Lista de obras - Heiko Herwald - Dominio Público Uruguay

A Farewell to Arms: Streptococcal Strategies to Cope with Innate Immunity

scientific article published on 25 June 2014

A fibrin biofilm covers the blood clot and protects from microbial invasion. ⬇️

artículo científico publicado en 2018

A human antithrombin isoform dampens inflammatory responses and protects from organ damage during bacterial infection

artículo científico publicado en 2019

A novel role for pro-coagulant microvesicles in the early host defense against streptococcus pyogenes.

artículo científico publicado en 2013

A rapid method for selecting suitable animal species for studying pathogen interactions with plasma protein ligands in vivo.

artículo científico publicado en 2017

Aberrant inflammatory response to Streptococcus pyogenes in mice lacking myeloid differentiation factor 88.

artículo científico publicado en 2009

Absorption of kininogen from human plasma by Streptococcus pyogenes is followed by the release of bradykinin

artículo científico publicado en 1997

Activation of TAFI on the Surface of Streptococcus pyogenes Evokes Inflammatory Reactions by Modulating the Kallikrein/Kinin System

artículo científico publicado en 2008

Activation of human polymorphonuclear neutrophils by streptolysin O from Streptococcus pyogenes leads to the release of proinflammatory mediators

artículo científico publicado en 2006

Activation of the contact-phase system on bacterial surfaces--a clue to serious complications in infectious diseases

artículo científico publicado en 1998

Activation of the human contact system on neutrophil extracellular traps.

artículo científico publicado en 2009

Active but inoperable thrombin is accumulated in a plasma protein layer surrounding Streptococcus pyogenes

article

Adsorption of components of the plasma kinin-forming system on the surface of Porphyromonas gingivalis involves gingipains as the major docking platforms.

artículo científico publicado en 2010

All That Glisters Is Not Gold - Staphylococcus aureus and Innate Immunity

scientific article published on 12 January 2015

Alteration of Leukocyte Count Correlates With Increased Pulmonary Vascular Permeability and Decreased PaO2:FiO2 Ratio Early After Major Burns

artículo científico publicado en 2015

An ecoimmunological approach to study evolutionary and ancient links between coagulation, complement and Innate immunity.

artículo científico publicado en 2018

Another Brick in the Wall

scientific article published on 26 February 2019

Anti-inflammatory, anti-coagulant, anti-biotic?

artículo científico publicado en 2013

Antibodies against a surface protein of Streptococcus pyogenes promote a pathological inflammatory response

artículo científico publicado en 2008

Antimicrobial activity of fibrinogen and fibrinogen-derived peptides – a novel link between coagulation and innate immunity

artículo científico publicado en 2013

Back to the Present

artículo científico publicado en 2015

Bacterial Proteases Disarming Host Defense

artículo científico publicado en 2008

Binding characteristics of thrombin-activatable fibrinolysis inhibitor to streptococcal surface collagen-like proteins A and B

scientific article published on 28 July 2011

Catch Me if You Can or Actors on the Run

artículo científico publicado en 2018

Cells of Innate and Adaptive Immunity: A Matter of Class?

artículo científico publicado en 2017

Chasing Flies because Time Flies

artículo científico publicado en 2014

Coagulation systems of invertebrates and vertebrates and their roles in innate immunity: the same side of two coins?

artículo científico publicado en 2010

Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense.

artículo científico publicado en 2011

Cold Atmospheric Plasma Disarms M1 Protein, an Important Streptococcal Virulence Factor

artículo científico publicado en 2019

Comprehensive Mass Spectrometric Survey of Streptococcus pyogenes Subcellular Proteomes

artículo científico publicado en 2017

Contact activation by pathogenic bacteria: a virulence mechanism contributing to the pathophysiology of sepsis.

artículo científico publicado en 2003

Contact system activation in severe infectious diseases

artículo científico publicado en 2010

Contact-system activation in children with vasculitis

scientific article published in The Lancet

DNA-fragmentation is a source of bactericidal activity against Pseudomonas aeruginosa.

