Lista de obras - Lori L. Isom - Dominio Público Uruguay

A functional null mutation of SCN1B in a patient with Dravet syndrome

artículo científico publicado en 2009

A novel adhesion molecule in human breast cancer cells: voltage-gated Na+ channel beta1 subunit.

artículo científico publicado en 2008

A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction

artículo científico publicado en 2004

Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability.

artículo científico publicado en 2012

Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome

artículo científico publicado en 2013

Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome

scientific article published on 01 August 2020

Auxiliary subunits of voltage-gated ion channels

artículo científico publicado en 1994

Cannabinoid-induced depression of synaptic transmission is switched to stimulation when dopaminergic tone is increased in the globus pallidus of the rodent

artículo científico publicado en 2016

Cardiac arrhythmia in a mouse model of sodium channel SCN8A epileptic encephalopathy

artículo científico publicado en 2016

Channelopathy as a SUDEP Biomarker in Dravet Syndrome Patient-Derived Cardiac Myocytes

Cloning and expression of a zebrafish SCN1B ortholog and identification of a species-specific splice variant

artículo científico publicado en 2007

Cloning, localization, and functional expression of sodium channel beta1A subunits

artículo científico publicado en 2000

Conduction block in PMP22 deficiency.

artículo científico publicado en 2010

Contactin associates with Na+ channels and increases their functional expression

artículo científico publicado en 2001

Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome

article published in 2019

Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier

artículo científico publicado en 2001

Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism

artículo científico publicado en 2013

Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat.

artículo científico publicado en 2004

Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents

artículo científico publicado en 2010

Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and disease

artículo científico publicado en 2010

Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52

scientific article published on 26 September 2020

Expecting the Unexpected: Lack of In Vivo Network Defects in an Scn1a Model of Dravet Syndrome

artículo científico publicado en 2016

Expression and regulation of voltage-gated sodium channel beta1 subunit protein in human gliosis-associated pathologies

artículo científico publicado en 2003

Floxed allele for conditional inactivation of the voltage-gated sodium channel β1 subunitScn1b

artículo científico publicado en 2007

Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1

artículo científico publicado en 2002

Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line

artículo científico publicado en 1995

Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth

artículo científico publicado en 2010

Heterophilic interactions of sodium channel beta1 subunits with axonal and glial cell adhesion molecules

artículo científico publicado en 2004

Identification of the cysteine residue responsible for disulfide linkage of Na+ channel α and β2 subunits

artículo científico publicado en 2012

Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes

artículo científico publicado en 2009

Loss of β1accessory Na+channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high-frequency firing via differential effects on persistent Na+currents

artículo científico publicado en 2012

Mechanisms of Epilepsy and Neuronal Synchronization Gordon Research Conference Power Hour Summary

artículo científico publicado en 2019

Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture

scientific journal article

Modulation of cardiac Na+ channel expression in Xenopus oocytes by beta 1 subunits

artículo científico publicado en 1995

Molecular determinants of Na+ channel function in the extracellular domain of the beta1 subunit

artículo científico publicado en 1998

More than a pore: ion channel signaling complexes

artículo científico publicado en 2014

Na+ Channel ? Subunits: Overachievers of the Ion Channel Family ⬇️

artículo científico publicado el 28 de septiembre de 2011

Na+ channel Scn1b gene regulates dorsal root ganglion nociceptor excitability in vivo

artículo científico publicado en 2011

Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy

artículo científico publicado en 2017

Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current

artículo científico publicado en 2005

PKCbeta co-localizes with the dopamine transporter in mesencephalic neurons

artículo científico publicado en 2010

Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel

artículo científico publicado en 1992

Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits

artículo científico publicado en 2002

Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels

artículo científico publicado en 2009

SCN1B-linked early infantile developmental and epileptic encephalopathy

scientific article published on 11 November 2019

SUMOylation of Neuronal K+ Channels: A Potential Therapeutic Pathway for Epilepsy and SUDEP?

artículo científico publicado en 2014

Scn1b deletion in adult mice results in seizures and SUDEP

scientific article published on 08 May 2019

Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts

artículo científico publicado en 2014

Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias.

artículo científico publicado en 2016

Scn2b,a Voltage-Gated Sodium Channel β2 Gene on Mouse Chromosome 9

article

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals

artículo científico publicado en 2007

Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin

artículo científico publicado en 2004

Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons

artículo científico publicado en 2004

Sodium channel beta1-subunit expression is increased in reactive astrocytes in a rat model for mesial temporal lobe epilepsy

artículo científico publicado en 2002

Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain.

artículo científico publicado en 2006

Sodium channel β1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis

artículo científico publicado en 2020

Structural requirements for interaction of sodium channel beta 1 subunits with ankyrin

artículo científico publicado en 2002

Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif

scientific journal article

Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes

artículo científico publicado en 2011

Tenascin-R is a functional modulator of sodium channel beta subunits

artículo científico publicado en 1999

The intracellular segment of the sodium channel beta 1 subunit is required for its efficient association with the channel alpha subunit

artículo científico publicado en 2001

The role of non-pore-forming β subunits in physiology and pathophysiology of voltage-gated sodium channels.

artículo científico

The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels.

artículo científico publicado en 2012

The voltage-gated Na+ channel beta3 subunit does not mediate trans homophilic cell adhesion or associate with the cell adhesion molecule contactin

artículo científico publicado en 2009

The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6.

