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Lista de obras de Janne Lehtiö

A Mitochondrial LYR Protein Is Required for Complex I Assembly

scientific article published on 10 October 2019

A Novel Prefractionation Method Combining Protein and Peptide Isoelectric Focusing in Immobilized pH Gradient Strips ⬇️

artículo científico publicado el 24 de diciembre de 2012

A combined proteomic and transcriptomic approach shows diverging molecular mechanisms in thoracic aortic aneurysm development in patients with tricuspid- and bicuspid aortic valve

artículo científico publicado en 2012

A comparison between protein profiles of B cell subpopulations and mantle cell lymphoma cells

artículo científico publicado en 2009

A multi-step peptidolytic cascade for amino acid recovery in chloroplasts.

artículo científico publicado en 2016

A novel method for sample preparation of fresh lung cancer tissue for proteomics analysis by tumor cell enrichment and removal of blood contaminants

artículo científico publicado en 2010

Affinity prefractionation for MS-based plasma proteomics

artículo científico publicado en 2009

Alpha-amylase inhibitors selected from a combinatorial library of a cellulose binding domain scaffold

artículo científico publicado en 2000

Alterations in the membrane-associated proteome fraction of alveolar macrophages in sarcoidosis

artículo científico publicado en 2016

Annotated regions of significance of SELDI-TOF-MS spectra for detecting protein biomarkers

artículo científico publicado en 2006

Author Correction: Extracellular nanovesicles released from the commensal yeast Malassezia sympodialis are enriched in allergens and interact with cells in human skin

artículo científico publicado en 2019

Comparative proteomics reveals signature metabolisms of exponentially growing and stationary phase marine bacteria

artículo científico publicado en 2017

Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via Nuclear Factor-KappaB Signaling

artículo científico publicado en 2016

Correlating gene and protein expression data using Correlated Factor Analysis

artículo científico publicado en 2009

Defining, comparing, and improving iTRAQ quantification in mass spectrometry proteomics data

artículo científico publicado en 2013

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

artículo científico publicado en 2011

Diagnostic and prognostic role of plasma levels of two forms of cytokeratin 18 in patients with non-small-cell lung cancer

Differential protein expression profiles of cyst fluid from papillary thyroid carcinoma and benign thyroid lesions

artículo científico publicado en 2015

Differentially expressed proteins in malignant and benign adrenocortical tumors

artículo científico publicado en 2014

Direct observation of structurally encoded metal discrimination and ether bond formation in a heterodinuclear metalloprotein

artículo científico publicado en 2013

Directed immobilization of recombinant staphylococci on cotton fibers by functional display of a fungal cellulose-binding domain

scientific article published on 01 February 2001

Discrimination of pancreatic cancer and pancreatitis by LC-MS metabolomics

artículo científico publicado en 2017

Early symptoms and sensations as predictors of lung cancer: a machine learning multivariate model

artículo científico publicado en 2019

Engineering of staphylococcal surfaces for biotechnological applications

artículo científico publicado en 2002

Enhanced information output from shotgun proteomics data by protein quantification and peptide quality control (PQPQ).

artículo científico publicado en 2011

Evaluation of three principally different intact protein prefractionation methods for plasma biomarker discovery.

artículo científico publicado en 2008

Extracellular nanovesicles released from the commensal yeast Malassezia sympodialis are enriched in allergens and interact with cells in human skin.

artículo científico publicado en 2018

Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema

artículo científico publicado en 2017

Finding regions of significance in SELDI measurements for identifying protein biomarkers

artículo científico publicado en 2006

Generation of metal-binding staphylococci through surface display of combinatorially engineered cellulose-binding domains

artículo científico publicado en 2001

Genetic and epigenetic background and protein expression profiles in relation to telomerase activation in medullary thyroid carcinoma

artículo científico publicado en 2016

Genomic insights into the atopic eczema-associated skin commensal yeast Malassezia sympodialis

artículo científico publicado en 2013

Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome

artículo científico publicado en 2018

HiRIEF LC-MS enables deep proteome coverage and unbiased proteogenomics.

artículo científico publicado en 2013

Identification of chromatophore membrane protein complexes formed under different nitrogen availability conditions in Rhodospirillum rubrum

artículo científico publicado en 2011

Identifying and Assessing Interesting Subgroups in a Heterogeneous Population.

artículo científico publicado en 2015

Immunoproteomics using polyclonal antibodies and stable isotope-labeled affinity-purified recombinant proteins

artículo científico publicado en 2014

In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome

scholarly article published in Stem Cells Translational Medicine

In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome.