artículo científico publicado en 2016

Differential neutrophil responses to bacterial stimuli: Streptococcal strains are potent inducers of heparin-binding protein and resistin-release

artículo científico publicado en 2016

Early depletion of contact system in patients with sepsis: a prospective matched control observational study

scientific article published on 05 November 2018

Editorial

artículo científico publicado en 2011

Elevated Plasma Levels of Antimicrobial Polypeptides in Patients with Severe Sepsis

artículo científico publicado en 2010

Evaluation of potential biomarkers for the discrimination of bacterial and viral infections

artículo científico publicado en 2011

Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo.

artículo científico publicado en 2015

Foodies of Innate Immunity

artículo científico publicado en 2015

Geranylgeranyl transferase regulates streptococcal M1 protein-induced CXC chemokine formation and neutrophil recruitment in the lung.

artículo científico publicado en 2013

Globular C1 q receptor (p33) binds and stabilizes pro-inflammatory MCP-1: a novel mechanism for regulation of MCP-1 production and function.

artículo científico publicado en 2018

Gone with the Wind--Innate Immunity and Airway Inflammation.

artículo científico publicado en 2016

Hemostasis in Invertebrates and Vertebrates: An Evolutionary Excursion

article

Heparin binding protein is increased in chronic leg ulcer fluid and released from granulocytes by secreted products of Pseudomonas aeruginosa

artículo científico publicado en 2004

Heparin-binding protein (HBP) in critically ill patients with influenza A(H1N1) infection.

artículo científico publicado en 2013

Heparin-binding protein (HBP): an early marker of respiratory failure after trauma?

artículo científico publicado en 2013

Heparin-binding protein (HBP/CAP37) - a link to endothelin-1 in endotoxemia-induced pulmonary oedema?

artículo científico publicado en 2014

Heparin-binding protein (HBP/CAP37): A missing link in neutrophil-evoked alteration of vascular permeability

artículo científico publicado en 2001

Heparin-binding protein as a biomarker of acute kidney injury in critical illness

artículo científico publicado en 2017

Heparin-binding protein as a biomarker of circulatory failure during severe infections: a report of three cases.

artículo científico publicado en 2010

Heparin-binding protein as a biomarker of post-injury sepsis in trauma patients.

artículo científico publicado en 2018

Heparin-binding protein release is strongly induced by Leptospira spp. and is a candidate for an early diagnostic marker of human leptospirosis

scientific article published on 01 February 2019

Heparin-binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosis

artículo científico publicado en 1999

Heparin-binding protein: an early marker of circulatory failure in sepsis

artículo científico publicado en 2009

Human endogenous peptide p33 inhibits detrimental effects of LL-37 on osteoblast viability

artículo científico publicado en 2014

Human kininogens interact with M protein, a bacterial surface protein and virulence determinant

artículo científico publicado en 1995

Identification of Two Protein-binding and Functional Regions of Curli, a Surface Organelle and Virulence Determinant of Escherichia coli

artículo científico publicado en 2002

Identification of an endothelial cell binding site on kininogen domain D3

artículo científico publicado en 1995

Immunological mechanisms underlying the genetic predisposition to severe Staphylococcus aureus infection in the mouse model

artículo científico publicado en 2008

Immunoregulation of Neutrophil Extracellular Trap Formation by Endothelial-Derived p33 (gC1q Receptor).

artículo científico publicado en 2017

Increased Plasma Levels of Heparin-Binding Protein on Admission to Intensive Care Are Associated with Respiratory and Circulatory Failure

artículo científico publicado en 2016

Increased plasma levels of heparin-binding protein in patients with shock: a prospective, cohort study

artículo científico publicado en 2011

Induction of anti-β2-glycoprotein I autoantibodies in mice by protein H of Streptococcus pyogenes

artículo científico publicado en 2011

Inflammatory role and prognostic value of platelet chemokines in acute coronary syndrome

article published in 2014

Innate immunity - a clinical perspective

artículo científico publicado en 2019

Interactions between surface proteins of Streptococcus pyogenes and coagulation factors modulate clotting of human plasma

artículo científico publicado en 2003

Interferon-λ: Inters Ferocity or Inter-Ferocities?

scientific article published on 24 March 2015

Intracellular Clearance by Nobel Laureates.

