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Lista de obras de Nicola Normanno

A multidisciplinary approach is required to increase the quality of phase II/III clinical studies on biotherapies in oncology

scientific article published on 16 April 2007

A novel case of rhabdoid colon carcinoma associated with a positive CpG island methylator phenotype and BRAF mutation.

artículo científico publicado en 2011

A “live” biopsy in a small-cell lung cancer patient by detection of circulating tumor cells

article by Simona Bevilacqua et al published July 2009 in Lung Cancer

ALK rearrangement testing by FISH analysis in non-small-cell lung cancer patients: results of the first italian external quality assurance scheme.

artículo científico publicado en 2014

AZD3409 inhibits the growth of breast cancer cells with intrinsic resistance to the EGFR tyrosine kinase inhibitor gefitinib.

artículo científico publicado en 2006

Activity of gefitinib in a non-small-cell lung cancer patient with both activating and resistance EGFR mutations

artículo científico publicado en 2013

Advanced non-small-cell lung cancer with epidermal growth factor receptor mutations: current evidence and future perspectives

artículo científico

Afatinib: An overview of its clinical development in non-small-cell lung cancer and other tumors

artículo científico

Aging and the hemopoietic system.

artículo científico publicado en 2003

Amphiregulin anti-sense oligodeoxynucleotides inhibit growth and transformation of a human colon carcinoma cell line

artículo científico publicado en 1995

Anaplastic lymphoma kinase: a glimmer of hope in lung cancer treatment?

artículo científico

Anti-tumor activity of the combination of cetuximab, an anti-EGFR blocking monoclonal antibody and ZD6474, an inhibitor of VEGFR and EGFR tyrosine kinases

artículo científico publicado en 2006

Anticancer effect of bisphosphonates: new insights from clinical trials and preclinical evidence.

artículo científico publicado en 2011

Application of the Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) to patients conservatively treated: Outcomes from an institutional series

artículo científico publicado en 2019

Assessing standardization of molecular testing for non-small-cell lung cancer: results of a worldwide external quality assessment (EQA) scheme for EGFR mutation testing

artículo científico publicado en 2014

Assessment of high-sensitive methods for the detection of EGFR mutations in circulating free tumor DNA from NSCLC patients

artículo científico publicado en 2015

BEVERLY: Rationale and Design of a Randomized Open-Label Phase III Trial Comparing Bevacizumab Plus Erlotinib Versus Erlotinib Alone as First-Line Treatment of Patients With EGFR-Mutated Advanced Nonsquamous Non-Small-Cell Lung Cancer

artículo científico publicado en 2016

BRAF V600E mutation in metastatic colorectal cancer: Methods of detection and correlation with clinical and pathologic features.

artículo científico publicado en 2016

Bone effect of adjuvant tamoxifen, letrozole or letrozole plus zoledronic acid in early-stage breast cancer: the randomized phase 3 HOBOE study

scientific article published on 12 March 2012

Breast cancer cells with acquired resistance to the EGFR tyrosine kinase inhibitor gefitinib show persistent activation of MAPK signaling

artículo científico publicado en 2007

Cetuximab continuation after first progression in metastatic colorectal cancer (CAPRI-GOIM): a randomized phase II trial of FOLFOX plus cetuximab versus FOLFOX.

artículo científico publicado en 2016

Cetuximab in non-small-cell lung cancer

Cetuximab, irinotecan and fluorouracile in fiRst-line treatment of immunologically-selected advanced colorectal cancer patients: the CIFRA study protocol

scientific article published on 09 September 2019

Circulating Tumor DNA Testing Opens New Perspectives in Melanoma Management

artículo científico publicado en 2020

Circulating free tumor DNA in non-small cell lung cancer (NSCLC): clinical application and future perspectives

artículo científico publicado en 2019

Circulating free tumor-derived DNA to detect EGFR mutations in patients with advanced NSCLC: French subset analysis of the ASSESS study.

artículo científico publicado en 2019

Circulating programmed death ligand-1 (cPD-L1) in non-small-cell lung cancer (NSCLC).

