Lista de obras - Darren Hargrave - Dominio Público Uruguay

'I have to live with the decisions I make': laying a foundation for decision making for children with life-limiting conditions and life-threatening illnesses

artículo científico publicado en 2016

18F-fluoroethylcholine (18F-Cho) PET/MRI functional parameters in pediatric astrocytic brain tumors

artículo científico publicado en 2015

A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory BRAF V600 Mutation-Positive Solid Tumors

scientific article published on 10 September 2019

A cell-based MAPK reporter assay reveals synergistic MAPK pathway activity suppression by MAPK inhibitor combination in BRAF-driven pediatric low-grade glioma cells

artículo científico publicado en 2020

A distinct spectrum of copy number aberrations in pediatric high-grade gliomas

artículo científico publicado en 2010

A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma.

artículo científico publicado en 2014

A phase 1 study of oral ridaforolimus in pediatric patients with advanced solid tumors

artículo científico publicado en 2016

A phase I trial of AT9283 (a selective inhibitor of aurora kinases) in children and adolescents with solid tumors: a Cancer Research UK study

artículo científico publicado en 2014

A phase II single-arm study of irinotecan in combination with temozolomide (TEMIRI) in children with newly diagnosed high grade glioma: a joint ITCC and SIOPE-brain tumour study

artículo científico

A population pharmacokinetic model of AT9283 in adults and children to predict the maximum tolerated dose in children with leukaemia

artículo científico publicado en 2017

Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation

artículo científico publicado en 2021

Case of interstitial 12q deletion in association with Wilms tumor

Central nervous system tumours in adolescents.

artículo científico publicado en 2003

Challenges to curing primary brain tumours

scientific article published on 01 August 2019

Challenges with defining response to antitumor agents in pediatric neuro-oncology: A report from the response assessment in pediatric neuro-oncology (RAPNO) working group

article

Childhood brain tumour information on the Internet in the Chinese language

artículo científico publicado en 2005

Clinical presentation and prognostic indicators in 100 adults and children with neurofibromatosis 1 associated non-optic pathway brain gliomas

artículo científico publicado en 2017

Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries.

artículo científico publicado en 2018

Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease

artículo científico publicado en 2015

Commentary on "Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes".

artículo científico publicado en 2016

Consensus and perspectives on treatment strategies in childhood craniopharyngioma: results of a meeting of the Craniopharyngioma Study Group (SIOP), Genova, 2004

scientific article published on 01 April 2006

Conventional MRI cannot predict survival in childhood diffuse intrinsic pontine glioma

artículo científico publicado en 2007

Delineation of the visual pathway in paediatric optic pathway glioma patients using probabilistic tractography, and correlations with visual acuity

artículo científico publicado en 2017

Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease

artículo científico publicado en 2017

Diagnostic and therapeutic challenges owing to concurrent pontine glioma and acute lymphoblastic leukemia.

artículo científico publicado en 2008

Diffuse brainstem glioma in children: critical review of clinical trials

artículo científico publicado en 2006

Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy--results of a United Kingdom phase II trial (CNS 2007 04).

artículo científico publicado en 2013

EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines

artículo científico

Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation-Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study

artículo científico publicado en 2019

Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRα/β.

artículo científico publicado en 2011

European paediatric hematology/oncology subspecialty training

artículo científico publicado en 2004

Evaluation of the Implementation of the Response Assessment in Neuro-Oncology Criteria in the HERBY Trial of Pediatric Patients with Newly Diagnosed High-Grade Gliomas

artículo científico publicado en 2019

Evaluation of treatment response using integrated 18F-labeled choline positron emission tomography/magnetic resonance imaging in adolescents with intracranial non-germinomatous germ cell tumours

artículo científico publicado en 2015

Extent of resection in medulloblastoma: time to reconsider?

artículo científico publicado en 2016

Gender as a disease modifier in neurofibromatosis type 1 optic pathway glioma

artículo científico publicado en 2014

Genetic heterogeneity for SMARCB1, H3F3A and BRAF in a malignant childhood brain tumour: genetic-pathological correlation

artículo científico publicado en 2015

Germinoma with synchronous lesions in the pineal and suprasellar regions

artículo científico publicado en 2006

HG-75CLINICAL, RADIOLOGICAL, AND HISTO-GENETIC CHARACTERISTICS OF LONG-TERM SURVIVORS OF DIFFUSE INTRINSIC PONTINE GLIOMA: A COLLABORATIVE REPORT FROM THE INTERNATIONAL AND SIOP-E DIPG REGISTRIES.

