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Lista de obras de Raquel Seruca

A malignant mixed gonadal stromal tumor of the testis with heterologous components and i(12p) in one of its metastases

artículo científico publicado en 1989

A model to infer the pathogenic significance of CDH1 germline missense variants

artículo científico publicado en 2006

A novel CDH1 germline missense mutation in a sporadic gastric cancer patient in north-east of Italy

artículo científico publicado en 2012

A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma

artículo científico publicado en 2003

A residual mature teratoma with a more balanced karyotype than the primary testicular nonseminoma?

artículo científico publicado en 1988

A subset of colorectal carcinomas express c-KIT protein independently of BRAF and/or KRAS activation

artículo científico publicado en 2007

Abnormalities of the E-cadherin/catenin adhesion complex in classical papillary thyroid carcinoma and in its diffuse sclerosing variant

artículo científico publicado en 2001

Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation

artículo científico publicado en 2004

Adherens junctions as targets of microorganisms: a focus on Helicobacter pylori

artículo científico

Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer

artículo científico publicado en 2009

Allelic gains and losses in distinct regions of chromosome 6 in gastric carcinoma

artículo científico publicado en 2001

Atomic force microscopy and graph analysis to study the P-cadherin/SFK mechanotransduction signalling in breast cancer cells.

artículo científico publicado en 2016

B-Raf(V600E) cooperates with alternative spliced Rac1b to sustain colorectal cancer cell survival

artículo científico publicado en 2008

BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC

artículo científico publicado en 2003

BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency

scientific article published on 01 December 2003

BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations

artículo científico publicado en 2008

BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?

artículo científico publicado en 2008

BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes

article

Benign and malignant thyroid lesions show instability at microsatellite loci

artículo científico publicado en 1997

Bilateral apocrine carcinoma of the breast Molecular and immunocytochemical evidence for two independent primary tumours

article

Biomarkers for gastric cancer: prognostic, predictive or targets of therapy?

artículo científico publicado en 2014

Blue intensity matters for cell cycle profiling in fluorescence DAPI-stained images.

artículo científico publicado en 2017

C/EBPbeta is over-expressed in gastric carcinogenesis and is associated with COX-2 expression

artículo científico publicado en 2006

C/EBPα expression is associated with homeostasis of the gastric epithelium and with gastric carcinogenesis

artículo científico publicado en 2010

CCAAT/enhancer binding protein β (C/EBPβ) isoforms as transcriptional regulators of the pro-invasive CDH3/P-cadherin gene in human breast cancer cells

artículo científico publicado en 2013

CD44 alternative splicing in gastric cancer cells is regulated by culture dimensionality and matrix stiffness

artículo científico publicado en 2016

CLMP is essential for intestinal development, but does not play a key role in cellular processes involved in intestinal epithelial development

artículo científico publicado en 2013

CLMP is required for intestinal development, and loss-of-function mutations cause congenital short-bowel syndrome

artículo científico publicado en 2012

CPEB1, a novel gene silenced in gastric cancer: a Drosophila approach.

artículo científico publicado en 2011

CagA associates with c-Met, E-cadherin, and p120-catenin in a multiproteic complex that suppresses Helicobacter pylori-induced cell-invasive phenotype

artículo científico publicado en 2009

Candidate driver genes in microsatellite-unstable colorectal cancer

artículo científico publicado en 2011

Causes and consequences of microsatellite instability in gastric carcinogenesis.

artículo científico publicado en 2014

Characterization of a recurrent germ line mutation of the E-cadherin gene: implications for genetic testing and clinical management.

artículo científico publicado en 2005

Characterization of the P373L E-cadherin germline missense mutation and implication for clinical management

artículo científico publicado en 2007

Cleft lip/palate and CDH1/E-cadherin mutations in families with hereditary diffuse gastric cancer

artículo científico publicado en 2005

Clinical utility gene card for: Hereditary diffuse gastric cancer (HDGC)

artículo científico publicado en 2013

Clonal cytogenetic abnormalities and telomeric associations in a fibroxanthoma of the stomach

scientific article published on 01 November 1992

Colorectal cancer and RASSF family--a special emphasis on RASSF1A.