artículo científico publicado en 2018

Clinical activity of FOLFIRI plus cetuximab according to extended gene mutation status by next-generation sequencing: findings from the CAPRI-GOIM trial.

artículo científico publicado en 2014

Clinical utility of circulating tumor cells in patients with non-small-cell lung cancer

artículo científico publicado en 2017

Comment on 'a comparison of three methods for detecting KRAS mutations in formalin-fixed colorectal cancer specimens'

artículo científico publicado en 2012

Conditioned medium of primary lung cancer cells induces EMT in A549 lung cancer cell line by TGF-ß1 and miRNA21 cooperation

scientific article published on 25 July 2019

Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth.

artículo científico publicado en 2002

Correction: Intratumor Heterogeneity of ALK-Rearrangements and Homogeneity of EGFR-Mutations in Mixed Lung Adenocarcinoma

artículo científico publicado en 2015

Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells

artículo científico publicado en 1997

Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells

artículo científico publicado en 2002

Cripto-1 overexpression leads to enhanced invasiveness and resistance to anoikis in human MCF-7 breast cancer cells

artículo científico publicado en 2004

Detection and localization of Cripto-1 binding in mouse mammary epithelial cells and in the mouse mammary gland using an immunoglobulin-cripto-1 fusion protein

artículo científico publicado en 2002

Detection of EGFR Variants in Plasma: A Multilaboratory Comparison of a Real-Time PCR EGFR Mutation Test in Europe

artículo científico publicado en 2018

Detection of EGFR mutations by TaqMan mutation detection assays powered by competitive allele-specific TaqMan PCR technology

artículo científico publicado en 2013

Detection of KRAS mutations in colorectal cancer with Fast COLD-PCR.

artículo científico publicado en 2011

Detection of KRAS mutations in colorectal carcinoma patients with an integrated PCR/sequencing and real-time PCR approach.

artículo científico publicado en 2010

Development of a semi-conductor sequencing-based panel for genotyping of colon and lung cancer by the Onconetwork consortium

artículo científico publicado en 2015

Development of leiomyosarcoma of the uterus in MMTV-CR-1 transgenic mice.

artículo científico publicado en 2007

EGF-related antisense oligonucleotides inhibit the proliferation of human ovarian carcinoma cells

artículo científico publicado en 2000

EGFR and MEK Blockade in Triple Negative Breast Cancer Cells.

artículo científico publicado en 2015

EGFR mutation prevalence in Asia-Pacific and Russian patients with advanced NSCLC of adenocarcinoma and non-adenocarcinoma histology: The IGNITE study.

artículo científico publicado en 2017

EGFR mutation testing practices within the Asia Pacific region: results of a multicenter diagnostic survey

artículo científico publicado en 2015

EGFR mutations in lung cancer: from tissue testing to liquid biopsy

artículo científico

EGFR-targeted therapy

artículo científico

ESMO consensus guidelines for the management of patients with metastatic colorectal cancer.

artículo científico publicado en 2016

Effects of the combined blockade of EGFR and ErbB-2 on signal transduction and regulation of cell cycle regulatory proteins in breast cancer cells.

artículo científico publicado en 2009

Efficacy and safety of rechallenge treatment with gefitinib in patients with advanced non-small cell lung cancer.

artículo científico publicado en 2016

Epidermal growth factor receptor tyrosine kinase inhibitors and bone metastases: different mechanisms of action for a novel therapeutic application?

scientific article published on 01 March 2006

Epidermal growth factor-related peptides in the pathogenesis of human breast cancer.

artículo científico publicado en 1994

Epithelial mesenchymal transition is a characteristic of hyperplasias and tumors in mammary gland from MMTV-Cripto-1 transgenic mice

artículo científico publicado en 2004

Epithelial to mesenchymal transition by TGFβ-1 induction increases stemness characteristics in primary non small cell lung cancer cell line

artículo científico publicado en 2011

Erlotinib in pancreatic cancer: are tumor cells the (only) target?

