Lista de obras - Miia Turpeinen - Dominio Público Uruguay

A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes

artículo científico publicado en 2009

A simple method for differentiation of monoisotopic drug metabolites with hydrogen-deuterium exchange liquid chromatography/electrospray mass spectrometry

artículo científico publicado en 2005

Adverse events due to unnecessary radiation exposure in medical imaging reported in Finland

artículo científico publicado en 2020

An evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomes.

artículo científico publicado en 2009

Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatography-tandem mass spectrometry utilizing sub 2 microm particle size column

artículo científico publicado en 2008

CYP2B6 and CYP2C19 as the major enzymes responsible for the metabolism of selegiline, a drug used in the treatment of Parkinson's disease, as revealed from experiments with recombinant enzymes

artículo científico publicado en 2001

Characterization of Diuron N-Demethylation by Mammalian Hepatic Microsomes and cDNA-Expressed Human Cytochrome P450 Enzymes

artículo científico publicado en 2007

Comparison of anti-p53 antibodies in immunoblotting

artículo científico publicado en 2002

Comparison of metabolic stability and metabolite identification of 55 ECVAM/ICCVAM validation compounds between human and rat liver homogenates and microsomes - a preliminary analysis.

artículo científico publicado en 2009

Cytochrome P450 (CYP) inhibition screening: comparison of three tests

artículo científico publicado en 2006

Cytochrome P450 2B6: function, genetics, and clinical relevance

artículo científico

Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor

artículo científico publicado en 2008

Drugs used for neurologic and psychiatric conditions increase the risk for bullous pemphigoid: A case-control study

scientific article published on 13 February 2019

Effect of Caffeine Intake 12 or 24 Hours Prior to Melatonin Intake and CYP1A2*1F Polymorphism on CYP1A2 Phenotyping by Melatonin

artículo científico publicado en 2006

Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation

artículo científico publicado en 2005

Effect of renal impairment on the pharmacokinetics of bupropion and its metabolites

artículo científico publicado en 2007

Effects of cytochrome P450 inhibitors and inducers on the metabolism and pharmacokinetics of ospemifene.

artículo científico publicado en 2013

Effects of selective serotonin reuptake inhibitors on timolol metabolism in human liver microsomes and cryo-preserved hepatocytes

artículo científico publicado en 2009

Estrogen receptor alpha genotype confers interindividual variability of response to estrogen and testosterone in mesenchymal-stem-cell-derived osteoblasts

artículo científico publicado en 2006

Exposure to oral S-ketamine is unaffected by itraconazole but greatly increased by ticlopidine

artículo científico publicado en 2011

Formation of GSH-trapped reactive metabolites in human liver microsomes, S9 fraction, HepaRG-cells, and human hepatocytes

article

From known knowns to known unknowns: predicting in vivo drug metabolites

artículo científico publicado en 2009

Functional expression, inhibition and induction of CYP enzymes in HepaRG cells

artículo científico publicado en 2009

Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

artículo científico publicado en 2008

Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites

artículo científico publicado en 2011

Glutathione trapping of reactive drug metabolites produced by biomimetic metalloporphyrin catalysts

scientific article published on 01 October 2015

Glutathione trapping of reactive drug metabolites produced by biomimetic metalloporphyrin catalysts

artículo científico publicado en 2015

Hospitalizations Due to Adverse Drug Events in the Elderly-A Retrospective Register Study

artículo científico publicado en 2016

Identification of bupropion urinary metabolites by liquid chromatography/mass spectrometry

scientific article published on 01 January 2007

Identification of inhibitors of the nicotine metabolising CYP2A6 enzyme--an in silico approach

artículo científico publicado en 2007

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone

artículo científico publicado en 2008

In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies

artículo científico publicado en 2007

In vitro-in vivo extrapolation of hepatic clearance: biological tools, scaling factors, model assumptions and correct concentrations

artículo científico publicado en 2007

In vivo-in vitro-in silico pharmacokinetic modelling in drug development: current status and future directions

artículo científico publicado en 2011

Inhibition and induction of CYP enzymes in humans: an update

scientific article published on 27 October 2020

Liquid chromatography-mass spectrometry in in vitro drug metabolite screening.

