Lista de obras - Emilia Pedone - Dominio Público Uruguay

A biophysical characterization of the folded domains of KCTD12: insights into interaction with the GABAB2 receptor

artículo científico publicado en 2013

A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells.

artículo científico publicado en 2016

A new cryptic host defense peptide identified in human 11-hydroxysteroid dehydrogenase-1 β-like: from in silico identification to experimental evidence

artículo científico publicado en 2017

A novel arsenate reductase from the bacterium Thermus thermophilus HB27: its role in arsenic detoxification

artículo científico publicado en 2013

A novel member of the protein disulfide oxidoreductase family from Aeropyrum pernix K1: structure, function and electrostatics

artículo científico publicado en 2006

A physicochemical investigation on the metal binding properties of TtSmtB, a thermophilic member of the ArsR/SmtB transcription factor family

artículo científico publicado en 2019

A selective αv β5 integrin antagonist hidden into the anophelin family protein cE5 from the malaria vector Anopheles gambiae

scholarly article published 1 March 2018

A single point mutation (Glu85Arg) increases the stability of the thioredoxin from Escherichia coli

artículo científico publicado en 2001

A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction

artículo científico publicado en 2014

An Integrated Structural and Computational Study of the Thermostability of Two Thioredoxin Mutants from Alicyclobacillus acidocaldarius

artículo científico publicado en 2003

Biochemical characterization of a novel thermostable β-glucosidase from Dictyoglomus turgidum.

artículo científico publicado en 2018

Biochemical characterization of a thermostable endomannanase/endoglucanase from Dictyoglomus turgidum.

artículo científico publicado en 2017

Biochemical phenotype of a common disease-causing mutation and a possible therapeutic approach for the phosphomannomutase 2-associated disorder of glycosylation

artículo científico publicado en 2013

C68 from the Sulfolobus islandicus plasmid-virus pSSVx is a novel member of the AbrB-like transcription factor family

artículo científico publicado en 2011

Cell milieu significantly affects the fate of AApoAI amyloidogenic variants: predestination or serendipity?

artículo científico publicado en 2017

Characterization of a multifunctional protein disulfide oxidoreductase from Sulfolobus solfataricus

artículo científico publicado en 2006

Computational analysis of the thermal stability in thioredoxins: a molecular dynamics approach

artículo científico publicado en 1998

Conformational studies of retro-inverso peptides: The crystal and molecular structure of the hydantoin from H-Ala-G-Ala-mGly-OBzl

artículo científico publicado en 1995

Crystal structure of the resuscitation-promoting factor (DeltaDUF)RpfB from M. tuberculosis

artículo científico publicado en 2009

Crystallization and preliminary X-ray diffraction studies of a protein disulfide oxidoreductase from Aeropyrum pernix K1

artículo científico publicado en 2005

Crystallization and preliminary X-ray diffraction studies of a protein disulfide oxidoreductase from Aquifex aeolicus

artículo científico publicado en 2004

Cullin 3 Recognition Is Not a Universal Property among KCTD Proteins

artículo científico publicado en 2015

Cullin3-BTB interface: a novel target for stapled peptides

artículo científico publicado en 2015

Cystatin B Involvement in Synapse Physiology of Rodent Brains and Human Cerebral Organoids

scientific article published on 16 August 2019

Design and analysis of EphA2-SAM peptide ligands: A multi-disciplinary screening approach

artículo científico publicado en 2018

Design, synthesis and characterization of a peptide able to bind proteins of the KCTD family: implications for KCTD-cullin 3 recognition

artículo científico publicado en 2011

Dimerisation and structural integrity of Heparin Binding Hemagglutinin A from Mycobacterium tuberculosis: implications for bacterial agglutination

artículo científico publicado en 2010

Dynamical properties of cold shock protein A from Mycobacterium tuberculosis.

artículo científico publicado en 2010

Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility

artículo científico publicado en 2017

Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis

scientific journal article

Exploring the binding of d(GGGT)4 to the HIV-1 integrase: An approach to investigate G-quadruplex aptamer/target protein interactions.

