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Lista de obras de Christopher J Lord

A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events.

artículo científico publicado en 2017

A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.

artículo científico publicado en 2007

A compendium of co-regulated protein complexes in breast cancer reveals collateral loss events

scholarly article published 26 June 2017

A genetic screen using the PiggyBac transposon in haploid cells identifies Parp1 as a mediator of olaparib toxicity

artículo científico publicado en 2013

A high-resolution integrated analysis of genetic and expression profiles of breast cancer cell lines

artículo científico publicado en 2009

A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity

artículo científico publicado en 2008

A high-throughput screen identifies PARP1/2 inhibitors as a potential therapy for ERCC1-deficient non-small cell lung cancer

artículo científico publicado en 2013

A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer

artículo científico publicado en 2010

A modified method for whole exome resequencing from minimal amounts of starting DNA

artículo científico publicado en 2012

A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors

artículo científico publicado en 2019

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

artículo científico

A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers

artículo científico publicado en 2012

APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer

artículo científico publicado en 2012

ATR Is a Therapeutic Target in Synovial Sarcoma.

artículo científico publicado en 2017

ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A.

artículo científico publicado en 2016

Abstract 2931: Cancer cells deficient in DNA mismatch repair (MMR) are selectively sensitive to inhibition of the DNA dependent protein kinase (DNA-PK)

artículo científico publicado en 2014

Abstract 3417: An in vivo functional screen to identify metastasis suppressor genes

article

Abstract 3917: EMSY amplification and overexpression is not associated with defective homologous recombination and does not predict sensitivity to cisplatin or PARP inhibitors

article by Paul Wilkerson et al published 15 April 2011 in Cancer Research

Abstract 4829: Massively parallel RNA sequencing analysis of micropapillary carcinomas of the breast

article by Rachael Natrajan et al published 15 April 2011 in Cancer Research

Abstract 4987: Identification of novel genes and pathways involved in resistance to HER2-targeting agents in breast cancer

article

Abstract 5076: Integrative genomic and transcriptomic analysis of metaplastic carcinomas of the breast

article by Alan G. Mackay et al published 15 April 2012 in Cancer Research

Abstract A09: Induced aggravation of oxidative DNA damage as a targeted synthetic lethal approach in mismatch repair-deficient tumors

article by Y. Fontebasso et al published 1 May 2013 in Molecular Cancer Therapeutics

Abstract A36: A transposon-based genetic screen in haploid mouse embryonic stem cells identifies Parp1 as a major mediator of olaparib toxicity

article

Abstracts

article by L. Bie et al published 1 April 2013 in Neuro-Oncology

Abstracts from the 2011 BNOS Conference, June 29 - July 1, 2011, Homerton College, Cambridge

article by S. Ammoun et al published 21 September 2011 in Neuro-Oncology

An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence

artículo científico publicado en 2011

An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor

artículo científico publicado en 2014

An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers

artículo científico publicado en 2009

Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors

artículo científico publicado en 2017

Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition

artículo científico publicado en 2010

BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency.

artículo científico publicado en 2013

BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency

artículo científico publicado en 2005

BRCAness revisited

artículo científico publicado en 2016

Biology-driven cancer drug development: back to the future

artículo científico publicado en 2010

Bringing DNA repair in tumors into focus

artículo científico publicado en 2009

CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

artículo científico publicado en 2016

CRK7 modifies the MAPK pathway and influences the response to endocrine therapy

artículo científico publicado en 2009

CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer

artículo científico publicado en 2017

CancerGD: a resource for identifying and interpreting genetic dependencies in cancer

scholarly article published 26 October 2016

Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast

artículo científico publicado en 2014

Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness

artículo científico publicado en 2018

Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition.

artículo científico publicado en 2017

Clinical BRCA1/2 reversion analysis identifies hotspot mutations and predicted neoantigens associated with therapy resistance

artículo científico publicado en 2020

Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity

artículo científico publicado en 2015

Comprehensive genomic analysis of a BRCA2 deficient human pancreatic cancer

artículo científico publicado en 2011

Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation

artículo científico publicado en 2009

Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1

article

Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping

artículo científico publicado en 2000

Correction: CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

artículo científico publicado en 2017

Correction: CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

artículo científico publicado en 2016

Correction: Correction: CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

artículo científico publicado en 2018

Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets.

