Lista de obras - Luciano Pirola - Dominio Público Uruguay

118th ENMC International Workshop on Advances in Myotubular Myopathy. 26-28 September 2003, Naarden, The Netherlands. (5th Workshop of the International Consortium on Myotubular Myopathy).

artículo científico publicado en 2004

A special BioFactors issue dedicated to resveratrol ⬇️

artículo científico publicado el 1 de septiembre de 2010

Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.

artículo científico publicado en 2001

Adipocytes, like their progenitors, contribute to inflammation of adipose tissues through promotion of Th-17 cells and activation of monocytes, in obese subjects

artículo científico publicado en 2016

Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation.

artículo científico publicado en 2015

Alterations of insulin signaling in type 2 diabetes: a review of the current evidence from humans

artículo científico publicado en 2008

Atrial fibrillation is associated with hypermethylation in human left atrium, and treatment with decitabine reduces atrial tachyarrhythmias in spontaneously hypertensive rats.

artículo científico

Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK

artículo científico publicado en 1998

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

artículo científico publicado en 2000

Dietary polyphenols and their effects on cell biochemistry and pathophysiology

artículo científico publicado en 2012

Dysregulation of sirtuins and key metabolic genes in skeletal muscle of pigs with spontaneous intrauterine growth restriction is associated with alterations of circulating IGF-1.

artículo científico publicado en 2016

Effect of a diet containing folate and hazelnut oil capsule on the methylation level of the ADRB3 gene, lipid profile and oxidative stress in overweight or obese women

artículo científico publicado en 2017

Effects of maternal low-protein diet and spontaneous physical activity on the transcription of neurotrophic factors in the placenta and the brains of mothers and offspring rats

artículo científico publicado en 2020

Epigenetic phenomena linked to diabetic complications.

artículo científico publicado en 2010

Epigenetics in transgenerational responses to environmental impacts: from facts and gaps

artículo científico publicado en 2016

Essential roles of four-carbon backbone chemicals in the control of metabolism

artículo científico publicado en 2015

Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport

artículo científico publicado en 2003

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells

artículo científico publicado en 2011

Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases

artículo científico publicado en 2019

Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension

artículo científico publicado en 2018

Insulin-dependent transcriptional control in L6 rat myotubes is associated with modulation of histone acetylation and accumulation of the histone variant H2A.Z in the proximity of the transcriptional start site

scientific journal article

Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients

artículo científico publicado en 2008

Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways

artículo científico publicado en 2000

Maternal physical activity-induced adaptive transcriptional response in brain and placenta of mothers and rat offspring

artículo científico publicado en 2019

Maternal protein restriction induced-hypertension is associated to oxidative disruption at transcriptional and functional levels in the medulla oblongata

artículo científico publicado en 2016

Maternal voluntary physical activity attenuates delayed neurodevelopment in malnourished rats

artículo científico publicado en 2017

Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States

scientific article published on 17 March 2020

Modulation of insulin action.

artículo científico publicado en 2004

Modulation of the vascular endothelium functioning by dietary components, the role of epigenetics.

artículo científico publicado en 2016

Modulators of insulin action and their role in insulin resistance

scientific article published on 01 December 2003

Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells

artículo científico publicado en 2017

Pharmacological inhibition of arginine and lysine methyltransferases induces nuclear abnormalities and suppresses angiogenesis in human endothelial cells.

artículo científico publicado en 2016

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

artículo científico publicado en 2011

Phosphoinositide 3-kinase signalling: no lipids.

artículo científico publicado en 1999

Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells

artículo científico publicado en 2003

Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes

artículo científico publicado en 2011

Phospholipase D2 regulates endothelial permeability through cytoskeleton reorganization and occludin downregulation

artículo científico publicado en 2009

Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells

artículo científico publicado en 2003

Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule

artículo científico publicado en 2019

Protein acetylation mechanisms in the regulation of insulin and insulin-like growth factor 1 signalling

artículo científico publicado en 2012

Resveratrol is a class IA phosphoinositide 3-kinase inhibitor

artículo científico publicado en 2007

Role of pro- and anti-inflammatory phenomena in the physiopathology of type 2 diabetes and obesity

artículo científico publicado en 2017

Structure and function of phosphoinositide 3-kinases

artículo científico publicado en 1998

The DCCT/EDIC study: epigenetic clues after three decades

artículo científico publicado en 2014

The Epigenetic Profile of Tumor Endothelial Cells. Effects of Combined Therapy with Antiangiogenic and Epigenetic Drugs on Cancer Progression

scientific article published on 09 April 2020

The Methylation Status of the Epigenome: Its Emerging Role in the Regulation of Tumor Angiogenesis and Tumor Growth, and Potential for Drug Targeting

artículo científico publicado en 2018

The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes

scientific journal article

The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation.

