Lista de obras - Dora Brites - Dominio Público Uruguay

A link between hyperbilirubinemia, oxidative stress and injury to neocortical synaptosomes

artículo científico publicado en 2004

A look at tricellulin and its role in tight junction formation and maintenance

artículo científico

Aging confers different sensitivity to the neurotoxic properties of unconjugated bilirubin.

artículo científico publicado en 2002

Alterations of erythrocyte morphology and lipid composition by hyperbilirubinemia

article

Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation

artículo científico publicado en 2014

Apoptosis and impairment of neurite network by short exposure of immature rat cortical neurons to unconjugated bilirubin increase with cell differentiation and are additionally enhanced by an inflammatory stimulus

artículo científico publicado en 2007

Apoptotic cell death does not parallel other indicators of liver damage in chronic hepatitis C patients.

artículo científico publicado en 2000

Assessment of bilirubin toxicity to erythrocytes. Implication in neonatal jaundice management

article

Astrocyte reactivity to unconjugated bilirubin requires TNF-α and IL-1β receptor signaling pathways

scientific journal article

Automated analysis of NeuronJ tracing data

artículo científico publicado en 2009

Axonal elongation and dendritic branching is enhanced by adenosine A2A receptors activation in cerebral cortical neurons

artículo científico publicado en 2015

Beneficial effect of ursodeoxycholic acid on alterations induced by cholestasis of pregnancy in bile acid transport across the human placenta.

artículo científico publicado en 1998

Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment

artículo científico publicado en 1999

Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis

artículo científico publicado en 2009

Bilirubin directly disrupts membrane lipid polarity and fluidity, protein order, and redox status in rat mitochondria.

artículo científico publicado en 2002

Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons.

artículo científico publicado en 2002

Bilirubin induces loss of membrane lipids and exposure of phosphatidylserine in human erythrocytes

artículo científico publicado en 2002

Bilirubin injury to neurons and glial cells: new players, novel targets, and newer insights

artículo científico publicado en 2011

Bilirubin injury to neurons: contribution of oxidative stress and rescue by glycoursodeoxycholic acid

artículo científico publicado en 2007

Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid.

artículo científico publicado en 2009

Bilirubin toxicity to human erythrocytes: a review

artículo científico publicado en 2006

Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid.

artículo científico publicado en 2001

Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state

artículo científico publicado en 2006

Bilirubin-induced inflammatory response, glutamate release, and cell death in rat cortical astrocytes are enhanced in younger cells

artículo científico publicado en 2005

Bilirubin-induced neural impairment: a special focus on myelination, age-related windows of susceptibility and associated co-morbidities

artículo científico

Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation

artículo científico publicado en 2016

Biological risks for neurological abnormalities associated with hyperbilirubinemia.

artículo científico publicado en 2009

Blood-brain barrier and bilirubin: clinical aspects and experimental data

artículo científico publicado en 2014

Blood-brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study

artículo científico publicado en 2017

Cerebellar axon/myelin loss, angiogenic sprouting, and neuronal increase of vascular endothelial growth factor in a preterm infant with kernicterus

artículo científico publicado en 2011

Contribution of inflammatory processes to nerve cell toxicity by bilirubin and efficacy of potential therapeutic agents

scientific article published on January 2009

Correction of maternal serum bile acid profile during ursodeoxycholic acid therapy in cholestasis of pregnancy

artículo científico publicado en 1998

Corrigendum to “A look at tricellulin and its role in tight junction formation and maintenance” [Eur. J. Cell Biol. 90 (2011) 787–796]

scholarly article published in European Journal of Cell Biology

Cortical Neurotoxic Astrocytes with Early ALS Pathology and miR-146a Deficit Replicate Gliosis Markers of Symptomatic SOD1G93A Mouse Model

artículo científico publicado en 2018

Cross-talk between neurons and astrocytes in response to bilirubin: adverse secondary impacts

artículo científico publicado en 2014

Cross-talk between neurons and astrocytes in response to bilirubin: early beneficial effects

artículo científico publicado en 2013

Cytokine production, glutamate release and cell death in rat cultured astrocytes treated with unconjugated bilirubin and LPS.

artículo científico publicado en 2004

Development of a high throughput methodology to screen cathinones' toxicological impact

artículo científico publicado en 2019

Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation.