artículo científico publicado en 2020

Therapeutic potential for phenytoin: targeting Na(v)1.5 sodium channels to reduce migration and invasion in metastatic breast cancer.

artículo científico publicado en 2012

Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes

scientific journal article

Untangling the dravet syndrome seizure network: the changing face of a rare genetic epilepsy

artículo científico

Upregulation of the Voltage-Gated Sodium Channel 2 Subunit in Neuropathic Pain Models: Characterization of Expression in Injured and Non-Injured Primary Sensory Neurons

article

Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo

scientific journal article

Voltage-gated Na+ channel β1B: a secreted cell adhesion molecule involved in human epilepsy

artículo científico publicado en 2011

Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets

artículo científico publicado en 2008

Voltage-gated sodium channel β subunits: The power outside the pore in brain development and disease

artículo científico publicado en 2017

deletion fails to rescue premature lethality in two models of sodium channel epilepsy

scn1bb, a zebrafish ortholog of SCN1B expressed in excitable and nonexcitable cells, affects motor neuron axon morphology and touch sensitivity

artículo científico publicado en 2008

β1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function

artículo científico publicado en 2016

Lista de obras de Lori L. Isom

A functional null mutation of SCN1B in a patient with Dravet syndrome

A novel adhesion molecule in human breast cancer cells: voltage-gated Na+ channel beta1 subunit.

A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction

Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability.

Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome

Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome

Auxiliary subunits of voltage-gated ion channels

Cannabinoid-induced depression of synaptic transmission is switched to stimulation when dopaminergic tone is increased in the globus pallidus of the rodent

Cardiac arrhythmia in a mouse model of sodium channel SCN8A epileptic encephalopathy

Channelopathy as a SUDEP Biomarker in Dravet Syndrome Patient-Derived Cardiac Myocytes

Cloning and expression of a zebrafish SCN1B ortholog and identification of a species-specific splice variant

Cloning, localization, and functional expression of sodium channel beta1A subunits

Conduction block in PMP22 deficiency.

Contactin associates with Na+ channels and increases their functional expression

Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome

Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier

Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism

Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat.

Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents

Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and disease

Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52

Expecting the Unexpected: Lack of In Vivo Network Defects in an Scn1a Model of Dravet Syndrome

Expression and regulation of voltage-gated sodium channel beta1 subunit protein in human gliosis-associated pathologies

Floxed allele for conditional inactivation of the voltage-gated sodium channel β1 subunitScn1b

Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1

Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line

Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth

Heterophilic interactions of sodium channel beta1 subunits with axonal and glial cell adhesion molecules

Identification of the cysteine residue responsible for disulfide linkage of Na+ channel α and β2 subunits

Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes

Loss of β1accessory Na+channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high-frequency firing via differential effects on persistent Na+currents

Mechanisms of Epilepsy and Neuronal Synchronization Gordon Research Conference Power Hour Summary

Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture

Modulation of cardiac Na+ channel expression in Xenopus oocytes by beta 1 subunits

Molecular determinants of Na+ channel function in the extracellular domain of the beta1 subunit

More than a pore: ion channel signaling complexes

Na+ Channel ? Subunits: Overachievers of the Ion Channel Family ⬇️

Na+ channel Scn1b gene regulates dorsal root ganglion nociceptor excitability in vivo

Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy

Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current

PKCbeta co-localizes with the dopamine transporter in mesencephalic neurons

Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel

Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits

Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels

SCN1B-linked early infantile developmental and epileptic encephalopathy

SUMOylation of Neuronal K+ Channels: A Potential Therapeutic Pathway for Epilepsy and SUDEP?

Scn1b deletion in adult mice results in seizures and SUDEP

Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts

Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias.

Scn2b,a Voltage-Gated Sodium Channel β2 Gene on Mouse Chromosome 9

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals

Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin

Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons

Sodium channel beta1-subunit expression is increased in reactive astrocytes in a rat model for mesial temporal lobe epilepsy

Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain.

Sodium channel β1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis

Structural requirements for interaction of sodium channel beta 1 subunits with ankyrin

Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif

Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes

Tenascin-R is a functional modulator of sodium channel beta subunits

The intracellular segment of the sodium channel beta 1 subunit is required for its efficient association with the channel alpha subunit

The role of non-pore-forming β subunits in physiology and pathophysiology of voltage-gated sodium channels.

The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels.

The voltage-gated Na+ channel beta3 subunit does not mediate trans homophilic cell adhesion or associate with the cell adhesion molecule contactin

The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6.

Therapeutic potential for phenytoin: targeting Na(v)1.5 sodium channels to reduce migration and invasion in metastatic breast cancer.

Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes

Untangling the dravet syndrome seizure network: the changing face of a rare genetic epilepsy

Upregulation of the Voltage-Gated Sodium Channel 2 Subunit in Neuropathic Pain Models: Characterization of Expression in Injured and Non-Injured Primary Sensory Neurons

Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo

Voltage-gated Na+ channel β1B: a secreted cell adhesion molecule involved in human epilepsy

Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets

Voltage-gated sodium channel β subunits: The power outside the pore in brain development and disease

deletion fails to rescue premature lethality in two models of sodium channel epilepsy

scn1bb, a zebrafish ortholog of SCN1B expressed in excitable and nonexcitable cells, affects motor neuron axon morphology and touch sensitivity

β1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function