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Lista de obras de Oliver Langer

(R)-[(11)C]verapamil is selectively transported by murine and human P-glycoprotein at the blood-brain barrier, and not by MRP1 and BCRP.

artículo científico publicado en 2013

18F, 11C and 68Ga in small animal PET imaging. Evaluation of partial volume correction methods

artículo científico publicado en 2013

A PET microdosing study with the P-glycoprotein inhibitor tariquidar

A Prediction Method for P-glycoprotein-Mediated Drug-Drug Interactions at the Human Blood-Brain Barrier From Blood Concentration-Time Profiles, Validated With PET Data.

artículo científico publicado en 2017

A Proof-of-Concept Study to Inhibit ABCG2- and ABCB1-Mediated Efflux Transport at the Human Blood-Brain Barrier

scientific article published on 20 September 2018

A combined accelerator mass spectrometry-positron emission tomography human microdose study with 14C- and 11C-labelled verapamil.

artículo científico publicado en 2011

A combined accelerator mass spectrometry/positron emission tomography microdose study to assess the plasma and brain tissue pharmacokinetics of C- and C-labelled verapamil in healthy volunteers

A comparative small-animal PET evaluation of [11C]tariquidar, [11C]elacridar and (R)-[11C]verapamil for detection of P-glycoprotein-expressing murine breast cancer

artículo científico publicado en 2011

A novel PET protocol for visualization of breast cancer resistance protein function at the blood-brain barrier

artículo científico publicado en 2012

A novel electrophilic synthesis and evaluation of medium specific radioactivity (1R,2S)-4-[18F]fluorometaraminol, a tracer for the assessment of cardiac sympathetic nerve integrity with PET.

artículo científico publicado en 2004

A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier

artículo científico publicado en 2011

A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PET

artículo científico publicado en 2009

A positron emission tomography microdosing study with a potential antiamyloid drug in healthy volunteers and patients with Alzheimer's disease

artículo científico publicado en 2006

Absolute quantitation of iodine-123 epidepride kinetics using single-photon emission tomography: comparison with carbon-11 epidepride and positron emission tomography.

artículo científico publicado en 1999

Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET

artículo científico publicado en 2018

Age dependency of cerebral P-gp function measured with (R)-[11C]verapamil and PET.

artículo científico publicado en 2009

Alzheimer's and ABC transporters--new opportunities for diagnostics and treatment.

artículo científico publicado en 2014

Amyloid PET and MRI in Alzheimer's disease and mild cognitive impairment.

artículo científico publicado en 2009

Approaches using molecular imaging technology — use of PET in clinical microdose studies ⬇️

artículo científico publicado el 29 de septiembre de 2010

Approaching complete inhibition of P-glycoprotein at the human blood-brain barrier: an (R)-[11C]verapamil PET study.

artículo científico publicado en 2015

Assessing the Activity of Multidrug Resistance-Associated Protein 1 at the Lung Epithelial Barrier

scientific article published on 13 April 2020

Assessment of P-Glycoprotein Transport Activity at the Human Blood-Retina Barrier with (R)-11C-Verapamil PET.

artículo científico publicado en 2016

Assessment of brain delivery of a model ABCB1/ABCG2 substrate in patients with non-contrast-enhancing brain tumors with positron emission tomography

scientific article published on 12 December 2019

Assessment of cerebral P-glycoprotein expression and function with PET by combined [11C]inhibitor and [11C]substrate scans in rats

artículo científico publicado en 2013

Assessment of regional differences in tariquidar-induced P-glycoprotein modulation at the human blood-brain barrier.

artículo científico publicado en 2009

Automated electrophilic radiosynthesis of [¹⁸F]FBPA using a modified nucleophilic GE TRACERlab FXFDG.

artículo científico publicado en 2015

Automated radiosynthesis of [(18)F]ciprofloxacin

artículo científico publicado en 2015

BEZ235 impairs gastric cancer growth by inhibition of PI3K/mTOR in vitro and in vivo.

artículo científico publicado en 2010

Biological evaluation of 2'-[18F]fluoroflumazenil ([18F]FFMZ), a potential GABA receptor ligand for PET.

