Lista de obras - Aldo Galeone - Dominio Público Uruguay

1H NMR studies of the 5-(hydroxymethyl)-2'-deoxyuridine containing TF1 binding site

artículo científico publicado en 1996

1H-NMR study of the quadruplex [d(TGGGT)]4 containing a modified thymine

artículo científico publicado en 2003

2'-Deoxy-8-(propyn-1-yl)adenosine-containing oligonucleotides: effects on stability of duplex and quadruplex structures.

artículo científico publicado en 2000

5-Hydroxymethyl-2'-deoxyuridine residues in the thrombin binding aptamer: investigating anticoagulant activity by making a tiny chemical modification

artículo científico

8-methyl-2'-deoxyguanosine incorporation into parallel DNA quadruplex structures

artículo científico publicado en 2005

A BUNCH-OLIGONUCLEOTIDE FORMING STABLE MONOMOLECULAR QUADRUPLEX CONTAINING A T-TETRAD

scientific article published on 01 January 2005

A Topological Classification of G-Quadruplex Structures

artículo científico publicado en 2007

A further contribution to the extreme variability of quadruplex structures from oligodeoxyribonucleotides containing inversion of polarity sites in the G-tract

A new class of DNA quadruplexes formed by oligodeoxyribonucleotides containing a 3′-3′ or 5′-5′ inversion of polarity site

A novel equilibrium relating to the helix handedness in G-quadruplexes formed by heterochiral oligonucleotides with an inversion of polarity site

artículo científico publicado en 2013

A novel pyrimidine tetrad contributing to stabilize tetramolecular G-quadruplex structures

artículo científico publicado en 2016

A straightforward modification in the thrombin binding aptamer improving the stability, affinity to thrombin and nuclease resistance

artículo científico

Affinity, stability and polarity of binding of the TATA binding protein governed by flexure at the TATA Box.

artículo científico publicado en 1998

Automated solid phase synthesis of cyclic oligonucleotides: a further improvement

artículo científico publicado en 1995

Backbone modified TBA analogues endowed with antiproliferative activity

artículo científico publicado en 2016

Biophysical properties of quadruple helices of modified human telomeric DNA.

artículo científico publicado en 2005

Circular dichroism and thermal melting differentiation of Hoechst 33258 binding to the curved (A(4)T(4)) and straight (T(4)A(4)) DNA sequences

artículo científico publicado en 2002

Conformation of the circular dumbbell d<pCGC-TT-GCG-TT>: structure determination and molecular dynamics

artículo científico publicado en 1995

Design and NMR Study of an Immobile DNA Four‐Way Junction Containing 38 Nucleotides ⬇️

artículo científico publicado el 15 de octubre de 1997

Design, synthesis, biophysical and biological studies of trisubstituted naphthalimides as G-quadruplex ligands

artículo científico publicado en 2011

Effect of a modified thymine on the structure and stability of [d(TGGGT)]4 quadruplex

artículo científico publicado en 2003

Effect of gamma-hydroxypropano deoxyguanosine, the major acrolein-derived adduct, on monomolecular quadruplex structure of telomeric repeat d(TTAGGG)(4).

artículo científico publicado en 2004

Effect of the Introduction of an A-Residue into A Quadruplex Forming Oligonucleotide Containing A 5′-5′ Polarity of Inversion Site

scientific article published on 01 January 2007

Effects of 8-methyl-2'-deoxyadenosine incorporation into quadruplex forming oligodeoxyribonucleotides

artículo científico publicado en 2005

Effects of 8-methylguanine on structure, stability and kinetics of formation of tetramolecular quadruplexes

artículo científico publicado en 2010

Effects of abasic sites on structural, thermodynamic and kinetic properties of quadruplex structures

artículo científico publicado en 2009

Effects of the introduction of inversion of polarity sites in the quadruplex forming oligonucleotide TGGGT

artículo científico publicado en 2009

Expanding the potential of G-quadruplex structures: formation of a heterochiral TBA analogue

artículo científico

Exploring the binding of d(GGGT)4 to the HIV-1 integrase: An approach to investigate G-quadruplex aptamer/target protein interactions.

