Lista de obras - Petrine Wellendorph - Dominio Público Uruguay

3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes

artículo científico publicado en 2011

A sequential high-yielding large-scale solution-method for synthesis of philanthotoxin analogues

artículo científico publicado en 2003

Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24.

artículo científico publicado en 2006

Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs

artículo científico publicado en 2017

Autoradiographic imaging and quantification of the high-affinity GHB binding sites in rodent brain using (3)H-HOCPCA.

artículo científico publicado en 2016

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets

artículo científico publicado en 2019

Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor

artículo científico publicado en 2011

Cyanohydrin glycosides of Passiflora: distribution pattern, a saturated cyclopentane derivative from P. guatemalensis, and formation of pseudocyanogenic alpha-hydroxyamides as isolation artefacts

artículo científico publicado en 2002

Cyclopentanoids of Mathurina penduliflora

artículo científico publicado en 2001

Delineation of the GPRC6A receptor signaling pathways using a mammalian cell line stably expressing the receptor

artículo científico publicado en 2013

Design, synthesis, and in vitro pharmacology of new radiolabeled gamma-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity gamma-hydroxybutyric acid binding sites

artículo científico publicado en 2010

Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties

artículo científico publicado en 2013

Development of a Robust Mammalian Cell-based Assay for Studying Recombinant α4 β1/3 δ GABAA Receptor Subtypes.

artículo científico publicado en 2017

Discovery of 2-(Imidazo[1,2- b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites

scientific article published on 27 February 2019

Elucidating Pathway and Anesthetic Mechanism of Action of Clove Oil Nanoformulations in Fish

artículo científico publicado en 2022

Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

artículo científico publicado en 2019

GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice.

artículo científico publicado en 2017

GHB receptor targets in the CNS: focus on high-affinity binding sites

artículo científico publicado en 2013

Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function

artículo científico publicado en 2016

Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke.

artículo científico publicado en 2017

Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds

artículo científico publicado en 2006

Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method.

artículo científico publicado en 2017

Identification of the First Highly Subtype-Selective Inhibitor of Human GABA Transporter GAT3.

artículo científico publicado en 2015

In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1.

artículo científico publicado en 2015

Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia.

artículo científico publicado en 2017

Known regulators of nitric oxide synthase and arginase are agonists at the human G-protein-coupled receptor GPRC6A.

artículo científico publicado en 2006

Lack of evidence for synaptic high-affinity γ-hydroxybutyric acid (GHB) transport in rat brain synaptosomes and 11 Na+ -dependent SLC neurotransmitter transporters

artículo científico publicado en 2019

Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABA(A) receptor subtypes indicate a different binding mode for GABA at these receptors

artículo científico publicado en 2012

Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analog

artículo científico publicado en 2017

Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients.

scientific article published on June 2009

Monastrol, a 3,4-dihydropyrimidin-2(1H)-thione, as structural scaffold for the development of modulators for GHB high-affinity binding sites and α1β2δ GABAA receptors

artículo científico publicado en 2017

New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites.

artículo científico publicado en 2013

No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions.

artículo científico publicado en 2008

Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain.

artículo científico publicado en 2005

Novel high-affinity and selective biaromatic 4-substituted gamma-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies.

artículo científico publicado en 2008

Novel radioiodinated {gamma}-hydroxybutyric acid analogues for radiolabeling and Photolinking of high-affinity {gamma}-hydroxybutyric acid binding sites

artículo científico publicado en 2010

Pharmacological Characterization of [3H]ATPCA as a Substrate for Studying the Functional Role of the Betaine/GABA Transporter 1 and the Creatine Transporter

artículo científico publicado en 2017

Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects

scientific article published on 04 April 2020

Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes

artículo científico publicado en 2015

Pharmacological identification of a guanidine-containing β-alanine analogue with low micromolar potency and selectivity for the betaine/GABA transporter 1 (BGT1).

artículo científico publicado en 2014

Phenylacetic acids and the structurally related non-steroidal anti-inflammatory drug diclofenac bind to specific gamma-hydroxybutyric acid sites in rat brain.

artículo científico publicado en 2009

Positive allosteric modulation of the GHB high-affinity binding site by the GABAA receptor modulator monastrol and the flavonoid catechin.

artículo científico publicado en 2014

Potency of GABA at human recombinant GABA(A) receptors expressed in Xenopus oocytes: a mini review

artículo científico

Promiscuous seven transmembrane receptors sensing L-α-amino acids

artículo científico

Radiosynthesis and Evaluation of [11C]3-Hydroxycyclopent-1-enecarboxylic Acid as Potential PET Ligand for the High-Affinity γ-Hydroxybutyric Acid Binding Sites

artículo científico publicado en 2016

Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization.

artículo científico publicado en 2013

Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice

artículo científico publicado en 2003

Structural and molecular aspects of betaine-GABA transporter 1 (BGT1) and its relation to brain function

artículo científico publicado en 2019

Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors

artículo científico publicado en 2007

Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1).

