Lista de obras - Alexandra Trkola - Dominio Público Uruguay

A Plea for Justice for Jailed Medical Workers

artículo científico publicado en 2006

A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

artículo científico publicado en 2000

A cell line-based neutralization assay for primary human immunodeficiency virus type 1 isolates that use either the CCR5 or the CXCR4 coreceptor.

artículo científico publicado en 1999

A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1 ⬇️

artículo científico publicado el 1 de noviembre de 1993

A luciferase-reporter gene-expressing T-cell line facilitates neutralization and drug-sensitivity assays that use either R5 or X4 strains of human immunodeficiency virus type 1.

artículo científico publicado en 2001

Amino-Terminal Substitutions in the CCR5 Coreceptor Impair gp120 Binding and Human Immunodeficiency Virus Type 1 Entry ⬇️

artículo científico publicado el 1 de enero de 1998

Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry.

artículo científico publicado en 2003

Antibodies for HIV treatment and prevention: window of opportunity?

artículo científico publicado en 2008

Antibody responses in primary HIV-1 infection.

artículo científico publicado en 2008

Association between specific HIV-1 Env traits and virologic control in vivo

artículo científico publicado en 2009

Astrovirus infection in hospitalized infants with severe combined immunodeficiency after allogeneic hematopoietic stem cell transplantation.

artículo científico publicado en 2011

Broadly neutralizing antibodies: What is needed to move from a rare event in HIV-1 infection to vaccine efficacy?

scholarly article by Harini Subbaraman published in July 2018

CD4 occupancy triggers sequential pre-fusion conformational states of the HIV-1 envelope trimer with relevance for broadly neutralizing antibody activity

article

CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.

artículo científico publicado en 1996

CD4-specific designed ankyrin repeat proteins are novel potent HIV entry inhibitors with unique characteristics

artículo científico publicado en 2008

Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-Dependent

artículo científico publicado en 2015

Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies

artículo científico publicado en 2012

Co-receptors for HIV-1 entry

artículo científico publicado en 1997

Complement dependent trapping of infectious HIV in human lymphoid tissues

article

Complement lysis activity in autologous plasma is associated with lower viral loads during the acute phase of HIV-1 infection

artículo científico publicado en 2006

Conformation of the native HIV-1 envelope protein raises questions for vaccine design

scientific article published on 01 April 2019

Conformation-dependent recognition of HIV Gp120 by DARPins provides novel possibilities to develop distinct HIV entry inhibitors

artículo científico publicado en 2012

Conformation-dependent recognition of HIV gp120 by designed ankyrin repeat proteins provides access to novel HIV entry inhibitors

artículo científico publicado en 2013

Correction to: Optimization and validation of sample preparation for metagenomic sequencing of viruses in clinical samples

artículo científico publicado en 2017

Correlates of broadly neutralizing antibody development

artículo científico publicado en 2019

Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG.

artículo científico publicado en 1995

Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies

article

Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality.

artículo científico publicado en 2017

Determinants of HIV-1 broadly neutralizing antibody induction.

artículo científico publicado en 2016

Development of a high-throughput bead based assay system to measure HIV-1 specific immune signatures in clinical samples

artículo científico publicado en 2017

Different infectivity of HIV-1 strains is linked to number of envelope trimers required for entry

artículo científico publicado en 2015

Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization

artículo científico publicado en 2021

Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity

artículo científico publicado en 2018

Divergent effects of cell environment on HIV entry inhibitor activity.

artículo científico publicado en 2009

Estimating the stoichiometry of human immunodeficiency virus entry

artículo científico publicado en 2008

Exclusive Transduction of Human CD4+ T Cells upon Systemic Delivery of CD4-Targeted Lentiviral Vectors

artículo científico publicado en 2015

Full-length haplotype reconstruction to infer the structure of heterogeneous virus populations

artículo científico publicado en 2014

Generation of Human Monoclonal Antibodies against HIV-1 Proteins; Electrofusion and Epstein-Barr Virus Transformation for Peripheral Blood Lymphocyte Immortalization ⬇️

artículo científico publicado el 1 de abril de 1994

Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines.

