Lista de obras - Chris Wallace - Dominio Público Uruguay

A genome-wide assessment of the role of untagged copy number variants in type 1 diabetes

artículo científico publicado en 2014

A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples

artículo científico publicado en 2014

A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations

artículo científico publicado en 2014

A method for identifying genetic heterogeneity within phenotypically defined disease subgroups

artículo científico publicado en 2016

A pleiotropy-informed Bayesian false discovery rate adapted to a shared control design finds new disease associations from GWAS summary statistics.

artículo científico publicado en 2015

A rareIL2RAhaplotype identifies SNP rs61839660 as causal for autoimmunity

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

artículo científico publicado en 2010

A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes.

artículo científico publicado en 2014

An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes ⬇️

artículo científico publicado en 2011

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

artículo científico publicado en 2007

Author Correction: Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks

scientific article published in Nature Communications

Bayesian test for colocalisation between pairs of genetic association studies using summary statistics

artículo científico publicado en 2014

Blood pressure loci identified with a gene-centric array

artículo científico publicado en 2011

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity

artículo científico publicado en 2017

Chromosome 2p Shows Significant Linkage to Antihypertensive Response in the British Genetics of Hypertension Study

article

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

artículo científico publicado en 2017

Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies

artículo científico publicado en 2009

Common variants near MC4R are associated with fat mass, weight and risk of obesity

artículo científico publicado en 2008

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration

artículo científico publicado en 2011

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

artículo científico publicado en 2011

Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

artículo científico publicado en 2015

Detecting chromosomal interactions in Capture Hi-C data with CHiCAGO and companion tools

artículo científico publicado en 2021

Detection of quantitative trait loci from RNA-seq data with or without genotypes using BaseQTL

artículo científico publicado en 2021

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping

artículo científico publicado en 2015

Dissection of a complex disease susceptibility region using a Bayesian stochastic search approach to fine mapping

Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing.

artículo científico publicado en 2015

Estimating the relative recurrence risk ratio for leprosy in Karonga District, Malawi.

artículo científico publicado en 2003

Estimating the relative recurrence risk ratio using a global cross-ratio model

artículo científico publicado en 2003

Extra-binomial variation approach for analysis of pooled DNA sequencing data

artículo científico publicado en 2012

Extreme clonality in lymphoblastoid cell lines with implications for allele specific expression analyses

artículo científico publicado en 2008

Fine mapping chromatin contacts in capture Hi-C data

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

artículo científico publicado en 2015

Functional effects of variation in transcription factor binding highlight long-range gene regulation by epromoters

scientific article published on 01 April 2020

Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes

artículo científico publicado en 2011

Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension

artículo científico publicado en 2007

Genetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases

artículo científico publicado en 2020

Genetic loci influencing kidney function and chronic kidney disease

artículo científico publicado en 2010

Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

artículo científico publicado en 2011

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

artículo científico publicado en 2009

Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia

artículo científico publicado en 2008

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

artículo científico publicado en 2011

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

artículo científico publicado en 2007

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

artículo científico publicado en 2010

Glutathione S-transferase variants and hypertension

artículo científico publicado en 2008

Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study

article

Haplotypes of the beta-2 adrenergic receptor associate with high diastolic blood pressure in the Caerphilly prospective study

scientific article published on 01 March 2006

IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients

artículo científico publicado en 2015

Improved power offered by a score test for linkage disequilibrium mapping of quantitative-trait loci by selective genotyping

artículo científico publicado en 2006

Improving the coverage of credible sets in Bayesian genetic fine-mapping ⬇️

scientific article published on 13 April 2020

Increased Support for Linkage of a Novel Locus on Chromosome 5q13 for Essential Hypertension in the British Genetics of Hypertension Study

article

Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates

artículo científico publicado en 2007

Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes

artículo científico publicado en 2011

Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases

artículo científico publicado en 2015

Leveraging auxiliary data from arbitrary distributions to boost GWAS discovery with Flexible cFDR

artículo científico publicado en 2021

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters

artículo científico publicado en 2016

Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension

artículo científico publicado en 2006

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations

artículo científico publicado en 2009

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

artículo científico publicado en 2010

Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes

artículo científico publicado en 2014

Multi-tissue transcriptome-wide association studies

artículo científico publicado en 2020

Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes

artículo científico publicado en 2015

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.

artículo científico publicado en 2017

Pervasive sharing of genetic effects in autoimmune disease

artículo científico publicado en 2011

Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients.