artículo científico publicado en 2004

Blood-brain barrier P-glycoprotein function in Alzheimer's disease

artículo científico publicado en 2011

Brain radioligands--state of the art and new trends

artículo científico publicado en 2001

Breast Cancer Resistance Protein and P-Glycoprotein Influence In Vivo Disposition of 11C-Erlotinib

artículo científico publicado en 2015

Carbon-11 epidepride: a suitable radioligand for PET investigation of striatal and extrastriatal dopamine D2 receptors

artículo científico publicado en 1999

Carbon-11 pb-12: an attempt to visualize the dopamine d(4) receptor in the primate brain with positron emission tomography

artículo científico publicado en 2000

Combined PET and microdialysis for in vivo assessment of intracellular drug pharmacokinetics in humans

artículo científico publicado en 2005

Comparison of three different purification methods for the routine preparation of [11C] Metomidate.

artículo científico publicado en 2003

Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib

artículo científico publicado en 2020

Decreased blood-brain barrier P-glycoprotein function with aging

artículo científico publicado en 2008

Development and performance test of an online blood sampling system for determination of the arterial input function in rats

artículo científico publicado en 2015

Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography

artículo científico publicado en 2015

Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.

artículo científico publicado en 2009

Dose-response assessment of tariquidar for inhibition of P-glycoprotein at the human blood-brain barrier using (R)-[11C]verapamil PET.

artículo científico publicado en 2010

EGFR is required for FOS-dependent bone tumor development via RSK2/CREB signaling

artículo científico publicado en 2018

Effect of P-glycoprotein inhibition at the blood-brain barrier on brain distribution of (R)-[11 C]verapamil in elderly vs. young subjects.

artículo científico publicado en 2017

Effect of Rifampicin on the Distribution of [11C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice

scientific article published on 14 September 2018

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

artículo científico publicado en 2017

FDG uptake is a surrogate marker for defining the optimal biological dose of the mTOR inhibitor everolimus in vivo

artículo científico publicado en 2009

Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography

artículo científico publicado en 2015

Factors that limit positron emission tomography imaging of p-glycoprotein density at the blood-brain barrier.

artículo científico publicado en 2013

Gastric cancer growth control by BEZ235 in vivo does not correlate with PI3K/mTOR target inhibition but with [18F]FLT uptake

artículo científico publicado en 2011

Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model

artículo científico publicado en 2016

Generation and Characterization of an Abcc1 Humanized Mouse Model (hABCC1flx/flx ) with Knockout Capability

scientific article published on 12 June 2019

Hepatocyte-specific deletion of EGFR in mice reduces hepatic Abcg2 transport activity measured with [(11)C]erlotinib and positron emission tomography

artículo científico

High specific radioactivity (1R,2S)-4-[(18)F]fluorometaraminol: a PET radiotracer for mapping sympathetic nerves of the heart

scientific article published on 01 April 2000

Humanization of the Blood-Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus - Lessons from Three Unsuccessful Approaches

scientific article published on 06 July 2018

Imaging P-Glycoprotein Function at the Blood-Brain Barrier as a Determinant of the Variability in Response to Central Nervous System Drugs

scientific article published on 23 March 2019

Imaging P-glycoprotein Induction at the Blood-Brain Barrier of a Beta-Amyloidosis Mouse Model with 11C-Metoclopramide PET

artículo científico publicado en 2019

Imaging techniques to study drug transporter function in vivo

artículo científico publicado en 2018

Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate 11C-Metoclopramide Assessed with PET Imaging in Humans

scientific article published on 10 January 2019

Impact of rifampicin-inhibitable transport on the liver distribution and tissue kinetics of erlotinib assessed with PET imaging in rats

artículo científico publicado en 2018

In vitro and in vivo evaluation of [18F]ciprofloxacin for the imaging of bacterial infections with PET.

artículo científico publicado en 2004

In vivo P-glycoprotein function before and after epilepsy surgery.