artículo científico publicado en 2008

Metabolic and Efflux Properties of Caco-2 Cells Stably Transfected with Nuclear Receptors

artículo científico publicado en 2006

Metabolism and metabolite profiles in vitro and in vivo of ospemifene in humans and preclinical species

artículo científico publicado en 2015

Metabolism of hyperforin, the active constituent of St. John's wort, in human liver microsomes

artículo científico publicado en 2010

Metabolism of oxycodone in human hepatocytes from different age groups and prediction of hepatic plasma clearance.

artículo científico publicado en 2011

Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay

artículo científico publicado en 2005

New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis

artículo científico publicado en 2007

New study designs in clinical drug development

artículo científico publicado en 2017

Oral diabetes medications other than dipeptidyl peptidase 4 inhibitors are not associated with bullous pemphigoid: A Finnish nationwide case-control study

artículo científico publicado en 2018

Ospemifene metabolism in humans in vitro and in vivo: metabolite identification, quantitation, and CYP assignment of major hydroxylations

artículo científico publicado en 2013

Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver.

artículo científico publicado en 2010

Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8.

artículo científico publicado en 2015

PharmGKB summary: venlafaxine pathway

artículo científico

Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation

artículo científico publicado en 2009

Prediction of drug metabolism and interactions on the basis of in vitro investigations.

artículo científico publicado en 2005

Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: A comparative studyin vitro

article

Preservation, induction or incorporation of metabolism into the in vitro cellular system − Views to current opportunities and limitations

scientific article published on 19 June 2012

Quantitative analysis of 4β- and 4α‑hydroxycholesterol in human plasma and serum by UHPLC/ESI-HR-MS

artículo científico publicado en 2018

Selective inhibition of CYP2B6-catalyzed bupropion hydroxylation in human liver microsomes in vitro

artículo científico publicado en 2004

Stability of sufentanil and levobupivacaine solutions and a mixture in a 0.9% sodium chloride infusion stored in polypropylene syringes

artículo científico publicado en 2003

Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells

artículo científico publicado en 2009

Tandem mass spectrometric analysis of S- and N-linked glutathione conjugates of pulegone and menthofuran and identification of P450 enzymes mediating their formation

artículo científico publicado en 2016

The Risks and Outcomes Resulting From Medication Errors Reported in the Finnish Tertiary Care Units:: A Cross-Sectional Retrospective Register Study

artículo científico publicado en 2019

The effect of oral contraceptives on the pharmacokinetics of melatonin in healthy subjects with CYP1A2 g.-163C>A polymorphism

artículo científico publicado en 2008

The functional role of CYP2B6 in human drug metabolism: substrates and inhibitors in vitro, in vivo and in silico.

artículo científico publicado en 2006

The prevalence of medication-related adverse events in inpatients-a systematic review and meta-analysis

artículo científico publicado en 2017

Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction

artículo científico publicado en 2012

Timolol Metabolism in Human Liver Microsomes Is Mediated Principally by CYP2D6

scientific article published on 12 April 2007

Toxicity of Carboxylic Acid-Containing Drugs: The Role of Acyl Migration and CoA Conjugation Investigated

article

Transfer of repaglinide in the dually perfused human placenta and the role of organic anion transporting polypeptides (OATPs)

article

Vildagliptin significantly increases the risk of bullous pemphigoid: A Finnish nationwide registry study

artículo científico publicado en 2018

Warfarin-induced calciphylaxis in patients with normal renal function

scientific article published on 19 June 2016

Lista de obras de Miia Turpeinen

A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes

A simple method for differentiation of monoisotopic drug metabolites with hydrogen-deuterium exchange liquid chromatography/electrospray mass spectrometry

Adverse events due to unnecessary radiation exposure in medical imaging reported in Finland

An evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomes.

Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatography-tandem mass spectrometry utilizing sub 2 microm particle size column

CYP2B6 and CYP2C19 as the major enzymes responsible for the metabolism of selegiline, a drug used in the treatment of Parkinson's disease, as revealed from experiments with recombinant enzymes

Characterization of Diuron N-Demethylation by Mammalian Hepatic Microsomes and cDNA-Expressed Human Cytochrome P450 Enzymes

Comparison of anti-p53 antibodies in immunoblotting

Comparison of metabolic stability and metabolite identification of 55 ECVAM/ICCVAM validation compounds between human and rat liver homogenates and microsomes - a preliminary analysis.