artículo científico publicado en 1998

HIV RNA in plasma rebounds within days during structured treatment interruptions

artículo científico publicado en 2003

HIV rebounds from latently infected cells, rather than from continuing low-level replication

artículo científico publicado en 2008

HIV sensitivity to neutralization is determined by target and virus producer cell properties

artículo científico publicado en 2009

HIV type 1 coreceptors, neutralization serotypes, and vaccine development

artículo científico publicado en 1997

HIV vaccines: an attainable goal? ⬇️

artículo científico publicado el 2 de marzo de 2012

HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

artículo científico publicado en 2002

HIV-1 replication activates CD4+ T cells with specificities for persistent herpes viruses

artículo científico publicado en 2010

HIV-1 resistance to neutralizing antibodies: Determination of antibody concentrations leading to escape mutant evolution

artículo científico publicado en 2015

HIV-1 superinfection in an HIV-2-infected woman with subsequent control of HIV-1 plasma viremia

artículo científico publicado en 2009

HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy

artículo científico publicado en 1999

HIV-host interactions: vital to the virus and key to its inhibition.

artículo científico publicado en 2004

HIV: Potency needs constancy

artículo científico publicado en 2014

HIV–host interactions: vital to the virus and key to its inhibition☆

article

High Efficacy of Saliva in Detecting SARS-CoV-2 by RT-PCR in Adults and Children

High-throughput sequencing of human immunoglobulin variable regions with subtype identification.

artículo científico publicado en 2014

Human immunodeficiency virus type 1 fitness is a determining factor in viral rebound and set point in chronic infection

artículo científico publicado en 2003

Humoral immunity to HIV-1: kinetics of antibody responses in chronic infection reflects capacity of immune system to improve viral set point

artículo científico publicado en 2004

Humoral immunity to HIV-1: neutralization and beyond.

artículo científico publicado en 2007

Immune senescence: relative contributions of age and cytomegalovirus infection

artículo científico publicado en 2012

In vivo and in vitro escape from neutralizing antibodies 2G12, 2F5, and 4E10.

artículo científico publicado en 2007

In vivo binding and retention of CD4-specific DARPin 57.2 in macaques

artículo científico publicado en 2010

In vivo efficacy of human immunodeficiency virus neutralizing antibodies: estimates for protective titers

artículo científico publicado en 2007

Influence of time to diagnosis of severe influenza on antibiotic use, length of stay, isolation precautions, and mortality: a retrospective study

artículo científico publicado en 2017

Interaction of the CC-chemokine RANTES with glycosaminoglycans activates a p44/p42 mitogen-activated protein kinase-dependent signaling pathway and enhances human immunodeficiency virus type 1 infectivity

artículo científico publicado en 2002

Interaction of the gp120 V1V2 loop with a neighboring gp120 unit shields the HIV envelope trimer against cross-neutralizing antibodies

artículo científico publicado en 2011

Interactions of polyclonal and monoclonal anti-glycoprotein 120 antibodies with oligomeric glycoprotein 120-glycoprotein 41 complexes of a primary HIV type 1 isolate: relationship to neutralization

artículo científico publicado en 1998

Long-term multiple-dose pharmacokinetics of human monoclonal antibodies (MAbs) against human immunodeficiency virus type 1 envelope gp120 (MAb 2G12) and gp41 (MAbs 4E10 and 2F5).

artículo científico publicado en 2006

Loss of Viral Control in Early HIV‐1 Infection Is Temporally Associated with Sequential Escape from CD8+T Cell Responses and Decrease in HIV–1–Specific CD4+and CD8+T Cell Frequencies

article

Low human immunodeficiency virus envelope diversity correlates with low in vitro replication capacity and predicts spontaneous control of plasma viremia after treatment interruptions

artículo científico publicado en 2005

Lower Broadly Neutralizing Antibody Responses in Female Versus Male HIV-1 Infected Injecting Drug Users. ⬇️

artículo científico publicado en 2019

MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1. ⬇️

artículo científico publicado en 2011

Mathematical models: a key to understanding HIV envelope interactions?

artículo científico publicado en 2013

Metagenomic Virome Sequencing in Living Donor and Recipient Kidney Transplant Pairs Revealed JC Polyomavirus Transmission

artículo científico publicado en 2019

Metagenomic sequencing complements routine diagnostics in identifying viral pathogens in lung transplant recipients with unknown etiology of respiratory infection

artículo científico publicado en 2017

MinVar: A rapid and versatile tool for HIV-1 drug resistance genotyping by deep sequencing

artículo científico publicado en 2016

Mucosal model of immunization against human immunodeficiency virus type 1 with a chimeric influenza virus

artículo científico publicado en 1995

Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity

artículo científico publicado en 2021

Neutralization sensitivity of human immunodeficiency virus type 1 primary isolates to antibodies and CD4-based reagents is independent of coreceptor usage.

artículo científico publicado en 1998

OMIP-047: High-Dimensional phenotypic characterization of B cells.

artículo científico publicado en 2018

Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors

artículo científico publicado en 2015

Optimization and validation of sample preparation for metagenomic sequencing of viruses in clinical samples

artículo científico publicado en 2017

Partial rescue of V1V2 mutant infectivity by HIV-1 cell-cell transmission supports the domain's exceptional capacity for sequence variation

artículo científico publicado en 2014

Peptidomimetic inhibitors targeting the CCR5-binding site on the human immunodeficiency virus type-1 gp120 glycoprotein complexed to CD4.

artículo científico publicado en 2010

Persistent mammalian orthoreovirus, coxsackievirus and adenovirus co-infection in a child with a primary immunodeficiency detected by metagenomic sequencing: a case report.

artículo científico publicado en 2018

Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage.

artículo científico publicado en 2018

Positive in vivo selection of the HIV-1 envelope protein gp120 occurs at surface-exposed regions

artículo científico publicado en 2007

Potent human immunodeficiency virus-neutralizing and complement lysis activities of antibodies are not obligatorily linked

artículo científico publicado en 2008

Potent, broad-spectrum inhibition of human immunodeficiency virus type 1 by the CCR5 monoclonal antibody PRO 140

artículo científico publicado en 2001

Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters.

artículo científico publicado en 2017

Quantification of infectious HIV-1 plasma viral load using a boosted in vitro infection protocol

artículo científico publicado en 2004

RANTES (CCL5) uses the proteoglycan CD44 as an auxiliary receptor to mediate cellular activation signals and HIV-1 enhancement

article

Reduced Relative Sensitivity of the Elecsys SARS-CoV-2 Antigen Assay in Saliva Compared to Nasopharyngeal Swabs

scholarly article

Reply to correspondence 'Conserved signatures indicate HIV-1 transmission is under strong selection and thus is not a "stochastic" process' by Gonzalez et al., Retrovirology 2017.

artículo científico publicado en 2017

Residual cell-associated unspliced HIV-1 RNA in peripheral blood of patients on potent antiretroviral therapy represents intracellular transcripts.

artículo científico publicado en 2002

Restricted antigenic variability of the epitope recognized by the neutralizing gp41 antibody 2F5

artículo científico publicado en 1996

Scale-up of recombinant protein purification by hydrophobic interaction chromatography

artículo científico publicado en 1992

Shifts in cell-associated HIV-1 RNA but not in episomal HIV-1 DNA correlate with new cycles of HIV-1 infection in vivo

artículo científico publicado en 2003

Single-dose safety, pharmacology, and antiviral activity of the human immunodeficiency virus (HIV) type 1 entry inhibitor PRO 542 in HIV-infected adults

artículo científico publicado en 2000

Synthetic virus-like particles and conformationally constrained peptidomimetics in vaccine design

artículo científico publicado en 2011

Tailored enrichment strategy detects low abundant small noncoding RNAs in HIV-1 infected cells

artículo científico publicado en 2012

The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity

artículo científico publicado en 2001

The CCR5 and CXCR4 coreceptors are both used by human immunodeficiency virus type 1 primary isolates from subtype C.

artículo científico publicado en 2003

The HIV-1 Entry Process: A Stoichiometric View

artículo científico

The TransFLUas influenza transmission study in acute healthcare - recruitment rates and protocol adherence in healthcare workers and inpatients

article

The differential sensitivity of human and rhesus macaque CCR5 to small-molecule inhibitors of human immunodeficiency virus type 1 entry is explained by a single amino acid difference and suggests a mechanism of action for these inhibitors

artículo científico publicado en 2004

The effect of highly active antiretroviral therapy on binding and neutralizing antibody responses to human immunodeficiency virus type 1 infection

artículo científico publicado en 2000

The orientation of HIV-1 gp120 binding to the CD4 receptor differentially modulates CD4+ T cell activation

artículo científico publicado en 2014

Therapeutic antibodies in HIV treatment--classical approaches to novel advances

artículo científico publicado en 2010

Tracing HIV-1 strains that imprint broadly neutralizing antibody responses

artículo científico publicado en 2018

Tracing HIV-1 transmission: envelope traits of HIV-1 transmitter and recipient pairs

artículo científico publicado en 2016

Unbiased metagenomic sequencing complements specific routine diagnostic methods and increases chances to detect rare viral strains.

artículo científico publicado en 2015

Use of alternate coreceptors on primary cells by two HIV-1 isolates

artículo científico publicado en 2005

Virus isolates during acute and chronic human immunodeficiency virus type 1 infection show distinct patterns of sensitivity to entry inhibitors

artículo científico publicado en 2005

Widespread B cell perturbations in HIV-1 infection afflict naive and marginal zone B cells

scientific article published on 20 June 2019

Lista de obras de Alexandra Trkola

A Plea for Justice for Jailed Medical Workers

A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

A cell line-based neutralization assay for primary human immunodeficiency virus type 1 isolates that use either the CCR5 or the CXCR4 coreceptor.

A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1 ⬇️

A luciferase-reporter gene-expressing T-cell line facilitates neutralization and drug-sensitivity assays that use either R5 or X4 strains of human immunodeficiency virus type 1.

Amino-Terminal Substitutions in the CCR5 Coreceptor Impair gp120 Binding and Human Immunodeficiency Virus Type 1 Entry ⬇️

Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry.

Antibodies for HIV treatment and prevention: window of opportunity?

Antibody responses in primary HIV-1 infection.

Association between specific HIV-1 Env traits and virologic control in vivo

Astrovirus infection in hospitalized infants with severe combined immunodeficiency after allogeneic hematopoietic stem cell transplantation.

Broadly neutralizing antibodies: What is needed to move from a rare event in HIV-1 infection to vaccine efficacy?

CD4 occupancy triggers sequential pre-fusion conformational states of the HIV-1 envelope trimer with relevance for broadly neutralizing antibody activity

CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.

CD4-specific designed ankyrin repeat proteins are novel potent HIV entry inhibitors with unique characteristics

Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-Dependent

Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies

Co-receptors for HIV-1 entry

Complement dependent trapping of infectious HIV in human lymphoid tissues

Complement lysis activity in autologous plasma is associated with lower viral loads during the acute phase of HIV-1 infection

Conformation of the native HIV-1 envelope protein raises questions for vaccine design

Conformation-dependent recognition of HIV Gp120 by DARPins provides novel possibilities to develop distinct HIV entry inhibitors

Conformation-dependent recognition of HIV gp120 by designed ankyrin repeat proteins provides access to novel HIV entry inhibitors

Correction to: Optimization and validation of sample preparation for metagenomic sequencing of viruses in clinical samples

Correlates of broadly neutralizing antibody development

Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG.

Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies

Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality.

Determinants of HIV-1 broadly neutralizing antibody induction.

Development of a high-throughput bead based assay system to measure HIV-1 specific immune signatures in clinical samples

Different infectivity of HIV-1 strains is linked to number of envelope trimers required for entry

Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization

Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity

Divergent effects of cell environment on HIV entry inhibitor activity.

Estimating the stoichiometry of human immunodeficiency virus entry

Exclusive Transduction of Human CD4+ T Cells upon Systemic Delivery of CD4-Targeted Lentiviral Vectors

Full-length haplotype reconstruction to infer the structure of heterogeneous virus populations

Generation of Human Monoclonal Antibodies against HIV-1 Proteins; Electrofusion and Epstein-Barr Virus Transformation for Peripheral Blood Lymphocyte Immortalization ⬇️

Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines.

HIV RNA in plasma rebounds within days during structured treatment interruptions

HIV rebounds from latently infected cells, rather than from continuing low-level replication

HIV sensitivity to neutralization is determined by target and virus producer cell properties

HIV type 1 coreceptors, neutralization serotypes, and vaccine development

HIV vaccines: an attainable goal? ⬇️

HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

HIV-1 replication activates CD4+ T cells with specificities for persistent herpes viruses

HIV-1 resistance to neutralizing antibodies: Determination of antibody concentrations leading to escape mutant evolution

HIV-1 superinfection in an HIV-2-infected woman with subsequent control of HIV-1 plasma viremia

HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy

HIV-host interactions: vital to the virus and key to its inhibition.

HIV: Potency needs constancy

HIV–host interactions: vital to the virus and key to its inhibition☆

High Efficacy of Saliva in Detecting SARS-CoV-2 by RT-PCR in Adults and Children

High-throughput sequencing of human immunoglobulin variable regions with subtype identification.

Human immunodeficiency virus type 1 fitness is a determining factor in viral rebound and set point in chronic infection

Humoral immunity to HIV-1: kinetics of antibody responses in chronic infection reflects capacity of immune system to improve viral set point

Humoral immunity to HIV-1: neutralization and beyond.

Immune senescence: relative contributions of age and cytomegalovirus infection

In vivo and in vitro escape from neutralizing antibodies 2G12, 2F5, and 4E10.

In vivo binding and retention of CD4-specific DARPin 57.2 in macaques

In vivo efficacy of human immunodeficiency virus neutralizing antibodies: estimates for protective titers

Influence of time to diagnosis of severe influenza on antibiotic use, length of stay, isolation precautions, and mortality: a retrospective study

Interaction of the CC-chemokine RANTES with glycosaminoglycans activates a p44/p42 mitogen-activated protein kinase-dependent signaling pathway and enhances human immunodeficiency virus type 1 infectivity

Interaction of the gp120 V1V2 loop with a neighboring gp120 unit shields the HIV envelope trimer against cross-neutralizing antibodies

Interactions of polyclonal and monoclonal anti-glycoprotein 120 antibodies with oligomeric glycoprotein 120-glycoprotein 41 complexes of a primary HIV type 1 isolate: relationship to neutralization

Long-term multiple-dose pharmacokinetics of human monoclonal antibodies (MAbs) against human immunodeficiency virus type 1 envelope gp120 (MAb 2G12) and gp41 (MAbs 4E10 and 2F5).

Loss of Viral Control in Early HIV‐1 Infection Is Temporally Associated with Sequential Escape from CD8+T Cell Responses and Decrease in HIV–1–Specific CD4+and CD8+T Cell Frequencies

Low human immunodeficiency virus envelope diversity correlates with low in vitro replication capacity and predicts spontaneous control of plasma viremia after treatment interruptions

Lower Broadly Neutralizing Antibody Responses in Female Versus Male HIV-1 Infected Injecting Drug Users. ⬇️

MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1. ⬇️

Mathematical models: a key to understanding HIV envelope interactions?

Metagenomic Virome Sequencing in Living Donor and Recipient Kidney Transplant Pairs Revealed JC Polyomavirus Transmission

Metagenomic sequencing complements routine diagnostics in identifying viral pathogens in lung transplant recipients with unknown etiology of respiratory infection

MinVar: A rapid and versatile tool for HIV-1 drug resistance genotyping by deep sequencing

Mucosal model of immunization against human immunodeficiency virus type 1 with a chimeric influenza virus

Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity

Neutralization sensitivity of human immunodeficiency virus type 1 primary isolates to antibodies and CD4-based reagents is independent of coreceptor usage.

OMIP-047: High-Dimensional phenotypic characterization of B cells.

Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors