental Samples of Alzheimer's Disease

artículo científico publicado en 2017

Metabotropic glutamate receptor activation and blockade: their role in long-term potentiation, learning and neurotoxicity

artículo científico publicado en 1999

Metabotropic glutamate receptors control gating of spike transmission in the hippocampus area CA1.

artículo científico publicado en 2002

Moving towards a more realistic concept of what constitutes Alzheimer's disease

scientific article published on 20 December 2018

Neural circuit interactions between the dorsal raphe nucleus and the lateral hypothalamus: an experimental and computational study.

artículo científico publicado en 2014

Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress

artículo científico publicado en 2013

Neuroprotective and restorative properties of the GLP-1/GIP dual agonist DA-JC1 compared with a GLP-1 single agonist in Alzheimer's disease

scientific article published on 16 October 2019

Neuroprotective effects of (Val8)GLP-1-Glu-PAL in the MPTP Parkinson's disease mouse model

artículo científico publicado en 2015

Neuroprotective effects of D-Ala2GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model ⬇️

artículo científico publicado el 19 de abril de 2013

Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model

artículo científico publicado en 2015

Neuroprotective effects of a novel antidiabetic drug (D-Ser2)Oxm on amyloid β protein-induced cytotoxicity

artículo científico publicado en 2016

Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease

artículo científico publicado en 2017

Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease

artículo científico publicado en 2015

Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson's disease

artículo científico publicado en 2015

Neuroprotective effects of geniposide on Alzheimer's disease pathology

artículo científico

Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer's disease

artículo científico

Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

artículo científico publicado en 2015

Neuroprotective effects of the novel GLP-1 long acting analogue semaglutide in the MPTP Parkinson's disease mouse model

artículo científico publicado en 2018

Neuroprotective role of (Val(8))GLP-1-Glu-PAL in an in vitro model of Parkinson's disease.

artículo científico publicado en 2016

New animal models of Alzheimer's disease that display insulin desensitization in the brain

artículo científico

New drug treatments show neuroprotective effects in Alzheimer's and Parkinson's diseases

artículo científico publicado en 2014

New roles for insulin-like hormones in neuronal signalling and protection: new hopes for novel treatments of Alzheimer's disease?

artículo científico publicado en 2008

Nitric oxide is required for expression of LTP that is induced by stimulation phase-locked with theta rhythm

artículo científico publicado en 1999

Nitric oxide, the enigmatic neuronal messenger: its role in synaptic plasticity.

artículo científico publicado en 1997

Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

artículo científico publicado en 2011

Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models

artículo científico publicado en 2018

Novel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells

artículo científico publicado en 2016

Peptide drugs that have been developed to treat type 2 diabetes show neuroprotective effects

artículo científico publicado en 2014

Perirhinal cortex neuronal activity is actively related to working memory in the macaque.

artículo científico publicado en 2002

Perirhinal cortex neuronal activity related to long-term familiarity memory in the macaque

artículo científico publicado en 2003

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology

artículo científico publicado en 2016

Possible Causes of Alzheimer's Disease: Amyloid Fragments, Free Radicals, and Calcium Homeostasis

artículo científico publicado en 1998

Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus

artículo científico publicado en 2018

Potential Role of Glucagon-Like Peptide-1 (GLP-1) in Neuroprotection

artículo científico publicado el 1 de octubre de 2012

Prolonged Drug Releasing Fibers Attenuate Alzheimer's Disease-like Pathogenesis

artículo científico publicado en 2018

Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice

artículo científico publicado en 2010

Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice

artículo científico publicado en 2015

Prostaglandins play a role in memory consolidation in the chick

artículo científico publicado en 1995

Quantitative measurement of [Na+] and [K+] in postmortem human brain tissue indicates disturbances in subjects with Alzheimer's disease and dementia with Lewy bodies.

artículo científico publicado en 2015

Quinacrine Acts like an Acetylcholine Receptor Antagonist Rather Than like a Phospholipase A2 Inhibitor in a Passive Avoidance Task in the Chick ⬇️

artículo científico publicado el 1 de marzo de 1995

Quinolinic acid lesion of the rat entorhinal cortex pars medialis produces selective amnesia in allocentric working memory (WM), but not in egocentric WM

artículo científico publicado en 1994

Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system.