artículo científico publicado en 2016

G-triplex stability in human telomeric DNA with epigenetic modification/oxidative damage to thymine

Human AP-endonuclease (Ape1) activity on telomeric G4 structures is modulated by acetylatable lysine residues in the N-terminal sequence

artículo científico publicado en 2018

INTERACTION OF DISTAMYCIN A AND NETROPSIN WITH QUADRUPLEX AND DUPLEX STRUCTURES: A COMPARATIVE1H-NMR STUDY

Improved thrombin binding aptamer analogues containing inversion of polarity sites: structural effects of extra-residues at the ends

artículo científico publicado en 2016

Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops.

artículo científico publicado en 2018

Interrelations of secondary structure stability and DNA-binding affinity in the bacteriophage SPO1-encoded type II DNA-binding protein TF1.

artículo científico

Investigating the properties of TBA variants with twin thrombin binding domains

scientific article published on 24 June 2019

Localized DNA flexibility contributes to target site selection by DNA-bending proteins.

artículo científico publicado en 1996

MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma

artículo científico publicado en 2011

MicroRNA 199b-5p delivery through stable nucleic acid lipid particles (SNALPs) in tumorigenic cell lines

artículo científico publicado en 2013

MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma

artículo científico publicado en 2009

Molecular Modelling Studies of Four Stranded Quadruplexes Containing A 3′-3′ or 5′-5′ Inversion of Polarity Site

scholarly article by Ada Virno et al published 26 November 2007 in Nucleosides, Nucleotides & Nucleic Acids

Monomolecular G-quadruplex structures with inversion of polarity sites: new topologies and potentiality

artículo científico publicado en 2017

More than one non-canonical phosphodiester bond in the G-tract: formation of unusual parallel G-quadruplex structures.

artículo científico publicado en 2013

Novel pyrimidopyrimidine derivatives for inhibition of cellular proliferation and motility induced by h-prune in breast cancer

artículo científico publicado en 2012

Oligonucleotide delivery in cancer therapy

artículo científico publicado en 2010

On the connection between inherent DNA flexure and preferred binding of hydroxymethyluracil-containing DNA by the type II DNA-binding protein TF1.

artículo científico publicado en 1996

PNA-DNA Chimeras Forming Quadruplex Structures ⬇️

artículo científico publicado el 1 de mayo de 2003

Probing the Importance of the G-Quadruplex Grooves for the Activity of the Anti-HIV-Integrase Aptamer T30923

artículo científico publicado en 2020

Ptaquiloside, the major carcinogen of bracken fern, in the pooled raw milk of healthy sheep and goats: an underestimated, global concern of food safety

artículo científico publicado en 2015

Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative

artículo científico publicado en 2015

Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity

artículo científico publicado en 2015

Slow conformational exchange in DNA minihairpin loops: a conformational study of the circular dumbbell d<pCGC-TT-GCG-TT>.

artículo científico publicado en 1995

Solid phase synthesis of 5-hydroxymethyluracil containing DNA

artículo científico publicado en 1992

Strand directionality affects cation binding and movement within tetramolecular G-quadruplexes

artículo científico publicado en 2012

Structural and thermodynamic studies of the interaction of distamycin A with the parallel quadruplex structure [d(TGGGGT)]4

artículo científico publicado en 2007

Structural investigations on the anti-HIV G-quadruplex-forming oligonucleotide TGGGAG and its analogues: evidence for the presence of an A-tetrad

artículo científico publicado en 2012

Structural model of the hUbA1-UbcH10 quaternary complex: in silico and experimental analysis of the protein-protein interactions between E1, E2 and ubiquitin

artículo científico publicado en 2014

Structural study of four-stranded quadruplex structures containing 2'-deoxy-8-(propyn-1-yl)adenosine

artículo científico publicado en 2004

Synthesis and characterisation of poly(d,l-lactic acid)–idoxuridine conjugate

artículo científico publicado en 1999

Synthesis and characterization of DNA quadruplexes containing T-tetrads formed by bunch-oligonucleotides

artículo científico publicado en 2006

Synthesis and characterization of a bunchy oligonucleotide forming a monomolecular parallel quadruplex structure in solution

