Lista de obras - Martin Noble - Dominio Público Uruguay

4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.

artículo científico publicado en 2003

8-Substituted O(6)-cyclohexylmethylguanine CDK2 inhibitors: using structure-based inhibitor design to optimize an alternative binding mode

artículo científico publicado en 2014

A new crystal form of Lys48-linked diubiquitin

artículo científico publicado en 2010

A structural explanation for the binding of multiple ligands by the alpha-adaptin appendage domain

artículo científico publicado en 1999

Active and inactive protein kinases: structural basis for regulation

artículo científico publicado en 1996

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects

artículo científico publicado en 2003

An inhibitor's-eye view of the ATP-binding site of CDKs in different regulatory states.

artículo científico publicado en 2014

Analysis of chemical shift changes reveals the binding modes of isoindolinone inhibitors of the MDM2-p53 interaction

artículo científico publicado en 2008

Analysis of the structure of Pseudomonas glumae lipase

article

Announcing mandatory submission of PDBx/mmCIF format files for crystallographic depositions to the Protein Data Bank (PDB)

scientific article published on 08 April 2019

Arylamine N-acetyltransferases in mycobacteria

artículo científico publicado en 2008

Aurora A regulates expression of AR-V7 in models of castrate resistant prostate cancer

artículo científico publicado en 2017

Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design.

artículo científico publicado en 2016

Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis.

artículo científico publicado en 2005

CCP4i2: the new graphical user interface to the CCP4 program suite.

artículo científico publicado en 2018

CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.

artículo científico publicado en 2015

Catalysis and regulation

article

Catalytic mechanism of phosphorylase kinase probed by mutational studies

artículo científico publicado en 1999

Chemical inhibitors of cyclin-dependent kinases: insights into design from X-ray crystallographic studies.

artículo científico publicado en 1999

Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity

artículo científico publicado en 2013

Comparison of the refined crystal structures of liganded and unliganded chicken, yeast and trypanosomal triosephosphate isomerase

artículo científico publicado en 1992

Computational analyses of the surface properties of protein-protein interfaces.

artículo científico publicado en 2006

Could Omega 3 Supplements Play a Role in the Prevention of Neurocognitive Impairment in Cancer Patients?

scientific article published on 07 October 2016

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

artículo científico publicado en 2020

Crystallographic binding studies with triosephosphate isomerases: Conformational changes induced by substrate and substrate-analogues ⬇️

artículo científico publicado el 27 de julio de 1992

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.

artículo científico publicado en 2016

Cyclin-Dependent Kinase Inhibition by New C-2 Alkynylated Purine Derivatives and Molecular Structure of a CDK2−Inhibitor Complex

artículo científico publicado en 2000

Cyclin-dependent kinases: inhibition and substrate recognition.

artículo científico publicado en 1999

Developments in the CCP4 molecular-graphics project

artículo científico publicado en 2004

Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition

artículo científico publicado en 2018

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System.

artículo científico publicado en 2017

Dissecting the determinants of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 inhibitor selectivity

artículo científico publicado en 2006

Distinctive properties of the hyaluronan-binding domain in the lymphatic endothelial receptor Lyve-1 and their implications for receptor function

artículo científico publicado en 2009

Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferase

artículo científico publicado en 2008

Dynamite extended: two new services to simplify protein dynamic analysis

artículo científico publicado en 2005

Dynamite: a simple way to gain insight into protein motions

artículo científico publicado en 2004

Exploiting structural principles to design cyclin-dependent kinase inhibitors.

artículo científico publicado en 2005

Expression, Purification and Crystallisation of Phosphorylase Kinase Catalytic Domain

artículo científico publicado en 1995

Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase

scientific journal article

FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation

artículo científico publicado en 2019

Generation of protein lattices by fusing proteins with matching rotational symmetry

artículo científico publicado en 2011

How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A.

artículo científico publicado en 2006

Identification and Characterization of an Irreversible Inhibitor of CDK2.

artículo científico publicado en 2015

Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach.

artículo científico publicado en 2018

Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4

scientific article published on 25 May 2019

Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate

artículo científico publicado en 2001

Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines

artículo científico publicado en 2005

Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency

artículo científico publicado en 2011

MDM2-p53 protein-protein interaction inhibitors: a-ring substituted isoindolinones.

artículo científico publicado en 2011

Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain

artículo científico publicado en 2005

Modular mutagenesis of a TIM-barrel enzyme: the crystal structure of a chimeric E. coli TIM having the eighth beta alpha-unit replaced by the equivalent unit of chicken TIM

artículo científico publicado en 1994

Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3

artículo científico publicado en 2005

Molecular cloning, characterisation and ligand-bound structure of an azoreductase from Pseudomonas aeruginosa

artículo científico publicado en 2007

Molecular motions of human cyclin-dependent kinase 2.

artículo científico publicado en 2005

Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor

artículo científico publicado en 2018

Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain

artículo científico publicado en 2003

N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2

artículo científico publicado en 2004

Overexpression of trypanosomal triosephosphate isomerase in Escherichia coli and characterisation of a dimer-interface mutant

artículo científico publicado en 1993

Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors

scientific article published on 13 March 2020

Plasticity of the TSG-6 HA-binding loop and mobility in the TSG-6-HA complex revealed by NMR and X-ray crystallography

artículo científico publicado en 2007

Presenting your structures: the CCP4mg molecular-graphics software

artículo científico publicado en 2011

Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives

artículo científico publicado en 2002

Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site

artículo científico publicado en 2010

Protein kinase inhibitors: insights into drug design from structure.

artículo científico publicado en 2004

Purification, characterization, and crystallization of an N-hydroxyarylamine O-acetyltransferase from Salmonella typhimurium

artículo científico publicado en 1998

Recent developments in cyclin-dependent kinase biochemical and structural studies.

artículo científico publicado en 2009

Replacing the (beta alpha)-unit 8 of E.coli TIM with its chicken homologue leads to a stable and active hybrid enzyme.

artículo científico publicado en 1993

Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4

artículo científico publicado en 2002

Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination

artículo científico publicado en 2006

Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A

artículo científico publicado en 2002

Structural Analysis of the Interactions Between Paxillin LD Motifs and α-Parvin

artículo científico publicado en 2008

Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation

artículo científico publicado en 2012

Structural characterization of the cyclin-dependent protein kinase family ⬇️

artículo científico publicado el 1 de agosto de 2013

Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH).

artículo científico publicado en 2017

Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase.

artículo científico publicado en 2003

Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2.

artículo científico publicado en 2002

Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis

artículo científico publicado en 2008

Structure of Mesorhizobium loti arylamine N-acetyltransferase 1.

artículo científico publicado en 2004

Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12

artículo científico publicado en 2010

Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44.

artículo científico publicado en 2004

Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinase 2

artículo científico publicado en 2007

Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2

artículo científico publicado en 2003

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

artículo científico publicado en 2002

Structure-based design of cyclin-dependent kinase inhibitors

artículo científico publicado en 2002

Structure-based discovery of cyclin-dependent protein kinase inhibitors.

artículo científico publicado en 2017

Structures of P. falciparum PfPK5 test the CDK regulation paradigm and suggest mechanisms of small molecule inhibition

artículo científico publicado en 2003

Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design

artículo científico publicado en 2008

Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction

artículo científico publicado en 2007

Structures of the Dsk2 UBL and UBA domains and their complex

artículo científico publicado en 2006

Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer Activities

artículo científico publicado en 2013

The CCP4 molecular-graphics project

artículo científico publicado en 2002

The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508

artículo científico publicado en 2012

The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b

artículo científico publicado en 2012

The Eleventh Datta Lecture. The structural basis for substrate recognition and control by protein kinases

artículo científico publicado en 1998

The crystal structure of triacylglycerol lipase from Pseudomonas glumae reveals a partially redundant catalytic aspartate

artículo científico publicado en 1993

The cyclin box fold: protein recognition in cell-cycle and transcription control

artículo científico publicado en 1997

The role of structure in kinase-targeted inhibitor design.

artículo científico publicado en 2004

The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases

artículo científico publicado en 2001

The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition

artículo científico publicado en 2006

The structural basis for control of eukaryotic protein kinases

artículo científico

The structural basis of localization and signaling by the focal adhesion targeting domain

artículo científico publicado en 2002

The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant

artículo científico publicado en 2013

The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis--an enzyme which inactivates the anti-tubercular drug, isoniazid

artículo científico publicado en 2002

Tuning the Binding Affinity and Selectivity of Perfluoroaryl-Stapled Peptides by Cysteine-Editing

scientific article published on 27 November 2018

Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product

artículo científico publicado en 1995

Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy

artículo científico publicado en 2011

Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.

artículo científico publicado en 2016

Xenopus phospho-CDK7/cyclin H expressed in baculoviral-infected insect cells

artículo científico publicado en 2001

Lista de obras de Martin Noble

4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.

8-Substituted O(6)-cyclohexylmethylguanine CDK2 inhibitors: using structure-based inhibitor design to optimize an alternative binding mode

A new crystal form of Lys48-linked diubiquitin

A structural explanation for the binding of multiple ligands by the alpha-adaptin appendage domain

Active and inactive protein kinases: structural basis for regulation

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects

An inhibitor's-eye view of the ATP-binding site of CDKs in different regulatory states.

Analysis of chemical shift changes reveals the binding modes of isoindolinone inhibitors of the MDM2-p53 interaction

Analysis of the structure of Pseudomonas glumae lipase

Announcing mandatory submission of PDBx/mmCIF format files for crystallographic depositions to the Protein Data Bank (PDB)

Arylamine N-acetyltransferases in mycobacteria

Aurora A regulates expression of AR-V7 in models of castrate resistant prostate cancer

Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design.

Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis.

CCP4i2: the new graphical user interface to the CCP4 program suite.

CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.

Catalysis and regulation

Catalytic mechanism of phosphorylase kinase probed by mutational studies

Chemical inhibitors of cyclin-dependent kinases: insights into design from X-ray crystallographic studies.

Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity

Comparison of the refined crystal structures of liganded and unliganded chicken, yeast and trypanosomal triosephosphate isomerase

Computational analyses of the surface properties of protein-protein interfaces.

Could Omega 3 Supplements Play a Role in the Prevention of Neurocognitive Impairment in Cancer Patients?

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

Crystallographic binding studies with triosephosphate isomerases: Conformational changes induced by substrate and substrate-analogues ⬇️

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.

Cyclin-Dependent Kinase Inhibition by New C-2 Alkynylated Purine Derivatives and Molecular Structure of a CDK2−Inhibitor Complex

Cyclin-dependent kinases: inhibition and substrate recognition.

Developments in the CCP4 molecular-graphics project

Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System.

Dissecting the determinants of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 inhibitor selectivity

Distinctive properties of the hyaluronan-binding domain in the lymphatic endothelial receptor Lyve-1 and their implications for receptor function

Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferase

Dynamite extended: two new services to simplify protein dynamic analysis

Dynamite: a simple way to gain insight into protein motions

Exploiting structural principles to design cyclin-dependent kinase inhibitors.

Expression, Purification and Crystallisation of Phosphorylase Kinase Catalytic Domain

Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase

FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation

Generation of protein lattices by fusing proteins with matching rotational symmetry

How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A.

Identification and Characterization of an Irreversible Inhibitor of CDK2.

Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach.

Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4

Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate

Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines

Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency

MDM2-p53 protein-protein interaction inhibitors: a-ring substituted isoindolinones.

Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain

Modular mutagenesis of a TIM-barrel enzyme: the crystal structure of a chimeric E. coli TIM having the eighth beta alpha-unit replaced by the equivalent unit of chicken TIM

Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3

Molecular cloning, characterisation and ligand-bound structure of an azoreductase from Pseudomonas aeruginosa

Molecular motions of human cyclin-dependent kinase 2.

Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor

Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain

N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2

Overexpression of trypanosomal triosephosphate isomerase in Escherichia coli and characterisation of a dimer-interface mutant

Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors

Plasticity of the TSG-6 HA-binding loop and mobility in the TSG-6-HA complex revealed by NMR and X-ray crystallography

Presenting your structures: the CCP4mg molecular-graphics software

Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives

Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site

Protein kinase inhibitors: insights into drug design from structure.

Purification, characterization, and crystallization of an N-hydroxyarylamine O-acetyltransferase from Salmonella typhimurium

Recent developments in cyclin-dependent kinase biochemical and structural studies.

Replacing the (beta alpha)-unit 8 of E.coli TIM with its chicken homologue leads to a stable and active hybrid enzyme.

Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4

Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination

Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A

Structural Analysis of the Interactions Between Paxillin LD Motifs and α-Parvin

Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation

Structural characterization of the cyclin-dependent protein kinase family ⬇️

Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH).

Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase.

Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2.

Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis

Structure of Mesorhizobium loti arylamine N-acetyltransferase 1.

Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12