Lista de obras - Pascual Sanz - Dominio Público Uruguay

A 13C nuclear magnetic resonance investigation of the metabolism of leucine to isoamyl alcohol in Saccharomyces cerevisiae.

artículo científico publicado en 1997

A PTG variant contributes to a milder phenotype in Lafora disease

artículo científico publicado en 2011

A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3.

artículo científico publicado en 2007

A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunits.

artículo científico publicado en 2007

A novel EPM2A mutation yields a slow progression form of Lafora disease

scientific article published on 21 July 2018

A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism

artículo científico publicado en 2008

AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTG-protein phosphatase 1 holoenzyme, and accelerates its down-regulation by the laforin-malin complex

artículo científico publicado en 2009

AMP-activated protein kinase: structure and regulation

artículo científico publicado en 2008

AMPKβ subunits: more than just a scaffold in the formation of AMPK complex

artículo científico

Active Snf1 protein kinase inhibits expression of the Saccharomyces cerevisiae HXT1 glucose transporter gene

artículo científico publicado en 2002

Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients.

artículo científico publicado en 2008

Cloning and characterization of the SEC18 gene from Candida albicans.

artículo científico publicado en 1993

Convergence of the target of rapamycin and the Snf1 protein kinase pathways in the regulation of the subcellular localization of Msn2, a transcriptional activator of STRE (Stress Response Element)-regulated genes

artículo científico publicado en 2002

DOGR1 and DOGR2: two genes from Saccharomyces cerevisiae that confer 2-deoxyglucose resistance when overexpressed

artículo científico publicado en 1995

Deciphering the role of malin in the lafora progressive myoclonus epilepsy

artículo científico publicado en 2012

Diagnostic difficulties in glucokinase hyperinsulinism.

artículo científico publicado en 2008

Dimerization of the glucan phosphatase laforin requires the participation of cysteine 329.

artículo científico publicado en 2013

Disruption and functional analysis of six ORFs on chromosome IV: YDL053c, YDL072c, YDL073w, YDL076c, YDL077c and YDL080c

artículo científico publicado en 2000

Disruption and functional analysis of six ORFs on chromosome IV: YDL053c, YDL072c, YDL073w, YDL076c, YDL077c and YDL080c

artículo científico publicado en 2000

Endocytosis of the glutamate transporter 1 is regulated by laforin and malin: Implications in Lafora disease

artículo científico publicado en 2020

Engineering baker's yeast: room for improvement

artículo científico publicado en 1999

Expression of the HXT1 low affinity glucose transporter requires the coordinated activities of the HOG and glucose signalling pathways

artículo científico publicado en 2004

Expression ofLIP1andLIP2Genes fromGeotrichumSpecies in Baker's Yeast Strains and Their Application to the Bread-Making Process

artículo científico publicado en 1999

Frataxin interacts functionally with mitochondrial electron transport chain proteins

artículo científico publicado en 2005

Glucose and type 2A protein phosphatase regulate the interaction between catalytic and regulatory subunits of AMP-activated protein kinase

artículo científico publicado en 2003

Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway

artículo científico publicado en 2012

Glycogenic activity of R6, a protein phosphatase 1 regulatory subunit, is modulated by the laforin–malin complex ⬇️

artículo científico publicado el 26 de abril de 2013

Hexokinase PII has a double cytosolic-nuclear localisation in Saccharomyces cerevisiae.

artículo científico publicado en 1998

Hexokinase PII: structural analysis and glucose signalling in the yeast Saccharomyces cerevisiae

artículo científico publicado en 2001

Histone carbonylation occurs in proliferating cells.

artículo científico publicado en 2012

Homeostasis of the astrocytic glutamate transporter GLT-1 is altered in mouse models of Lafora disease

artículo científico publicado en 2016

Human pancreatic beta-cell glucokinase: subcellular localization and glucose repression signalling function in the yeast cell

artículo científico publicado en 2008

Human pancreatic glucokinase (GlkB) complements the glucose signalling defect of Saccharomyces cerevisiae hxk2 mutants

artículo científico publicado en 2001

In vivo glutamate clearance defects in a mouse model of Lafora disease

artículo científico publicado en 2019

Increased endoplasmic reticulum stress and decreased proteasomal function in lafora disease models lacking the phosphatase laforin

artículo científico publicado en 2009

Increased oxidative stress and impaired antioxidant response in Lafora disease.