artículo científico publicado en 2015

In vitro oxidative inactivation of human presequence protease (hPreP).

artículo científico publicado en 2012

In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta

artículo científico publicado en 2019

Integrated molecular portrait of non-small cell lung cancers

artículo científico publicado en 2013

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines

artículo científico publicado en 2022

Investigating the applicability of antibodies generated within the human protein atlas as capture agents in immunoenrichment coupled to mass spectrometry

artículo científico publicado en 2014

Isoelectric point-based fractionation by HiRIEF coupled to LC-MS allows for in-depth quantitative analysis of the phosphoproteome

artículo científico publicado en 2017

Lung cancer proteomics, clinical and technological considerations

scientific article published on June 2010

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

artículo científico publicado en 2013

Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease

artículo científico publicado en 2013

Mass spectrometry-based plasma proteomics: state of the art and future outlook

artículo científico

Mesenchymal state of intimal cells may explain higher propensity to ascending aortic aneurysm in bicuspid aortic valves

artículo científico publicado en 2016

Metabolic reprogramming of acute lymphoblastic leukemia cells in response to glucocorticoid treatment

scientific article published on 28 August 2018

Multi-level omics analysis in a murine model of dystrophin loss and therapeutic restoration.

artículo científico publicado en 2015

Multi-omic data analysis using Galaxy.

artículo científico publicado en 2015

Multiple ionization mass spectrometry strategy used to reveal the complexity of metabolomics

artículo científico publicado en 2007

Multivariate meta-analysis of proteomics data from human prostate and colon tumours

artículo científico publicado en 2010

N(alpha)-tosyl-L-phenylalanine chloromethyl ketone induces caspase-dependent apoptosis in transformed human B cell lines with transcriptional down-regulation of anti-apoptotic HS1-associated protein X-1.

artículo científico publicado en 2009

Network enrichment analysis: extension of gene-set enrichment analysis to gene networks

artículo científico publicado en 2012

Observed peptide pI and retention time shifts as a result of post-translational modifications in multidimensional separations using narrow-range IPG-IEF.

artículo científico publicado en 2010

Optimizing Analytical Depth and Cost Efficiency of IEF-LC/MS Proteomics

artículo científico publicado en 2017

Organellar oligopeptidase (OOP) provides a complementary pathway for targeting peptide degradation in mitochondria and chloroplasts

artículo científico publicado en 2013

PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer

artículo científico publicado en 2020

Penicillin-binding protein 5 can form a homo-oligomeric complex in the inner membrane of Escherichia coli

artículo científico publicado en 2011

Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM.

artículo científico publicado en 2016

Phosphoproteomic profiling of NSCLC cells reveals that ephrin B3 regulates pro-survival signaling through Akt1-mediated phosphorylation of the EphA2 receptor.

artículo científico publicado en 2011

Pre-fractionation of archival frozen tumours for proteomics applications

artículo científico

Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia

artículo científico publicado en 2019

Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune evasion mechanisms

artículo científico publicado en 2021

Proteogenomics produces comprehensive and highly accurate protein-coding gene annotation in a complete genome assembly of Malassezia sympodialis

artículo científico publicado en 2017

Proteome screening of pleural effusions identifies galectin 1 as a diagnostic biomarker and highlights several prognostic biomarkers for malignant mesothelioma

artículo científico publicado en 2013

Proteomic data analysis workflow for discovery of candidate biomarker peaks predictive of clinical outcome for patients with acute myeloid leukemia

artículo científico publicado en 2008

Proteomic profiling of follicular and papillary thyroid tumors

artículo científico publicado en 2012

Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway.

artículo científico publicado en 2012

Proteomic study of thyroid tumors reveals frequent up-regulation of the Ca2+ -binding protein S100A6 in papillary thyroid carcinoma

artículo científico publicado en 2010

Proteomics Analysis Reveals Distinct Corona Composition on Magnetic Nanoparticles with Different Surface Coatings: Implications for Interactions with Primary Human Macrophages

artículo científico

Proteomics Suggests a Role for APC-Survivin in Response to Somatostatin Analog Treatment of Neuroendocrine Tumors

artículo científico publicado en 2016

Proteomics analysis of melanoma metastases: association between S100A13 expression and chemotherapy resistance.