Synthesis and characterization of monomolecular DNA G-quadruplexes formed by tetra-end-linked oligonucleotides

artículo científico publicado en 2006

Synthesis and characterization of tetra-end linked oligonucleotides capable of forming monomolecular G-quadruplexes

artículo científico publicado en 2007

Synthesis and structural study of quadruplex structures containing 2'-deoxy-8-methyladenosine

artículo científico publicado en 2005

Synthesis of 3′−3′-Linked Pyrimidine Oligonucleotides Containing an Acridine Moiety for Alternate Strand Triple Helix Formation

Synthesis of 5-methylamino-2'-deoxyuridine derivatives

artículo científico publicado en 2001

Synthesis of quadruplex-forming tetra-end-linked oligonucleotides: effects of the linker size on quadruplex topology and stability

artículo científico publicado en 2009

Synthesis, structural studies and biological properties of new TBA analogues containing an acyclic nucleotide.

artículo científico publicado en 2008

Tetra-end-linked oligonucleotides forming DNA G-quadruplexes: a new class of aptamers showing anti-HIV activity

article

The "Janus face" of the thrombin binding aptamer: Investigating the anticoagulant and antiproliferative properties through straightforward chemical modifications.

artículo científico publicado en 2017

The Introduction of Inversion of Polarity Sites in DNA G-Quadruplex Structures: Effects and Perspectives.

artículo científico

The abasic site lesions in the human telomeric sequence d[TA(G(3)T(2)A)(3)G(3)]: a thermodynamic point of view

artículo científico publicado en 2012

The insertion of two 8-methyl-2'-deoxyguanosine residues in tetramolecular quadruplex structures: trying to orientate the strands

artículo científico publicado en 2011

The oxidative damage to the human telomere: effects of 5-hydroxymethyl-2'-deoxyuridine on telomeric G-quadruplex structures

artículo científico publicado en 2015

Thermodynamics of melting of the circular dumbbell d<pCGC-TT-GCG-TT>.

artículo científico publicado en 1995

Transferrin-conjugated SNALPs encapsulating 2'-O-methylated miR-34a for the treatment of multiple myeloma.

artículo científico publicado en 2014

Twin hydroxymethyluracil-A base pair steps define the binding site for the DNA-binding protein TF1.

artículo científico publicado en 1997

Unprecedented right- and left-handed quadruplex structures formed by heterochiral oligodeoxyribonucleotides

scientific article published on 20 April 2011

Unusual Chair-Like G-Quadruplex Structures: Heterochiral TBA Analogues Containing Inversion of Polarity Sites

scholarly article in Journal of Chemistry, 2015

Unusual monomolecular DNA quadruplex structures using bunch-oligonucleotides

artículo científico publicado en 2005

Lista de obras de Aldo Galeone

1H NMR studies of the 5-(hydroxymethyl)-2'-deoxyuridine containing TF1 binding site

1H-NMR study of the quadruplex [d(TGGGT)]4 containing a modified thymine

2'-Deoxy-8-(propyn-1-yl)adenosine-containing oligonucleotides: effects on stability of duplex and quadruplex structures.