artículo científico publicado en 2007

European Consensus Conference for external quality assessment in molecular pathology ⬇️

artículo científico publicado el 23 de abril de 2013

Evaluation of the pharmacokinetics of ixabepilone for the treatment of breast cancer.

artículo científico

Expression and functional role of CRIPTO-1 in cutaneous melanoma ⬇️

artículo científico publicado el 23 de agosto de 2011

Expression of messenger RNA for amphiregulin, heregulin, and cripto-1, three new members of the epidermal growth factor family, in human breast carcinomas

scientific article published on 01 September 1995

Expression of transforming growth factor alpha, amphiregulin and cripto-1 in human breast carcinomas.

artículo científico publicado en 1994

External quality assessment unravels interlaboratory differences in quality of RAS testing for anti-EGFR therapy in colorectal cancer

artículo científico publicado en 2015

Extracellular matrix proteins as circulating biomarkers for the diagnosis of non-small cell lung cancer patients.

artículo científico publicado en 2019

FGFR Fusions in Cancer: From Diagnostic Approaches to Therapeutic Intervention

scientific article published on 18 September 2020

FGFR-targeted therapeutics for the treatment of breast cancer.

artículo científico publicado en 2017

Gefitinib and cisplatin-based chemotherapy in non-small-cell lung cancer: simply a bad combination?

artículo científico publicado en 2005

Gefitinib in non small cell lung cancer

artículo científico publicado en 2011

Gefitinib inhibits the ability of human bone marrow stromal cells to induce osteoclast differentiation: implications for the pathogenesis and treatment of bone metastasis

artículo científico publicado en 2005

Gefitinib inhibits the cross-talk between mesenchymal stem cells and prostate cancer cells leading to tumor cell proliferation and inhibition of docetaxel activity.

artículo científico publicado en 2013

Gene methylation in liquid biopsy and risk of recurrence in lung cancer.

artículo científico publicado en 2018

Genomic Profiling of KRAS/NRAS/BRAF/PIK3CA Wild-Type Metastatic Colorectal Cancer Patients Reveals Novel Mutations in Genes Potentially Associated with Resistance to Anti-EGFR Agents

scientific article published on 20 June 2019

Genomics driven-oncology: challenges and perspectives

artículo científico publicado en 2015

Guidance for laboratories performing molecular pathology for cancer patients

artículo científico publicado en 2014

Guide to detecting epidermal growth factor receptor (EGFR) mutations in ctDNA of patients with advanced non-small-cell lung cancer

artículo científico publicado en 2016

Guideline on the requirements of external quality assessment programs in molecular pathology.

artículo científico publicado en 2012

HER2 Signaling and Resistance to the Anti-EGFR Monoclonal Antibody Cetuximab: A Further Step toward Personalized Medicine for Patients with Colorectal Cancer ⬇️

artículo científico publicado el 1 de noviembre de 2011

Heterogeneity of KRAS, NRAS, BRAF and PIK3CA mutations in metastatic colorectal cancer and potential effects on therapy in the CAPRI GOIM trial.

artículo científico publicado en 2015

Higher quality of molecular testing, an unfulfilled priority: Results from external quality assessment for KRAS mutation testing in colorectal cancer

artículo científico publicado en 2014

Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma

artículo científico publicado en 2005

Human lung adenocarcinoma cell cultures derived from malignant pleural effusions as model system to predict patients chemosensitivity

artículo científico publicado en 2016

Identification of cripto-1 as a novel serologic marker for breast and colon cancer.

artículo científico publicado en 2006

Immune checkpoint inhibitor treatment in patients with oncogene- addicted non-small cell lung cancer (NSCLC): summary of a multidisciplinary round-table discussion

scientific article published on 17 June 2019

Immunotherapy in Small Cell Lung Cancer

artículo científico publicado en 2020

Impact of circulating tumor DNA mutant allele fraction on prognosis in RAS-mutant metastatic colorectal cancer

scientific article published on 31 July 2019

Implementing TMB measurement in clinical practice: considerations on assay requirements

artículo científico publicado en 2019

Implementing anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer: challenges and future perspectives

artículo científico publicado en 2020

Implications for KRAS status and EGFR-targeted therapies in metastatic CRC.