artículo científico publicado en 2012

Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy

artículo científico publicado en 2015

Comments on: Mutations in Mitochondrial Control Region DNA in Gastric Tumours of Japanese Patients, Tamura, et al. Eur J Cancer 1999, 35, 316–319

artículo científico publicado en 1999

Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer

artículo científico publicado en 2005

Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas.

artículo científico publicado en 2003

Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid

artículo científico publicado en 2013

Cytogenetic findings in eleven gastric carcinomas.

artículo científico publicado en 1993

Cytogenetic study of a sclerosing stromal tumor of the ovary.

artículo científico publicado en 1990

Cytogenetics of a case of osteosarcoma

scientific article published on 01 May 1988

DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo.

artículo científico publicado en 2013

De novo expression of CD44 variants in sporadic and hereditary gastric cancer

artículo científico publicado en 2010

Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites

artículo científico publicado en 1998

Different patterns of beta-catenin expression in gastric carcinomas: relationship with clinicopathological parameters and prognostic outcome

artículo científico publicado en 2002

Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation

artículo científico publicado en 2014

Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status

artículo científico publicado en 2004

Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization

artículo científico publicado en 2012

E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients.

artículo científico publicado en 2004

E-cadherin alterations in hereditary disorders with emphasis on hereditary diffuse gastric cancer

artículo científico

E-cadherin and adherens-junctions stability in gastric carcinoma: functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V.

artículo científico publicado en 2013

E-cadherin changes in gastric carcimona

artículo científico publicado en 1999

E-cadherin destabilization accounts for the pathogenicity of missense mutations in hereditary diffuse gastric cancer

artículo científico publicado en 2012

E-cadherin dysfunction in gastric cancer--cellular consequences, clinical applications and open questions

artículo científico publicado en 2012

E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma

article

E-cadherin genetic screening and clinico-pathologic characteristics of early onset gastric cancer

artículo científico publicado en 2010

E-cadherin germline missense mutations and cell phenotype: evidence for the independence of cell invasion on the motile capabilities of the cells

artículo científico publicado en 2003

E-cadherin germline mutation carriers: clinical management and genetic implications

artículo científico publicado en 2014

E-cadherin impairment increases cell survival through Notch-dependent upregulation of Bcl-2

scientific article published on 11 October 2011

E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia

artículo científico publicado en 2006

E-cadherin mutations and cell motility: a genotype-phenotype correlation.

artículo científico publicado en 2009

E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade

artículo científico publicado en 2015

EGFR regulates RhoA-GTP dependent cell motility in E-cadherin mutant cells.

artículo científico publicado en 2007

Early Gastric Cancer in Young, Asymptomatic Carriers of Germ-Line E-Cadherin Mutations

artículo científico publicado en 2001

Endoplasmic reticulum quality control: a new mechanism of E-cadherin regulation and its implication in cancer.

artículo científico publicado en 2008

Epidermal growth factor receptor structural alterations in gastric cancer

artículo científico publicado en 2008

Epithelial E- and P-cadherins: role and clinical significance in cancer

artículo científico

Estrogens, MSI and Lynch syndrome-associated tumors.

artículo científico publicado en 2009

Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR.

artículo científico publicado en 2002

Evidence of tumor microsatellite instability in gastric cancer with familial aggregation

scientific article published on 17 January 2009

Extended structural variation of a pentanucleotide repeat in the GSTP1 gene: characterisation in a normal population and in thyroid and gastric tumours

article

Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells.

artículo científico publicado en 2009

Familial gastric cancer: genetic susceptibility, pathology, and implications for management

artículo científico publicado en 2015

Familial gastric carcinoma

Frequent ki-ras mutations in gastric tumors of the MSI phenotype

article

Gastric cancer: adding glycosylation to the equation

artículo científico publicado en 2013

Gastric cardia carcinoma is associated with the promoter -77T>C gene polymorphism of X-ray cross-complementing group 1 (XRCC1).