artículo científico publicado en 2016

Isolation and characterization of the kininogen-binding protein p33 from endothelial cells. Identity with the gC1q receptor

artículo científico publicado en 1996

Journal of Innate Immunity Ten Years Later

artículo científico publicado en 2018

Kinin B2 receptor-mediated bradykinin internalization and metalloendopeptidase EP24.15-dependent intracellular bradykinin degradation

artículo científico publicado en 2008

Kinin receptor expression during Staphylococcus aureus infection

artículo científico publicado en 2006

LL-37-induced host cell cytotoxicity depends on cellular expression of the globular C1q receptor (p33).

artículo científico publicado en 2015

Leptospira interrogans outer membrane protein LipL21 is a potent inhibitor of neutrophil myeloperoxidase.

artículo científico publicado en 2017

Leucocyte recruitment and molecular fortification of keratinocytes triggered by streptococcal M1 protein.

artículo científico publicado en 2017

M protein from Streptococcus pyogenes induces tissue factor expression and pro-coagulant activity in human monocytes

artículo científico publicado en 2007

M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage

artículo científico publicado en 2004

M1 protein from streptococcus pyogenes induces nitric oxide-mediated vascular hyporesponsiveness to phenylephrine: involvement of toll-like receptor activation

artículo científico publicado en 2010

Macrophages: past, present and future.

artículo científico publicado en 2013

Mapping of the H-kininogen binding site exposed by the prekallikrein heavy chain

artículo científico publicado el 1 de enero de 1992

Mapping of the discontinuous kininogen binding site of prekallikrein. A distal binding segment is located in the heavy chain domain A4.

artículo científico publicado en 1996

Mapping of the high molecular weight kininogen binding site of prekallikrein. Evidence for a discontinuous epitope formed by distinct segments of the prekallikrein heavy chain ⬇️

artículo científico publicado el 5 de julio de 1993

Mapping the cell binding site on high molecular weight kininogen domain 5.

artículo científico publicado en 1995

Modulation of Hemostatic and Inflammatory Responses by Leptospira Spp

artículo científico publicado en 2016

Modulation of membrane traffic by microorganisms.

artículo científico publicado en 2003

Modulation of the coagulation system during severe streptococcal disease.

artículo científico publicado en 2013

Neutrophil degranulation mediates severe lung damage triggered by streptococcal M1 protein

artículo científico publicado en 2008

Neutrophil extracellular trap-microparticle complexes enhance thrombin generation via the intrinsic pathway of coagulation in mice.

artículo científico publicado en 2018

Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages

artículo científico publicado en 2008

Neutrophil secretion products pave the way for inflammatory monocytes

artículo científico publicado en 2008

Neutrophil-Derived Hyperresistinemia in Severe Acute Streptococcal Infections

artículo científico publicado en 2009

Neutrophil-derived heparin binding protein--a mediator of increased vascular permeability after burns?

artículo científico publicado en 2009

Neutrophils engage the kallikrein-kinin system to open up the endothelial barrier in acute inflammation

article

Nobel Parasites in the Kingdom of Invertebrates.

artículo científico publicado en 2015

Of DAMPs and macrophages.

artículo científico publicado en 2012

On PAMPs and DAMPs

artículo científico publicado en 2016

Osteopontin That Is Elevated in the Airways during COPD Impairs the Antibacterial Activity of Common Innate Antibiotics.

artículo científico publicado en 2016

Osteopontin protects against lung injury caused by extracellular histones

scientific article published on 16 August 2018

Osteopontin protects against pneumococcal infection in a murine model of allergic airway inflammation

artículo científico publicado en 2018

Paracelsus, poison, and colistin.

artículo científico publicado en 2017

Pathogen entrapment by transglutaminase--a conserved early innate immune mechanism

artículo científico publicado en 2010

Peptidoglycan from Staphylococcus aureus induces tissue factor expression and procoagulant activity in human monocytes

artículo científico publicado en 2002

Plasma Levels of Hepcidin and Reticulocyte Haemoglobin during Septic Shock

scientific article published on 18 September 2020

Protein C inhibitor.

artículo científico

Protein SIC Secreted from Streptococcus pyogenes Forms Complexes with Extracellular Histones That Boost Cytokine Production.