artículo científico publicado en 2014

Lafora Disease: A Ubiquitination-Related Pathology

scientific article published on 26 July 2018

Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy

artículo científico publicado en 2011

Lafora disease E3-ubiquitin ligase malin is related to TRIM32 at both the phylogenetic and functional level

artículo científico publicado en 2011

Lafora disease fibroblasts exemplify the molecular interdependence between thioredoxin 1 and the proteasome in mammalian cells.

artículo científico publicado en 2013

Lafora progressive myoclonus epilepsy: NHLRC1 mutations affect glycogen metabolism

artículo científico publicado en 2011

Laforin, a dual specificity phosphatase involved in Lafora disease, is present mainly as monomeric form with full phosphatase activity

artículo científico publicado en 2011

Laforin, a dual specificity phosphatase involved in Lafora disease, regulates insulin response and whole-body energy balance in mice.

artículo científico publicado en 2011

Laforin, a dual-specificity phosphatase involved in Lafora disease, is phosphorylated at Ser25 by AMP-activated protein kinase.

artículo científico publicado en 2011

Laforin, a protein with many faces: glucan phosphatase, adapter protein, et alii.

artículo científico publicado en 2012

Laforin, the dual-phosphatase responsible for Lafora disease, interacts with R5 (PTG), a regulatory subunit of protein phosphatase-1 that enhances glycogen accumulation

artículo científico publicado en 2003

Laforin, the most common protein mutated in Lafora disease, regulates autophagy

artículo científico publicado en 2010

Large Islets, Beta-Cell Proliferation, and a Glucokinase Mutation

artículo científico publicado en 2010

Malin knockout mice support a primary role of autophagy in the pathogenesis of Lafora disease

artículo científico publicado en 2012

Modulators of Neuroinflammation Have a Beneficial Effect in a Lafora Disease Mouse Model

artículo científico publicado en 2021

Molecular characterization of Ypi1, a novel Saccharomyces cerevisiae type 1 protein phosphatase inhibitor.

artículo científico publicado en 2003

Molecular characterization of a gene that confers 2-deoxyglucose resistance in yeast

artículo científico publicado en 1994

Neuroinflammation and progressive myoclonus epilepsies: from basic science to therapeutic opportunities

scientific article published on 17 September 2020

New mutations of Saccharomyces cerevisiae that partially relieve both glucose and galactose repression activate the protein kinase Snf1.

artículo científico publicado en 2003

Nucleotide sequence of a putative peroxisomal protein from the yeast Lipomyces kononenkoae

artículo científico publicado en 1994

Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene.

artículo científico publicado en 2009

Plasmodium falciparum inhibitor-3 homolog increases protein phosphatase type 1 activity and is essential for parasitic survival

artículo científico publicado en 2012

Reactive Glia Inflammatory Signaling Pathways and Epilepsy

scientific article published on 08 June 2020

Reactive Glia-Derived Neuroinflammation: a Novel Hallmark in Lafora Progressive Myoclonus Epilepsy That Progresses with Age

scientific article published on 05 December 2019

Reg1p targets protein phosphatase 1 to dephosphorylate hexokinase II in Saccharomyces cerevisiae: characterizing the effects of a phosphatase subunit on the yeast proteome

artículo científico publicado en 1999

Regulation of glycogen synthesis by the laforin-malin complex is modulated by the AMP-activated protein kinase pathway

artículo científico publicado en 2007

Regulatory interactions between the Reg1-Glc7 protein phosphatase and the Snf1 protein kinase

artículo científico publicado en 2000

Role of AMP-activated protein kinase in autophagy and proteasome function

artículo científico publicado en 2008

Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 participate in the process of catabolite inactivation of maltose permease

artículo científico publicado en 2003

Secretion in yeast: preprotein binding to a membrane receptor and ATP-dependent translocation are sequential and separable events in vitro

artículo científico publicado en 1989

Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation

artículo científico publicado en 2004

Stable high-copy-number integration of Aspergillus oryzae alpha-AMYLASE cDNA in an industrial baker's yeast strain

artículo científico publicado en 1999

Structural mechanism of laforin function in glycogen dephosphorylation and lafora disease

artículo científico publicado en 2014

Structure-function analysis of the alpha5 and the alpha13 helices of human glucokinase: description of two novel activating mutations.