artículo científico publicado en 2016

Exploring the catalytic mechanism of the first dimeric Bcp: Functional, structural and docking analyses of Bcp4 from Sulfolobus solfataricus

article by Danila Limauro et al published October 2010 in Biochimie

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis

artículo científico publicado en 2007

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the L,D-transpeptidase LdtMt1 from Mycobacterium tuberculosis

artículo científico publicado en 2013

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the resuscitation promoting factor interacting protein RipA from M. tuberculosis.

artículo científico publicado en 2010

Focusing on the functional characterization of the anserinase from Oreochromis niloticus

scientific article published on 22 February 2019

Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins.

artículo científico publicado en 2018

Functional analyses yield detailed insight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae.

artículo científico publicado en 2017

Functional and structural characterization of protein disulfide oxidoreductase from Thermus thermophilus HB27.

artículo científico publicado en 2014

Functional properties of the protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus: a member of a novel protein family related to protein disulfide-isomerase

artículo científico publicado en 2004

Heparin-binding hemagglutinin HBHA from Mycobacterium tuberculosis affects actin polymerisation

artículo científico publicado en 2011

Heterotypic Sam-Sam association between Odin-Sam1 and Arap3-Sam: binding affinity and structural insights

artículo científico publicado en 2012

High hydrostatic pressure-induced conformational changes in protein disulfide oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus. A Fourier-transform infrared spectroscopic study

artículo científico publicado en 2010

High-level expression of Aliciclobacillus acidocaldarius thioredoxin in Pichia pastoris and Bacillus subtilis

artículo científico publicado en 2003

Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

artículo científico publicado en 2010

Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress

artículo científico publicado en 2006

Insight into conformational modification of alpha-synuclein in the presence of neuronal whole cells and of their isolated membranes

artículo científico publicado en 2015

Insights into the anticancer properties of the first antimicrobial peptide from Archaea.

artículo científico publicado en 2017

Insights into the catalytic mechanism of the Bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus

artículo científico publicado en 2009

Insights on a new PDI-like family: structural and functional analysis of a protein disulfide oxidoreductase from the bacterium Aquifex aeolicus

artículo científico publicado en 2005

Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding Mode

artículo científico publicado en 2015

Investigating the properties of TBA variants with twin thrombin binding domains

scientific article published on 24 June 2019

KCTD1: A novel modulator of adipogenesis through the interaction with the transcription factor AP2α

artículo científico publicado en 2019

Mapping functional interaction sites of human prune C-terminal domain by NMR spectroscopy in human cell lysates.

artículo científico publicado en 2013

Mapping key interactions in the dimerization process of HBHA from Mycobacterium tuberculosis, insights into bacterial agglutination.

artículo científico publicado en 2012

Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-β-OTX2-SNAIL via PTEN inhibition.

artículo científico publicado en 2018

Molecular basis of the PED/PEA15 interaction with the C-terminal fragment of phospholipase D1 revealed by NMR spectroscopy.

artículo científico publicado en 2013

Molecular basis of the scalp-ear-nipple syndrome unraveled by the characterization of disease-causing KCTD1 mutants

scientific article published on 19 July 2019

Molecular insights into the role of the polyalanine region in mediating PHOX2B aggregation

artículo científico publicado en 2019

Molecular organization of the cullin E3 ligase adaptor KCTD11.

artículo científico publicado en 2011

Molecular recognition of Cullin3 by KCTDs: Insights from experimental and computational investigations

artículo científico publicado en 2014

Multiple catalytically active thioredoxin folds: a winning strategy for many functions

artículo científico publicado en 2010

NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites

artículo científico publicado en 2010

NMR solution structure of a novel thioredoxin from Bacillus acidocaldarius

artículo científico publicado en 2000

NMR solution structure of a novel thioredoxin from Bacillus acidocaldarius possible determinants of protein stability

artículo científico publicado en 2000

Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction

artículo científico publicado en 2013

Novel propanamides as fatty acid amide hydrolase inhibitors.