artículo científico publicado en 2014

In vivo characterization of [18F]AVT-011 as a radiotracer for PET imaging of multidrug resistance

artículo científico publicado en 2019

Influence of 24-Nor-Ursodeoxycholic Acid on Hepatic Disposition of [(18)F]Ciprofloxacin, a Positron Emission Tomography Study in Mice

artículo científico publicado en 2016

Influence of Multidrug Resistance-Associated Proteins on the Excretion of the ABCC1 Imaging Probe 6-Bromo-7-[11C]Methylpurine in Mice

scientific article published on 01 April 2019

Influence of OATPs on Hepatic Disposition of Erlotinib Measured With Positron Emission Tomography

artículo científico publicado en 2017

Influence of breast cancer resistance protein and P-glycoprotein on tissue distribution and excretion of Ko143 assessed with PET imaging in mice

artículo científico publicado en 2018

Influence of functional haplotypes in the drug transporter gene ABCB1 on central nervous system drug distribution in humans

artículo científico publicado en 2005

Inhibition of ABCB1 and ABCG2 at the Mouse Blood-Brain Barrier with Marketed Drugs To Improve Brain Delivery of the Model ABCB1/ABCG2 Substrate [11C]erlotinib

artículo científico publicado en 2019

Inhibition of breast cancer resistance protein at the murine blood-brain barrier by Ko143 studied with [11C]tariquidar and PET.

artículo científico publicado en 2011

Interaction of 11C-tariquidar and 11C-elacridar with P-glycoprotein and breast cancer resistance protein at the human blood-brain barrier

artículo científico publicado en 2013

Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with positron emission tomography

artículo científico publicado en 2012

Intravenous infusion for the controlled exposure to the dual ABCB1 and ABCG2 inhibitor elacridar in nonhuman primates.

artículo científico publicado en 2018

Limitations of small animal PET imaging with [18F]FDDNP and FDG for quantitative studies in a transgenic mouse model of Alzheimer's disease

artículo científico publicado en 2009

Liver Imaging and Hepatobiliary Contrast Media

artículo científico publicado en 2018

Measurement of Hepatic ABCB1 and ABCG2 Transport Activity with [11C]Tariquidar and PET in Humans and Mice

artículo científico publicado en 2019

Measurement of cerebral ABCC1 transport activity in wild-type and APP/PS1-21 mice with positron emission tomography

scientific article published on 13 June 2019

Methods to assess tissue-specific distribution and metabolism of drugs.

artículo científico publicado en 2004

Microdialysis versus other techniques for the clinical assessment of in vivo tissue drug distribution

artículo científico publicado en 2006

Molar activity - The keystone in C-radiochemistry: An explorative study using the gas phase method

scientific article published on 12 October 2018

New ultrasensitive detection technologies and techniques for use in microdosing studies

artículo científico publicado en 2009

On the applicability of [18F]FBPA to predict L-BPA concentration after amino acid preloading in HuH-7 liver tumor model and the implication for liver boron neutron capture therapy

artículo científico publicado en 2016

P-Glycoprotein (ABCB1) Inhibits the Influx and Increases the Efflux of 11C-Metoclopramide Across the Blood-Brain Barrier: A PET Study on Nonhuman Primates

scientific article published on 10 May 2018

P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study

artículo científico publicado en 2013

PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo

artículo científico publicado en 2011

PET and SPET tracers for mapping the cardiac nervous system

artículo científico publicado en 2002

PET imaging of the mouse brain reveals a dynamic regulation of SERT density in a chronic stress model

scientific article published on 11 February 2019

Peripheral metabolism of (R)-[11C]verapamil in epilepsy patients

artículo científico publicado en 2007

Pgp-mediated interaction between (R)-[11C]verapamil and tariquidar at the human blood-brain barrier: a comparison with rat data

artículo científico publicado en 2011

Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood-brain barriers studied with (R)-[11C]verapamil positron emission tomography

artículo científico publicado en 2012

Pharmacokinetics of single ascending doses of the P-glycoprotein inhibitor tariquidar in healthy subjects

artículo científico publicado en 2012

Pharmacokinetics of the P-gp Inhibitor Tariquidar in Rats After Intravenous, Oral, and Intraperitoneal Administration

artículo científico publicado en 2018

Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil

artículo científico publicado en 2007

Pilot PET Study to Assess the Functional Interplay Between ABCB1 and ABCG2 at the Human Blood-Brain Barrier

scientific article published on 03 March 2016

Pitfalls and solutions of the fully-automated radiosynthesis of [11C]metoclopramide

scientific article published on 18 December 2019

Positron emission tomographic evaluation of the putative dopamine-D3 receptor ligand, [11C]RGH-1756 in the monkey brain

artículo científico publicado en 2004

Positron emission tomography for use in microdosing studies.

artículo científico publicado en 2008

Preloading with L-BPA, L-tyrosine and L-DOPA enhances the uptake of [ 18 F]FBPA in human and mouse tumour cell lines

scientific article published on 01 September 2016

Proof-of-Concept Study of Drug Brain Permeability Between in Vivo Human Brain and an in Vitro iPSCs-Human Blood-Brain Barrier Model

artículo científico publicado en 2019

Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier.

artículo científico

Radiosynthesis and Assessment of Ocular Pharmacokinetics of 124I-Labeled Chitosan in Rabbits Using Small-Animal PET

scientific article published on 01 April 2011

Radiosynthesis and in vivo evaluation of 1-[18F]fluoroelacridar as a positron emission tomography tracer for P-glycoprotein and breast cancer resistance protein

artículo científico publicado en 2011

Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR System.

artículo científico publicado en 2017

Role of (drug) transporters in imaging in health and disease

artículo científico publicado en 2014

Small-animal PET evaluation of [11C]MC113 as a PET tracer for P-glycoprotein.

artículo científico publicado en 2010

Some new methods for the synthesis of cardiac neurotransmission PET radiotracers.

artículo científico publicado en 1995

Strategies to Inhibit ABCB1- and ABCG2-Mediated Efflux Transport of Erlotinib at the Blood-Brain Barrier: A PET Study on Nonhuman Primates.

artículo científico publicado en 2016

Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor

artículo científico publicado en 2010

Synthesis and in vivo evaluation of the putative breast cancer resistance protein inhibitor [11C]methyl 4-((4-(2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl)phenyl)amino-carbonyl)-2-(quinoline-2-carbonylamino)benzoate

artículo científico publicado en 2010

Synthesis and preclinical characterization of 1-(6'-deoxy-6'-[18F]fluoro-β-d-allofuranosyl)-2-nitroimidazole (β-6'-[18F]FAZAL) as a positron emission tomography radiotracer to assess tumor hypoxia

artículo científico publicado en 2016

Synthesis and preclinical evaluation of the radiolabeled P-glycoprotein inhibitor [(11)C]MC113.

artículo científico publicado en 2012

Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier

artículo científico publicado en 2009

Synthesis of fluorine-18-labeled ciprofloxacin for PET studies in humans

artículo científico publicado en 2003

Synthesis of high-specific-radioactivity 4- and 6-[18F]fluorometaraminol-PET tracers for the adrenergic nervous system of the heart

artículo científico publicado en 2001

Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal positron emission tomography and in vitro study

artículo científico publicado en 2013

Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET.

artículo científico publicado en 2008

The antiepileptic drug mephobarbital is not transported by P-glycoprotein or multidrug resistance protein 1 at the blood-brain barrier: a positron emission tomography study

artículo científico publicado en 2012

The third-generation P-glycoprotein inhibitor tariquidar may overcome bacterial multidrug resistance by increasing intracellular drug concentration.

artículo científico publicado en 2011

Towards Improved Pharmacokinetic Models for the Analysis of Transporter-Mediated Hepatic Disposition of Drug Molecules with Positron Emission Tomography

artículo científico publicado en 2019

Use of PET Imaging to Evaluate Transporter-Mediated Drug-Drug Interactions.

artículo científico publicado en 2016

Use of imaging to assess the activity of hepatic transporters

scientific article published on 23 January 2020

Using positron emission tomography to study transporter-mediated drug-drug interactions in tissues

artículo científico publicado en 2014

Whole-Body Distribution and Radiation Dosimetry of 11C-Elacridar and 11C-Tariquidar in Humans.

artículo científico publicado en 2016

[(18)F]FDG is not transported by P-glycoprotein and breast cancer resistance protein at the rodent blood-brain barrier

artículo científico publicado en 2015

[11C]Elacridar as a novel P-glycoprotein PET tracer, assessment of whole-body distribution and radiation dosimetry in humans.

artículo científico publicado en 2011

[11C]Erlotinib PET cannot detect acquired erlotinib resistance in NSCLC tumor xenografts in mice.

artículo científico publicado en 2017

[18F]Ciprofloxacin, a new positron emission tomography tracer for noninvasive assessment of the tissue distribution and pharmacokinetics of ciprofloxacin in humans.

artículo científico publicado en 2004

[18F]FE@SUPPY: a suitable PET tracer for the adenosine A3 receptor? An in vivo study in rodents

artículo científico publicado en 2015

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