Lista de obras - David J. Timson - Dominio Público Uruguay

<i>Escherichia coli</i>Modulator of Drug Activity B (MdaB) Has Different Enzymological Properties to Eukaryote Quinone Oxidoreductases

artículo científico publicado en 2019

A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer

artículo científico publicado en 2019

A calcium-dependent interaction between calmodulin and the calponin homology domain of human IQGAP1.

artículo científico publicado en 2012

A galactokinase-like protein from the liver fluke Fasciola hepatica

artículo científico publicado en 2018

A ligand predication tool based on modeling and reasoning with imprecise probabilistic knowledge

artículo científico publicado en 2009

A mysterious family of calcium-binding proteins from parasitic worms

artículo científico publicado en 2016

A novel calmodulin-like protein from the liver fluke, Fasciola hepatica

artículo científico publicado en 2012

A plasma membrane Ca(2+)-ATPase (PMCA) from the liver fluke, Fasciola hepatica.

artículo científico publicado en 2012

A universal measure of chaotropicity and kosmotropicity.

artículo científico publicado en 2012

Altered cofactor binding affects stability and activity of human UDP-galactose 4′-epimerase: Implications for type III galactosemia ⬇️

artículo científico publicado el 18 de mayo de 2012

Analysis of UDP-galactose 4'-epimerase mutations associated with the intermediate form of type III galactosaemia

artículo científico publicado en 2008

Antioxidant properties and global metabolite screening of the probiotic yeast Saccharomyces cerevisiae var. boulardii

artículo científico publicado en 2016

Antiproton induced DNA damage: proton like in flight, carbon-ion like near rest.

artículo científico publicado en 2013

Artemisinins act through at least two targets in a yeast model

artículo científico publicado en 2010

Binding of serum albumin to the anthelmintic drugs albendazole, triclabendazole and their sulphoxides

artículo científico publicado en 2010

Biochemical analysis of the interactions of IQGAP1 C-terminal domain with CDC42

artículo científico publicado en 2012

Biochemical characterisation of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) from the liver fluke, Fasciola hepatica

artículo científico publicado en 2014

Calmodulin disruption impacts growth and motility in juvenile liver fluke

artículo científico publicado en 2016

Calmodulins from Schistosoma mansoni: Biochemical analysis and interaction with IQ-motifs from voltage-gated calcium channels

artículo científico publicado en 2018

Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity

scientific article published on 06 September 2019

Catalytic mechanism of mevalonate kinase revisited, a QM/MM study

scientific article published on 01 February 2019

Chaotropicity: a key factor in product tolerance of biofuel-producing microorganisms.

artículo científico

Characterisation of eppin function: expression and activity in the lung

artículo científico publicado en 2017

Characterisation of two calmodulin-like proteins from the liver fluke, Fasciola hepatica

artículo científico publicado en 2007

Characterization of Calcium-Binding Proteins from Parasitic Worms

scientific article published on 01 January 2019

Characterization of the Saccharomyces cerevisiae galactose mutarotase/UDP-galactose 4-epimerase protein, Gal10p.

artículo científico publicado en 2007

Citrate synthase from the liver fluke Fasciola hepatica

artículo científico publicado en 2013

Comparative biochemical analysis of three members of the Schistosoma mansoni TAL family: Differences in ion and drug binding properties

artículo científico publicado en 2014

Comparison of dynamics of wildtype and V94M human UDP-galactose 4-epimerase-A computational perspective on severe epimerase-deficiency galactosemia.

artículo científico publicado en 2013

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands

artículo científico publicado en 2016

Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity.

artículo científico publicado en 2007

DNA damage by low-energy ions

artículo científico publicado en 2009

Damage to plasmid DNA induced by low energy carbon ions

artículo científico publicado en 2007

Destressing Yeast for Higher Biofuel Yields: Can Excess Chaotropicity Be Mitigated?

