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Lista de obras de Fernando Remião

Acute Paraquat Poisoning

artículo científico publicado en 2006

Adaptative response of antioxidant enzymes in different areas of rat brain after repeated d-amphetamine administration

artículo científico publicado en 2001

Adrenaline and reactive oxygen species elicit proteome and energetic metabolism modifications in freshly isolated rat cardiomyocytes

artículo científico publicado en 2009

Adrenaline in pro-oxidant conditions elicits intracellular survival pathways in isolated rat cardiomyocytes

artículo científico publicado en 2008

Alzheimer's disease, cholesterol, and statins: the junctions of important metabolic pathways

artículo científico

An effective antidote for paraquat poisonings: the treatment with lysine acetylsalicylate

artículo científico publicado en 2008

Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents

artículo científico publicado en 2019

Bioisosteric OH- to SH-replacement changes the antioxidant profile of ferulic acid

scientific article published on 01 November 2019

Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity

article

Boosting Drug Discovery for Parkinson's: Enhancement of the Delivery of a Monoamine Oxidase-B Inhibitor by Brain-Targeted PEGylated Polycaprolactone-Based Nanoparticles

artículo científico publicado en 2019

CARDIOTOXICITY STUDIES USING FRESHLY ISOLATED CALCIUM-TOLERANT CARDIOMYOCYTES FROM ADULT RAT

artículo científico publicado en 2001

CYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA)

artículo científico publicado en 2007

Cellular Models and In Vitro Assays for the Screening of modulators of P-gp, MRP1 and BCRP.

artículo científico publicado en 2017

Chiral Resolution and Enantioselectivity of Synthetic Cathinones: A Brief Review.

artículo científico publicado en 2017

Chiral Thioxanthones as Modulators of P-glycoprotein: Synthesis and Enantioselectivity Studies.

artículo científico publicado en 2018

Chiral enantioresolution of cathinone derivatives present in "legal highs", and enantioselectivity evaluation on cytotoxicity of 3,4-methylenedioxypyrovalerone (MDPV)

artículo científico publicado en 2016

Chronic exposure to ethanol exacerbates MDMA-induced hyperthermia and exposes liver to severe MDMA-induced toxicity in CD1 mice

artículo científico publicado en 2008

Collection of biological samples in forensic toxicology.

artículo científico publicado en 2010

Comparative metabolism of the designer drug 4-methylthioamphetamine by hepatocytes from man, monkey, dog, rabbit, rat and mouse.

artículo científico publicado en 2003

Comprehensive review of cardiovascular toxicity of drugs and related agents.

artículo científico publicado en 2018

Copper enhances isoproterenol toxicity in isolated rat cardiomyocytes: effects on oxidative stress

artículo científico publicado en 2001

Correction to Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors

scientific article published on 29 May 2018

Cu2+-induced isoproterenol oxidation into isoprenochrome in adult rat calcium-tolerant cardiomyocytes

artículo científico publicado en 2002

Cumulative mitoxantrone-induced haematological and hepatic adverse effects in a subchronic in vivo study

artículo científico publicado en 2013

Cytotoxicity and cell signalling induced by continuous mild hyperthermia in freshly isolated mouse hepatocytes

artículo científico publicado en 2006

D-amphetamine-induced hydrogen peroxide production in skeletal muscle is modulated by monoamine oxidase inhibition

artículo científico publicado en 2004

Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies

artículo científico publicado en 2019

Desrisking the Cytotoxicity of a Mitochondriotropic Antioxidant Based on Caffeic Acid by a PEGylated Strategy

scholarly article by Carlos Fernandes et al published 2 July 2018 in Bioconjugate Chemistry

Development and validation of a GC/IT-MS method for simultaneous quantitation of para and meta-synephrine in biological samples

artículo científico publicado en 2010

Development of Blood-Brain Barrier Permeable Nitrocatechol-Based Catechol O-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity

artículo científico publicado en 2016

Development of a PEGylated-Based Platform for Efficient Delivery of Dietary Antioxidants Across the Blood-Brain Barrier.

artículo científico publicado en 2018

Development of novel rifampicin-derived P-glycoprotein activators/inducers. synthesis, in silico analysis and application in the RBE4 cell model, using paraquat as substrate

artículo científico publicado en 2013

Disclosing the Antifungal Mechanisms of the Cyclam Salt H4[H2(4-CF3PhCH2)2Cyclam]Cl4 against Candida albicans and Candida krusei

artículo científico publicado en 2024

Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors.

artículo científico publicado en 2016

Doxorubicin Is Key for the Cardiotoxicity of FAC (5-Fluorouracil + Adriamycin + Cyclophosphamide) Combination in Differentiated H9c2 Cells

artículo científico publicado en 2019

Doxorubicin decreases paraquat accumulation and toxicity in Caco-2 cells

artículo científico publicado en 2012

Ecstasy induces apoptosis via 5-HT(2A)-receptor stimulation in cortical neurons

artículo científico publicado en 2007

Effect of 3,4-methylenedioxymethamphetamine ("ecstasy") on body temperature and liver antioxidant status in mice: influence of ambient temperature

artículo científico publicado en 2002

Effect of Subchronic Intravenous Morphine Infusion and Naloxone-Precipitated Morphine Withdrawal on P-gp and Bcrp at the Rat Blood-Brain Barrier

scientific journal article

Effect of chronic ethanol exposure on the hepatotoxicity of ecstasy in mice: an ex vivo study.