artículo científico publicado en 2018

Ras regulates alveolar macrophage formation of CXC chemokines and neutrophil activation in streptococcal M1 protein-induced lung injury

artículo científico publicado en 2014

Regulation of kinin B(2) receptors by bradykinin in human lung cells

artículo científico publicado en 2008

Renal clearance of heparin-binding protein and elimination during renal replacement therapy: Studies in ICU patients and healthy volunteers

scientific article published on 29 August 2019

STAT3-dependent CXC chemokine formation and neutrophil migration in streptococcal M1 protein-induced acute lung inflammation

artículo científico publicado en 2015

Selected Biomarkers Correlate with the Origin and Severity of Sepsis.

artículo científico publicado en 2018

Sepsis--the unknown public disease of our time

artículo científico publicado en 2015

Serious, Severe, Sepsis

scientific article published on 31 January 2020

Severe lung lesions caused by Salmonella are prevented by inhibition of the contact system.

artículo científico publicado en 2000

Signaling via beta(2) integrins triggers neutrophil-dependent alteration in endothelial barrier function.

artículo científico publicado en 2000

Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury.

artículo científico publicado en 2013

Simvastatin regulates CXC chemokine formation in streptococcal M1 protein-induced neutrophil infiltration in the lung.

artículo científico publicado en 2011

Soluble M1 protein of Streptococcus pyogenes triggers potent T cell activation

artículo científico publicado en 2007

Staphylococcus aureus induces release of bradykinin in human plasma

artículo científico publicado en 2001

Staphylococcus aureus-induced clotting of plasma is an immune evasion mechanism for persistence within the fibrin network

artículo científico publicado en 2014

Stimulation of blood mononuclear cells with bacterial virulence factors leads to the release of pro-coagulant and pro-inflammatory microparticles.

artículo científico publicado en 2011

Streptococcal M protein: a multipotent and powerful inducer of inflammation

artículo científico publicado en 2006

Streptococcal M proteins and their role as virulence determinants.

artículo científico publicado en 2010

Streptococcal M1 Protein-Induced Lung Injury is Independent of Platelets in Mice

artículo científico publicado en 2011

Streptococcal M1 protein triggers chemokine formation, neutrophil infiltration, and lung injury in an NFAT-dependent manner

artículo científico publicado en 2015

Streptococcal M1 protein-provoked CXC chemokine formation, neutrophil recruitment and lung damage are regulated by Rho-kinase signaling.

artículo científico publicado en 2012

Streptococcal cysteine proteinase releases kinins: a virulence mechanism

artículo científico publicado en 1996

Streptococcal inhibitor of complement-mediated lysis (SIC): an anti-inflammatory virulence determinant.

artículo científico publicado en 2010

Streptococcal m1 protein triggers farnesyltransferase-dependent formation of CXC chemokines in alveolar macrophages and neutrophil infiltration of the lungs

artículo científico publicado en 2012

Superantigens from Staphylococcus aureus induce procoagulant activity and monocyte tissue factor expression in whole blood and mononuclear cells via IL-1beta

article

Surveillance and Countermeasures in Innate Immunity

artículo científico publicado en 2013

TFPI-2 Protects Against Gram-Negative Bacterial Infection

artículo científico publicado en 2018

Tackling the Pros and Cons of Inflammation

scientific article published on 30 August 2019

Targeted mass spectrometry analysis of neutrophil-derived proteins released during sepsis progression.

artículo científico publicado en 2014

Targeting Rac1 signaling inhibits streptococcal M1 protein-induced CXC chemokine formation, neutrophil infiltration and lung injury

artículo científico publicado en 2013

The Extracellular Matrix: Reloaded Revolutions

artículo científico publicado en 2019

The Janus Face of Macrophages in Immunity

article

The Neutrophil: A Beautiful Beast or a Beastly Beauty?

artículo científico publicado en 2015

The Nonantibiotic Macrolide EM703 Improves Survival in a Model of Quinolone-Treated Pseudomonas aeruginosa Airway Infection.

artículo científico publicado en 2017

The Origin of a Paradigm

scientific article published on 28 April 2016

The antibacterial activity of peptides derived from human beta-2 glycoprotein I is inhibited by protein H and M1 protein from Streptococcus pyogenes.

