Lista de obras - Loic Yengo - Dominio Público Uruguay

A unified framework for association and prediction from vertex-wise grey-matter structure

scientific article published on 20 July 2020

ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo-HDL-Cholesterolemia in a/a Carriers Compared to the G/G Carriers

Alzheimer's disease genetic risk and sleep phenotypes: association with more slow-waves and daytime sleepiness

artículo científico publicado en 2020

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

artículo científico publicado en 2017

Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children.

artículo científico publicado en 2013

Association Between Population Density and Genetic Risk for Schizophrenia

Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications

artículo científico publicado en 2013

Associations Between Type 2 Diabetes-Related Genetic Scores and Metabolic Traits, in Obese and Normal-Weight Youths.

artículo científico publicado en 2016

Assortative Mating in Autism Spectrum Disorder: Toward an Evidence Base From DNA Data, but Not There Yet

artículo científico publicado en 2019

Assortative mating on complex traits revisited: Double first cousins and the X-chromosome

Author Correction: Misestimation of heritability and prediction accuracy of male-pattern baldness

scientific article published in Nature Communications

Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children.

artículo científico publicado en 2014

CO-68: L'étude génomique et fonctionnelle des gènes du diabète de type 2 confirme leur rôle dans les cellules beta-pancréatiques

artículo científico publicado en 2016

Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-results from the EPIC cohort study.

artículo científico publicado en 2013

Combined Global Sensitivity Analysis and Population PBPK Modeling for Assessing Consistency of TCDD Toxicokinetics Data in Mice

Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations

artículo científico publicado en 2013

Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population

artículo científico publicado en 2012

Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

artículo científico publicado en 2017

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2016

Defining the role of common variation in the genomic and biological architecture of adult human height

artículo científico publicado en 2014

Detection of human adaptation during the past 2000 years

artículo científico publicado en 2016

Directional dominance on stature and cognition in diverse human populations

artículo científico publicado en 2015

Discovery and implications of polygenicity of common diseases

artículo científico

Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.

artículo científico publicado en 2011

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

scientific journal article

Early metabolic markers identify potential targets for the prevention of type 2 diabetes

artículo científico

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study

artículo científico publicado en 2015

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

artículo científico publicado en 2018

Erratum: The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

scholarly article published in Obesity

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

artículo científico publicado en 2020

European genetic variants associated with type 2 diabetes in North African Arabs

artículo científico publicado en 2012

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.

artículo científico publicado en 2012

Expectation of the intercept from bivariate LD score regression in the presence of population stratification

Extreme inbreeding in a European ancestry sample from the contemporary UK population

artículo científico publicado en 2019

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

artículo científico publicado en 2018

GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm

artículo científico publicado en 2013

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

article

Genetic analyses of medication-use and implications for precision medicine

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

artículo científico publicado en 2016

Genetic correlates of social stratification in Great Britain

artículo científico publicado en 2019

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

artículo científico publicado en 2015

Genetic studies of body mass index yield new insights for obesity biology

artículo científico publicado en 2015

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

artículo científico publicado en 2018

Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals

scientific article published on 01 July 2019

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

artículo científico publicado en 2016

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

artículo científico publicado en 2018

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

artículo científico publicado en 2013

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

artículo científico publicado en 2015

Genome-wide association study of medication-use and associated disease in the UK Biobank

artículo científico publicado en 2019

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

artículo científico publicado en 2017

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

artículo científico publicado en 2017

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

artículo científico publicado en 2014

Genomic insights into the origin of farming in the ancient Near East

artículo científico publicado en 2016

Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity

artículo científico publicado en 2011

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

artículo científico publicado en 2013

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood.

artículo científico publicado en 2018

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

artículo científico publicado en 2017

Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling

artículo científico publicado en 2016

Imprint of Assortative Mating on the Human Genome

Imprint of assortative mating on the human genome

scientific article published on 26 November 2018

Improved polygenic prediction by Bayesian multiple regression on summary statistics

scientific article published on 08 November 2019

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes.

artículo científico publicado en 2018

KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response

artículo científico publicado en 2016

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

artículo científico publicado en 2016

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

artículo científico publicado en 2012

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

artículo científico publicado en 2012

Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles

artículo científico publicado en 2017

Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk

artículo científico publicado en 2011

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry

article by Sara Pulit et al published 1 January 2019 in Human Molecular Genetics

Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

scholarly article published 2 March 2018

Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

article

Misestimation of heritability and prediction accuracy of male-pattern baldness.

artículo científico publicado en 2018

New genetic loci link adipose and insulin biology to body fat distribution

artículo científico publicado en 2015

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

artículo científico publicado en 2016

No Evidence for Social Genetic Effects or Genetic Similarity Among Friends Beyond that Due to Population Stratification: A Reappraisal of Domingue et al (2018)

artículo científico publicado en 2019

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

artículo científico publicado en 2020

O06 Le mutant perte de fonction p.R46L de PCSK9 n’est pas associé à un risque accru de diabète chez l’homme

artículo científico publicado en 2015

O31 Deux scores de risque génétique sont fortement associés aux variations de glycémie à jeun et à l’incidence d’hyperglycémie et de diabète de type 2 dans l’étude prospective D.E.S.I.R

artículo científico publicado en 2014

O52 L’activité enzymatique plasmatique de l’amylase pancréatique est associée à une diminution de l’indice de masse corporelle et protège du risque de diabète dans la cohorte D.E.S.I.R