artículo científico publicado en 2016

Hereditary leiomyomatosis and renal cell carcinoma: very early diagnosis of renal cancer in a paediatric patient

artículo científico publicado en 2010

Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma

artículo científico publicado en 2011

Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN.

artículo científico publicado en 2013

Hypofractionation vs conventional radiation therapy for newly diagnosed diffuse intrinsic pontine glioma: a matched-cohort analysis

artículo científico publicado en 2012

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes

scientific article published on 01 April 2020

Innovative Therapies for Children with Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors

artículo científico publicado en 2010

Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease

artículo científico publicado en 2010

MEK inhibition appears to improve symptom control in primary NRAS-driven CNS melanoma in children

artículo científico publicado en 2017

MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature

artículo científico publicado en 2010

MRI-based radiomics for prognosis of pediatric diffuse intrinsic pontine glioma: an international study

artículo científico publicado en 2021

Microsatellite instability in pediatric high grade glioma is associated with genomic profile and differential target gene inactivation

artículo científico publicado en 2011

Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development

artículo científico publicado en 2009

Movement disorders in association with herpes simplex virus encephalitis in children: a review.

artículo científico publicado en 1998

Mutations of the BRAF gene in human cancer

artículo científico publicado en 2002

Natural history and outcome of optic pathway gliomas in children

artículo científico publicado en 2009

New drugs for children and adolescents with cancer: the need for novel development pathways.

artículo científico publicado en 2013

Nocturnal oxygen saturation and painful sickle cell crises in children

artículo científico publicado en 2002

On-treatment relapse of medulloblastoma as prolonged pyrexia of unknown origin

artículo científico publicado en 2007

Paediatric and adult malignant glioma: close relatives or distant cousins?

artículo científico publicado en 2012

Paediatric high and low grade glioma: the impact of tumour biology on current and future therapy

artículo científico publicado en 2009

Palliative and end-of-life care for children with diffuse intrinsic pontine glioma: results from a London cohort study and international survey

artículo científico publicado en 2015

Parents' responses to prognostic disclosure at diagnosis of a child with a high-risk brain tumor: Analysis of clinician-parent interactions and implications for clinical practice

artículo científico publicado en 2020

Pattern of recurrence in paediatric malignant glioma: an institutional experience

artículo científico publicado en 2007

Pediatric CNS tumors: current treatment and future directions.

artículo científico publicado en 2007

Pediatric Low-Grade Gliomas: Next Biologically Driven Steps

artículo científico publicado en 2017

Pediatric diffuse intrinsic pontine glioma: can optimism replace pessimism?

artículo científico publicado en 2012

Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity

artículo científico publicado en 2020

Phase I study of fotemustine in pediatric patients with refractory brain tumors

artículo científico publicado en 2002

Phase II study of irinotecan in combination with temozolomide (TEMIRI) in children with recurrent or refractory medulloblastoma: a joint ITCC and SIOPE brain tumor study

artículo científico publicado en 2013

Phase II study of weekly vinblastine in recurrent or refractory pediatric low-grade glioma

artículo científico publicado en 2012

Pontine glioma. To biopsy or not to biopsy: that is the question

artículo científico publicado en 2008

Pre-existing neurodevelopmental and neuropsychiatric difficulties in children with brain tumours: implications for future outcome studies

artículo científico publicado en 2010

Preclinical drug development for childhood cancer

artículo científico publicado en 2010

Primary Pericardial Synovial Sarcoma Confirmed by Molecular Genetic Studies

artículo científico publicado en 2007

Prognostic factors of overall survival in children and adolescents enrolled in dose-finding trials in Europe: An Innovative Therapies for Children with Cancer study.

artículo científico publicado en 2016

Progressive reduction in treatment-related deaths in Medical Research Council childhood lymphoblastic leukaemia trials from 1980 to 1997 (UKALL VIII, X and XI)

scientific article published on 01 February 2001

Quality of health information on the Internet in pediatric neuro-oncology

artículo científico publicado en 2006

Quantitative MRI demonstrates abnormalities of the third ventricle subventricular zone in neurofibromatosis type-1 and sporadic paediatric optic pathway glioma

artículo científico publicado en 2020

Radiological Evaluation of Newly Diagnosed Non-Brainstem Pediatric High-Grade Glioma in the HERBY Phase II Trial

scientific article published on 10 January 2020

Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

artículo científico publicado en 2014

Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'

artículo científico publicado en 2019

Response Assessment in Pediatric Neuro-Oncology: Implementation and Expansion of the RANO Criteria in a Randomized Phase II Trial of Pediatric Patients with Newly Diagnosed High-Grade Gliomas.

artículo científico publicado en 2016

Response to low dose temozolomide in radiation induced gliomatosis cerebri

artículo científico publicado en 2003

Safety and pharmacokinetics of temozolomide using a dose-escalation, metronomic schedule in recurrent paediatric brain tumours

artículo científico publicado en 2006

State of affairs in use of steroids in diffuse intrinsic pontine glioma: an international survey and a review of the literature

artículo científico publicado en 2016

Surveillance imaging of grade 1 astrocytomas in children: can duration and frequency of follow-up imaging and the use of contrast agents be reduced?

artículo científico publicado en 2020

Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria

artículo científico publicado en 2014

The addition of high-dose tamoxifen to standard radiotherapy does not improve the survival of patients with diffuse intrinsic pontine glioma

artículo científico publicado en 2010

The value of magnetic resonance spectroscopy in tumour imaging

artículo científico publicado en 2008

Tobacco smoke exposure in children and adolescents with diabetes mellitus

artículo científico publicado en 1999

Toxicity and outcome of children and adolescents participating in phase I/II trials of novel anticancer drugs: the Royal Marsden experience.

artículo científico publicado en 2014

Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target.

artículo científico publicado en 2018

Vincristine and carboplatin chemotherapy for unresectable and/or recurrent low-grade astrocytoma of the brainstem

artículo científico publicado en 2010

Visual outcomes in children with neurofibromatosis type 1-associated optic pathway glioma following chemotherapy: a multicenter retrospective analysis

artículo científico publicado en 2012

What are the experiences of the child with a brain tumour and their parents?

artículo científico publicado en 2009

[Analysis of paediatric neuro-oncological information on the Internet in German language]

artículo científico publicado en 2003

[Quality of childhood brain tumour information on the Internet in French language].

artículo científico publicado en 2003

Lista de obras de Darren Hargrave

'I have to live with the decisions I make': laying a foundation for decision making for children with life-limiting conditions and life-threatening illnesses

18F-fluoroethylcholine (18F-Cho) PET/MRI functional parameters in pediatric astrocytic brain tumors

A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory BRAF V600 Mutation-Positive Solid Tumors

A cell-based MAPK reporter assay reveals synergistic MAPK pathway activity suppression by MAPK inhibitor combination in BRAF-driven pediatric low-grade glioma cells

A distinct spectrum of copy number aberrations in pediatric high-grade gliomas

A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma.

A phase 1 study of oral ridaforolimus in pediatric patients with advanced solid tumors

A phase I trial of AT9283 (a selective inhibitor of aurora kinases) in children and adolescents with solid tumors: a Cancer Research UK study

A phase II single-arm study of irinotecan in combination with temozolomide (TEMIRI) in children with newly diagnosed high grade glioma: a joint ITCC and SIOPE-brain tumour study

A population pharmacokinetic model of AT9283 in adults and children to predict the maximum tolerated dose in children with leukaemia

Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation

Case of interstitial 12q deletion in association with Wilms tumor

Central nervous system tumours in adolescents.

Challenges to curing primary brain tumours

Challenges with defining response to antitumor agents in pediatric neuro-oncology: A report from the response assessment in pediatric neuro-oncology (RAPNO) working group

Childhood brain tumour information on the Internet in the Chinese language

Clinical presentation and prognostic indicators in 100 adults and children with neurofibromatosis 1 associated non-optic pathway brain gliomas

Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries.

Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease

Commentary on "Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes".

Consensus and perspectives on treatment strategies in childhood craniopharyngioma: results of a meeting of the Craniopharyngioma Study Group (SIOP), Genova, 2004

Conventional MRI cannot predict survival in childhood diffuse intrinsic pontine glioma

Delineation of the visual pathway in paediatric optic pathway glioma patients using probabilistic tractography, and correlations with visual acuity

Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease

Diagnostic and therapeutic challenges owing to concurrent pontine glioma and acute lymphoblastic leukemia.

