Lista de obras - Stefano Rivella - Dominio Público Uruguay

A Red Carpet for Iron Metabolism.

artículo científico publicado en 2017

A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction

artículo científico publicado en 2012

A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer

artículo científico publicado en 2002

A preclinical approach for gene therapy of beta-thalassemia.

artículo científico publicado en 2010

A validated cellular biobank for β-thalassemia

artículo científico publicado en 2016

Altered erythropoiesis and iron metabolism in carriers of thalassemia

artículo científico publicado en 2014

Alternative splicing of EKLF/KLF1 in murine primary erythroid tissues

artículo científico publicado en 2014

Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia

artículo científico publicado en 2010

Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in β-thalassemia

artículo científico publicado en 2010

Basic principles of gene transfer in hematopoietic stem cells.

artículo científico publicado en 1999

Cancer cells with irons in the fire

artículo científico publicado en 2015

Changes in bone microarchitecture and biomechanical properties in the th3 thalassemia mouse are associated with decreased bone turnover and occur during the period of bone accrual.

artículo científico publicado en 2010

Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia

artículo científico publicado en 2015

Combining gene therapy and fetal hemoglobin induction for treatment of β-thalassemia

artículo científico publicado en 2013

Comparative mapping of the actin-binding protein 280 genes in human and mouse

artículo científico publicado en 1994

Crosstalk between Erythropoiesis and Iron Metabolism

artículo científico publicado en 2010

Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia

artículo científico publicado en 2008

Decreased hepcidin expression in murine β-thalassemia is associated with suppression of Bmp/Smad signaling

scientific article published on 01 March 2012

Decreased hepcidin mRNA expression in thalassemic mice

artículo científico publicado en 2004

Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice

artículo científico publicado en 2017

Development of K562 cell clones expressing beta-globin mRNA carrying the beta039 thalassaemia mutation for the screening of correctors of stop-codon mutations

artículo científico publicado en 2009

Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus

scientific journal article

Do not super-excess me!

artículo científico publicado en 2012

Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera.

artículo científico publicado en 2006

Efficacy and safety of ruxolitinib in regularly transfused patients with thalassemia: results from a phase 2a study

artículo científico publicado en 2017

Enucleate or replicate? Ask the cytoskeleton.

artículo científico publicado en 2014

Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in beta-thalassemia

artículo científico publicado en 2005

FGF-23 is a negative regulator of prenatal and postnatal erythropoiesis

artículo científico publicado en 2014

FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis.

artículo científico publicado en 2014

Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers

artículo científico publicado en 2016

Gene Addition Strategies for β-Thalassemia and Sickle Cell Anemia

artículo científico publicado en 2017

Gene therapy in thalassemia and hemoglobinopathies.

artículo científico publicado en 2009

Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β -Globin Gene with the IVSI-6 Thalassemia Mutation.

artículo científico publicado en 2015

Genetic treatment of severe hemoglobinopathies: the combat against transgene variegation and transgene silencing.

artículo científico publicado en 1998

HMGB1 mediates anemia of inflammation in murine sepsis survivors.

artículo científico publicado en 2015

Hepcidin agonists as therapeutic tools.

artículo científico publicado en 2018

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

artículo científico publicado en 2010

Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt.

artículo científico publicado en 2016

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.

artículo científico publicado en 2017

Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis

artículo científico publicado en 2009

Identification and characterization of small molecules that inhibit nonsense-mediated RNA decay and suppress nonsense p53 mutations

artículo científico publicado en 2014

Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy

artículo científico publicado en 1994

Identification of erythroferrone as an erythroid regulator of iron metabolism

artículo científico publicado en 2014

Identification of novel RFLPs in the vicinity of CpG islands in Xq28: application to the analysis of the pattern of X chromosome inactivation ⬇️

artículo científico publicado el 1 de enero de 1992

In vivo gene transfer strategies to achieve partial correction of von Willebrand disease.

artículo científico publicado en 2012

In vivo hematopoietic stem cell modification by mRNA delivery

artículo científico publicado en 2023

Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation

artículo científico publicado en 2015

Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

artículo científico publicado en 2007

Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia

artículo científico publicado en 2013

Intestine-specific Disruption of Hypoxia-inducible Factor (HIF)-2α Improves Anemia in Sickle Cell Disease.