artículo científico publicado en 2005

Sumoylation of AMPKβ2 subunit enhances AMP-activated protein kinase activity.

artículo científico publicado en 2013

TOR kinase pathway and 14-3-3 proteins regulate glucose-induced expression of HXT1, a yeast low-affinity glucose transporter

artículo científico publicado en 2005

TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase

artículo científico publicado en 2006

The Saccharomyces cerevisiae 14-3-3 protein Bmh2 is required for regulation of the phosphorylation status of Fin1, a novel intermediate filament protein

artículo científico publicado en 2002

The expression of a specific 2-deoxyglucose-6P phosphatase prevents catabolite repression mediated by 2-deoxyglucose in yeast

artículo científico publicado en 1995

The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits.

artículo científico publicado en 2010

Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the proteasome, as a novel interaction partner of AMP-activated protein kinase

artículo científico publicado en 2009

YPI1 and SDS22 proteins regulate the nuclear localization and function of yeast type 1 phosphatase Glc7.

artículo científico publicado en 2007

Yeast as a model system to study glucose-mediated signalling and response

artículo científico publicado en 2007

Lista de obras de Pascual Sanz

A 13C nuclear magnetic resonance investigation of the metabolism of leucine to isoamyl alcohol in Saccharomyces cerevisiae.

A PTG variant contributes to a milder phenotype in Lafora disease

A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3.

A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunits.

A novel EPM2A mutation yields a slow progression form of Lafora disease

A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism

AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTG-protein phosphatase 1 holoenzyme, and accelerates its down-regulation by the laforin-malin complex

AMP-activated protein kinase: structure and regulation

AMPKβ subunits: more than just a scaffold in the formation of AMPK complex

Active Snf1 protein kinase inhibits expression of the Saccharomyces cerevisiae HXT1 glucose transporter gene

Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients.

Cloning and characterization of the SEC18 gene from Candida albicans.

Convergence of the target of rapamycin and the Snf1 protein kinase pathways in the regulation of the subcellular localization of Msn2, a transcriptional activator of STRE (Stress Response Element)-regulated genes

DOGR1 and DOGR2: two genes from Saccharomyces cerevisiae that confer 2-deoxyglucose resistance when overexpressed

Deciphering the role of malin in the lafora progressive myoclonus epilepsy

Diagnostic difficulties in glucokinase hyperinsulinism.

Dimerization of the glucan phosphatase laforin requires the participation of cysteine 329.

Disruption and functional analysis of six ORFs on chromosome IV: YDL053c, YDL072c, YDL073w, YDL076c, YDL077c and YDL080c

Disruption and functional analysis of six ORFs on chromosome IV: YDL053c, YDL072c, YDL073w, YDL076c, YDL077c and YDL080c

Endocytosis of the glutamate transporter 1 is regulated by laforin and malin: Implications in Lafora disease

Engineering baker's yeast: room for improvement

Expression of the HXT1 low affinity glucose transporter requires the coordinated activities of the HOG and glucose signalling pathways

Expression ofLIP1andLIP2Genes fromGeotrichumSpecies in Baker's Yeast Strains and Their Application to the Bread-Making Process

Frataxin interacts functionally with mitochondrial electron transport chain proteins

Glucose and type 2A protein phosphatase regulate the interaction between catalytic and regulatory subunits of AMP-activated protein kinase

Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway

Glycogenic activity of R6, a protein phosphatase 1 regulatory subunit, is modulated by the laforin–malin complex ⬇️

Hexokinase PII has a double cytosolic-nuclear localisation in Saccharomyces cerevisiae.

Hexokinase PII: structural analysis and glucose signalling in the yeast Saccharomyces cerevisiae

Histone carbonylation occurs in proliferating cells.

Homeostasis of the astrocytic glutamate transporter GLT-1 is altered in mouse models of Lafora disease

Human pancreatic beta-cell glucokinase: subcellular localization and glucose repression signalling function in the yeast cell

Human pancreatic glucokinase (GlkB) complements the glucose signalling defect of Saccharomyces cerevisiae hxk2 mutants

In vivo glutamate clearance defects in a mouse model of Lafora disease

Increased endoplasmic reticulum stress and decreased proteasomal function in lafora disease models lacking the phosphatase laforin

Increased oxidative stress and impaired antioxidant response in Lafora disease.

