Lista de obras - Ingebrigt Sylte - Dominio Público Uruguay

1,2,3-triazole analogs of combretastatin A-4 as potential microtubule-binding agents

artículo científico publicado en 2010

1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin

artículo científico publicado en 2008

A combined simulation with ab initio MO and classical vibrational analysis on the specific interactions between thermolysin and dipeptide ligands

A homology model of SERT based on the LeuTAa template

artículo científico publicado en 2006

A linear combination of pharmacophore hypotheses as a new tool in search of new active compounds--an application for 5-HT1A receptor ligands

artículo científico publicado en 2013

A molecular model of a putative substrate releasing conformation of multidrug resistance protein 5 (MRP5).

artículo científico publicado en 2008

A short update on the structure of drug binding sites on neurotransmitter transporters.

artículo científico publicado en 2011

An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity

artículo científico publicado en 2012

Atypical and typical antipsychotic drug interactions with the dopamine D2 receptor

artículo científico publicado en 2005

Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure

artículo científico publicado en 2009

Bioinformatics: from genome to drug targets

scientific article published on 01 January 2002

Comparative Molecular Dynamics of Mesophilic and Psychrophilic Protein Homologues Studied by 1.2 ns Simulations

artículo científico publicado en 1999

Comparative molecular dynamic simulations of wild type and Thr114Val mutated Scaptodrosophila lebanonensis alcohol dehydrogenase

artículo científico publicado en 2013

Comparative molecular dynamics simulations of mitogen-activated protein kinase-activated protein kinase 5.

scientific article published on 19 March 2014

Comparative sequence and structure analysis reveal features of cold adaptation of an enzyme in the thermolysin family

artículo científico publicado en 2006

Conformational restrictions in ligand binding to the human intestinal di-/tripeptide transporter: implications for design of hPEPT1 targeted prodrugs

artículo científico publicado en 2005

Determinants for psychrophilic and thermophilic features of metallopeptidases of the M4 family.

artículo científico publicado en 2009

Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models

artículo científico publicado en 2014

Differences in PAR-2 activating potential by king crab (Paralithodes camtschaticus), salmon (Salmo salar), and bovine (Bos taurus) trypsin

artículo científico publicado en 2013

Dipeptide inhibitors of thermolysin and angiotensin I-converting enzyme.

artículo científico publicado en 2012

Discovery of potent thermolysin inhibitors using structure based virtual screening and binding assays

artículo científico publicado en 2009

Effect of the glutathione/glutathione disulfide redox couple on thiopurine methyltransferase

artículo científico publicado en 2001

Environmental Chemicals Modulate Polar Bear (Ursus maritimus) Peroxisome Proliferator-Activated Receptor Gamma (PPARG) and Adipogenesis in Vitro

artículo científico publicado en 2016

From Homology Models to a Set of Predictive Binding Pockets-a 5-HT1A Receptor Case Study

artículo científico publicado en 2017

From genomics to drug targets

artículo científico publicado en 2006

Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor Ligands

artículo científico publicado en 2015

High-level expression of pseudolysin, the extracellular elastase of Pseudomonas aeruginosa, in Escherichia coli and its purification

artículo científico publicado en 2015

Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5).

artículo científico publicado en 2013

Homology modeling of human γ-butyric acid transporters and the binding of pro-drugs 5-aminolevulinic acid and methyl aminolevulinic acid used in photodynamic therapy

artículo científico publicado en 2013

Homology modeling of transporter proteins (carriers and ion channels).

artículo científico

Homology modelling of metabotropic glutamate receptor 2.

artículo científico publicado en 2011

Identification of novel quinazolin-4(3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases

artículo científico publicado en 2010

Identification of novel serotonin transporter compounds by virtual screening

artículo científico publicado en 2014

In Silico Methods for the Discovery of Orthosteric GABA Receptor Compounds

In Vitro and In Silico Competitive Binding of Brominated Polyphenyl Ether Contaminants With Human and Gull Thyroid Hormone Transport Proteins.

artículo científico publicado en 2017

Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors.

artículo científico publicado en 2014

Interaction of 1,2,4-substituted piperazines, new serotonin receptor ligands, with 5-HT1A and 5-HT2A receptors

artículo científico publicado en 2002

Intrinsic activity and comparative molecular dynamics of buspirone analogues at the 5-HT(1A) receptors.

artículo científico publicado en 2004

Ligand induced conformational states of the 5-HT(1A) receptor

artículo científico publicado en 2001

Ligand-directed trafficking of receptor stimulus

artículo científico publicado en 2014

Ligand-guided homology modelling of the GABAB2 subunit of the GABAB receptor

artículo científico publicado en 2017

Ligand-induced stabilization and activation of peroxisome proliferator-activated receptor gamma

artículo científico publicado en 2008

Mapping the suramin-binding sites of human neutrophil elastase: investigation by fluorescence resonance energy transfer and molecular modeling.