artículo científico publicado en 2004

The histone deacetylase inhibitor sodium butyrate improves insulin signalling in palmitate-induced insulin resistance in L6 rat muscle cells through epigenetically-mediated up-regulation of Irs1.

artículo científico publicado en 2016

The new paradigm of the developmental origin of health and diseases (DOHaD)--Epigenetics and environment: evidence and missing links

artículo científico publicado en 2016

The suppression of hepatic glucose production improves metabolism and insulin sensitivity in subcutaneous adipose tissue in mice

artículo científico publicado en 2016

Therapeutic potential of activators and inhibitors of sirtuins ⬇️

artículo científico publicado el 1 de septiembre de 2010

Transcriptional response of skeletal muscle to a low protein perinatal diet in rat offspring at different ages: The role of key enzymes of glucose-fatty acid oxidation

artículo científico publicado en 2016

Lista de obras de Luciano Pirola

118th ENMC International Workshop on Advances in Myotubular Myopathy. 26-28 September 2003, Naarden, The Netherlands. (5th Workshop of the International Consortium on Myotubular Myopathy).

A special BioFactors issue dedicated to resveratrol ⬇️

Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.

Adipocytes, like their progenitors, contribute to inflammation of adipose tissues through promotion of Th-17 cells and activation of monocytes, in obese subjects

Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation.

Alterations of insulin signaling in type 2 diabetes: a review of the current evidence from humans

Atrial fibrillation is associated with hypermethylation in human left atrium, and treatment with decitabine reduces atrial tachyarrhythmias in spontaneously hypertensive rats.

Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

Dietary polyphenols and their effects on cell biochemistry and pathophysiology

Dysregulation of sirtuins and key metabolic genes in skeletal muscle of pigs with spontaneous intrauterine growth restriction is associated with alterations of circulating IGF-1.

Effect of a diet containing folate and hazelnut oil capsule on the methylation level of the ADRB3 gene, lipid profile and oxidative stress in overweight or obese women

Effects of maternal low-protein diet and spontaneous physical activity on the transcription of neurotrophic factors in the placenta and the brains of mothers and offspring rats

Epigenetic phenomena linked to diabetic complications.

Epigenetics in transgenerational responses to environmental impacts: from facts and gaps

Essential roles of four-carbon backbone chemicals in the control of metabolism

Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells

Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases

Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension

Insulin-dependent transcriptional control in L6 rat myotubes is associated with modulation of histone acetylation and accumulation of the histone variant H2A.Z in the proximity of the transcriptional start site

Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients

Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways

Maternal physical activity-induced adaptive transcriptional response in brain and placenta of mothers and rat offspring

Maternal protein restriction induced-hypertension is associated to oxidative disruption at transcriptional and functional levels in the medulla oblongata

Maternal voluntary physical activity attenuates delayed neurodevelopment in malnourished rats

Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States

Modulation of insulin action.

Modulation of the vascular endothelium functioning by dietary components, the role of epigenetics.

Modulators of insulin action and their role in insulin resistance

Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells

Pharmacological inhibition of arginine and lysine methyltransferases induces nuclear abnormalities and suppresses angiogenesis in human endothelial cells.

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

Phosphoinositide 3-kinase signalling: no lipids.

Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells

Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes

Phospholipase D2 regulates endothelial permeability through cytoskeleton reorganization and occludin downregulation

Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells

Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule

Protein acetylation mechanisms in the regulation of insulin and insulin-like growth factor 1 signalling

Resveratrol is a class IA phosphoinositide 3-kinase inhibitor

Role of pro- and anti-inflammatory phenomena in the physiopathology of type 2 diabetes and obesity

Structure and function of phosphoinositide 3-kinases

The DCCT/EDIC study: epigenetic clues after three decades

The Epigenetic Profile of Tumor Endothelial Cells. Effects of Combined Therapy with Antiangiogenic and Epigenetic Drugs on Cancer Progression

The Methylation Status of the Epigenome: Its Emerging Role in the Regulation of Tumor Angiogenesis and Tumor Growth, and Potential for Drug Targeting

The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes

The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation.

The histone deacetylase inhibitor sodium butyrate improves insulin signalling in palmitate-induced insulin resistance in L6 rat muscle cells through epigenetically-mediated up-regulation of Irs1.

The new paradigm of the developmental origin of health and diseases (DOHaD)--Epigenetics and environment: evidence and missing links

The suppression of hepatic glucose production improves metabolism and insulin sensitivity in subcutaneous adipose tissue in mice

Therapeutic potential of activators and inhibitors of sirtuins ⬇️

Transcriptional response of skeletal muscle to a low protein perinatal diet in rat offspring at different ages: The role of key enzymes of glucose-fatty acid oxidation