artículo científico publicado en 2017

Peptide Fragments of Odin-Sam1: Conformational Analysis and Interaction Studies with EphA2-Sam

artículo científico publicado en 2015

Peroxiredoxins as cellular guardians in Sulfolobus solfataricus: characterization of Bcp1, Bcp3 and Bcp4.

artículo científico publicado en 2008

Prediction and experimental testing of Bacillus acidocaldarius thioredoxin stability

artículo científico publicado en 1999

Proteins involved in sleep homeostasis: Biophysical characterization of INC and its partners.

artículo científico publicado en 2016

Regulating levels of the neuromodulator d-serine in human brain: structural insight into pLG72 and d-amino acid oxidase interaction

artículo científico publicado en 2016

Responding to toxic compounds: a genomic and functional overview of Archaea

artículo científico

Sam domain-based stapled peptides: Structural analysis and interaction studies with the Sam domains from the EphA2 receptor and the lipid phosphatase Ship2

scientific article published on 20 July 2018

Selective Photo-Assisted Eradication of Triple-Negative Breast Cancer Cells through Aptamer Decoration of Doped Conjugated Polymer Nanoparticles

artículo científico publicado en 2022

Sensing and adapting to environmental stress: the archaeal tactic

artículo científico publicado en 2004

Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor

artículo científico publicado en 2012

Solution structure and backbone dynamics of the K18G/R82E Alicyclobacillus acidocaldarius thioredoxin mutant: a molecular analysis of its reduced thermal stability

artículo científico publicado en 2004

Structural and functional studies of Stf76 from the Sulfolobus islandicus plasmid-virus pSSVx: a novel peculiar member of the winged helix-turn-helix transcription factor family

artículo científico publicado en 2014

Structural and thermal stability analysis of Escherichia coli and Alicyclobacillus acidocaldarius thioredoxin revealed a molten globule-like state in thermal denaturation pathway of the proteins: an infrared spectroscopic study

artículo científico publicado en 2003

Structural investigation of a C-terminal EphA2 receptor mutant: Does mutation affect the structure and interaction properties of the Sam domain?

artículo científico publicado en 2017

Structural model of the hUbA1-UbcH10 quaternary complex: in silico and experimental analysis of the protein-protein interactions between E1, E2 and ubiquitin

artículo científico publicado en 2014

Structure and functional regulation of RipA, a mycobacterial enzyme essential for daughter cell separation

artículo científico publicado en 2010

Structures of free and inhibited forms of the L,D-transpeptidase LdtMt1 from Mycobacterium tuberculosis

artículo científico publicado en 2013

Sulfolobus solfataricus protein disulphide oxidoreductase: insight into the roles of its redox sites

artículo científico publicado en 2008

Sulfolobus solfataricus thiol redox puzzle: characterization of an atypical protein disulfide oxidoreductase

artículo científico publicado en 2014

Synthesis of diglycosylated (di)sulfides and comparative evaluation of their antiproliferative effect against tumor cell lines: A focus on the nature of sugar-recognizing mediators involved

scientific article published on 02 July 2019

Targeting EphA2-Sam and Its Interactome: Design and Evaluation of Helical Peptides Enriched in Charged Residues

artículo científico publicado en 2016

Temperature-, SDS-, and pH-induced conformational changes in protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus: a dynamic simulation and fourier transform infrared spectroscopic study

artículo científico publicado en 2005

The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states

scientific journal article

The Sam-Sam interaction between Ship2 and the EphA2 receptor: design and analysis of peptide inhibitors

artículo científico publicado en 2017

The essential player in adipogenesis GRP78 is a novel KCTD15 interactor.