artículo científico publicado en 2015

Iron age: novel targets for iron overload

artículo científico publicado en 2014

Iron and reactive oxygen species: friends or foes of cancer cells?

artículo científico publicado en 2013

Iron metabolism and ineffective erythropoiesis in beta-thalassemia mouse models

artículo científico publicado en 2010

Iron metabolism under conditions of ineffective erythropoiesis in beta-thalassemia

artículo científico publicado en 2018

Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response

artículo científico publicado en 2013

Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae

artículo científico publicado en 1994

Lack of Gdf11 does not improve anemia or prevent the activity of RAP-536 in a mouse model of β-thalassemia

artículo científico publicado en 2019

Lack of hepcidin ameliorates anemia and improves growth in an adenine-induced mouse model of chronic kidney disease

artículo científico publicado en 2016

Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis

scientific article published on 01 October 2019

Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7

artículo científico publicado en 1993

Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera

artículo científico publicado en 2016

Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia

artículo científico publicado en 2014

Modulators of erythropoiesis: emerging therapies for hemoglobinopathies and disorders of red cell production.

scientific article published on 18 January 2014

Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injury

artículo científico publicado en 2012

New strategies to target iron metabolism for the treatment of beta thalassemia

artículo científico publicado en 2016

Polycythemia is associated with bone loss and reduced osteoblast activity in mice.

artículo científico publicado en 2015

Probes for CpG islands on the distal long arm of the human X chromosome are clustered in Xq24 and Xq28.

artículo científico publicado en 1990

Production of beta-globin and adult hemoglobin following G418 treatment of erythroid precursor cells from homozygous beta(0)39 thalassemia patients

artículo científico publicado en 2009

Progress toward the genetic treatment of the beta-thalassemias.

artículo científico publicado en 2005

Prospects for a hepcidin mimic to treat β-thalassemia and hemochromatosis

artículo científico publicado en 2011

Protective role of calreticulin in HFE hemochromatosis

artículo científico publicado en 2007

RBCs Homeostatically Bind mtDNA Through TLR9 to Maintain Quiescence and Prevent Lung Injury

artículo científico publicado en 2017

Reactivation of developmentally silenced globin genes by forced chromatin looping.

artículo científico publicado en 2014

Recent trends in the gene therapy of β-thalassemia

artículo científico publicado en 2015

Recommendations regarding splenectomy in hereditary hemolytic anemias.

artículo científico publicado en 2017

Regulation of iron absorption in hemoglobinopathies.

artículo científico publicado en 2008

Selection and fine mapping of chromosome-specific cDNAs: application to human chromosome 1.

artículo científico publicado en 1996

Selection and mapping of replication origins from a 500-kb region of the human X chromosome and their relationship to gene expression

artículo científico publicado en 1999

Short-term administration of JAK2 inhibitors reduces splenomegaly in mouse models of β-thalassemia intermedia and major

artículo científico publicado en 2017

Successful treatment of murine beta-thalassemia intermedia by transfer of the human beta-globin gene

scientific article published on 01 March 2002

Targeting iron metabolism in drug discovery and delivery

artículo científico publicado en 2017

The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites.

artículo científico publicado en 2000

The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice.

artículo científico publicado en 2012

The role of ineffective erythropoiesis in non-transfusion-dependent thalassemia

artículo científico

Therapeutic globin gene delivery using lentiviral vectors.

artículo científico publicado en 2002

Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin

artículo científico publicado en 2000

Therapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patients

artículo científico publicado en 2012

Tropomodulin 1 controls erythroblast enucleation via regulation of F-actin in the enucleosome

artículo científico publicado en 2017

Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells

artículo científico publicado en 2009

What can we learn from ineffective erythropoiesis in thalassemia?

artículo científico publicado en 2017

beta-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload

artículo científico publicado en 2010

mRNA expression of iron regulatory genes in β-thalassemia intermedia and β-thalassemia major mouse models

article

β-Thalassemia and Polycythemia vera: targeting chronic stress erythropoiesis.

artículo científico publicado en 2014

β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies

artículo científico publicado en 2015

Lista de obras de Stefano Rivella

A Red Carpet for Iron Metabolism.

A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction

A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer

A preclinical approach for gene therapy of beta-thalassemia.