artículo científico publicado en 2018

Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib

artículo científico publicado en 2012

Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells

artículo científico publicado en 2021

Cytosine-based nucleoside analogs are selectively lethal to DNA mismatch repair-deficient tumour cells by enhancing levels of intracellular oxidative stress

artículo científico publicado en 2013

DAISY: picking synthetic lethals from cancer genomes

artículo científico publicado en 2014

DIFFERENTIAL GLYCOSYLATION OF INTERLEUKIN 2, THE MOLECULAR BASIS FOR THE NOD Idd3 TYPE 1 DIABETES GENE?

article

DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1

artículo científico publicado en 2010

DNA repair deficiency as a therapeutic target in cancer

artículo científico publicado en 2008

DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade

artículo científico publicado en 2018

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer ⬇️

artículo científico publicado en 2015

DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells

scientific journal article

De Novo Truncating Mutations in the Last and Penultimate Exons of PPM1D Cause an Intellectual Disability Syndrome

artículo científico publicado en 2017

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition

article by Nuala McCabe et al published 15 August 2006 in Cancer Research

Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors

article

Directing the use of DDR kinase inhibitors in cancer treatment.

artículo científico publicado en 2017

Dissecting resistance to endocrine therapy in breast cancer

artículo científico publicado en 2008

Driver Oncogenes but Not as We Know Them: Targetable Fusion Genes in Breast Cancer

article

Dsh homolog DVL3 mediates resistance to IGFIR inhibition by regulating IGF-RAS signaling

artículo científico publicado en 2014

Dysregulated TRK signalling is a therapeutic target in CYLD defective tumours

artículo científico

E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer.

artículo científico publicado en 2018

Efficacy of chemotherapy in BRCA1/2 mutation carrier ovarian cancer in the setting of PARP inhibitor resistance: a multi-institutional study

artículo científico

Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells

artículo científico publicado en 2017

Establishment and characterisation of a new breast cancer xenograft obtained from a woman carrying a germline BRCA2 mutation

artículo científico publicado en 2010

Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response-Targeted Therapies in Breast Cancer.

artículo científico publicado en 2017

Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways.

artículo científico publicado en 2015

Functional analysis of Drosophila melanogaster BRCA2 in DNA repair

artículo científico publicado en 2007

Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element

artículo científico publicado en 2021

Functional characterization of EMSY gene amplification in human cancers

artículo científico publicado en 2011

Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance

artículo científico publicado en 2022

Functional viability profiles of breast cancer

artículo científico publicado en 2011

Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma

artículo científico publicado en 2017

Genetic Interactions in Cancer Progression and Treatment

scientific article published on 01 April 2011

Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation

artículo científico publicado en 2012

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.

artículo científico publicado en 2018

Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

artículo científico publicado en 2012

Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells

artículo científico publicado en 2017

Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress

artículo científico publicado en 2014

Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen

artículo científico publicado en 2011

Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity

artículo científico publicado en 2014

Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers

artículo científico publicado en 2015

Genomic characterisation of acral melanoma cell lines

artículo científico publicado en 2012

Genomic instability and the selection of treatments for cancer

artículo científico publicado en 2010

Germline mutations in RAD51D confer susceptibility to ovarian cancer

artículo científico publicado en 2011

HG-97PAEDIATRIC GBM AND DIPG SUBCLONES CO-OPERATE TO PROMOTE TUMORIGENESIS.

artículo científico publicado en 2016

HGG-07. MUTATIONS IN ATRX INCREASE GENETIC INSTABILITY AND SENSITIVITY TO PARP INHIBITORS IN PAEDIATRIC GLIOBLASTOMA CELLS.

artículo científico publicado en 2017

HLA-B*5603: sequence of a novel hybrid allele comprising B*56 and B*4601 segments

artículo científico publicado en 1997

High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing

artículo científico publicado en 2011

High-throughput RNAi screening reveals novel regulators of telomerase

artículo científico publicado en 2011

Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN.

artículo científico publicado en 2013

Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer

artículo científico publicado en 2008

Identification of a Structurally Distinct CD101 Molecule Encoded in the 950-kb Idd10 Region of NOD Mice

scientific article published on 01 June 2003

Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma

artículo científico publicado en 2011

Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer

scientific article published on 18 June 2018

Identification of miRNA modulators to PARP inhibitor response

artículo científico publicado en 2013

Identification of novel determinants of resistance to lapatinib in ERBB2-amplified cancers

artículo científico publicado en 2013

Identifying Genetic Dependencies in Cancer by Analyzing siRNA Screens in Tumor Cell Line Panels

artículo científico publicado en 2018

Identifying Modifiers of Tamoxifen Sensitivity Using High-Throughput Genetic and Chemical Screens

scholarly article

Integrated functional, gene expression and genomic analysis for the identification of cancer targets

artículo científico publicado en 2009

Integrative molecular and functional profiling of ERBB2-amplified breast cancers identifies new genetic dependencies

artículo científico publicado en 2013

Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment

artículo científico publicado en 2006

Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma

artículo científico publicado en 2012

Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines

artículo científico publicado en 2016

MESH: Phase II trial of methotrexate as a synthetic lethal therapy for metastatic MSH2-deficient colorectal and other tumors

article by M. Hewish et al published 20 May 2010 in Journal of Clinical Oncology

Mapping by Genetic Interaction: High-Resolution Congenic Mapping of the Type 1 Diabetes Loci Idd10 and Idd18 in the NOD Mouse

scientific article published on 01 November 2001

Mapping genetic vulnerabilities reveals BTK as a novel therapeutic target in oesophageal cancer

artículo científico publicado en 2017

Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene.

artículo científico publicado en 1997

Mapping the diabetes polygene Idd3 on mouse chromosome 3 by use of novel congenic strains

artículo científico publicado en 1995

Mechanisms of resistance to therapies targeting BRCA-mutant cancers

artículo científico

Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2

artículo científico publicado en 2009

Mismatch repair deficient colorectal cancer in the era of personalized treatment

artículo científico

Modeling Therapy Resistance in BRCA1/2-Mutant Cancers

artículo científico publicado en 2017

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer

artículo científico publicado en 2013

NLK is a novel therapeutic target for PTEN deficient tumour cells

artículo científico publicado en 2012

Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway

artículo científico publicado en 2015

Optimised ARID1A immunohistochemistry is an accurate predictor of ARID1A mutational status in gynaecological cancers.

artículo científico publicado en 2018

Overexpression of MYB drives proliferation of CYLD-defective cylindroma cells

artículo científico publicado en 2016

PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer

article by Roman M Chabanon et al published 1 March 2019 in Journal of Clinical Investigation

PARP inhibitor combination therapy

artículo científico publicado en 2016

PARP inhibitors: Synthetic lethality in the clinic

artículo científico publicado en 2017

PD-0017 * DRUGGABLE GENETIC DEPENDENCIES FOR MOLECULARLY DEFINED SUBGROUPS OF OESOPHAGEAL CANCER IDENTIFIED FROM HIGH-THROUGHPUT FUNCTIONAL PROFILING

artículo científico publicado en 2014

PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study

artículo científico publicado en 2010

PPM1D is a potential therapeutic target in ovarian clear cell carcinomas

artículo científico publicado en 2009

PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors

artículo científico publicado en 2010

Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization

artículo científico publicado en 2009

Parallel high-throughput RNA interference screens identify PINK1 as a potential therapeutic target for the treatment of DNA mismatch repair-deficient cancers

artículo científico publicado en 2011

Phenotypic effects of heterozygosity for a BRCA2 mutation

artículo científico publicado en 2003

Phosphoproteomic Profiling Reveals ALK and MET as Novel Actionable Targets across Synovial Sarcoma Subtypes

artículo científico publicado en 2017

Poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of advanced germline BRCA2 mutant prostate cancer

artículo científico publicado en 2013

Preclinical evaluation of PARP inhibition as a treatment for endometrioid endometrial carcinomas

article by K. J. Dedes et al published 20 May 2010 in Journal of Clinical Oncology

RAD51, BRCA2 and DNA repair: a partial resolution

artículo científico publicado en 2007

RNA interference screening demystified

artículo científico publicado en 2009

Regulator of G-protein signalling 2 mRNA is differentially expressed in mammary epithelial subpopulations and over-expressed in the majority of breast cancers

artículo científico publicado en 2007

Resistance to therapy caused by intragenic deletion in BRCA2

artículo científico publicado en 2008

Searching for synthetic lethality in cancer

artículo científico publicado en 2011

Secondary mutations inBRCA2associated with clinical resistance to a PARP inhibitor

article by Louise J Barber et al published 25 January 2013 in Journal of Pathology

Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer

artículo científico publicado en 2015

Sequential interactions with Sec23 control the direction of vesicle traffic

artículo científico publicado en 2011

Sit4p/PP6 regulates ER-to-Golgi traffic by controlling the dephosphorylation of COPII coat subunits

artículo científico publicado en 2013

Statistical modeling of interlocus interactions in a complex disease: rejection of the multiplicative model of epistasis in type 1 diabetes

artículo científico publicado en 2001

Structural basis for allosteric PARP-1 retention on DNA breaks

artículo científico publicado en 2020

Structural basis for recruitment of BRCA2 by PALB2

artículo científico publicado en 2009

Structural basis for recruitment of BRCA2 by PALB2.

artículo científico publicado en 2017

Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma

artículo científico publicado en 2016

Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib

artículo científico publicado en 2016

Synthetic Lethality and Cancer - Penetrance as the Major Barrier

article by Colm J. Ryan et al published October 2018 in Trends in cancer

Synthetic lethal approaches to breast cancer therapy

artículo científico publicado en 2010

Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

artículo científico publicado en 2009

Synthetic lethal targeting of PTEN-deficient cancer cells using selective disruption of polynucleotide kinase/phosphatase

artículo científico publicado en 2013

Synthetic lethal therapies for cancer: what's next after PARP inhibitors?

article by Alan Ashworth et al published September 2018 in Nature Reviews Clinical Oncology

Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors

artículo científico publicado en 2014

Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells

artículo científico publicado en 2012

Synthetic lethality: the road to novel therapies for breast cancer

artículo científico publicado en 2016

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family

artículo científico publicado en 2012

Targeted therapy for cancer using PARP inhibitors

artículo científico publicado en 2008

Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer.

artículo científico publicado en 2009

Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers

artículo científico publicado en 2012

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

artículo científico publicado en 2005

Targeting the Vulnerability of RB Tumor Suppressor Loss in Triple-Negative Breast Cancer

artículo científico publicado en 2018

Targeting the double-strand DNA break repair pathway as a therapeutic strategy

artículo científico publicado en 2006

The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.

artículo científico publicado en 2018

The DNA damage response and cancer therapy

artículo científico publicado en 2012

The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137.

artículo científico publicado en 2000

The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate notch signalling

artículo científico publicado en 2014

The derivation of highly germline-competent embryonic stem cells containing NOD-derived genome

artículo científico publicado en 2003

The genomic landscape of oesophagogastric junctional adenocarcinoma

artículo científico publicado en 2013

The genomic profile of HER2-amplified breast cancers: the influence of ER status

artículo científico publicado en 2008

The murine type 1 diabetes loci, Idd1, Idd3, Idd5, Idd9, and Idd17/10/18, do not control thymic CD4 − CD8 − /TCRαβ + deficiency in the nonobese diabetic mouse

scientific article published on 01 February 2001

The potential of exploiting DNA-repair defects for optimizing lung cancer treatment

artículo científico publicado en 2012

The promise of combining inhibition of PI3K and PARP as cancer therapy.

artículo científico publicado en 2012

The proteasome is involved in determining differential utilization of double-strand break repair pathways

article by K Gudmundsdottir et al published 29 November 2007 in Oncogene

The shieldin complex mediates 53BP1-dependent DNA repair

scientific article published in Nature

The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module

artículo científico publicado en 2008

Therapeutic targeting of the DNA mismatch repair pathway

artículo científico publicado en 2010

Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model

artículo científico publicado en 2016

Tiling path genomic profiling of grade 3 invasive ductal breast cancers

artículo científico publicado en 2009

Transition from cylindroma to spiradenoma in CYLD-defective tumours is associated with reduced DKK2 expression

artículo científico publicado en 2011

Utilizing RNA interference to enhance cancer drug discovery

artículo científico publicado en 2007

Whole genome in vivo RNAi screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor

artículo científico publicado en 2012

Whole genome sequencing of matched primary and metastatic acral melanomas

artículo científico publicado en 2011

Whole-exome DNA sequence analysis of Brca2- and Trp53-deficient mouse mammary gland tumours

artículo científico publicado en 2015

p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene

artículo científico publicado en 2006

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