artículo científico publicado en 2009

Restoration of cerebral and systemic microvascular architecture in APP/PS1 transgenic mice following treatment with Liraglutide™.

artículo científico publicado en 2015

Reward modulates neuronal activity in the hippocampus of the rat.

artículo científico publicado en 2003

Soluble beta-amyloid[25-35] reversibly impairs hippocampal synaptic plasticity and spatial learning

artículo científico publicado en 2007

Stimulation on the positive phase of hippocampal theta rhythm induces long-term potentiation that can Be depotentiated by stimulation on the negative phase in area CA1 in vivo

artículo científico publicado en 1997

Stress impairs performance in spatial water maze learning tasks

artículo científico publicado en 1999

Synaptic plasticity in the hippocampus of a APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice

artículo científico publicado en 2010

TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.

artículo científico publicado en 2013

The Dual GLP-1/GIP Receptor Agonist DA4-JC Shows Superior Protective Properties Compared to the GLP-1 Analogue Liraglutide in the APP/PS1 Mouse Model of Alzheimer's Disease

scientific article published on 01 January 2020

The Novel DA-CH3 Dual Incretin Restores Endoplasmic Reticulum Stress and Autophagy Impairments to Attenuate Alzheimer-Like Pathology and Cognitive Decrements in the APPSWE/PS1ΔE9 Mouse Model

artículo científico publicado en 2018

The Novel Dual GLP-1/GIP Receptor Agonist DA-CH5 Is Superior to Single GLP-1 Receptor Agonists in the MPTP Model of Parkinson's Disease

scientific article published on 01 January 2020

The Role of GLP-1 in Neuronal Activity and Neurodegeneration

artículo científico publicado el 1 de enero de 2010

The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease.

artículo científico publicado en 2012

The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.

artículo científico publicado en 2011

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease.

artículo científico publicado en 2018

The diabetes drug semaglutide reduces infarct size, inflammation, and apoptosis, and normalizes neurogenesis in a rat model of stroke

scientific article published on 26 August 2019

The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease

artículo científico publicado en 2012

The effect of mGlu8 deficiency in animal models of psychiatric diseases

artículo científico publicado en 2009

The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease

artículo científico publicado en 2012

The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease

artículo científico publicado en 2014

The novel GLP-1/GIP analogue DA5-CH reduces tau phosphorylation and normalizes theta rhythm in the icv. STZ rat model of AD

scientific article published on 20 January 2020

The novel GLP-1/GIP dual receptor agonist DA3-CH is neuroprotective in the pilocarpine-induced epileptogenesis rat model

scientific article published on 08 May 2019

The selective neuronal NO synthase inhibitor 7-nitro-indazole blocks both long-term potentiation and depotentiation of field EPSPs in rat hippocampal CA1 in vivo.

artículo científico publicado en 1996

The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain.

artículo científico publicado en 2012

Therapeutic Potential of Baicalein in Alzheimer's Disease and Parkinson's Disease

artículo científico publicado en 2017

Therapeutic Potential of Genipin in Central Neurodegenerative Diseases

artículo científico publicado en 2016

Therapeutic potential of flavonoids in spinal cord injury

artículo científico publicado en 2017

Time, space and hippocampal functions.

artículo científico publicado en 2003

Training in the Morris water maze occludes the synergism between ACPD and arachidonic acid on glutamate release in synaptosomes prepared from rat hippocampus

artículo científico publicado en 1996

Two novel dual GLP-1/GIP receptor agonists are neuroprotective in the MPTP mouse model of Parkinson's disease

artículo científico publicado en 2018

Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease ⬇️

artículo científico publicado en 2015

Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

artículo científico publicado en 2010

Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats

artículo científico publicado en 2010

Val⁸-GLP-1 remodels synaptic activity and intracellular calcium homeostasis impaired by amyloid β peptide in rats

artículo científico publicado en 2013

Wide-ranging alterations in the brain fatty acid complement of subjects with late Alzheimer's disease as detected by GC-MS

artículo científico publicado en 2016

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