artículo científico publicado en 2007

The coagulation system and its function in early immune defense.

artículo científico publicado en 2014

The conversion of fibrinogen to fibrin at the surface of curliated Escherichia coli bacteria leads to the generation of proinflammatory fibrinopeptides

artículo científico publicado en 2003

The dual role of the contact system in bacterial infectious disease

article

The interplay between host haemostatic systems and Leptospira spp. infections

scientific article published on 06 March 2020

Thrombin-activatable fibrinolysis inhibitor binds to Streptococcus pyogenes by interacting with collagen-like proteins A and B.

artículo científico publicado en 2007

Treatment of invasive streptococcal infection with a peptide derived from human high-molecular weight kininogen.

artículo científico publicado en 2009

Treatment with p33 curtails morbidity and mortality in a histone-induced murine shock model.

artículo científico publicado en 2014

Unexpected and Novel Functions of Complement Proteins

artículo científico publicado en 2014

Vigilant keratinocytes trigger pathogen-associated molecular pattern signaling in response to streptococcal M1 protein.

artículo científico publicado en 2015

Visions and the Progress of Science.

artículo científico publicado en 2017

Zinc-dependent conformational changes in domain D5 of high molecular mass kininogen modulate contact activation

artículo científico publicado en 2001

p33 (gC1q receptor) prevents cell damage by blocking the cytolytic activity of antimicrobial peptides.

artículo científico publicado en 2013

β₂-glycoprotein I: a novel component of innate immunity.

artículo científico publicado en 2011

Lista de obras de Heiko Herwald

A Farewell to Arms: Streptococcal Strategies to Cope with Innate Immunity

A fibrin biofilm covers the blood clot and protects from microbial invasion. ⬇️

A human antithrombin isoform dampens inflammatory responses and protects from organ damage during bacterial infection

A novel role for pro-coagulant microvesicles in the early host defense against streptococcus pyogenes.

A rapid method for selecting suitable animal species for studying pathogen interactions with plasma protein ligands in vivo.

Aberrant inflammatory response to Streptococcus pyogenes in mice lacking myeloid differentiation factor 88.

Absorption of kininogen from human plasma by Streptococcus pyogenes is followed by the release of bradykinin

Activation of TAFI on the Surface of Streptococcus pyogenes Evokes Inflammatory Reactions by Modulating the Kallikrein/Kinin System

Activation of human polymorphonuclear neutrophils by streptolysin O from Streptococcus pyogenes leads to the release of proinflammatory mediators

Activation of the contact-phase system on bacterial surfaces--a clue to serious complications in infectious diseases

Activation of the human contact system on neutrophil extracellular traps.

Active but inoperable thrombin is accumulated in a plasma protein layer surrounding Streptococcus pyogenes

Adsorption of components of the plasma kinin-forming system on the surface of Porphyromonas gingivalis involves gingipains as the major docking platforms.

All That Glisters Is Not Gold - Staphylococcus aureus and Innate Immunity

Alteration of Leukocyte Count Correlates With Increased Pulmonary Vascular Permeability and Decreased PaO2:FiO2 Ratio Early After Major Burns

An ecoimmunological approach to study evolutionary and ancient links between coagulation, complement and Innate immunity.

Another Brick in the Wall

Anti-inflammatory, anti-coagulant, anti-biotic?

Antibodies against a surface protein of Streptococcus pyogenes promote a pathological inflammatory response

Antimicrobial activity of fibrinogen and fibrinogen-derived peptides – a novel link between coagulation and innate immunity

Back to the Present

Bacterial Proteases Disarming Host Defense

Binding characteristics of thrombin-activatable fibrinolysis inhibitor to streptococcal surface collagen-like proteins A and B

Catch Me if You Can or Actors on the Run

Cells of Innate and Adaptive Immunity: A Matter of Class?

Chasing Flies because Time Flies

Coagulation systems of invertebrates and vertebrates and their roles in innate immunity: the same side of two coins?

Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense.

Cold Atmospheric Plasma Disarms M1 Protein, an Important Streptococcal Virulence Factor

Comprehensive Mass Spectrometric Survey of Streptococcus pyogenes Subcellular Proteomes

Contact activation by pathogenic bacteria: a virulence mechanism contributing to the pathophysiology of sepsis.