artículo científico publicado en 2017

Synthesis and Pharmacological Evaluation of [11C]4-Methoxy-N-[2-(thiophen-2-yl)imidazo[1,2-a]pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the δ-Subunit-Containing γ-Aminobutyric Acid Type A Receptors

artículo científico publicado en 2019

Tetraphyllin B, volkenin and cyclopentenylglycine in Androsiphonia adenostegia

artículo científico publicado en 2001

The GPCR, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function

artículo científico

The L-α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release

artículo científico publicado en 2012

The emerging role of promiscuous 7TM receptors as chemosensors for food intake

artículo científico publicado en 2010

The rat GPRC6A: cloning and characterization

artículo científico publicado en 2007

The γ-hydroxybutyric acid (GHB) analogue NCS-382 is a substrate for both monocarboxylate transporters subtypes 1 and 4

artículo científico publicado en 2019

Tuning Wasp Toxin Structure for Nicotinic Receptor Antagonism: Cyclohexylalanine-Containing Analogues as Potent and Voltage-Dependent Blockers

artículo científico publicado en 2006

α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)

artículo científico publicado en 2012

Lista de obras de Petrine Wellendorph

3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes

A sequential high-yielding large-scale solution-method for synthesis of philanthotoxin analogues

Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24.

Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs

Autoradiographic imaging and quantification of the high-affinity GHB binding sites in rodent brain using (3)H-HOCPCA.

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets

Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor

Cyanohydrin glycosides of Passiflora: distribution pattern, a saturated cyclopentane derivative from P. guatemalensis, and formation of pseudocyanogenic alpha-hydroxyamides as isolation artefacts

Cyclopentanoids of Mathurina penduliflora

Delineation of the GPRC6A receptor signaling pathways using a mammalian cell line stably expressing the receptor

Design, synthesis, and in vitro pharmacology of new radiolabeled gamma-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity gamma-hydroxybutyric acid binding sites

Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties

Development of a Robust Mammalian Cell-based Assay for Studying Recombinant α4 β1/3 δ GABAA Receptor Subtypes.

Discovery of 2-(Imidazo[1,2- b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites

Elucidating Pathway and Anesthetic Mechanism of Action of Clove Oil Nanoformulations in Fish

Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice.

GHB receptor targets in the CNS: focus on high-affinity binding sites

Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function

Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke.

Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds

Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method.

Identification of the First Highly Subtype-Selective Inhibitor of Human GABA Transporter GAT3.

In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1.

Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia.

Known regulators of nitric oxide synthase and arginase are agonists at the human G-protein-coupled receptor GPRC6A.

Lack of evidence for synaptic high-affinity γ-hydroxybutyric acid (GHB) transport in rat brain synaptosomes and 11 Na+ -dependent SLC neurotransmitter transporters

Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABA(A) receptor subtypes indicate a different binding mode for GABA at these receptors

Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analog

Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients.

Monastrol, a 3,4-dihydropyrimidin-2(1H)-thione, as structural scaffold for the development of modulators for GHB high-affinity binding sites and α1β2δ GABAA receptors

New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites.

No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions.

Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain.

Novel high-affinity and selective biaromatic 4-substituted gamma-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies.

Novel radioiodinated {gamma}-hydroxybutyric acid analogues for radiolabeling and Photolinking of high-affinity {gamma}-hydroxybutyric acid binding sites

Pharmacological Characterization of [3H]ATPCA as a Substrate for Studying the Functional Role of the Betaine/GABA Transporter 1 and the Creatine Transporter

Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects

Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes

Pharmacological identification of a guanidine-containing β-alanine analogue with low micromolar potency and selectivity for the betaine/GABA transporter 1 (BGT1).

Phenylacetic acids and the structurally related non-steroidal anti-inflammatory drug diclofenac bind to specific gamma-hydroxybutyric acid sites in rat brain.

Positive allosteric modulation of the GHB high-affinity binding site by the GABAA receptor modulator monastrol and the flavonoid catechin.

Potency of GABA at human recombinant GABA(A) receptors expressed in Xenopus oocytes: a mini review

Promiscuous seven transmembrane receptors sensing L-α-amino acids

Radiosynthesis and Evaluation of [11C]3-Hydroxycyclopent-1-enecarboxylic Acid as Potential PET Ligand for the High-Affinity γ-Hydroxybutyric Acid Binding Sites

Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization.

Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice

Structural and molecular aspects of betaine-GABA transporter 1 (BGT1) and its relation to brain function

Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors

Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1).

Synthesis and Pharmacological Evaluation of [11C]4-Methoxy-N-[2-(thiophen-2-yl)imidazo[1,2-a]pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the δ-Subunit-Containing γ-Aminobutyric Acid Type A Receptors

Tetraphyllin B, volkenin and cyclopentenylglycine in Androsiphonia adenostegia

The GPCR, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function

The L-α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release

The emerging role of promiscuous 7TM receptors as chemosensors for food intake

The rat GPRC6A: cloning and characterization

The γ-hydroxybutyric acid (GHB) analogue NCS-382 is a substrate for both monocarboxylate transporters subtypes 1 and 4

Tuning Wasp Toxin Structure for Nicotinic Receptor Antagonism: Cyclohexylalanine-Containing Analogues as Potent and Voltage-Dependent Blockers

α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)