artículo científico publicado en 2015

O53 L’altération du récepteur des acides gras insaturés de type omega-3 GPR120 entraîne une obésité chez l’Homme et la Souris

artículo científico publicado en 2012

O61 Le diabète de type 2 est responsable d’anomalies chromosomiques somatiques en mosaïques qui sont pré-cancéreuses

artículo científico publicado en 2013

PO11 Deux nouveaux loci associés au diabète de type 2 dans la population mexicaine identifiés par les puces Metabochip

artículo científico publicado en 2015

Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts

artículo científico publicado en 2013

Pathogenic variants in actionable MODY genes are associated with type 2 diabetes

artículo científico publicado en 2020

Phenotypic and genetic factors associated with differential consent to record linkage for prescription history in the Australian Genetics of Depression Study

artículo científico publicado en 2021

Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individuals

artículo científico publicado en 2021

Polygenic burden could explain high rates of affective disorders in a community with restricted founder population

artículo científico publicado en 2021

Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis

artículo científico publicado en 2016

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

artículo científico publicado en 2012

Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes.

artículo científico publicado en 2012

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

article

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

artículo científico publicado en 2018

Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach

artículo científico publicado en 2017

Reply to Kardos et al.: Estimation of inbreeding depression from SNP data

article published in the Proceedings of the National Academy of Sciences of the United States of America

Risk in Relatives, Heritability, SNP-Based Heritability, and Genetic Correlations in Psychiatric Disorders: A Review

scientific article published on 10 June 2020

Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture

scientific article published on 23 September 2020

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

artículo científico publicado en 2017

Signatures of negative selection in the genetic architecture of human complex traits

artículo científico publicado en 2018

Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases

artículo científico publicado en 2012

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2015

The genetic architecture of type 2 diabetes

artículo científico publicado en 2016

The genetic structure of the world's first farmers

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

artículo científico publicado en 2016

The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

article

The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis

artículo científico publicado en 2015

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

artículo científico publicado en 2020

Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms

artículo científico publicado en 2016

Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family

artículo científico publicado en 2013

Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study

artículo científico publicado en 2014

Using prior information from humans to prioritize genes and gene-associated variants for complex traits in livestock

artículo científico publicado en 2020

Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients

artículo científico publicado en 2014

Widespread signatures of natural selection across human complex traits and functional genomic categories

artículo científico publicado en 2021

Widespread signatures of negative selection in the genetic architecture of human complex traits

scholarly article published 3 June 2017

Lista de obras de Loic Yengo

A unified framework for association and prediction from vertex-wise grey-matter structure

ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo-HDL-Cholesterolemia in a/a Carriers Compared to the G/G Carriers

Alzheimer's disease genetic risk and sleep phenotypes: association with more slow-waves and daytime sleepiness

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children.

Association Between Population Density and Genetic Risk for Schizophrenia

Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications

Associations Between Type 2 Diabetes-Related Genetic Scores and Metabolic Traits, in Obese and Normal-Weight Youths.

Assortative Mating in Autism Spectrum Disorder: Toward an Evidence Base From DNA Data, but Not There Yet

Assortative mating on complex traits revisited: Double first cousins and the X-chromosome

Author Correction: Misestimation of heritability and prediction accuracy of male-pattern baldness

Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children.

CO-68: L'étude génomique et fonctionnelle des gènes du diabète de type 2 confirme leur rôle dans les cellules beta-pancréatiques

Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-results from the EPIC cohort study.

Combined Global Sensitivity Analysis and Population PBPK Modeling for Assessing Consistency of TCDD Toxicokinetics Data in Mice

Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations

Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population

Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Defining the role of common variation in the genomic and biological architecture of adult human height

Detection of human adaptation during the past 2000 years

Directional dominance on stature and cognition in diverse human populations

Discovery and implications of polygenicity of common diseases

Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

Early metabolic markers identify potential targets for the prevention of type 2 diabetes

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Erratum: The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

European genetic variants associated with type 2 diabetes in North African Arabs

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.

Expectation of the intercept from bivariate LD score regression in the presence of population stratification

Extreme inbreeding in a European ancestry sample from the contemporary UK population

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

Genetic analyses of medication-use and implications for precision medicine

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Genetic correlates of social stratification in Great Britain

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Genetic studies of body mass index yield new insights for obesity biology

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

Genome-wide association study of medication-use and associated disease in the UK Biobank

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Genomic insights into the origin of farming in the ancient Near East

Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood.

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling

Imprint of Assortative Mating on the Human Genome

Imprint of assortative mating on the human genome

Improved polygenic prediction by Bayesian multiple regression on summary statistics

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes.

KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles

Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry

Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

Misestimation of heritability and prediction accuracy of male-pattern baldness.

New genetic loci link adipose and insulin biology to body fat distribution

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

No Evidence for Social Genetic Effects or Genetic Similarity Among Friends Beyond that Due to Population Stratification: A Reappraisal of Domingue et al (2018)

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

O06 Le mutant perte de fonction p.R46L de PCSK9 n’est pas associé à un risque accru de diabète chez l’homme

O31 Deux scores de risque génétique sont fortement associés aux variations de glycémie à jeun et à l’incidence d’hyperglycémie et de diabète de type 2 dans l’étude prospective D.E.S.I.R