5-Hydroxymethyl-2'-deoxyuridine residues in the thrombin binding aptamer: investigating anticoagulant activity by making a tiny chemical modification

8-methyl-2'-deoxyguanosine incorporation into parallel DNA quadruplex structures

A BUNCH-OLIGONUCLEOTIDE FORMING STABLE MONOMOLECULAR QUADRUPLEX CONTAINING A T-TETRAD

A Topological Classification of G-Quadruplex Structures

A further contribution to the extreme variability of quadruplex structures from oligodeoxyribonucleotides containing inversion of polarity sites in the G-tract

A new class of DNA quadruplexes formed by oligodeoxyribonucleotides containing a 3′-3′ or 5′-5′ inversion of polarity site

A novel equilibrium relating to the helix handedness in G-quadruplexes formed by heterochiral oligonucleotides with an inversion of polarity site

A novel pyrimidine tetrad contributing to stabilize tetramolecular G-quadruplex structures

A straightforward modification in the thrombin binding aptamer improving the stability, affinity to thrombin and nuclease resistance

Affinity, stability and polarity of binding of the TATA binding protein governed by flexure at the TATA Box.

Automated solid phase synthesis of cyclic oligonucleotides: a further improvement

Backbone modified TBA analogues endowed with antiproliferative activity

Biophysical properties of quadruple helices of modified human telomeric DNA.

Circular dichroism and thermal melting differentiation of Hoechst 33258 binding to the curved (A(4)T(4)) and straight (T(4)A(4)) DNA sequences

Conformation of the circular dumbbell d<pCGC-TT-GCG-TT>: structure determination and molecular dynamics

Design and NMR Study of an Immobile DNA Four‐Way Junction Containing 38 Nucleotides ⬇️

Design, synthesis, biophysical and biological studies of trisubstituted naphthalimides as G-quadruplex ligands

Effect of a modified thymine on the structure and stability of [d(TGGGT)]4 quadruplex

Effect of gamma-hydroxypropano deoxyguanosine, the major acrolein-derived adduct, on monomolecular quadruplex structure of telomeric repeat d(TTAGGG)(4).

Effect of the Introduction of an A-Residue into A Quadruplex Forming Oligonucleotide Containing A 5′-5′ Polarity of Inversion Site

Effects of 8-methyl-2'-deoxyadenosine incorporation into quadruplex forming oligodeoxyribonucleotides

Effects of 8-methylguanine on structure, stability and kinetics of formation of tetramolecular quadruplexes

Effects of abasic sites on structural, thermodynamic and kinetic properties of quadruplex structures

Effects of the introduction of inversion of polarity sites in the quadruplex forming oligonucleotide TGGGT

Expanding the potential of G-quadruplex structures: formation of a heterochiral TBA analogue

Exploring the binding of d(GGGT)4 to the HIV-1 integrase: An approach to investigate G-quadruplex aptamer/target protein interactions.

G-triplex stability in human telomeric DNA with epigenetic modification/oxidative damage to thymine

Human AP-endonuclease (Ape1) activity on telomeric G4 structures is modulated by acetylatable lysine residues in the N-terminal sequence

INTERACTION OF DISTAMYCIN A AND NETROPSIN WITH QUADRUPLEX AND DUPLEX STRUCTURES: A COMPARATIVE1H-NMR STUDY

Improved thrombin binding aptamer analogues containing inversion of polarity sites: structural effects of extra-residues at the ends

Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops.

Interrelations of secondary structure stability and DNA-binding affinity in the bacteriophage SPO1-encoded type II DNA-binding protein TF1.

Investigating the properties of TBA variants with twin thrombin binding domains

Localized DNA flexibility contributes to target site selection by DNA-bending proteins.

MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma

MicroRNA 199b-5p delivery through stable nucleic acid lipid particles (SNALPs) in tumorigenic cell lines

MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma

Molecular Modelling Studies of Four Stranded Quadruplexes Containing A 3′-3′ or 5′-5′ Inversion of Polarity Site

Monomolecular G-quadruplex structures with inversion of polarity sites: new topologies and potentiality

More than one non-canonical phosphodiester bond in the G-tract: formation of unusual parallel G-quadruplex structures.