artículo científico publicado en 2009

Inhibition of proliferation and induction of apoptosis in breast cancer cells by the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ZD1839 ('Iressa') is independent of EGFR expression level

artículo científico publicado en 2004

Integration of next-generation sequencing in clinical diagnostic molecular pathology laboratories for analysis of solid tumours; an expert opinion on behalf of IQN Path ASBL.

artículo científico publicado en 2016

International pilot external quality assessment scheme for analysis and reporting of circulating tumour DNA

scientific article published on 09 August 2018

Intratumor Heterogeneity of ALK-Rearrangements and Homogeneity of EGFR-Mutations in Mixed Lung Adenocarcinoma

artículo científico publicado en 2015

Is epirubicin effective in first-line chemotherapy of metastatic breast cancer (MBC) after an epirubicin-containing adjuvant treatment? A single centre phase III trial.

artículo científico publicado en 2006

Is the gefitinib plus trastuzumab combination feasible in breast cancer patients?

artículo científico publicado en 2005

KRAS early testing: consensus initiative and cost-effectiveness evaluation for metastatic colorectal patients in an Italian setting

artículo científico publicado en 2014

KRAS mutations testing in colorectal carcinoma patients in Italy: from guidelines to external quality assessment

artículo científico publicado en 2011

KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer.

artículo científico publicado en 2011

Leptin signaling in breast cancer: An overview

artículo científico publicado en 2008

Limits and potential of targeted sequencing analysis of liquid biopsy in patients with lung and colon carcinoma.

scientific article published on 19 July 2016

Liquid Biopsy Testing Can Improve Selection of Advanced Non-Small-Cell Lung Cancer Patients to Rechallenge with Gefitinib

scientific article published on 25 September 2019

Long time response with chemotherapy in ROS1 NSCLC patient with unusual metastatic site

artículo científico publicado en 2016

Maintenance Treatment with Cetuximab and BAY86-9766 Increases Antitumor Efficacy of Irinotecan plus Cetuximab in Human Colorectal Cancer Xenograft Models

artículo científico publicado en 2015

Measuring tumor mutation burden in non-small cell lung cancer: tissue versus liquid biopsy

artículo científico publicado en 2018

Mechanisms of endocrine resistance and novel therapeutic strategies in breast cancer

artículo científico publicado en 2005

Mesenchymal stem cell‐derived interleukin‐6 and vascular endothelial growth factor promote breast cancer cell migration

artículo científico publicado en 2012

Modulation of Epidermal Growth Factor Receptor–Positive Circulating Tumor Cells by Chemotherapy in Non–Small-Cell Lung Cancer Patients

scientific article published on 01 October 2005

Molecular diagnostics and personalized medicine in oncology: Challenges and opportunities

artículo científico publicado en 2013

Molecular markers to predict response to gefitinib: EGFR, ErbB-2, or more?

artículo científico publicado en 2004

Molecular typing of lung adenocarcinoma on cytological samples using a multigene next generation sequencing panel

artículo científico publicado en 2013

Mutational Profile of Malignant Pleural Mesothelioma (MPM) in the Phase II RAMES Study

scientific article published on 13 October 2020

Netrin-1 regulates invasion and migration of mouse mammary epithelial cells overexpressing Cripto-1 in vitro and in vivo.

artículo científico publicado en 2005

Neuronal guidance protein Netrin-1 induces differentiation in human embryonal carcinoma cells.

scientific article published on 17 February 2009

New drugs in advanced non-small-cell lung cancer: searching for the correct clinical development

artículo científico publicado en 2010

New drugs in cancer therapy, National Tumor Institute, Naples, 17-18 June 2004.

artículo científico publicado en 2005

New molecular targets for anticancer therapy. The First International Conference on New Molecular Targets for Anticancer Therapy. Naples, Italy. June 22-23 1998

scientific article published on 01 December 1998

Next Generation Sequencing-Based Profiling of Cell Free DNA in Patients with Advanced Non-Small Cell Lung Cancer: Advantages and Pitfalls

artículo científico publicado en 2020

Osteoblastic metastases in non-small cell lung cancer and its possible significance

artículo científico publicado en 2008

Osteoblastosis and activating epidermal growth factor receptor mutations: a relationship?