artículo científico publicado en 2009

Genetic screening for familial gastric cancer

artículo científico publicado en 2004

Genetic screening for hereditary diffuse gastric cancer

artículo científico publicado en 2003

Genetics of hereditary diffuse gastric cancer: progress and future challenges.

artículo científico publicado en 2006

Genetics, pathology, and clinics of familial gastric cancer

artículo científico publicado en 2006

Germline CDH1 deletions in hereditary diffuse gastric cancer families

artículo científico publicado en 2009

H-RAS 81 polymorphism is significantly associated with aneuploidy in follicular tumors of the thyroid

artículo científico publicado en 2006

Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner

artículo científico publicado en 2006

Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells

artículo científico publicado en 2013

Helicobacter pylori infection generates genetic instability in gastric cells

artículo científico publicado en 2010

Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells.

artículo científico publicado en 2009

Helicobacter pylori's cholesterol uptake impacts resistance to docosahexaenoic acid.

artículo científico publicado en 2013

Hereditary diffuse gastric cancer - pathophysiology and clinical management.

artículo científico publicado en 2014

Hereditary diffuse gastric cancer and E-cadherin: description of the first germline mutation in an Italian family.

artículo científico publicado en 2006

Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers

artículo científico publicado en 2015

Hereditary gastric cancer

artículo científico publicado en 2009

High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability.

artículo científico publicado en 2006

High Incidence of Familial Gastric Cancer in Tuscany, a Region in Italy

article

High-throughput molecular profiling of a P-cadherin overexpressing breast cancer model reveals new targets for the anti-cancer bacterial protein azurin

artículo científico publicado en 2014

Highlights of the EORTC St. Gallen International Expert Consensus on the primary therapy of gastric, gastroesophageal and oesophageal cancer - differential treatment strategies for subtypes of early gastroesophageal cancer.

artículo científico

ICI 182,780 induces P-cadherin overexpression in breast cancer cells through chromatin remodelling at the promoter level: a role for C/EBPbeta in CDH3 gene activation

artículo científico publicado en 2010

Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands

artículo científico publicado en 2003

Identification of germline mutations in the cancer predisposing gene CDH1 in patients with orofacial clefts.

artículo científico publicado en 2012

Identification of two distinct regions of deletion at 6q in gastric carcinoma.

artículo científico publicado en 1995

In vitro demonstration of intra-locus compensation using the ornithine transcarbamylase protein as model.

artículo científico publicado en 2007

Increasing levels of MYC and MET co-amplification during tumor progression of a case of gastric cancer

artículo científico publicado en 1995

Insulin/IGF-I signaling pathways enhances tumor cell invasion through bisecting GlcNAc N-glycans modulation. an interplay with E-cadherin

artículo científico publicado en 2013

Integrin β1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells

artículo científico publicado en 2021

Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma

artículo científico publicado en 2001

Intragenic deletion of CDH1 as the inactivating mechanism of the wild-type allele in an HDGC tumour

artículo científico publicado en 2004

Intricate Macrophage-Colorectal Cancer Cell Communication in Response to Radiation

artículo científico publicado en 2016

Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities

artículo científico publicado en 2016

KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression

article

KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program.

artículo científico publicado en 2008

KRAS signaling pathway alterations in microsatellite unstable gastrointestinal cancers

scientific article published on January 2010

KRASMutations and Anti–Epidermal Growth Factor Receptor Therapy in Colorectal Cancer With Lymph Node Metastases

scientific article published on 01 December 2008

Karyotyping and DNA flow cytometry of an orchidoblastoma

artículo científico publicado en 1988

Lack of microRNA-101 causes E-cadherin functional deregulation through EZH2 up-regulation in intestinal gastric cancer

artículo científico publicado en 2012

Loss and recovery of Mgat3 and GnT-III Mediated E-cadherin N-glycosylation is a mechanism involved in epithelial-mesenchymal-epithelial transitions

artículo científico publicado en 2012

Loss of Y chromosome in gastric carcinoma

artículo científico publicado en 1992

Loss of functional E-cadherin renders cells more resistant to the apoptotic agent taxol in vitro

artículo científico publicado en 2005

Loss of heterozygosity and promoter methylation, but not mutation, may underlie loss of TFF1 in gastric carcinoma.

artículo científico publicado en 2002

Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells

artículo científico publicado en 2009

MBD4 mutations are rare in gastric carcinomas with microsatellite instability

artículo científico publicado en 2003

MSI phenotype and MMR alterations in familial and sporadic gastric cancer

artículo científico publicado en 2010

MUC1 gene polymorphism and gastric cancer--an epidemiological study.

artículo científico publicado en 1997

Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y(1086), c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity

artículo científico publicado en 2013

Matrix metalloproteases as maestros for the dual role of LPS- and IL-10-stimulated macrophages in cancer cell behaviour

artículo científico publicado en 2015

Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancers ⬇️

artículo científico publicado el 1 de noviembre de 2010

Microbial-based therapy of cancer: current progress and future prospects

scientific article published on 02 December 2009

Microsatellite instability at multiple loci in gastric carcinoma: Clinicopathologic implications and prognosis

artículo científico publicado en 1996

Microsatellite instability in hyperplastic and adenomatous polyps of the stomach

artículo científico publicado en 1999

Microsatellite instability, mitochondrial DNA large deletions, and mitochondrial DNA mutations in gastric carcinoma

artículo científico publicado en 2001

Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours

artículo científico publicado en 2009

Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers and its implications for patient screening

artículo científico publicado en 2004

Modulation of E-cadherin function and dysfunction by N-glycosylation.

artículo científico publicado en 2010

Molecular cloning of the synovial sarcoma-specific translocation (X;18)(p11.2;q11.2) breakpoint

artículo científico publicado en 1994

Molecular targets and biological modifiers in gastric cancer

artículo científico publicado en 2008

Mononucleotide precedes dinucleotide repeat instability during colorectal tumour development in Lynch syndrome patients

artículo científico publicado en 2009

Mutant BRAF Induces DNA Strand Breaks, Activates DNA Damage Response Pathway, and Up-Regulates Glucose Transporter-1 in Nontransformed Epithelial Cells ⬇️

artículo científico publicado el 5 de enero de 2012

NOD2/CARD15 and TNFA, But Not ILLB and ILLRN, are Associated With Crohnʼs Disease

artículo científico publicado en 2005

New target genes in endometrial tumors show a role for the estrogen-receptor pathway in microsatellite-unstable cancers.

artículo científico publicado en 2014

Non-CDH1-Associated Familial Gastric Cancer and Epigenetics Factors

Novel expressed sequences obtained by means of a suppression subtractive hybridisation analysis from the 6q21 region that is frequently deleted in gastric cancer

article

O-mannosylation and N-glycosylation: two coordinated mechanisms regulating the tumour suppressor functions of E-cadherin in cancer.

artículo científico publicado en 2016

Oncogenic mutations in gastric cancer with microsatellite instability

artículo científico publicado en 2011

P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model

artículo científico publicado en 2013

P-cadherin is coexpressed with CD44 and CD49f and mediates stem cell properties in basal-like breast cancer.

artículo científico publicado en 2012

P-cadherin role in normal breast development and cancer

artículo científico

PCR amplification of DNA obtained from archived hematoxylin-eosin--and giemsa-stained breast cancer aspirates

artículo científico publicado en 1998

Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer.

artículo científico publicado en 2017

Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer

artículo científico publicado en 2015

Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations.

artículo científico publicado en 2009

Promoter methylation of TGFbeta receptor I and mutation of TGFbeta receptor II are frequent events in MSI sporadic gastric carcinomas

artículo científico publicado en 2003

Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression

artículo científico publicado en 2009

Quantification of mutant E-cadherin using bioimaging analysis of in situ fluorescence microscopy. A new approach to CDH1 missense variants.

artículo científico publicado en 2014

Quantification of topological features in cell meshes to explore E-cadherin dysfunction

artículo científico publicado en 2016

Rare Variants in the Epithelial Cadherin Gene Underlying the Genetic Etiology of Nonsyndromic Cleft Lip with or without Cleft Palate

artículo científico publicado en 2015

Re. ‘Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways’

scientific article published on 01 December 2001

Role of pathology in the identification of hereditary diffuse gastric cancer: report of a Portuguese family

article

Role of site-specific promoter hypomethylation in aberrant MUC2 mucin expression in mucinous gastric carcinomas

artículo científico publicado en 2003

S100P is a molecular determinant of E-cadherin function in gastric cancer

artículo científico publicado en 2019

SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells

artículo científico publicado en 2018

Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred

article

Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2.

artículo científico publicado en 2006

Somatic Mutations and Deletions of the E-Cadherin Gene Predict Poor Survival of Patients With Gastric Cancer

article

Somatic mutations in mismatch repair genes in sporadic gastric carcinomas are not a cause but a consequence of the mutator phenotype

artículo científico publicado en 2008

Specific clinical and biological features characterize inflammatory bowel disease associated colorectal cancers showing microsatellite instability

artículo científico publicado en 2007

Sporadic gastric carcinomas with microsatellite instability display a particular clinicopathologic profile.

artículo científico publicado en 1995

Substantial reduction of the gastric carcinoma critical region at 6q16.3-q23.1

artículo científico publicado en 1999

TP53 germline mutations in Portugal and genetic modifiers of age at cancer onset

artículo científico publicado en 2009

Target gene mutational pattern in Lynch syndrome colorectal carcinomas according to tumour location and germline mutation

artículo científico publicado en 2015

Tetra- and pentanucleotide short tandem repeat instability in gastric cancer.

artículo científico publicado en 1997

The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers

artículo científico publicado en 2008

The bacterial protein azurin impairs invasion and FAK/Src signaling in P-cadherin-overexpressing breast cancer cell models

artículo científico publicado en 2013

The germline CDH1 c.48 G>C substitution contributes to cancer predisposition through generation of a pro-invasive mutation

artículo científico publicado en 2014

The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC.

artículo científico publicado en 2012

The interferon gamma receptor 1 (IFNGR1) -56C/T gene polymorphism is associated with increased risk of early gastric carcinoma

artículo científico publicado en 2008

The interleukin-8-251*T/*A polymorphism is not associated with risk for gastric carcinoma development in a Portuguese population

artículo científico publicado en 2008

The intracellular E-cadherin germline mutation V832 M lacks the ability to mediate cell-cell adhesion and to suppress invasion

artículo científico publicado en 2003

The mechanisms underlying MMR deficiency in immunodeficiency-related non-Hodgkin lymphomas are different from those in other sporadic microsatellite instable neoplasms

artículo científico publicado en 2009

The prevalence of PIK3CA mutations in gastric and colon cancer.

artículo científico publicado en 2005

The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin

artículo científico publicado en 2009

Therapeutic targets associated to E-cadherin dysfunction in gastric cancer.

artículo científico

Transcription initiation arising from E-cadherin/CDH1 intron2: a novel protein isoform that increases gastric cancer cell invasion and angiogenesis

artículo científico publicado en 2012

Tumor Necrosis Factor Alpha Extended Haplotypes and Risk of Gastric Carcinoma

artículo científico publicado en 2008

Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells

artículo científico publicado en 2006

Unmasking the role of KRAS and BRAF pathways in MSI colorectal tumors

artículo científico publicado en 2009

WNT-inducible signaling pathway protein 3, WISP-3, is mutated in microsatellite unstable gastrointestinal carcinomas but not in endometrial carcinomas

artículo científico publicado en 2003

beta-catenin (CTNNB1) gene amplification: a new mechanism of protein overexpression in cancer.

artículo científico publicado en 2005

p53 alterations in gastric carcinoma:

artículo científico publicado en 1994

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