Cytochrome P450 (CYP) inhibition screening: comparison of three tests

Cytochrome P450 2B6: function, genetics, and clinical relevance

Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor

Drugs used for neurologic and psychiatric conditions increase the risk for bullous pemphigoid: A case-control study

Effect of Caffeine Intake 12 or 24 Hours Prior to Melatonin Intake and CYP1A2*1F Polymorphism on CYP1A2 Phenotyping by Melatonin

Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation

Effect of renal impairment on the pharmacokinetics of bupropion and its metabolites

Effects of cytochrome P450 inhibitors and inducers on the metabolism and pharmacokinetics of ospemifene.

Effects of selective serotonin reuptake inhibitors on timolol metabolism in human liver microsomes and cryo-preserved hepatocytes

Estrogen receptor alpha genotype confers interindividual variability of response to estrogen and testosterone in mesenchymal-stem-cell-derived osteoblasts

Exposure to oral S-ketamine is unaffected by itraconazole but greatly increased by ticlopidine

Formation of GSH-trapped reactive metabolites in human liver microsomes, S9 fraction, HepaRG-cells, and human hepatocytes

From known knowns to known unknowns: predicting in vivo drug metabolites

Functional expression, inhibition and induction of CYP enzymes in HepaRG cells

Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites

Glutathione trapping of reactive drug metabolites produced by biomimetic metalloporphyrin catalysts

Glutathione trapping of reactive drug metabolites produced by biomimetic metalloporphyrin catalysts

Hospitalizations Due to Adverse Drug Events in the Elderly-A Retrospective Register Study

Identification of bupropion urinary metabolites by liquid chromatography/mass spectrometry

Identification of inhibitors of the nicotine metabolising CYP2A6 enzyme--an in silico approach

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone

In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies

In vitro-in vivo extrapolation of hepatic clearance: biological tools, scaling factors, model assumptions and correct concentrations

In vivo-in vitro-in silico pharmacokinetic modelling in drug development: current status and future directions

Inhibition and induction of CYP enzymes in humans: an update

Liquid chromatography-mass spectrometry in in vitro drug metabolite screening.

Metabolic and Efflux Properties of Caco-2 Cells Stably Transfected with Nuclear Receptors

Metabolism and metabolite profiles in vitro and in vivo of ospemifene in humans and preclinical species

Metabolism of hyperforin, the active constituent of St. John's wort, in human liver microsomes

Metabolism of oxycodone in human hepatocytes from different age groups and prediction of hepatic plasma clearance.

Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay

New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis

New study designs in clinical drug development

Oral diabetes medications other than dipeptidyl peptidase 4 inhibitors are not associated with bullous pemphigoid: A Finnish nationwide case-control study

Ospemifene metabolism in humans in vitro and in vivo: metabolite identification, quantitation, and CYP assignment of major hydroxylations

Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver.

Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8.

PharmGKB summary: venlafaxine pathway

Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation

Prediction of drug metabolism and interactions on the basis of in vitro investigations.

Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: A comparative studyin vitro

Preservation, induction or incorporation of metabolism into the in vitro cellular system − Views to current opportunities and limitations

Quantitative analysis of 4β- and 4α‑hydroxycholesterol in human plasma and serum by UHPLC/ESI-HR-MS

Selective inhibition of CYP2B6-catalyzed bupropion hydroxylation in human liver microsomes in vitro

Stability of sufentanil and levobupivacaine solutions and a mixture in a 0.9% sodium chloride infusion stored in polypropylene syringes

Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells

Tandem mass spectrometric analysis of S- and N-linked glutathione conjugates of pulegone and menthofuran and identification of P450 enzymes mediating their formation

The Risks and Outcomes Resulting From Medication Errors Reported in the Finnish Tertiary Care Units:: A Cross-Sectional Retrospective Register Study

The effect of oral contraceptives on the pharmacokinetics of melatonin in healthy subjects with CYP1A2 g.-163C>A polymorphism

The functional role of CYP2B6 in human drug metabolism: substrates and inhibitors in vitro, in vivo and in silico.

The prevalence of medication-related adverse events in inpatients-a systematic review and meta-analysis

Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction

Timolol Metabolism in Human Liver Microsomes Is Mediated Principally by CYP2D6

Toxicity of Carboxylic Acid-Containing Drugs: The Role of Acyl Migration and CoA Conjugation Investigated

Transfer of repaglinide in the dually perfused human placenta and the role of organic anion transporting polypeptides (OATPs)

Vildagliptin significantly increases the risk of bullous pemphigoid: A Finnish nationwide registry study

Warfarin-induced calciphylaxis in patients with normal renal function