artículo científico publicado en 2018

The identification of a novel Sulfolobus islandicus CAMP-like peptide points to archaeal microorganisms as cell factories for the production of antimicrobial molecules

artículo científico publicado en 2015

The machinery for oxidative protein folding in thermophiles

artículo científico publicado en 2008

The prokaryotic Cys2His2 zinc-finger adopts a novel fold as revealed by the NMR structure of Agrobacterium tumefaciens Ros DNA-binding domain

artículo científico publicado en 2007

Thermal and chemical stability of two homologous POZ/BTB domains of KCTD proteins characterized by a different oligomeric organization.

artículo científico publicado en 2013

Thioredoxin from Bacillus acidocaldarius: characterization, high-level expression in Escherichia coli and molecular modelling

artículo científico publicado en 1997

Ubiquitin binds the amyloid β peptide and interferes with its clearance pathways

artículo científico publicado en 2019

gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins

artículo científico publicado en 2013

Lista de obras de Emilia Pedone

A biophysical characterization of the folded domains of KCTD12: insights into interaction with the GABAB2 receptor

A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells.

A new cryptic host defense peptide identified in human 11-hydroxysteroid dehydrogenase-1 β-like: from in silico identification to experimental evidence

A novel arsenate reductase from the bacterium Thermus thermophilus HB27: its role in arsenic detoxification

A novel member of the protein disulfide oxidoreductase family from Aeropyrum pernix K1: structure, function and electrostatics

A physicochemical investigation on the metal binding properties of TtSmtB, a thermophilic member of the ArsR/SmtB transcription factor family

A selective αv β5 integrin antagonist hidden into the anophelin family protein cE5 from the malaria vector Anopheles gambiae

A single point mutation (Glu85Arg) increases the stability of the thioredoxin from Escherichia coli

A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction

An Integrated Structural and Computational Study of the Thermostability of Two Thioredoxin Mutants from Alicyclobacillus acidocaldarius

Biochemical characterization of a novel thermostable β-glucosidase from Dictyoglomus turgidum.

Biochemical characterization of a thermostable endomannanase/endoglucanase from Dictyoglomus turgidum.

Biochemical phenotype of a common disease-causing mutation and a possible therapeutic approach for the phosphomannomutase 2-associated disorder of glycosylation

C68 from the Sulfolobus islandicus plasmid-virus pSSVx is a novel member of the AbrB-like transcription factor family

Cell milieu significantly affects the fate of AApoAI amyloidogenic variants: predestination or serendipity?

Characterization of a multifunctional protein disulfide oxidoreductase from Sulfolobus solfataricus

Computational analysis of the thermal stability in thioredoxins: a molecular dynamics approach

Conformational studies of retro-inverso peptides: The crystal and molecular structure of the hydantoin from H-Ala-G-Ala-mGly-OBzl

Crystal structure of the resuscitation-promoting factor (DeltaDUF)RpfB from M. tuberculosis

Crystallization and preliminary X-ray diffraction studies of a protein disulfide oxidoreductase from Aeropyrum pernix K1

Crystallization and preliminary X-ray diffraction studies of a protein disulfide oxidoreductase from Aquifex aeolicus

Cullin 3 Recognition Is Not a Universal Property among KCTD Proteins

Cullin3-BTB interface: a novel target for stapled peptides

Cystatin B Involvement in Synapse Physiology of Rodent Brains and Human Cerebral Organoids

Design and analysis of EphA2-SAM peptide ligands: A multi-disciplinary screening approach

Design, synthesis and characterization of a peptide able to bind proteins of the KCTD family: implications for KCTD-cullin 3 recognition

Dimerisation and structural integrity of Heparin Binding Hemagglutinin A from Mycobacterium tuberculosis: implications for bacterial agglutination

Dynamical properties of cold shock protein A from Mycobacterium tuberculosis.

Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility

Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis

Exploring the binding of d(GGGT)4 to the HIV-1 integrase: An approach to investigate G-quadruplex aptamer/target protein interactions.