artículo científico publicado en 2008

Effect of d -amphetamine repeated administration on rat antioxidant defences

artículo científico publicado en 1999

Effects of exercise training on endothelial progenitor cells in cardiovascular disease: a systematic review

artículo científico publicado en 2013

Electrospray tandem mass spectrometry of aminochromes

artículo científico publicado en 2001

Enantioselectivity on the absorption of methylone and pentedrone using Caco-2 cell line: Development and validation of an UHPLC method for cathinones quantification

scientific article published on 29 March 2020

Ethanol, the forgotten artifact in cell culture

artículo científico publicado en 2008

Evaluation of GSH adducts of adrenaline in biological samples

artículo científico publicado en 2007

Exploring the Multi-Target Performance of Mitochondriotropic Antioxidants against the Pivotal Alzheimer's Disease Pathophysiological Hallmarks

scientific article published on 09 January 2020

Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction

scientific article published on 06 February 2019

Full survival of paraquat-exposed rats after treatment with sodium salicylate☆

artículo científico publicado en 2007

Gas chromatography-ion trap mass spectrometry method for the simultaneous measurement of MDMA (ecstasy) and its metabolites, MDA, HMA, and HMMA in plasma and urine

artículo científico publicado en 2010

Hepatoprotective activity of xanthones and xanthonolignoids against tert-butylhydroperoxide-induced toxicity in isolated rat hepatocytes--comparison with silybin

artículo científico publicado en 1995

Hepatotoxicity of 3,4-methylenedioxyamphetamine and alpha-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugates

artículo científico publicado en 2003

Histological and toxicological evaluation, in rat, of a P-glycoprotein inducer and activator: 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5)

artículo científico publicado en 2019

Hydrogen peroxide production in mouse tissues after acute d-amphetamine administration. Influence of monoamine oxidase inhibition.

artículo científico publicado en 2001

Hydroxybenzoic Acid Derivatives as Dual-Target Ligands: Mitochondriotropic Antioxidants and Cholinesterase Inhibitors.

artículo científico publicado en 2018

Identification of 4-methylthioamphetamine and some of its metabolites in mouse urine by GC-MS after acute administration.

artículo científico publicado en 2002

In vitro study of P-glycoprotein induction as an antidotal pathway to prevent cytotoxicity in Caco-2 cells ⬇️

artículo científico publicado el 21 de septiembre de 2010

Induction and activation of P-glycoprotein by dihydroxylated xanthones protect against the cytotoxicity of the P-glycoprotein substrate paraquat

artículo científico publicado en 2014

Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine ('Ecstasy') cytotoxicity

artículo científico publicado en 2006

Insights into the Discovery of Novel Neuroprotective Agents: A Comparative Study between Sulfanylcinnamic Acid Derivatives and Related Phenolic Analogues

scientific article published on 02 December 2019

Investigation of the insulin-like properties of zinc(II) complexes of 3-hydroxy-4-pyridinones: Identification of a compound with glucose lowering effect in STZ-induced type I diabetic animals

artículo científico publicado en 2011

Kale extract increases glutathione levels in V79 cells, but does not protect them against acute toxicity induced by hydrogen peroxide.

artículo científico publicado en 2012

Lessons from black pepper: piperine and derivatives thereof

artículo científico publicado en 2015

Leucoisoprenochrome-o-semiquinone formation in freshly isolated adult rat cardiomyocytes

artículo científico publicado en 2004

Lipidomic characterization of streptozotocin-induced heart mitochondrial dysfunction

artículo científico publicado en 2013

Mechanisms of P-gp inhibition and effects on membrane fluidity of a new rifampicin derivative, 1,8-dibenzoyl-rifampicin.

artículo científico publicado en 2013

Mechanisms underlying the hepatotoxic effects of ecstasy

scientific article published on August 2010

Metabolic interactions between ethanol and MDMA in primary cultured rat hepatocytes.

artículo científico publicado en 2010

Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro

artículo científico publicado en 2004

Metabolism of the designer drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in mice, after acute administration

artículo científico publicado en 2004

Mitochondrial Cumulative Damage Induced by Mitoxantrone: Late Onset Cardiac Energetic Impairment

Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy.

artículo científico publicado en 2014

Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: an overview.