Diffuse brainstem glioma in children: critical review of clinical trials

Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy--results of a United Kingdom phase II trial (CNS 2007 04).

EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines

Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation-Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study

Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRα/β.

European paediatric hematology/oncology subspecialty training

Evaluation of the Implementation of the Response Assessment in Neuro-Oncology Criteria in the HERBY Trial of Pediatric Patients with Newly Diagnosed High-Grade Gliomas

Evaluation of treatment response using integrated 18F-labeled choline positron emission tomography/magnetic resonance imaging in adolescents with intracranial non-germinomatous germ cell tumours

Extent of resection in medulloblastoma: time to reconsider?

Gender as a disease modifier in neurofibromatosis type 1 optic pathway glioma

Genetic heterogeneity for SMARCB1, H3F3A and BRAF in a malignant childhood brain tumour: genetic-pathological correlation

Germinoma with synchronous lesions in the pineal and suprasellar regions

HG-75CLINICAL, RADIOLOGICAL, AND HISTO-GENETIC CHARACTERISTICS OF LONG-TERM SURVIVORS OF DIFFUSE INTRINSIC PONTINE GLIOMA: A COLLABORATIVE REPORT FROM THE INTERNATIONAL AND SIOP-E DIPG REGISTRIES.

Hereditary leiomyomatosis and renal cell carcinoma: very early diagnosis of renal cancer in a paediatric patient

Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma

Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN.

Hypofractionation vs conventional radiation therapy for newly diagnosed diffuse intrinsic pontine glioma: a matched-cohort analysis

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes

Innovative Therapies for Children with Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors

Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease

MEK inhibition appears to improve symptom control in primary NRAS-driven CNS melanoma in children

MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature

MRI-based radiomics for prognosis of pediatric diffuse intrinsic pontine glioma: an international study

Microsatellite instability in pediatric high grade glioma is associated with genomic profile and differential target gene inactivation

Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development

Movement disorders in association with herpes simplex virus encephalitis in children: a review.

Mutations of the BRAF gene in human cancer

Natural history and outcome of optic pathway gliomas in children

New drugs for children and adolescents with cancer: the need for novel development pathways.

Nocturnal oxygen saturation and painful sickle cell crises in children

On-treatment relapse of medulloblastoma as prolonged pyrexia of unknown origin

Paediatric and adult malignant glioma: close relatives or distant cousins?

Paediatric high and low grade glioma: the impact of tumour biology on current and future therapy

Palliative and end-of-life care for children with diffuse intrinsic pontine glioma: results from a London cohort study and international survey

Parents' responses to prognostic disclosure at diagnosis of a child with a high-risk brain tumor: Analysis of clinician-parent interactions and implications for clinical practice

Pattern of recurrence in paediatric malignant glioma: an institutional experience

Pediatric CNS tumors: current treatment and future directions.

Pediatric Low-Grade Gliomas: Next Biologically Driven Steps

Pediatric diffuse intrinsic pontine glioma: can optimism replace pessimism?

Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity

Phase I study of fotemustine in pediatric patients with refractory brain tumors

Phase II study of irinotecan in combination with temozolomide (TEMIRI) in children with recurrent or refractory medulloblastoma: a joint ITCC and SIOPE brain tumor study

Phase II study of weekly vinblastine in recurrent or refractory pediatric low-grade glioma

Pontine glioma. To biopsy or not to biopsy: that is the question

Pre-existing neurodevelopmental and neuropsychiatric difficulties in children with brain tumours: implications for future outcome studies

Preclinical drug development for childhood cancer

Primary Pericardial Synovial Sarcoma Confirmed by Molecular Genetic Studies

Prognostic factors of overall survival in children and adolescents enrolled in dose-finding trials in Europe: An Innovative Therapies for Children with Cancer study.

Progressive reduction in treatment-related deaths in Medical Research Council childhood lymphoblastic leukaemia trials from 1980 to 1997 (UKALL VIII, X and XI)

Quality of health information on the Internet in pediatric neuro-oncology

Quantitative MRI demonstrates abnormalities of the third ventricle subventricular zone in neurofibromatosis type-1 and sporadic paediatric optic pathway glioma

Radiological Evaluation of Newly Diagnosed Non-Brainstem Pediatric High-Grade Glioma in the HERBY Phase II Trial

Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'