Lafora Disease: A Ubiquitination-Related Pathology

Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy

Lafora disease E3-ubiquitin ligase malin is related to TRIM32 at both the phylogenetic and functional level

Lafora disease fibroblasts exemplify the molecular interdependence between thioredoxin 1 and the proteasome in mammalian cells.

Lafora progressive myoclonus epilepsy: NHLRC1 mutations affect glycogen metabolism

Laforin, a dual specificity phosphatase involved in Lafora disease, is present mainly as monomeric form with full phosphatase activity

Laforin, a dual specificity phosphatase involved in Lafora disease, regulates insulin response and whole-body energy balance in mice.

Laforin, a dual-specificity phosphatase involved in Lafora disease, is phosphorylated at Ser25 by AMP-activated protein kinase.

Laforin, a protein with many faces: glucan phosphatase, adapter protein, et alii.

Laforin, the dual-phosphatase responsible for Lafora disease, interacts with R5 (PTG), a regulatory subunit of protein phosphatase-1 that enhances glycogen accumulation

Laforin, the most common protein mutated in Lafora disease, regulates autophagy

Large Islets, Beta-Cell Proliferation, and a Glucokinase Mutation

Malin knockout mice support a primary role of autophagy in the pathogenesis of Lafora disease

Modulators of Neuroinflammation Have a Beneficial Effect in a Lafora Disease Mouse Model

Molecular characterization of Ypi1, a novel Saccharomyces cerevisiae type 1 protein phosphatase inhibitor.

Molecular characterization of a gene that confers 2-deoxyglucose resistance in yeast

Neuroinflammation and progressive myoclonus epilepsies: from basic science to therapeutic opportunities

New mutations of Saccharomyces cerevisiae that partially relieve both glucose and galactose repression activate the protein kinase Snf1.

Nucleotide sequence of a putative peroxisomal protein from the yeast Lipomyces kononenkoae

Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene.

Plasmodium falciparum inhibitor-3 homolog increases protein phosphatase type 1 activity and is essential for parasitic survival

Reactive Glia Inflammatory Signaling Pathways and Epilepsy

Reactive Glia-Derived Neuroinflammation: a Novel Hallmark in Lafora Progressive Myoclonus Epilepsy That Progresses with Age

Reg1p targets protein phosphatase 1 to dephosphorylate hexokinase II in Saccharomyces cerevisiae: characterizing the effects of a phosphatase subunit on the yeast proteome

Regulation of glycogen synthesis by the laforin-malin complex is modulated by the AMP-activated protein kinase pathway

Regulatory interactions between the Reg1-Glc7 protein phosphatase and the Snf1 protein kinase

Role of AMP-activated protein kinase in autophagy and proteasome function

Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 participate in the process of catabolite inactivation of maltose permease

Secretion in yeast: preprotein binding to a membrane receptor and ATP-dependent translocation are sequential and separable events in vitro

Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation

Stable high-copy-number integration of Aspergillus oryzae alpha-AMYLASE cDNA in an industrial baker's yeast strain

Structural mechanism of laforin function in glycogen dephosphorylation and lafora disease

Structure-function analysis of the alpha5 and the alpha13 helices of human glucokinase: description of two novel activating mutations.

Sumoylation of AMPKβ2 subunit enhances AMP-activated protein kinase activity.

TOR kinase pathway and 14-3-3 proteins regulate glucose-induced expression of HXT1, a yeast low-affinity glucose transporter

TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase

The Saccharomyces cerevisiae 14-3-3 protein Bmh2 is required for regulation of the phosphorylation status of Fin1, a novel intermediate filament protein

The expression of a specific 2-deoxyglucose-6P phosphatase prevents catabolite repression mediated by 2-deoxyglucose in yeast

The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits.

Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the proteasome, as a novel interaction partner of AMP-activated protein kinase

YPI1 and SDS22 proteins regulate the nuclear localization and function of yeast type 1 phosphatase Glc7.

Yeast as a model system to study glucose-mediated signalling and response