artículo científico publicado en 2009

Multi-milligram resolution and determination of absolute configuration of pentedrone and methylone enantiomers

artículo científico publicado en 2018

Multifunctionality and cytotoxicity of a layered coordination polymer

scientific article published on 17 January 2020

Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy

artículo científico publicado en 2016

Neurotoxicity mechanisms of thioether ecstasy metabolites

artículo científico publicado en 2007

Neurotoxicity of Ecstasy metabolites in rat cortical neurons, and influence of hyperthermia

artículo científico publicado en 2005

New marine-derived indolymethyl pyrazinoquinazoline alkaloids with promising antimicrobial profiles

artículo científico publicado en 2020

Newly Synthesized Oxygenated Xanthones as Potential P-Glycoprotein Activators: , , and Studies

artículo científico publicado en 2019

Opioids and the blood-brain barrier: a dynamic interaction with consequences on drug disposition in brain.

artículo científico publicado en 2017

Oxidation Process of Adrenaline in Freshly Isolated Rat Cardiomyocytes: Formation of Adrenochrome, Quinoproteins, and GSH Adduct

artículo científico publicado en 2007

P-glycoprotein activation by 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5) in rat distal ileum: ex vivo and in vivo studies

scientific article published on 19 November 2019

P-glycoprotein activity in human Caucasian male lymphocytes does not follow its increased expression during aging

artículo científico publicado en 2011

P-glycoprotein induction in Caco-2 cells by newly synthetized thioxanthones prevents paraquat cytotoxicity.

artículo científico publicado en 2014

P-glycoprotein induction: an antidotal pathway for paraquat-induced lung toxicity

article

PEGylated PLGA nanoparticles as a smart carrier to increase the cellular uptake of a coumarin-based monoamine oxidase B inhibitor

artículo científico publicado en 2018

Pixantrone, a new anticancer drug with the same old cardiac problems? An in vitro study with differentiated and non-differentiated H9c2 cells

artículo científico publicado en 2018

Postmortem analyses unveil the poor efficacy of decontamination, anti-inflammatory and immunosuppressive therapies in paraquat human intoxications

artículo científico publicado en 2009

Quantification of 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5), a newly synthetized P-glycoprotein inducer/activator, in biological samples: method development and validation.

artículo científico publicado en 2016

Quantification of morphine and its major metabolites M3G and M6G in antemortem and postmortem samples.

artículo científico publicado en 2014

RBE4 cells are highly resistant to paraquat-induced cytotoxicity: studies on uptake and efflux mechanisms.

artículo científico publicado en 2013

Reactivity of paraquat with sodium salicylate: formation of stable complexes.

artículo científico publicado en 2008

Renalase regulates peripheral and central dopaminergic activities

artículo científico publicado en 2014

Repurposing nitrocatechols: 5-Nitro-α-cyanocarboxamide derivatives of caffeic acid and caffeic acid phenethyl ester effectively inhibit aggregation of tau-derived hexapeptide AcPHF6

artículo científico publicado en 2019

Several transport systems contribute to the intestinal uptake of Paraquat, modulating its cytotoxic effects.

artículo científico publicado en 2014

Simultaneous determination of amphetamine derivatives in human urine after SPE extraction and HPLC-UV analysis.

artículo científico publicado en 2004

Single high dose dexamethasone treatment decreases the pathological score and increases the survival rate of paraquat-intoxicated rats

artículo científico publicado en 2006

Structural isomerization of synephrine influences its uptake and ensuing glutathione depletion in rat-isolated cardiomyocytes

artículo científico publicado en 2010

Synephrine: from trace concentrations to massive consumption in weight-loss

artículo científico publicado en 2010

Synergistic toxicity of ethanol and MDMA towards primary cultured rat hepatocytes

artículo científico publicado en 2008

Synthesis and analysis of aminochromes by HPLC-photodiode array. Adrenochrome evaluation in rat blood.

artículo científico publicado en 2003

The Main Metabolites of Fluorouracil + Adriamycin + Cyclophosphamide (FAC) Are Not Major Contributors to FAC Toxicity in H9c2 Cardiac Differentiated Cells ⬇️

article

The Secretome of Human Neonatal Mesenchymal Stem Cells Modulates Doxorubicin-Induced Cytotoxicity: Impact in Non-Tumor Cells

artículo científico publicado en 2021

The heart as a target for xenobiotic toxicity: the cardiac susceptibility to oxidative stress

artículo científico

The metabolic profile of mitoxantrone and its relation with mitoxantrone-induced cardiotoxicity

artículo científico publicado en 2013

The study of oxidative stress in freshly isolated Ca(2+)-tolerant cardiomyocytes from the adult rat.

artículo científico publicado en 2001

The toxicity of N-methyl-alpha-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine

artículo científico publicado en 2004

Therapeutic concentrations of mitoxantrone elicit energetic imbalance in H9c2 cells as an earlier event

artículo científico publicado en 2013

Toxicity of amphetamines: an update

artículo científico publicado en 2012

Water extracts of Brassica oleracea var. costata potentiate paraquat toxicity to rat hepatocytes in vitro.

artículo científico publicado en 2009

d-Amphetamine Interaction with Glutathione in Freshly Isolated Rat Hepatocytes

artículo científico publicado en 1996

d-Amphetamine-induced hepatotoxicity: possible contribution of catecholamines and hyperthermia to the effect studied in isolated rat hepatocytes.

artículo científico publicado en 1997

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