Novel pyrimidopyrimidine derivatives for inhibition of cellular proliferation and motility induced by h-prune in breast cancer

Oligonucleotide delivery in cancer therapy

On the connection between inherent DNA flexure and preferred binding of hydroxymethyluracil-containing DNA by the type II DNA-binding protein TF1.

PNA-DNA Chimeras Forming Quadruplex Structures ⬇️

Probing the Importance of the G-Quadruplex Grooves for the Activity of the Anti-HIV-Integrase Aptamer T30923

Ptaquiloside, the major carcinogen of bracken fern, in the pooled raw milk of healthy sheep and goats: an underestimated, global concern of food safety

Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative

Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity

Slow conformational exchange in DNA minihairpin loops: a conformational study of the circular dumbbell d<pCGC-TT-GCG-TT>.

Solid phase synthesis of 5-hydroxymethyluracil containing DNA

Strand directionality affects cation binding and movement within tetramolecular G-quadruplexes

Structural and thermodynamic studies of the interaction of distamycin A with the parallel quadruplex structure [d(TGGGGT)]4

Structural investigations on the anti-HIV G-quadruplex-forming oligonucleotide TGGGAG and its analogues: evidence for the presence of an A-tetrad

Structural model of the hUbA1-UbcH10 quaternary complex: in silico and experimental analysis of the protein-protein interactions between E1, E2 and ubiquitin

Structural study of four-stranded quadruplex structures containing 2'-deoxy-8-(propyn-1-yl)adenosine

Synthesis and characterisation of poly(d,l-lactic acid)–idoxuridine conjugate

Synthesis and characterization of DNA quadruplexes containing T-tetrads formed by bunch-oligonucleotides

Synthesis and characterization of a bunchy oligonucleotide forming a monomolecular parallel quadruplex structure in solution

Synthesis and characterization of monomolecular DNA G-quadruplexes formed by tetra-end-linked oligonucleotides

Synthesis and characterization of tetra-end linked oligonucleotides capable of forming monomolecular G-quadruplexes

Synthesis and structural study of quadruplex structures containing 2'-deoxy-8-methyladenosine

Synthesis of 3′−3′-Linked Pyrimidine Oligonucleotides Containing an Acridine Moiety for Alternate Strand Triple Helix Formation

Synthesis of 5-methylamino-2'-deoxyuridine derivatives

Synthesis of quadruplex-forming tetra-end-linked oligonucleotides: effects of the linker size on quadruplex topology and stability

Synthesis, structural studies and biological properties of new TBA analogues containing an acyclic nucleotide.

Tetra-end-linked oligonucleotides forming DNA G-quadruplexes: a new class of aptamers showing anti-HIV activity

The "Janus face" of the thrombin binding aptamer: Investigating the anticoagulant and antiproliferative properties through straightforward chemical modifications.

The Introduction of Inversion of Polarity Sites in DNA G-Quadruplex Structures: Effects and Perspectives.

The abasic site lesions in the human telomeric sequence d[TA(G(3)T(2)A)(3)G(3)]: a thermodynamic point of view

The insertion of two 8-methyl-2'-deoxyguanosine residues in tetramolecular quadruplex structures: trying to orientate the strands

The oxidative damage to the human telomere: effects of 5-hydroxymethyl-2'-deoxyuridine on telomeric G-quadruplex structures

Thermodynamics of melting of the circular dumbbell d<pCGC-TT-GCG-TT>.

Transferrin-conjugated SNALPs encapsulating 2'-O-methylated miR-34a for the treatment of multiple myeloma.

Twin hydroxymethyluracil-A base pair steps define the binding site for the DNA-binding protein TF1.

Unprecedented right- and left-handed quadruplex structures formed by heterochiral oligodeoxyribonucleotides

Unusual Chair-Like G-Quadruplex Structures: Heterochiral TBA Analogues Containing Inversion of Polarity Sites