Lista de obras - Aaron B Bowman - Dominio Público Uruguay

A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease

artículo científico publicado en 2015

ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology

artículo científico publicado en 2006

Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson's disease

artículo científico publicado en 2015

Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.

artículo científico publicado en 2015

Altered manganese homeostasis and manganese toxicity in a Huntington's disease striatal cell model are not explained by defects in the iron transport system.

artículo científico publicado en 2010

Animal models of autism spectrum disorders: information for neurotoxicologists

artículo científico publicado en 2009

BDNF and Huntingtin protein modifications by manganese: implications for striatal medium spiny neuron pathology in manganese neurotoxicity.

artículo científico publicado en 2014

Brain Manganese and the Balance between Essential Roles and Neurotoxicity

scientific article published on 18 March 2020

Cellular fura-2 manganese extraction assay (CFMEA).

artículo científico publicado en 2011

Cellular manganese content is developmentally regulated in human dopaminergic neurons

artículo científico publicado en 2014

Changes in the striatal proteome of YAC128Q mice exhibit gene-environment interactions between mutant huntingtin and manganese

artículo científico publicado en 2012

Chronic exposure to methylmercury induces puncta formation in cephalic dopaminergic neurons in Caenorhabditis elegans

scientific article published on 11 January 2020

Combinatorial polymer matrices enhance in vitro maturation of human induced pluripotent stem cell-derived cardiomyocytes

artículo científico publicado en 2015

Combined exposure to methylmercury and manganese during L1 larval stage causes motor dysfunction, cholinergic and monoaminergic up-regulation and oxidative stress in L4 Caenorhabditis elegans

scholarly article by Maria Rosa C Schetinger et al published 15 October 2018 in Toxicology

DHCEO accumulation is a critical mediator of pathophysiology in a Smith–Lemli–Opitz syndrome model ⬇️

artículo científico publicado el 11 de diciembre de 2011

DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction.

artículo científico publicado en 2012

Disease-toxicant interactions in manganese exposed Huntington disease mice: early changes in striatal neuron morphology and dopamine metabolism

artículo científico publicado en 2012

Disease-toxicant screen reveals a neuroprotective interaction between Huntington's disease and manganese exposure

artículo científico publicado en 2009

Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes

artículo científico publicado en 2007

Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation

artículo científico publicado en 2010

Functional characterization of a testis-specific DNA binding activity at the H19/Igf2 imprinting control region.

artículo científico publicado en 2003

Gammaretroviral vector encoding a fluorescent marker to facilitate detection of reprogrammed human fibroblasts during iPSC generation

artículo científico publicado en 2013

Gender and manganese exposure interactions on mouse striatal neuron morphology

artículo científico publicado en 2011

Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects

artículo científico publicado en 2012

Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.

artículo científico publicado en 2006

Huntington's disease associated resistance to Mn neurotoxicity is neurodevelopmental stage and neuronal lineage dependent

scientific article published on 20 September 2019

Huntington's disease genotype suppresses global manganese-responsive processes in pre-manifest and manifest YAC128 mice

scientific article published on 18 May 2020

Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension.

artículo científico publicado en 2014

Identification of a selective manganese ionophore that enables nonlethal quantification of cellular manganese

scientific article published on 11 February 2020

Lipid modifications of Sonic hedgehog ligand dictate cellular reception and signal response.

artículo científico publicado en 2011

Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans

artículo científico publicado en 2015

Manganese Acts upon Insulin/IGF Receptors to Phosphorylate AKT and Increase Glucose Uptake in Huntington's Disease Cells

scientific article published on 04 December 2019

Manganese Is Essential for Neuronal Health

artículo científico

Manganese homeostasis in the nervous system

artículo científico publicado en 2015

Manganese-Induced Parkinsonism and Parkinson's Disease: Shared and Distinguishable Features

artículo científico publicado en 2015

Manganese-induced Neurotoxicity: From C. elegans to Humans

artículo científico publicado en 2015

Morphometric analysis in neurodegenerative disorders

artículo científico publicado en 2010

Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

artículo científico publicado en 2005

Novel high-throughput assay to assess cellular manganese levels in a striatal cell line model of Huntington's disease confirms a deficit in manganese accumulation

artículo científico publicado en 2011

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

artículo científico publicado en 2008

Optimization of Fluorescence Assay of Cellular Manganese Status for High Throughput Screening ⬇️

artículo científico publicado el 20 de noviembre de 2012

PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper

artículo científico publicado en 2014

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor ⬇️

artículo científico publicado en 2015

Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2.

artículo científico publicado en 2005

Role of astrocytes in brain function and disease

artículo científico publicado en 2010

Role of manganese in neurodegenerative diseases

artículo científico

SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity

scientific journal article

Sex- and structure-specific differences in antioxidant responses to methylmercury during early development

artículo científico publicado en 2016

The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans

artículo científico

The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk ⬇️

artículo científico publicado el 11 de febrero de 2012

Lista de obras de Aaron B Bowman

A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease

ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology

Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson's disease

Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.

Altered manganese homeostasis and manganese toxicity in a Huntington's disease striatal cell model are not explained by defects in the iron transport system.

Animal models of autism spectrum disorders: information for neurotoxicologists

BDNF and Huntingtin protein modifications by manganese: implications for striatal medium spiny neuron pathology in manganese neurotoxicity.

Brain Manganese and the Balance between Essential Roles and Neurotoxicity

Cellular fura-2 manganese extraction assay (CFMEA).

Cellular manganese content is developmentally regulated in human dopaminergic neurons

Changes in the striatal proteome of YAC128Q mice exhibit gene-environment interactions between mutant huntingtin and manganese

Chronic exposure to methylmercury induces puncta formation in cephalic dopaminergic neurons in Caenorhabditis elegans

Combinatorial polymer matrices enhance in vitro maturation of human induced pluripotent stem cell-derived cardiomyocytes

Combined exposure to methylmercury and manganese during L1 larval stage causes motor dysfunction, cholinergic and monoaminergic up-regulation and oxidative stress in L4 Caenorhabditis elegans

DHCEO accumulation is a critical mediator of pathophysiology in a Smith–Lemli–Opitz syndrome model ⬇️

DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction.

Disease-toxicant interactions in manganese exposed Huntington disease mice: early changes in striatal neuron morphology and dopamine metabolism

Disease-toxicant screen reveals a neuroprotective interaction between Huntington's disease and manganese exposure

Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes

Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation

Functional characterization of a testis-specific DNA binding activity at the H19/Igf2 imprinting control region.

Gammaretroviral vector encoding a fluorescent marker to facilitate detection of reprogrammed human fibroblasts during iPSC generation

Gender and manganese exposure interactions on mouse striatal neuron morphology

Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects

Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.

Huntington's disease associated resistance to Mn neurotoxicity is neurodevelopmental stage and neuronal lineage dependent

Huntington's disease genotype suppresses global manganese-responsive processes in pre-manifest and manifest YAC128 mice

Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension.

Identification of a selective manganese ionophore that enables nonlethal quantification of cellular manganese

Lipid modifications of Sonic hedgehog ligand dictate cellular reception and signal response.

Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans

Manganese Acts upon Insulin/IGF Receptors to Phosphorylate AKT and Increase Glucose Uptake in Huntington's Disease Cells

Manganese Is Essential for Neuronal Health

Manganese homeostasis in the nervous system

Manganese-Induced Parkinsonism and Parkinson's Disease: Shared and Distinguishable Features

Manganese-induced Neurotoxicity: From C. elegans to Humans

Morphometric analysis in neurodegenerative disorders

Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

Novel high-throughput assay to assess cellular manganese levels in a striatal cell line model of Huntington's disease confirms a deficit in manganese accumulation

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

Optimization of Fluorescence Assay of Cellular Manganese Status for High Throughput Screening ⬇️

PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor ⬇️

Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2.

Role of astrocytes in brain function and disease

Role of manganese in neurodegenerative diseases

SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity

Sex- and structure-specific differences in antioxidant responses to methylmercury during early development

The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans

The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk ⬇️