Lista de obras - Omer Dushek - Dominio Público Uruguay

A THEMIS:SHP1 complex promotes T-cell survival

artículo científico publicado en 2015

A cell topography-based mechanism for ligand discrimination by the T cell receptor

scientific article published on 20 June 2019

A role for rebinding in rapid and reliable T cell responses to antigen

artículo científico publicado en 2009

A tissue-like platform for studying engineered quiescent human T-cells' interactions with dendritic cells

artículo científico publicado en 2019

A tissue-like platform for studying engineered quiescent human T-cells’ interactions with dendritic cells

article published in 2019

An induced rebinding model of antigen discrimination

artículo científico publicado en 2014

Analysis of membrane-localized binding kinetics with FRAP.

artículo científico publicado en 2008

Analysis of serial engagement and peptide-MHC transport in T cell receptor microclusters

artículo científico publicado en 2008

Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation

artículo científico publicado en 2011

Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose

artículo científico publicado en 2016

Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling

artículo científico publicado en 2011

Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1.

artículo científico publicado en 2017

Biosensor architectures for high-fidelity reporting of cellular signaling

artículo científico publicado en 2014

CD8 helps TCR catch slippery self pMHC

scientific article published on 01 December 2018

Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains

artículo científico publicado en 2017

Constitutively active Lck kinase in T cells drives antigen receptor signal transduction

artículo científico publicado en 2010

Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand

artículo científico publicado en 2015

Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time

artículo científico publicado en 2010

Determination of the molecular reach of the protein tyrosine phosphatase SHP-1

artículo científico publicado en 2021

Dynamic regulation of CD28 conformation and signaling by charged lipids and ions

artículo científico publicado en 2017

Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery

artículo científico publicado en 2008

Elementary steps in T cell receptor triggering

artículo científico publicado en 2011

Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function

artículo científico publicado en 2020

Human CD8+ T Cells Exhibit a Shared Antigen Threshold for Different Effector Responses

artículo científico publicado en 2020

Improving parameter estimation for cell surface FRAP data

artículo científico publicado en 2007

Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands

artículo científico publicado en 2012

Mechanical modulation of receptor-ligand interactions at cell-cell interfaces

artículo científico publicado en 2012

Mechanisms for T cell receptor triggering

artículo científico publicado en 2010

Membrane Ultrastructure and T Cell Activation

Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants

scientific article published on 02 March 2022

Molecular flexibility of DNA as a key determinant of RAD51 recruitment

scientific article published on 14 January 2020

Molecular flexibility of DNA as a major determinant of RAD51 recruitment

artículo científico publicado en 2018

Molecular mechanisms of T cell sensitivity to antigen

scientific article published on 01 September 2018

Multisite Phosphorylation Modulates the T Cell Receptor ζ-Chain Potency but not the Switchlike Response

artículo científico publicado en 2016

Non-catalytic tyrosine-phosphorylated receptors

artículo científico publicado en 2012

PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy

artículo científico publicado en 2016

Phenotypic models of T cell activation

artículo científico publicado en 2014

Quantitative phosphoproteome analysis unveils LAT as a modulator of CD3ζ and ZAP-70 tyrosine phosphorylation

artículo científico publicado en 2013

Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions

artículo científico publicado en 2016

Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation

artículo científico publicado en 2013

SpyAvidin hubs enable precise and ultrastable orthogonal nanoassembly

artículo científico publicado en 2014

Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity

artículo científico publicado en 2013

TCR-pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding

artículo científico publicado en 2019

The Influence of Molecular Reach and Diffusivity on the Efficacy of Membrane-Confined Reactions

artículo científico publicado en 2019

The contribution of major histocompatibility complex contacts to the affinity and kinetics of T cell receptor binding

artículo científico publicado en 2016

The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor

artículo científico publicado en 2010

Ultrasensitivity in multisite phosphorylation of membrane-anchored proteins

artículo científico publicado en 2011

Lista de obras de Omer Dushek

A THEMIS:SHP1 complex promotes T-cell survival

A cell topography-based mechanism for ligand discrimination by the T cell receptor

A role for rebinding in rapid and reliable T cell responses to antigen

A tissue-like platform for studying engineered quiescent human T-cells' interactions with dendritic cells

A tissue-like platform for studying engineered quiescent human T-cells’ interactions with dendritic cells

An induced rebinding model of antigen discrimination

Analysis of membrane-localized binding kinetics with FRAP.

Analysis of serial engagement and peptide-MHC transport in T cell receptor microclusters

Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation

Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose

Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling

Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1.

Biosensor architectures for high-fidelity reporting of cellular signaling

CD8 helps TCR catch slippery self pMHC

Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains

Constitutively active Lck kinase in T cells drives antigen receptor signal transduction

Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand

Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time

Determination of the molecular reach of the protein tyrosine phosphatase SHP-1

Dynamic regulation of CD28 conformation and signaling by charged lipids and ions

Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery

Elementary steps in T cell receptor triggering

Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function

Human CD8+ T Cells Exhibit a Shared Antigen Threshold for Different Effector Responses

Improving parameter estimation for cell surface FRAP data

Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands

Mechanical modulation of receptor-ligand interactions at cell-cell interfaces

Mechanisms for T cell receptor triggering

Membrane Ultrastructure and T Cell Activation

Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants

Molecular flexibility of DNA as a key determinant of RAD51 recruitment

Molecular flexibility of DNA as a major determinant of RAD51 recruitment

Molecular mechanisms of T cell sensitivity to antigen

Multisite Phosphorylation Modulates the T Cell Receptor ζ-Chain Potency but not the Switchlike Response

Non-catalytic tyrosine-phosphorylated receptors

PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy

Phenotypic models of T cell activation

Quantitative phosphoproteome analysis unveils LAT as a modulator of CD3ζ and ZAP-70 tyrosine phosphorylation

Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions

Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation

SpyAvidin hubs enable precise and ultrastable orthogonal nanoassembly

Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity

TCR-pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding

The Influence of Molecular Reach and Diffusivity on the Efficacy of Membrane-Confined Reactions

The Influence of Molecular Reach and Diffusivity on the Efficacy of Membrane-Confined Reactions

The contribution of major histocompatibility complex contacts to the affinity and kinetics of T cell receptor binding

The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor

Ultrasensitivity in multisite phosphorylation of membrane-anchored proteins