A validated cellular biobank for β-thalassemia

Altered erythropoiesis and iron metabolism in carriers of thalassemia

Alternative splicing of EKLF/KLF1 in murine primary erythroid tissues

Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia

Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in β-thalassemia

Basic principles of gene transfer in hematopoietic stem cells.

Cancer cells with irons in the fire

Changes in bone microarchitecture and biomechanical properties in the th3 thalassemia mouse are associated with decreased bone turnover and occur during the period of bone accrual.

Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia

Combining gene therapy and fetal hemoglobin induction for treatment of β-thalassemia

Comparative mapping of the actin-binding protein 280 genes in human and mouse

Crosstalk between Erythropoiesis and Iron Metabolism

Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia

Decreased hepcidin expression in murine β-thalassemia is associated with suppression of Bmp/Smad signaling

Decreased hepcidin mRNA expression in thalassemic mice

Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice

Development of K562 cell clones expressing beta-globin mRNA carrying the beta039 thalassaemia mutation for the screening of correctors of stop-codon mutations

Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus

Do not super-excess me!

Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera.

Efficacy and safety of ruxolitinib in regularly transfused patients with thalassemia: results from a phase 2a study

Enucleate or replicate? Ask the cytoskeleton.

Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in beta-thalassemia

FGF-23 is a negative regulator of prenatal and postnatal erythropoiesis

FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis.

Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers

Gene Addition Strategies for β-Thalassemia and Sickle Cell Anemia

Gene therapy in thalassemia and hemoglobinopathies.

Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β -Globin Gene with the IVSI-6 Thalassemia Mutation.

Genetic treatment of severe hemoglobinopathies: the combat against transgene variegation and transgene silencing.

HMGB1 mediates anemia of inflammation in murine sepsis survivors.

Hepcidin agonists as therapeutic tools.

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt.

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.

Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis

Identification and characterization of small molecules that inhibit nonsense-mediated RNA decay and suppress nonsense p53 mutations

Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy

Identification of erythroferrone as an erythroid regulator of iron metabolism

Identification of novel RFLPs in the vicinity of CpG islands in Xq28: application to the analysis of the pattern of X chromosome inactivation ⬇️

In vivo gene transfer strategies to achieve partial correction of von Willebrand disease.

In vivo hematopoietic stem cell modification by mRNA delivery

Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation

Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia

Intestine-specific Disruption of Hypoxia-inducible Factor (HIF)-2α Improves Anemia in Sickle Cell Disease.

Iron age: novel targets for iron overload

Iron and reactive oxygen species: friends or foes of cancer cells?

Iron metabolism and ineffective erythropoiesis in beta-thalassemia mouse models

Iron metabolism under conditions of ineffective erythropoiesis in beta-thalassemia

Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response

Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae

Lack of Gdf11 does not improve anemia or prevent the activity of RAP-536 in a mouse model of β-thalassemia

Lack of hepcidin ameliorates anemia and improves growth in an adenine-induced mouse model of chronic kidney disease

Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis

Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7

Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera

Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia

Modulators of erythropoiesis: emerging therapies for hemoglobinopathies and disorders of red cell production.

Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injury

New strategies to target iron metabolism for the treatment of beta thalassemia

Polycythemia is associated with bone loss and reduced osteoblast activity in mice.

Probes for CpG islands on the distal long arm of the human X chromosome are clustered in Xq24 and Xq28.

Production of beta-globin and adult hemoglobin following G418 treatment of erythroid precursor cells from homozygous beta(0)39 thalassemia patients

Progress toward the genetic treatment of the beta-thalassemias.

Prospects for a hepcidin mimic to treat β-thalassemia and hemochromatosis

Protective role of calreticulin in HFE hemochromatosis

RBCs Homeostatically Bind mtDNA Through TLR9 to Maintain Quiescence and Prevent Lung Injury

Reactivation of developmentally silenced globin genes by forced chromatin looping.

Recent trends in the gene therapy of β-thalassemia

Recommendations regarding splenectomy in hereditary hemolytic anemias.

Regulation of iron absorption in hemoglobinopathies.

Selection and fine mapping of chromosome-specific cDNAs: application to human chromosome 1.

Selection and mapping of replication origins from a 500-kb region of the human X chromosome and their relationship to gene expression

Short-term administration of JAK2 inhibitors reduces splenomegaly in mouse models of β-thalassemia intermedia and major