artículo científico publicado en 2016

Directing mouse embryonic neurosphere differentiation toward an enriched neuronal population

artículo científico publicado en 2014

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

artículo científico publicado en 2017

Dynamics of neuron-glia interplay upon exposure to unconjugated bilirubin

artículo científico publicado en 2011

ER stress, mitochondrial dysfunction and calpain/JNK activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin

artículo científico publicado en 2012

Effect of acidosis on bilirubin-induced toxicity to human erythrocytes

artículo científico publicado en 2003

Effect of bilirubin on erythrocyte shape and haemolysis, under hypotonic, aggregating or non-aggregating conditions, and correlation with cell age ⬇️

artículo científico publicado el 1 de julio de 1997

Effect of bilirubin on toxicity induced by trifluoperazine, dibucaine and praziquantel to erythrocytes

artículo científico publicado en 2001

Effects of bilirubin molecular species on membrane dynamic properties of human erythrocyte membranes: a spin label electron paramagnetic resonance spectroscopy study

artículo científico publicado en 2001

Elevated levels of bile acids in colostrum of patients with cholestasis of pregnancy are decreased following ursodeoxycholic acid therapy

artículo científico publicado en 1998

Elevated levels of bilirubin and long-term exposure impair human brain microvascular endothelial cell integrity

artículo científico publicado en 2011

Endocytosis in rat cultured astrocytes is inhibited by unconjugated bilirubin

artículo científico publicado en 2001

Erythropoietin reduces acute lung injury and multiple organ failure/dysfunction associated to a scald-burn inflammatory injury in the rat.

artículo científico publicado en 2015

Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier

artículo científico publicado en 2010

Evidence of tricellulin expression by immune cells, particularly microglia

article

Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype.

artículo científico publicado en 2017

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization

artículo científico publicado en 2016

Exposure to lipopolysaccharide and/or unconjugated bilirubin impair the integrity and function of brain microvascular endothelial cells

artículo científico publicado en 2012

Features of bilirubin-induced reactive microglia: from phagocytosis to inflammation.

artículo científico publicado en 2010

Frailty in mouse ageing: A conceptual approach

artículo científico publicado en 2016

Glio-vascular changes during ageing in wild-type and Alzheimer's disease-like APP/PS1 mice.

artículo científico publicado en 2015

Glycoursodeoxycholic Acid and Interleukin-10 Modulate the Reactivity of Rat Cortical Astrocytes to Unconjugated Bilirubin

artículo científico publicado en 2007

Glycoursodeoxycholic acid reduces matrix metalloproteinase-9 and caspase-9 activation in a cellular model of superoxide dismutase-1 neurodegeneration

artículo científico publicado en 2014

Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study

artículo científico publicado en 2015

Identification of a novel deletion in UDP-glucuronosyltransferase gene in a patient with Crigler-Najjar syndrome type I.

artículo científico publicado en 2009

Impaired oligodendrogenesis and myelination by elevated S100B levels during neurodevelopment

artículo científico publicado en 2017

Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin

artículo científico publicado en 2006

Influence of hypoxia and ischemia preconditioning on bilirubin damage to astrocytes

artículo científico publicado en 2007

Inhibition of Glutamate Uptake by Unconjugated Bilirubin in Cultured Cortical Rat Astrocytes: Role of Concentration and pH

artículo científico publicado en 1999

Inhibition of glycogen synthase kinase-3β attenuates organ injury and dysfunction associated with liver ischemia-reperfusion and thermal injury in the rat.

artículo científico publicado en 2015

Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches ⬇️

artículo científico publicado el 26 de mayo de 2010

MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes

artículo científico publicado en 2007

Membrane effects of trifluoperazine, dibucaine and praziquantel on human erythrocytes

artículo científico publicado en 2000

Membrane structural changes support the involvement of mitochondria in the bile salt-induced apoptosis of rat hepatocytes.

artículo científico publicado en 2002

Microglia centered pathogenesis in ALS: insights in cell interconnectivity

artículo científico publicado en 2014

Microglia change from a reactive to an age-like phenotype with the time in culture

artículo científico publicado en 2014

Molecular basis of bilirubin-induced neurotoxicity

artículo científico publicado en 2004

N-methyl-aspartate receptor and neuronal nitric oxide synthase activation mediate bilirubin-induced neurotoxicity

artículo científico publicado en 2010

Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10.

artículo científico publicado en 2012

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

artículo científico publicado en 2015

Neuroprotective effects of erythropoietin pretreatment in a rodent model of transient middle cerebral artery occlusion

artículo científico publicado en 2014

Neurotoxic Astrocytes Directly Converted from Sporadic and Familial ALS Patient Fibroblasts Reveal Signature Diversities and miR-146a Theragnostic Potential in Specific Subtypes

artículo científico publicado en 2022

Neurovascular unit: a focus on pericytes

artículo científico

New autopsy findings in different brain regions of a preterm neonate with kernicterus: neurovascular alterations and up-regulation of efflux transporters

artículo científico publicado en 2013

Oligodendrocyte Development and Myelination in Neurodevelopment: Molecular Mechanisms in Health and Disease

artículo científico

Phenotypic Effects of Wild-Type and Mutant SOD1 Expression in N9 Murine Microglia at Steady State, Inflammatory and Immunomodulatory Conditions

artículo científico publicado en 2019

Polyphenols journey through blood-brain barrier towards neuronal protection.

artículo científico publicado en 2017

Potential for brain accessibility and analysis of stability of selected flavonoids in relation to neuroprotection in vitro.

artículo científico publicado en 2016

Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin.

artículo científico publicado en 2011

Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat.

artículo científico publicado en 2016

Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis

article

Rat cerebellar slice cultures exposed to bilirubin evidence reactive gliosis, excitotoxicity and impaired myelinogenesis that is prevented by AMPA and TNF-α inhibitors

scientific journal article

Rat cultured neuronal and glial cells respond differently to toxicity of unconjugated bilirubin

artículo científico publicado en 2002

Recovery of Depleted miR-146a in ALS Cortical Astrocytes Reverts Cell Aberrancies and Prevents Paracrine Pathogenicity on Microglia and Motor Neurons

artículo científico publicado en 2021

Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia

artículo científico publicado en 2015

Regulatory function of microRNAs in microglia

artículo científico publicado en 2020

Relevance of serum bile acid profile in the diagnosis of intrahepatic cholestasis of pregnancy in an high incidence area: Portugal.

artículo científico publicado en 1998

Response to the Letter to the Editor by Mamdouha Ahdab-Barmada and Jon F. Watchko

scientific article published on 17 February 2014

Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin

scientific journal article

S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis.

artículo científico publicado en 2015

Secretome from SH-SY5Y APP Swe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling

article by Adelaide Fernandes et al published May 2018 in Biochimie

Selective vulnerability of rat brain regions to unconjugated bilirubin

artículo científico publicado en 2011

Synthesis and friedländer reactions of 5-amino-4-cyano-1,3-oxazoles

Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects

artículo científico publicado en 2015

Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference?

artículo científico publicado en 2016

Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability

scientific article published on 22 March 2019

The Sedentary Lifestyle and Masticatory Dysfunction: Time to Review the Contribution to Age-Associated Cognitive Decline and Astrocyte Morphotypes in the Dentate Gyrus

artículo científico publicado en 2022

The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation

artículo científico publicado en 2012

Time-dependent dual effects of high levels of unconjugated bilirubin on the human blood-brain barrier lining

artículo científico publicado en 2012

Tricellulin expression in brain endothelial and neural cells

artículo científico publicado en 2012

Unconjugated bilirubin activates and damages microglia

artículo científico publicado en 2006

Unconjugated bilirubin differentially affects the redox status of neuronal and astroglial cells

artículo científico publicado en 2007

Unconjugated bilirubin restricts oligodendrocyte differentiation and axonal myelination

artículo científico publicado en 2012

Unusual case of severe cholestasis of pregnancy with early onset, improved by ursodeoxycholic acid administration

artículo científico publicado en 1998

Lista de obras de Dora Brites

A link between hyperbilirubinemia, oxidative stress and injury to neocortical synaptosomes

A look at tricellulin and its role in tight junction formation and maintenance

Aging confers different sensitivity to the neurotoxic properties of unconjugated bilirubin.

Alterations of erythrocyte morphology and lipid composition by hyperbilirubinemia

Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation

Apoptosis and impairment of neurite network by short exposure of immature rat cortical neurons to unconjugated bilirubin increase with cell differentiation and are additionally enhanced by an inflammatory stimulus

Apoptotic cell death does not parallel other indicators of liver damage in chronic hepatitis C patients.

Assessment of bilirubin toxicity to erythrocytes. Implication in neonatal jaundice management

Astrocyte reactivity to unconjugated bilirubin requires TNF-α and IL-1β receptor signaling pathways

Automated analysis of NeuronJ tracing data

Axonal elongation and dendritic branching is enhanced by adenosine A2A receptors activation in cerebral cortical neurons

Beneficial effect of ursodeoxycholic acid on alterations induced by cholestasis of pregnancy in bile acid transport across the human placenta.

Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment

Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis

Bilirubin directly disrupts membrane lipid polarity and fluidity, protein order, and redox status in rat mitochondria.

Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons.

Bilirubin induces loss of membrane lipids and exposure of phosphatidylserine in human erythrocytes

Bilirubin injury to neurons and glial cells: new players, novel targets, and newer insights

Bilirubin injury to neurons: contribution of oxidative stress and rescue by glycoursodeoxycholic acid

Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid.

Bilirubin toxicity to human erythrocytes: a review

Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid.

Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state

Bilirubin-induced inflammatory response, glutamate release, and cell death in rat cortical astrocytes are enhanced in younger cells

Bilirubin-induced neural impairment: a special focus on myelination, age-related windows of susceptibility and associated co-morbidities

Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation

Biological risks for neurological abnormalities associated with hyperbilirubinemia.

Blood-brain barrier and bilirubin: clinical aspects and experimental data

Blood-brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study

Cerebellar axon/myelin loss, angiogenic sprouting, and neuronal increase of vascular endothelial growth factor in a preterm infant with kernicterus

Contribution of inflammatory processes to nerve cell toxicity by bilirubin and efficacy of potential therapeutic agents

Correction of maternal serum bile acid profile during ursodeoxycholic acid therapy in cholestasis of pregnancy

Corrigendum to “A look at tricellulin and its role in tight junction formation and maintenance” [Eur. J. Cell Biol. 90 (2011) 787–796]

Cortical Neurotoxic Astrocytes with Early ALS Pathology and miR-146a Deficit Replicate Gliosis Markers of Symptomatic SOD1G93A Mouse Model

Cross-talk between neurons and astrocytes in response to bilirubin: adverse secondary impacts

Cross-talk between neurons and astrocytes in response to bilirubin: early beneficial effects

Cytokine production, glutamate release and cell death in rat cultured astrocytes treated with unconjugated bilirubin and LPS.

Development of a high throughput methodology to screen cathinones' toxicological impact

Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation.

Directing mouse embryonic neurosphere differentiation toward an enriched neuronal population

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

Dynamics of neuron-glia interplay upon exposure to unconjugated bilirubin

ER stress, mitochondrial dysfunction and calpain/JNK activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin

Effect of acidosis on bilirubin-induced toxicity to human erythrocytes

Effect of bilirubin on erythrocyte shape and haemolysis, under hypotonic, aggregating or non-aggregating conditions, and correlation with cell age ⬇️

Effect of bilirubin on toxicity induced by trifluoperazine, dibucaine and praziquantel to erythrocytes

Effects of bilirubin molecular species on membrane dynamic properties of human erythrocyte membranes: a spin label electron paramagnetic resonance spectroscopy study

Elevated levels of bile acids in colostrum of patients with cholestasis of pregnancy are decreased following ursodeoxycholic acid therapy

Elevated levels of bilirubin and long-term exposure impair human brain microvascular endothelial cell integrity

Endocytosis in rat cultured astrocytes is inhibited by unconjugated bilirubin

Erythropoietin reduces acute lung injury and multiple organ failure/dysfunction associated to a scald-burn inflammatory injury in the rat.

Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier

Evidence of tricellulin expression by immune cells, particularly microglia

Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype.

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization

Exposure to lipopolysaccharide and/or unconjugated bilirubin impair the integrity and function of brain microvascular endothelial cells

Features of bilirubin-induced reactive microglia: from phagocytosis to inflammation.

Frailty in mouse ageing: A conceptual approach

Glio-vascular changes during ageing in wild-type and Alzheimer's disease-like APP/PS1 mice.

Glycoursodeoxycholic Acid and Interleukin-10 Modulate the Reactivity of Rat Cortical Astrocytes to Unconjugated Bilirubin

Glycoursodeoxycholic acid reduces matrix metalloproteinase-9 and caspase-9 activation in a cellular model of superoxide dismutase-1 neurodegeneration

Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study

Identification of a novel deletion in UDP-glucuronosyltransferase gene in a patient with Crigler-Najjar syndrome type I.

Impaired oligodendrogenesis and myelination by elevated S100B levels during neurodevelopment

Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin

Influence of hypoxia and ischemia preconditioning on bilirubin damage to astrocytes

Inhibition of Glutamate Uptake by Unconjugated Bilirubin in Cultured Cortical Rat Astrocytes: Role of Concentration and pH

Inhibition of glycogen synthase kinase-3β attenuates organ injury and dysfunction associated with liver ischemia-reperfusion and thermal injury in the rat.

Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches ⬇️

MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes

Membrane effects of trifluoperazine, dibucaine and praziquantel on human erythrocytes

Membrane structural changes support the involvement of mitochondria in the bile salt-induced apoptosis of rat hepatocytes.

Microglia centered pathogenesis in ALS: insights in cell interconnectivity

Microglia change from a reactive to an age-like phenotype with the time in culture

Molecular basis of bilirubin-induced neurotoxicity

N-methyl-aspartate receptor and neuronal nitric oxide synthase activation mediate bilirubin-induced neurotoxicity

Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10.

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

Neuroprotective effects of erythropoietin pretreatment in a rodent model of transient middle cerebral artery occlusion