Exploring the catalytic mechanism of the first dimeric Bcp: Functional, structural and docking analyses of Bcp4 from Sulfolobus solfataricus

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the L,D-transpeptidase LdtMt1 from Mycobacterium tuberculosis

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the resuscitation promoting factor interacting protein RipA from M. tuberculosis.

Focusing on the functional characterization of the anserinase from Oreochromis niloticus

Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins.

Functional analyses yield detailed insight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae.

Functional and structural characterization of protein disulfide oxidoreductase from Thermus thermophilus HB27.

Functional properties of the protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus: a member of a novel protein family related to protein disulfide-isomerase

Heparin-binding hemagglutinin HBHA from Mycobacterium tuberculosis affects actin polymerisation

Heterotypic Sam-Sam association between Odin-Sam1 and Arap3-Sam: binding affinity and structural insights

High hydrostatic pressure-induced conformational changes in protein disulfide oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus. A Fourier-transform infrared spectroscopic study

High-level expression of Aliciclobacillus acidocaldarius thioredoxin in Pichia pastoris and Bacillus subtilis

Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress

Insight into conformational modification of alpha-synuclein in the presence of neuronal whole cells and of their isolated membranes

Insights into the anticancer properties of the first antimicrobial peptide from Archaea.

Insights into the catalytic mechanism of the Bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus

Insights on a new PDI-like family: structural and functional analysis of a protein disulfide oxidoreductase from the bacterium Aquifex aeolicus

Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding Mode

Investigating the properties of TBA variants with twin thrombin binding domains

KCTD1: A novel modulator of adipogenesis through the interaction with the transcription factor AP2α

Mapping functional interaction sites of human prune C-terminal domain by NMR spectroscopy in human cell lysates.

Mapping key interactions in the dimerization process of HBHA from Mycobacterium tuberculosis, insights into bacterial agglutination.

Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-β-OTX2-SNAIL via PTEN inhibition.

Molecular basis of the PED/PEA15 interaction with the C-terminal fragment of phospholipase D1 revealed by NMR spectroscopy.

Molecular basis of the scalp-ear-nipple syndrome unraveled by the characterization of disease-causing KCTD1 mutants

Molecular insights into the role of the polyalanine region in mediating PHOX2B aggregation

Molecular organization of the cullin E3 ligase adaptor KCTD11.

Molecular recognition of Cullin3 by KCTDs: Insights from experimental and computational investigations

Multiple catalytically active thioredoxin folds: a winning strategy for many functions

NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites

NMR solution structure of a novel thioredoxin from Bacillus acidocaldarius

NMR solution structure of a novel thioredoxin from Bacillus acidocaldarius possible determinants of protein stability

Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction

Novel propanamides as fatty acid amide hydrolase inhibitors.

Peptide Fragments of Odin-Sam1: Conformational Analysis and Interaction Studies with EphA2-Sam

Peroxiredoxins as cellular guardians in Sulfolobus solfataricus: characterization of Bcp1, Bcp3 and Bcp4.

Prediction and experimental testing of Bacillus acidocaldarius thioredoxin stability

Proteins involved in sleep homeostasis: Biophysical characterization of INC and its partners.

Regulating levels of the neuromodulator d-serine in human brain: structural insight into pLG72 and d-amino acid oxidase interaction

Responding to toxic compounds: a genomic and functional overview of Archaea

Sam domain-based stapled peptides: Structural analysis and interaction studies with the Sam domains from the EphA2 receptor and the lipid phosphatase Ship2

Selective Photo-Assisted Eradication of Triple-Negative Breast Cancer Cells through Aptamer Decoration of Doped Conjugated Polymer Nanoparticles

Sensing and adapting to environmental stress: the archaeal tactic

Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor

Solution structure and backbone dynamics of the K18G/R82E Alicyclobacillus acidocaldarius thioredoxin mutant: a molecular analysis of its reduced thermal stability

Structural and functional studies of Stf76 from the Sulfolobus islandicus plasmid-virus pSSVx: a novel peculiar member of the winged helix-turn-helix transcription factor family