artículo científico publicado en 2013

Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion

artículo científico publicado en 2009

Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors

artículo científico publicado en 2013

Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks.

artículo científico publicado en 2018

Reduced expression of IFIH1 is protective for type 1 diabetes

artículo científico publicado en 2010

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

artículo científico publicado en 2016

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

artículo científico publicado en 2007

SLC2A9 is a high-capacity urate transporter in humans

artículo científico publicado en 2008

Seven newly identified loci for autoimmune thyroid disease

artículo científico publicado en 2012

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

artículo científico publicado en 2009

Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls

artículo científico publicado en 2015

Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes

artículo científico publicado en 2012

Statistical testing of shared genetic control for potentially related traits.

artículo científico publicado en 2013

Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases

scientific article published on 19 July 2019

The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age.

artículo científico publicado en 2017

The flashfm approach for fine-mapping multiple quantitative traits

artículo científico publicado en 2021

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

artículo científico publicado en 2009

Trends in drug overdose deaths in England and Wales 1993-98: methadone does not kill more people than heroin

artículo científico publicado en 2003

Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension

article

VSEAMS: a pipeline for variant set enrichment analysis using summary GWAS data identifies IKZF3, BATF and ESRRA as key transcription factors in type 1 diabetes ⬇️

artículo científico publicado en 2014

Widespread seasonal gene expression reveals annual differences in human immunity and physiology

artículo científico publicado en 2015

fcfdr: an R package to leverage continuous and binary functional genomic data in GWAS

artículo científico publicado en 2022

simGWAS: a fast method for simulation of large scale case-control GWAS summary statistics

artículo científico publicado en 2019

Lista de obras de Chris Wallace

A genome-wide assessment of the role of untagged copy number variants in type 1 diabetes

A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples

A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations

A method for identifying genetic heterogeneity within phenotypically defined disease subgroups

A pleiotropy-informed Bayesian false discovery rate adapted to a shared control design finds new disease associations from GWAS summary statistics.

A rareIL2RAhaplotype identifies SNP rs61839660 as causal for autoimmunity

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes.

An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes ⬇️

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Author Correction: Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks

Bayesian test for colocalisation between pairs of genetic association studies using summary statistics

Blood pressure loci identified with a gene-centric array

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity

Chromosome 2p Shows Significant Linkage to Antihypertensive Response in the British Genetics of Hypertension Study

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies

Common variants near MC4R are associated with fat mass, weight and risk of obesity

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

Detecting chromosomal interactions in Capture Hi-C data with CHiCAGO and companion tools

Detection of quantitative trait loci from RNA-seq data with or without genotypes using BaseQTL

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping

Dissection of a complex disease susceptibility region using a Bayesian stochastic search approach to fine mapping

Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing.

Estimating the relative recurrence risk ratio for leprosy in Karonga District, Malawi.

Estimating the relative recurrence risk ratio using a global cross-ratio model

Extra-binomial variation approach for analysis of pooled DNA sequencing data

Extreme clonality in lymphoblastoid cell lines with implications for allele specific expression analyses

Fine mapping chromatin contacts in capture Hi-C data

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

Functional effects of variation in transcription factor binding highlight long-range gene regulation by epromoters

Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes

Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension

Genetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases

Genetic loci influencing kidney function and chronic kidney disease

Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

Glutathione S-transferase variants and hypertension

Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study

Haplotypes of the beta-2 adrenergic receptor associate with high diastolic blood pressure in the Caerphilly prospective study

IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients

Improved power offered by a score test for linkage disequilibrium mapping of quantitative-trait loci by selective genotyping

Improving the coverage of credible sets in Bayesian genetic fine-mapping ⬇️

Increased Support for Linkage of a Novel Locus on Chromosome 5q13 for Essential Hypertension in the British Genetics of Hypertension Study

Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates

Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes

Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases

Leveraging auxiliary data from arbitrary distributions to boost GWAS discovery with Flexible cFDR

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters

Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes

Multi-tissue transcriptome-wide association studies

Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.

Pervasive sharing of genetic effects in autoimmune disease

Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients.

Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion

Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors

Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks.

Reduced expression of IFIH1 is protective for type 1 diabetes

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

SLC2A9 is a high-capacity urate transporter in humans

Seven newly identified loci for autoimmune thyroid disease

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls

Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes

Statistical testing of shared genetic control for potentially related traits.

Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases

The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age.

The flashfm approach for fine-mapping multiple quantitative traits