scientific article published on 01 April 2010

Pembrolizumab in lung cancer: current evidence and future perspectives

scientific article published on 21 August 2019

Pharmacokinetic drug evaluation of palbociclib for the treatment of breast cancer

artículo científico publicado en 2018

Pharmacokinetic evaluation of capecitabine in breast cancer

artículo científico

Pharmacokinetic evaluation of zoledronic acid.

artículo científico publicado en 2011

Phase III study with FOLFIRI + cetuximab versus FOLFIRI + cetuximab followed by cetuximab alone in RAS and BRAF WT mCRC

artículo científico publicado en 2018

Phorbol 12-myristate 13-acetate induces resistance of human melanoma cells to natural-killer- and lymphokine-activated-killer-mediated cytotoxicity

artículo científico publicado en 1992

Positron emission tomography and circulating tumor cells to monitor a dramatic response to gefitinib.

artículo científico publicado en 2012

Prognostic applications of gene expression signatures in breast cancer

artículo científico publicado en 2009

Prognostic factor for non-small cell lung cancer with bone metastases at the time of diagnosis

scientific article published on 06 September 2012

Prognostic value of cancer stem cells, epithelial-mesenchymal transition and circulating tumor cells in lung cancer

artículo científico publicado en 2013

Prognostic value of circulating tumor cells' reduction in patients with extensive small-cell lung cancer

artículo científico publicado en 2014

Prolonged control of bone metastases in non-small-cell lung cancer patients treated with gefitinib

artículo científico publicado en 2008

Quercetin‐3‐methyl ether inhibits lapatinib‐sensitive and ‐resistant breast cancer cell growth by inducing G2/M arrest and apoptosis ⬇️

artículo científico publicado el 15 de noviembre de 2011

RANTES and IL-6 cooperate in inducing a more aggressive phenotype in breast cancer cells.

artículo científico publicado en 2018

RAS testing in metastatic colorectal cancer: advances in Europe

artículo científico publicado en 2015

RAS testing of liquid biopsy correlates with the outcome of metastatic colorectal cancer patients treated with first-line FOLFIRI plus cetuximab in the CAPRI-GOIM trial.

artículo científico publicado en 2017

Re: Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer

artículo científico publicado en 2010

Recommendations for the analysis of ALK gene rearrangements in non-small-cell lung cancer: a consensus of the Italian Association of Medical Oncology and the Italian Society of Pathology and Cytopathology.

artículo científico publicado en 2013

Recommendations for the implementation of BRCA testing in ovarian cancer patients and their relatives

scientific article published on 25 May 2019

Recommendations for the implementation of BRCA testing in the care and treatment pathways of ovarian cancer patients

artículo científico publicado en 2016

Regulation of human Cripto-1 gene expression by TGF-beta1 and BMP-4 in embryonal and colon cancer cells

scientific article published on 01 April 2008

Results of the First Italian External Quality Assurance Scheme for somatic EGFR mutation testing in non-small-cell lung cancer

artículo científico publicado en 2013

Retracted: Epigenetic Silencing of Peroxisome Proliferator-Activated Receptor γ Is a Biomarker for Colorectal Cancer Progression and Adverse Patients' Outcome

artículo científico publicado en 2010

Review of the implementation of plasma ctDNA testing on behalf of IQN Path ASBL: a perspective from an EQA providers' survey

artículo científico publicado en 2017

Role of human cripto-1 in tumor angiogenesis.

artículo científico publicado en 2005

Role of the EGFR ligand/receptor system in the secretion of angiogenic factors in mesenchymal stem cells

artículo científico publicado en 2011

Role of the cripto (EGF-CFC) family in embryogenesis and cancer.

artículo científico publicado en 2004

Self-assembling nanoparticles encapsulating zoledronic acid inhibit mesenchymal stromal cells differentiation, migration and secretion of proangiogenic factors and their interactions with prostate cancer cells.

artículo científico publicado en 2017

Should epidermal growth factor receptor tyrosine kinase inhibitors be considered ideal drugs for the treatment of selected advanced non-small cell lung cancer patients?

artículo científico publicado en 2012

Simultaneous blockage of different EGF-like growth factors results in efficient growth inhibition of human colon carcinoma xenografts.

artículo científico publicado en 2000

Src and CXCR4 are involved in the invasiveness of breast cancer cells with acquired resistance to lapatinib

artículo científico publicado en 2013

Structure-fluctuation-function relationships of seven pro-angiogenic isoforms of VEGFA, important mediators of tumorigenesis

artículo científico publicado en 2015

Study of Ras Mutations' Prognostic Value in Metastatic Colorectal Cancer: STORIA Analysis

scientific article published on 16 July 2020

TGF-β1 exposure induces epithelial to mesenchymal transition both in CSCs and non-CSCs of the A549 cell line, leading to an increase of migration ability in the CD133+ A549 cell fraction.

artículo científico publicado en 2013

Target-based therapies in breast cancer: current status and future perspectives.

scientific article published on 12 June 2009

Targeting the EGFR T790M mutation in non-small-cell lung cancer

artículo científico publicado en 2016

The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer.

artículo científico publicado en 2000

The ErbB receptors and their ligands in cancer: an overview.

artículo científico publicado en 2005

The European Society for Medical Oncology (ESMO) Precision Medicine Glossary

artículo científico publicado en 2017

The Italian external quality assessment for RAS testing in colorectal carcinoma identifies methods-related inter-laboratory differences

artículo científico publicado en 2015

The MEK/MAPK pathway is involved in the resistance of breast cancer cells to the EGFR tyrosine kinase inhibitor gefitinib

artículo científico publicado en 2006

The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches.

artículo científico

The S492R EGFR ectodomain mutation is never detected in KRAS wild-type colorectal carcinoma before exposure to EGFR monoclonal antibodies

scientific article published on 23 September 2013

The liquid biopsy in the management of colorectal cancer patients: Current applications and future scenarios

artículo científico publicado en 2018

The potential of monitoring treatment response in non-small cell lung cancer using circulating tumour cells

artículo científico publicado en 2019

The prognostic role of circulating tumor cells in lung cancer.

artículo científico publicado en 2016

The role of amphiregulin in breast cancer.

artículo científico publicado en 1995

The role of circulating free DNA in the management of NSCLC

scientific article published on 29 November 2018

The role of the EGFR signaling in tumor microenvironment.

artículo científico publicado en 2008

The significance of a Cripto-1 positive subpopulation of human melanoma cells exhibiting stem cell-like characteristics

artículo científico publicado en 2013

Treatment of small cell lung cancer

scholarly article by Alessandro Morabito et al published September 2014 in Critical Reviews in Oncology Hematology

Trying to compose the puzzle with all the pieces: epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer

artículo científico publicado en 2005

Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: current status and future directions.

artículo científico publicado en 2006

Uptake of KRAS mutation testing in patients with metastatic colorectal cancer in Europe, Latin America and Asia

artículo científico publicado en 2011

VEGF as a potential target in lung cancer

artículo científico publicado en 2017

Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: current status and future directions.

scientific article published on 06 April 2009

Vandetanib as a potential treatment for breast cancer.

artículo científico

Vandetanib: An overview of its clinical development in NSCLC and other tumors.

artículo científico publicado en 2010

Vascular Endothelial Growth Factor A Regulates the Secretion of Different Angiogenic Factors in Lung Cancer Cells

artículo científico publicado en 2015

Zoledronic acid blocks the interaction between mesenchymal stem cells and breast cancer cells: implications for adjuvant therapy of breast cancer.

artículo científico publicado en 2011

Zoledronic acid in early-stage breast cancer

artículo científico publicado en 2011

ctDNA Determination of EGFR Mutation Status in European and Japanese Patients with Advanced NSCLC: The ASSESS Study

artículo científico publicado en 2016

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