artículo científico publicado en 1997

Mass-spectrometric studies of new 6-nitroquipazines-serotonin transporter inhibitors

artículo científico publicado en 2011

Membrane Transporters: Structure, Function and Targets for Drug Design

Molecular Interactions Stabilizing the Promatrix Metalloprotease-9·Serglycin Heteromer

artículo científico publicado en 2020

Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues.

artículo científico publicado en 2001

Molecular dynamics of NPY Y 1 receptor activation

artículo científico publicado en 1999

Molecular dynamics of buspirone analogues interacting with the 5-HT1A and 5-HT2A serotonin receptors

artículo científico publicado en 2001

Molecular dynamics of serotonin and ritanserin interacting with the 5-HT2 receptor

artículo científico publicado en 1992

Molecular dynamics of the 5-HT1a receptor and ligands.

artículo científico publicado en 1993

Molecular insight into pseudolysin inhibition using the MM-PBSA and LIE methods.

artículo científico publicado en 2005

Molecular mechanism of citalopram and cocaine interactions with neurotransmitter transporters

artículo científico publicado en 2003

Molecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol

artículo científico publicado en 2011

Molecular model of the Escherichia coli Na1/H1 antiporter NhaA.

artículo científico publicado en 2001

Molecular model of the neural dopamine transporter

artículo científico publicado en 2003

Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)

artículo científico publicado en 2007

Molecular modeling of neurotransmitter receptors and ligands

artículo científico publicado en 1993

Molecular modelling of UH-301 and 5-HTla receptor interactions

artículo científico publicado en 1996

Molecular modelling of drug targets: the past, the present and the future.

artículo científico publicado en 2005

Molecular recognition of docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-X receptor alpha

artículo científico publicado en 2008

Molecular recognition of long chain fatty acids by peroxisome proliferator-activated receptor α

Molecular structure and dynamics of cis(Z)-and trans(E)-flupenthixol and clopenthixol

artículo científico publicado en 1991

Molecular structure and dynamics of dopamine, serotonin and the D2, 5-HT2 and 5-HT1A receptors

scholarly article by S.G Dahl et al published September 1991 in European Neuropsychopharmacology

Multivariate Linear Regression Models Based on ADME Descriptors and Predictions of ADMET Profile for Structurally Diverse Thermolysin Inhibitors

scholarly article by Mahmud Khan & Ingebrigt Sylte published 1 September 2009 in Letters in drug design & discovery

New techniques for optimization of thiopurine therapy in leukemia and transplantation

artículo científico publicado en 2002

Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2.

artículo científico publicado en 2009

PAC-1 and isatin derivatives are weak matrix metalloproteinase inhibitors

artículo científico publicado en 2014

Pancreatic trypsin activates human promatrix metalloproteinase-2.

artículo científico publicado en 2005

Predictive QSAR modeling for the successful predictions of the ADMET properties of candidate drug molecules

artículo científico publicado en 2007

Protein binding site analysis by means of structural interaction fingerprint patterns

artículo científico publicado en 2011

Putative drug binding conformations of monoamine transporters

artículo científico publicado en 2005

Receptor-binding and pharmacokinetic properties of dopaminergic agonists

scientific article published on January 2008

Regulation of liver X receptor target genes by 22-functionalized oxysterols. Synthesis, in silico and in vitro evaluations

artículo científico publicado en 2016

Regulation of matrix metalloproteinase activity in health and disease

artículo científico publicado en 2010

Serotonin transporter and receptor ligands with antidepressant activity as neuroprotective and proapoptotic agents

artículo científico publicado en 2017

Specific interactions and binding energies between thermolysin and potent inhibitors: Molecular simulations based on ab initio molecular orbital method

artículo científico publicado en 2011

Specific interactions and binding free energies between thermolysin and dipeptides: Molecular simulations combined with Ab initio molecular orbital and classical vibrational analysis

artículo científico publicado en 2011

Specific interactions between zinc metalloproteinase and its inhibitors: Ab initio fragment molecular orbital calculations

artículo científico publicado en 2017

Stereochemical activity of lone pairs. The crystal and molecular structure of a complex of 18-crown-6 (1,4,7,10,13,16-hexaoxacyclooctadecane) with bismuth(III) chloride

Structure and localisation of drug binding sites on neurotransmitter transporters.

artículo científico publicado en 2009

Structures and models of transporter proteins

artículo científico publicado en 2004

Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines

artículo científico publicado en 2014

Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations.