Contact system activation in severe infectious diseases

Contact-system activation in children with vasculitis

DNA-fragmentation is a source of bactericidal activity against Pseudomonas aeruginosa.

Differential neutrophil responses to bacterial stimuli: Streptococcal strains are potent inducers of heparin-binding protein and resistin-release

Early depletion of contact system in patients with sepsis: a prospective matched control observational study

Editorial

Elevated Plasma Levels of Antimicrobial Polypeptides in Patients with Severe Sepsis

Evaluation of potential biomarkers for the discrimination of bacterial and viral infections

Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo.

Foodies of Innate Immunity

Geranylgeranyl transferase regulates streptococcal M1 protein-induced CXC chemokine formation and neutrophil recruitment in the lung.

Globular C1 q receptor (p33) binds and stabilizes pro-inflammatory MCP-1: a novel mechanism for regulation of MCP-1 production and function.

Gone with the Wind--Innate Immunity and Airway Inflammation.

Hemostasis in Invertebrates and Vertebrates: An Evolutionary Excursion

Heparin binding protein is increased in chronic leg ulcer fluid and released from granulocytes by secreted products of Pseudomonas aeruginosa

Heparin-binding protein (HBP) in critically ill patients with influenza A(H1N1) infection.

Heparin-binding protein (HBP): an early marker of respiratory failure after trauma?

Heparin-binding protein (HBP/CAP37) - a link to endothelin-1 in endotoxemia-induced pulmonary oedema?

Heparin-binding protein (HBP/CAP37): A missing link in neutrophil-evoked alteration of vascular permeability

Heparin-binding protein as a biomarker of acute kidney injury in critical illness

Heparin-binding protein as a biomarker of circulatory failure during severe infections: a report of three cases.

Heparin-binding protein as a biomarker of post-injury sepsis in trauma patients.

Heparin-binding protein release is strongly induced by Leptospira spp. and is a candidate for an early diagnostic marker of human leptospirosis

Heparin-binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosis

Heparin-binding protein: an early marker of circulatory failure in sepsis

Human endogenous peptide p33 inhibits detrimental effects of LL-37 on osteoblast viability

Human kininogens interact with M protein, a bacterial surface protein and virulence determinant

Identification of Two Protein-binding and Functional Regions of Curli, a Surface Organelle and Virulence Determinant of Escherichia coli

Identification of an endothelial cell binding site on kininogen domain D3

Immunological mechanisms underlying the genetic predisposition to severe Staphylococcus aureus infection in the mouse model

Immunoregulation of Neutrophil Extracellular Trap Formation by Endothelial-Derived p33 (gC1q Receptor).

Increased Plasma Levels of Heparin-Binding Protein on Admission to Intensive Care Are Associated with Respiratory and Circulatory Failure

Increased plasma levels of heparin-binding protein in patients with shock: a prospective, cohort study

Induction of anti-β2-glycoprotein I autoantibodies in mice by protein H of Streptococcus pyogenes

Inflammatory role and prognostic value of platelet chemokines in acute coronary syndrome

Innate immunity - a clinical perspective

Interactions between surface proteins of Streptococcus pyogenes and coagulation factors modulate clotting of human plasma

Interferon-λ: Inters Ferocity or Inter-Ferocities?

Intracellular Clearance by Nobel Laureates.

Isolation and characterization of the kininogen-binding protein p33 from endothelial cells. Identity with the gC1q receptor

Journal of Innate Immunity Ten Years Later

Kinin B2 receptor-mediated bradykinin internalization and metalloendopeptidase EP24.15-dependent intracellular bradykinin degradation

Kinin receptor expression during Staphylococcus aureus infection

LL-37-induced host cell cytotoxicity depends on cellular expression of the globular C1q receptor (p33).

Leptospira interrogans outer membrane protein LipL21 is a potent inhibitor of neutrophil myeloperoxidase.

Leucocyte recruitment and molecular fortification of keratinocytes triggered by streptococcal M1 protein.

M protein from Streptococcus pyogenes induces tissue factor expression and pro-coagulant activity in human monocytes

M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage