Lista de obras - Etienne Lefai - Dominio Público Uruguay

A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.

artículo científico publicado en 2013

A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation

artículo científico publicado en 2009

A nutrient cocktail prevents lipid metabolism alterations induced by 20 days of daily steps reduction and fructose overfeeding: Result from a randomized study

artículo científico publicado en 2018

A socio-ecological approach promoting physical activity and limiting sedentary behavior in adolescence showed weight benefits maintained 2.5 years after intervention cessation.

artículo científico publicado en 2014

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

scientific journal article

ANT2-Mediated ATP Import into Mitochondria Protects against Hypoxia Lethal Injury

scientific article published on 25 November 2020

Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells.

artículo científico publicado en 2006

Activity energy expenditure is a major determinant of dietary fat oxidation and trafficking, but the deleterious effect of detraining is more marked than the beneficial effect of training at current recommendations

artículo científico publicado en 2013

Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity

artículo científico publicado en 2013

Addendum: Gouriou et al. ANT2-Mediated ATP Import into Mitochondria Protects against Hypoxia Lethal Injury. Cells 2020, 9, 2542

publication published on 24 August 2021

Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation.

artículo científico publicado en 2015

An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site

artículo científico publicado en 2014

BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase

artículo científico publicado en 2006

Bis(monoacylglycero)phosphate accumulation in macrophages induces intracellular cholesterol redistribution, attenuates liver-X receptor/ATP-Binding cassette transporter A1/ATP-binding cassette transporter G1 pathway, and impairs cholesterol efflux

artículo científico publicado en 2013

Correction: Proteomic Analysis of C2C12 Myoblast and Myotube Exosome-Like Vesicles: A New Paradigm for Myoblast-Myotube Cross Talk?

artículo científico publicado en 2014

Differential regulation of the catalytic and accessory subunit genes of Drosophila mitochondrial DNA polymerase

artículo científico

Disruption of Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans

artículo científico publicado en 2018

Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia

artículo científico publicado en 2010

Effect of enforced physical inactivity induced by 60-day of bed rest on hepatic markers of NAFLD in healthy normal-weight women

artículo científico publicado en 2015

Effects of training and detraining on adiponectin plasma concentration and muscle sensitivity in lean and overweight men.

artículo científico publicado en 2016

Enzymatic activities of mitochondrial respiratory complexes from children muscular biopsies. Age-related evolutions

artículo científico publicado en 1995

Ether lipids, sphingolipids, and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients

artículo científico publicado en 2020

Evidence for mitochondrial respiratory deficiency in rat rhabdomyosarcoma cells

artículo científico publicado en 2010

Exercise training improves fat metabolism independent of total energy expenditure in sedentary overweight men, but does not restore lean metabolic phenotype.

artículo científico publicado en 2017

Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice

artículo científico publicado en 2014

Expression of the splice variants of the p85alpha regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patients

artículo científico publicado en 2001

FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction

artículo científico publicado en 2010

Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth

artículo científico publicado en 2017

Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth.

scientific article published on 27 July 2016

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice

artículo científico publicado en 2017

GPIHBP1 C89F neomutation and hydrophobic C-terminal domain G175R mutation in two pedigrees with severe hyperchylomicronemia.

artículo científico publicado en 2011

Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes.

artículo científico publicado en 2017

Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

artículo científico publicado en 2015

Human skeletal myotubes display a cell-autonomous circadian clock implicated in basal myokine secretion

artículo científico publicado en 2015

Hypergravity as a gravitational therapy mitigates the effects of knee osteoarthritis on the musculoskeletal system in a murine model

scientific article published on 09 December 2020

In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes

artículo científico publicado en 2019

Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis

artículo científico publicado en 2016

Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs

artículo científico publicado en 2006

Insulin resistance is associated with MCP1-mediated macrophage accumulation in skeletal muscle in mice and humans

artículo científico publicado en 2014

Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos)

artículo científico publicado en 2019

Lipidomics Reveals Seasonal Shifts in a Large-Bodied Hibernator, the Brown Bear

artículo científico publicado en 2019

Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro.

artículo científico publicado en 2017

Metabolic inflexibility is an early marker of bed-rest induced glucose intolerance even when fat mass is stable.

artículo científico publicado en 2018

Metabolic reprogramming involving glycolysis in the hibernating brown bear skeletal muscle

artículo científico publicado en 2019

MicroRNAs facilitate skeletal muscle maintenance and metabolic suppression in hibernating brown bears

scientific article published on 23 October 2019

Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle

artículo científico publicado en 2008

Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2).

artículo científico

Multiple microRNA regulation of lipoprotein lipase gene abolished by 3′UTR polymorphisms in a triglyceride-lowering haplotype harboring p.Ser474Ter

article

Myostatin gene inactivation prevents skeletal muscle wasting in cancer

artículo científico publicado en 2014

Myotube-derived exosomal miRNAs downregulate Sirtuin1 in myoblasts during muscle cell differentiation

artículo científico publicado en 2013

Overexpression of the catalytic subunit of DNA polymerase gamma results in depletion of mitochondrial DNA in Drosophila melanogaster.

artículo científico publicado en 2000

Pdro, a protein associated with late endosomes and lysosomes and implicated in cellular cholesterol homeostasis

artículo científico publicado en 2010

Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes

artículo científico publicado en 2011

Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling

artículo científico publicado en 2013

Proteolysis inhibition by hibernating bear serum leads to increased protein content in human muscle cells.

artículo científico publicado en 2018

Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk?

artículo científico publicado en 2014

Quantitative decrease of human cytochrome c oxidase during development: evidences for a post-transcriptional regulation

artículo científico publicado en 1997

Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues

artículo científico publicado en 2005

Regulation of mitochondrial single-stranded DNA-binding protein gene expression links nuclear and mitochondrial DNA replication in drosophila

artículo científico publicado en 2000

SREBP-1 transcription factors regulate skeletal muscle cell size by controlling protein synthesis through myogenic regulatory factors

artículo científico publicado en 2012

Seasonal changes in eicosanoid metabolism in the brown bear

artículo científico publicado en 2018

Sirtuin 1 regulates SREBP-1c expression in a LXR-dependent manner in skeletal muscle

artículo científico publicado en 2012

Specific shifts in the endocannabinoid system in hibernating brown bears

artículo científico publicado en 2020

Sterol regulatory element-binding protein-1 mediates the effect of insulin on hexokinase II gene expression in human muscle cells

artículo científico publicado en 2004

TNF-α- and tumor-induced skeletal muscle atrophy involves sphingolipid metabolism

artículo científico publicado en 2012

TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia

scientific article published on 21 June 2018

The highly compact structure of the mitochondrial DNA polymerase genomic region of Drosophila melanogaster: functional and evolutionary implications

artículo científico publicado en 2000

The microRNA signature in response to insulin reveals its implication in the transcriptional action of insulin in human skeletal muscle and the role of a sterol regulatory element-binding protein-1c/myocyte enhancer factor 2C pathway

artículo científico publicado en 2009

Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle.

artículo científico publicado en 2018

Transition from physical activity to inactivity increases skeletal muscle miR-148b content and triggers insulin resistance.

artículo científico publicado en 2016

Validity of combining heart rate and uniaxial acceleration to measure free-living physical activity energy expenditure in young men.

artículo científico publicado en 2012

Lista de obras de Etienne Lefai

A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.

A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation

A nutrient cocktail prevents lipid metabolism alterations induced by 20 days of daily steps reduction and fructose overfeeding: Result from a randomized study

A socio-ecological approach promoting physical activity and limiting sedentary behavior in adolescence showed weight benefits maintained 2.5 years after intervention cessation.

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

ANT2-Mediated ATP Import into Mitochondria Protects against Hypoxia Lethal Injury

Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells.

Activity energy expenditure is a major determinant of dietary fat oxidation and trafficking, but the deleterious effect of detraining is more marked than the beneficial effect of training at current recommendations

Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity

Addendum: Gouriou et al. ANT2-Mediated ATP Import into Mitochondria Protects against Hypoxia Lethal Injury. Cells 2020, 9, 2542

Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation.

An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site

BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase

Bis(monoacylglycero)phosphate accumulation in macrophages induces intracellular cholesterol redistribution, attenuates liver-X receptor/ATP-Binding cassette transporter A1/ATP-binding cassette transporter G1 pathway, and impairs cholesterol efflux

Correction: Proteomic Analysis of C2C12 Myoblast and Myotube Exosome-Like Vesicles: A New Paradigm for Myoblast-Myotube Cross Talk?

Differential regulation of the catalytic and accessory subunit genes of Drosophila mitochondrial DNA polymerase

Disruption of Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans

Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia

Effect of enforced physical inactivity induced by 60-day of bed rest on hepatic markers of NAFLD in healthy normal-weight women

Effects of training and detraining on adiponectin plasma concentration and muscle sensitivity in lean and overweight men.

Enzymatic activities of mitochondrial respiratory complexes from children muscular biopsies. Age-related evolutions

Ether lipids, sphingolipids, and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients

Evidence for mitochondrial respiratory deficiency in rat rhabdomyosarcoma cells

Exercise training improves fat metabolism independent of total energy expenditure in sedentary overweight men, but does not restore lean metabolic phenotype.

Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice

Expression of the splice variants of the p85alpha regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patients

FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction

Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth

Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth.

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice

GPIHBP1 C89F neomutation and hydrophobic C-terminal domain G175R mutation in two pedigrees with severe hyperchylomicronemia.

Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes.

Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

Human skeletal myotubes display a cell-autonomous circadian clock implicated in basal myokine secretion

Hypergravity as a gravitational therapy mitigates the effects of knee osteoarthritis on the musculoskeletal system in a murine model

In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes

Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis

Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs

Insulin resistance is associated with MCP1-mediated macrophage accumulation in skeletal muscle in mice and humans

Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos)

Lipidomics Reveals Seasonal Shifts in a Large-Bodied Hibernator, the Brown Bear

Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro.

Metabolic inflexibility is an early marker of bed-rest induced glucose intolerance even when fat mass is stable.

Metabolic reprogramming involving glycolysis in the hibernating brown bear skeletal muscle

MicroRNAs facilitate skeletal muscle maintenance and metabolic suppression in hibernating brown bears

Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle

Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2).

Multiple microRNA regulation of lipoprotein lipase gene abolished by 3′UTR polymorphisms in a triglyceride-lowering haplotype harboring p.Ser474Ter

Myostatin gene inactivation prevents skeletal muscle wasting in cancer

Myotube-derived exosomal miRNAs downregulate Sirtuin1 in myoblasts during muscle cell differentiation

Overexpression of the catalytic subunit of DNA polymerase gamma results in depletion of mitochondrial DNA in Drosophila melanogaster.

Pdro, a protein associated with late endosomes and lysosomes and implicated in cellular cholesterol homeostasis

Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes

Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling

Proteolysis inhibition by hibernating bear serum leads to increased protein content in human muscle cells.

Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk?

Quantitative decrease of human cytochrome c oxidase during development: evidences for a post-transcriptional regulation

Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues

Regulation of mitochondrial single-stranded DNA-binding protein gene expression links nuclear and mitochondrial DNA replication in drosophila

SREBP-1 transcription factors regulate skeletal muscle cell size by controlling protein synthesis through myogenic regulatory factors

Seasonal changes in eicosanoid metabolism in the brown bear

Sirtuin 1 regulates SREBP-1c expression in a LXR-dependent manner in skeletal muscle

Specific shifts in the endocannabinoid system in hibernating brown bears

Sterol regulatory element-binding protein-1 mediates the effect of insulin on hexokinase II gene expression in human muscle cells

TNF-α- and tumor-induced skeletal muscle atrophy involves sphingolipid metabolism

TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia

The highly compact structure of the mitochondrial DNA polymerase genomic region of Drosophila melanogaster: functional and evolutionary implications

The microRNA signature in response to insulin reveals its implication in the transcriptional action of insulin in human skeletal muscle and the role of a sterol regulatory element-binding protein-1c/myocyte enhancer factor 2C pathway

Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle.

Transition from physical activity to inactivity increases skeletal muscle miR-148b content and triggers insulin resistance.

Validity of combining heart rate and uniaxial acceleration to measure free-living physical activity energy expenditure in young men.