artículo científico publicado en 2011

Synthesis and initial biological evaluation of new mimics of the LXR-modulator 22(S)-hydroxycholesterol

artículo científico publicado en 2013

Synthesis, Biological Evaluation and Molecular Modeling of GW 501516 Analogues

scientific article published on 01 November 2010

Synthesis, antidepressant evaluation and docking studies of long-chain alkylnitroquipazines as serotonin transporter inhibitors

artículo científico publicado en 2013

Synthesis, biological evaluation and molecular modeling of new analogs of the anti-cancer agent 2-methoxyestradiol: potent inhibitors of angiogenesis

scholarly article in RSC Advances, vol. 5 no. 41, 2015

Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618

scientific article published on 05 March 2015

Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors

artículo científico publicado en 2015

Synthesis, in vitro and in vivo biological evaluation of new oxysterols as modulators of the liver X receptors

artículo científico publicado en 2016

Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors

artículo científico publicado en 2012

Synthesis, molecular modeling and biological evaluation of potent analogs of 2-methoxyestradiol.

artículo científico publicado en 2018

Synthesis, molecular modeling studies and biological evaluation of fluorine substituted analogs of GW 501516

article

Templates and models of monoamine transporter proteins.

artículo científico publicado en 2011

The GABAB Receptor-Structure, Ligand Binding and Drug Development

artículo científico publicado en 2020

The catalytic triad in Drosophila alcohol dehydrogenase: pH, temperature and molecular modelling studies.

artículo científico publicado en 1999

The development and validation of a novel virtual screening cascade protocol to identify potential serotonin 5-HT(7)R antagonists

artículo científico publicado en 2010

The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor

scientific journal article

The ligand binding site of NPY at the rat Y1 receptor investigated by site-directed mutagenesis and molecular modeling

artículo científico publicado en 1998

The ligand-binding site of buspirone analogues at the 5-HT1A receptor.

artículo científico publicado en 1997

The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism

artículo científico publicado en 2011

The molecular interactions of buspirone analogues with the serotonin transporter

artículo científico publicado en 2008

The protein-protein interactions between SMPI and thermolysin studied by molecular dynamics and MM/PBSA calculations.

artículo científico publicado en 2005

The selectivity of galardin and an azasugar-based hydroxamate compound for human matrix metalloproteases and bacterial metalloproteases

scientific article published in PLoS ONE

The thermolysin family (M4) of enzymes: therapeutic and biotechnological potential

scientific article published on January 2009

Theoretical calculations of the catalytic triad in short-chain alcohol dehydrogenases/reductases

artículo científico publicado en 2007

Theoretical models of interactions between buspirone analogues and 5-HT1A and 5-HT2A serotonin receptor subtypes

scholarly article by A Bronowska et al published November 2000 in Acta Poloniae Pharmaceutica: drug research

Three-dimensional structure and molecular dynamics of cis(Z)- and trans(E)-chlorprothixene

artículo científico publicado en 1991

Lista de obras de Ingebrigt Sylte

1,2,3-triazole analogs of combretastatin A-4 as potential microtubule-binding agents

1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin

A combined simulation with ab initio MO and classical vibrational analysis on the specific interactions between thermolysin and dipeptide ligands

A homology model of SERT based on the LeuTAa template

A linear combination of pharmacophore hypotheses as a new tool in search of new active compounds--an application for 5-HT1A receptor ligands

A molecular model of a putative substrate releasing conformation of multidrug resistance protein 5 (MRP5).

A short update on the structure of drug binding sites on neurotransmitter transporters.

An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity

Atypical and typical antipsychotic drug interactions with the dopamine D2 receptor

Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure

Bioinformatics: from genome to drug targets

Comparative Molecular Dynamics of Mesophilic and Psychrophilic Protein Homologues Studied by 1.2 ns Simulations

Comparative molecular dynamic simulations of wild type and Thr114Val mutated Scaptodrosophila lebanonensis alcohol dehydrogenase

Comparative molecular dynamics simulations of mitogen-activated protein kinase-activated protein kinase 5.

Comparative sequence and structure analysis reveal features of cold adaptation of an enzyme in the thermolysin family

Conformational restrictions in ligand binding to the human intestinal di-/tripeptide transporter: implications for design of hPEPT1 targeted prodrugs

Determinants for psychrophilic and thermophilic features of metallopeptidases of the M4 family.

Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models

Differences in PAR-2 activating potential by king crab (Paralithodes camtschaticus), salmon (Salmo salar), and bovine (Bos taurus) trypsin

Dipeptide inhibitors of thermolysin and angiotensin I-converting enzyme.

Discovery of potent thermolysin inhibitors using structure based virtual screening and binding assays

Effect of the glutathione/glutathione disulfide redox couple on thiopurine methyltransferase

Environmental Chemicals Modulate Polar Bear (Ursus maritimus) Peroxisome Proliferator-Activated Receptor Gamma (PPARG) and Adipogenesis in Vitro

From Homology Models to a Set of Predictive Binding Pockets-a 5-HT1A Receptor Case Study

From genomics to drug targets

Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor Ligands

High-level expression of pseudolysin, the extracellular elastase of Pseudomonas aeruginosa, in Escherichia coli and its purification

Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5).

Homology modeling of human γ-butyric acid transporters and the binding of pro-drugs 5-aminolevulinic acid and methyl aminolevulinic acid used in photodynamic therapy

Homology modeling of transporter proteins (carriers and ion channels).

Homology modelling of metabotropic glutamate receptor 2.

Identification of novel quinazolin-4(3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases

Identification of novel serotonin transporter compounds by virtual screening

In Silico Methods for the Discovery of Orthosteric GABA Receptor Compounds

In Vitro and In Silico Competitive Binding of Brominated Polyphenyl Ether Contaminants With Human and Gull Thyroid Hormone Transport Proteins.

Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors.

Interaction of 1,2,4-substituted piperazines, new serotonin receptor ligands, with 5-HT1A and 5-HT2A receptors

Intrinsic activity and comparative molecular dynamics of buspirone analogues at the 5-HT(1A) receptors.

Ligand induced conformational states of the 5-HT(1A) receptor

Ligand-directed trafficking of receptor stimulus

Ligand-guided homology modelling of the GABAB2 subunit of the GABAB receptor

Ligand-induced stabilization and activation of peroxisome proliferator-activated receptor gamma

Mapping the suramin-binding sites of human neutrophil elastase: investigation by fluorescence resonance energy transfer and molecular modeling.

Mass-spectrometric studies of new 6-nitroquipazines-serotonin transporter inhibitors

Membrane Transporters: Structure, Function and Targets for Drug Design

Molecular Interactions Stabilizing the Promatrix Metalloprotease-9·Serglycin Heteromer

Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues.

Molecular dynamics of NPY Y 1 receptor activation

Molecular dynamics of buspirone analogues interacting with the 5-HT1A and 5-HT2A serotonin receptors

Molecular dynamics of serotonin and ritanserin interacting with the 5-HT2 receptor

Molecular dynamics of the 5-HT1a receptor and ligands.

Molecular insight into pseudolysin inhibition using the MM-PBSA and LIE methods.

Molecular mechanism of citalopram and cocaine interactions with neurotransmitter transporters

Molecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol

Molecular model of the Escherichia coli Na1/H1 antiporter NhaA.

Molecular model of the neural dopamine transporter

Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)

Molecular modeling of neurotransmitter receptors and ligands

Molecular modelling of UH-301 and 5-HTla receptor interactions

Molecular modelling of drug targets: the past, the present and the future.

Molecular recognition of docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-X receptor alpha

Molecular recognition of long chain fatty acids by peroxisome proliferator-activated receptor α

Molecular structure and dynamics of cis(Z)-and trans(E)-flupenthixol and clopenthixol

Molecular structure and dynamics of dopamine, serotonin and the D2, 5-HT2 and 5-HT1A receptors

Multivariate Linear Regression Models Based on ADME Descriptors and Predictions of ADMET Profile for Structurally Diverse Thermolysin Inhibitors

New techniques for optimization of thiopurine therapy in leukemia and transplantation

Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2.

PAC-1 and isatin derivatives are weak matrix metalloproteinase inhibitors

Pancreatic trypsin activates human promatrix metalloproteinase-2.

Predictive QSAR modeling for the successful predictions of the ADMET properties of candidate drug molecules

Protein binding site analysis by means of structural interaction fingerprint patterns

Putative drug binding conformations of monoamine transporters

Receptor-binding and pharmacokinetic properties of dopaminergic agonists

Regulation of liver X receptor target genes by 22-functionalized oxysterols. Synthesis, in silico and in vitro evaluations

Regulation of matrix metalloproteinase activity in health and disease

Serotonin transporter and receptor ligands with antidepressant activity as neuroprotective and proapoptotic agents

Specific interactions and binding energies between thermolysin and potent inhibitors: Molecular simulations based on ab initio molecular orbital method

Specific interactions and binding free energies between thermolysin and dipeptides: Molecular simulations combined with Ab initio molecular orbital and classical vibrational analysis

Specific interactions between zinc metalloproteinase and its inhibitors: Ab initio fragment molecular orbital calculations