artículo científico publicado en 2014

Proteomics and pathway analysis identifies JNK signaling as critical for high linear energy transfer radiation-induced apoptosis in non-small lung cancer cells

artículo científico publicado en 2009

Proteomics in clinical prostate research

artículo científico publicado en 2007

Proteomics profiling identify CAPS as a potential predictive marker of tamoxifen resistance in estrogen receptor positive breast cancer

artículo científico publicado en 2015

Quantitative accuracy in mass spectrometry based proteomics of complex samples: the impact of labeling and precursor interference

artículo científico publicado en 2013

Quantitative membrane proteomics applying narrow range peptide isoelectric focusing for studies of small cell lung cancer resistance mechanisms

artículo científico publicado en 2008

Quantitative proteomics profiling of primary lung adenocarcinoma tumors reveals functional perturbations in tumor metabolism

artículo científico publicado en 2013

RIFINs are adhesins implicated in severe Plasmodium falciparum malaria

artículo científico publicado en 2015

Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer

artículo científico publicado en 2013

Rewired metabolism in drug-resistant leukemia cells: a metabolic switch hallmarked by reduced dependence on exogenous glutamine

artículo científico publicado en 2015

Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy

scientific article published on 17 January 2020

Robustness and accuracy of high speed LC-MS separations for global peptide quantitation and biomarker discovery

artículo científico publicado en 2009

S100A4 interacts with p53 in the nucleus and promotes p53 degradation

artículo científico publicado en 2013

Secretome protein signature of human gastrointestinal stromal tumor cells

artículo científico publicado en 2015

Selectivity analysis of single binder assays used in plasma protein profiling

artículo científico publicado en 2013

Serum-free culture alters the quantity and protein composition of neuroblastoma-derived extracellular vesicles

artículo científico publicado en 2015

Significantly higher levels of vascular endothelial growth factor (VEGF) and shorter survival times for patients with primary operable triple-negative breast cancer.

artículo científico publicado en 2009

Single base resolution analysis of 5-hydroxymethylcytosine in 188 human genes: implications for hepatic gene expression

artículo científico publicado en 2016

Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis

artículo científico publicado en 2018

SpliceVista, a tool for splice variant identification and visualization in shotgun proteomics data

artículo científico publicado en 2014

Splicing of platelet resident pre-mRNAs upon activation by physiological stimuli results in functionally relevant proteome modifications.

artículo científico publicado en 2018

Stable linker peptides for a cellulose-binding domain-lipase fusion protein expressed in Pichia pastoris

artículo científico publicado en 2001

Structural Basis for Oxygen Activation at a Heterodinuclear Manganese/Iron Cofactor

artículo científico publicado en 2015

Subcellular proteomics

artículo científico

Support systems to guide clinical decision-making in precision oncology: The Cancer Core Europe Molecular Tumor Board Portal

artículo científico publicado en 2020

Systematic analysis of native membrane protein complexes in Escherichia coli.

artículo científico publicado en 2011

Systems biology of SLE: biochemical characterisation of subgroups within sle for improved diagnosis and treatment

Thapsigargin down-regulates protein levels of GRP78/BiP in INS-1E cells

scientific journal article

The binding specificity and affinity determinants of family 1 and family 3 cellulose binding modules

artículo científico publicado en 2003

The viral protein corona directs viral pathogenesis and amyloid aggregation

artículo científico publicado en 2019

Trichoderma reesei cellobiohydrolase I with an endoglucanase cellulose-binding domain: action on bacterial microcrystalline cellulose

artículo científico publicado en 1997

Tumor expression of S100A6 correlates with survival of patients with stage I non-small-cell lung cancer

artículo científico publicado en 2008

Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes

artículo científico publicado en 2012

Tumour suppressor p16(INK4a) - anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model.

artículo científico publicado en 2012

Tuning Metabolome Coverage in Reversed Phase LC-MS Metabolomics of MeOH Extracted Samples Using the Reconstitution Solvent Composition

artículo científico publicado en 2017

Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties

artículo científico publicado en 2015

Up-regulation, modification, and translocation of S100A6 induced by exposure to ionizing radiation revealed by proteomics profiling

artículo científico publicado en 2007

Use of narrow-range peptide IEF to improve detection of lung adenocarcinoma markers in plasma and pleural effusion

artículo científico publicado en 2009

Validation and development of MTH1 inhibitors for treatment of cancer.

artículo científico publicado en 2016

Vascular endothelial growth factor receptor 2 and downstream p38 mitogen-activated protein kinase are possible candidate markers of intrinsic resistance to adjuvant endocrine treatment in steroid receptor positive breast cancer.

artículo científico publicado en 2010

iTRAQ compatibility of peptide immobilized pH gradient isoelectric focusing

scholarly article by Johan Lengqvist published in June 2007

p53 is involved in clearance of ionizing radiation-induced RAD51 foci in a human colon cancer cell line

artículo científico publicado en 2006

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