scientific article published on 17 August 2020

Detection and localisation of protein-protein interactions in Saccharomyces cerevisiae using a split-GFP method

artículo científico publicado en 2008

Development and implementation of split-GFP-based bimolecular fluorescence complementation (BiFC) assays in yeast

artículo científico publicado en 2008

Development of a novel mass spectrometric technique for studying DNA damage

artículo científico publicado en 2009

Dicoumarol: A Drug which Hits at Least Two Very Different Targets in Vitamin K Metabolism

artículo científico publicado en 2015

Different specificities of two aldehyde dehydrogenases from Saccharomyces cerevisiae var. boulardii

artículo científico publicado en 2017

Differential expression of liver fluke β-tubulin isotypes at selected life cycle stages

artículo científico publicado en 2013

Dynamic origins of substrate promiscuity in bacterial galactokinases

scientific article published on 17 October 2019

Effects of alcohols and compatible solutes on the activity of β-galactosidase.

artículo científico publicado en 2012

Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

artículo científico publicado en 2017

Evidence for chaotropicity/kosmotropicity offset in a yeast growth model

scientific article published on 26 September 2019

Expression, purification and crystallization of a novel metagenome-derived salicylaldehyde dehydrogenase from Alpine soil

artículo científico publicado en 2022

FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1.

artículo científico publicado en 2014

Fasciola hepatica calcium-binding protein FhCaBP2: structure of the dynein light chain-like domain

artículo científico publicado en 2016

Fasciola hepatica expresses multiple alpha- and beta-tubulin isotypes.

artículo científico publicado en 2008

FhCaBP1 (FH22): A Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains

artículo científico publicado en 2016

FhCaBP2: a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains

artículo científico publicado en 2015

FhCaBP3: a Fasciola hepatica calcium binding protein with EF-hand and dynein light chain domains.

artículo científico publicado en 2012

FhCaBP4: a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains.

artículo científico publicado en 2012

Fine tuning the myosin motor: the role of the essential light chain in striated muscle myosin.

artículo científico publicado en 2003

Fragmentation of neutral amino acids and small peptides by intense, femtosecond laser pulses.

artículo científico publicado en 2013

Fructose 1,6-phosphatase: getting the message across

artículo científico publicado en 2019

Functional analysis of disease-causing mutations in human UDP-galactose 4-epimerase

artículo científico publicado en 2005

Functional analysis of disease‐causing mutations in human galactokinase ⬇️

artículo científico publicado el 1 de abril de 2003

Functional domains of an NAD + -dependent DNA ligase 1 1Edited by A. R. Fersht

artículo científico publicado en 1999

Functional domains of the human epididymal protease inhibitor, eppin

artículo científico publicado en 2008

Galactokinase promiscuity: a question of flexibility?

artículo científico publicado en 2016

Glycerol enhances fungal germination at the water-activity limit for life

artículo científico publicado en 2016

Hydrophobic substances induce water stress in microbial cells.

artículo científico publicado en 2010

IQ motif selectivity in human IQGAP1: binding of myosin essential light chain and S100B

scientific article published on 28 June 2008

IQ-motif peptides as novel anti-microbial agents

scientific article published on 10 December 2012

IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain

artículo científico publicado en 2011

IQGAP1 Interaction with RHO Family Proteins Revisited: KINETIC AND EQUILIBRIUM EVIDENCE FOR MULTIPLE DISTINCT BINDING SITES.

artículo científico publicado en 2016

Identification and characterisation of human aldose 1-epimerase

artículo científico publicado en 2003

Improving the Activity and Stability of Human Galactokinase for Therapeutic and Biotechnological Applications.

artículo científico publicado en 2018

In Silico Analysis of the Effects of Point Mutations on α-Globin: Implications for α-Thalassemia

scientific article published on 18 May 2020

In Silico Prediction of the Effects of Mutations in the Human Mevalonate Kinase Gene: Towards a Predictive Framework for Mevalonate Kinase Deficiency.

artículo científico publicado en 2015

In silico identification and biochemical characterization of novel inhibitors of NQO1

artículo científico publicado en 2006

In silico prediction of the effects of mutations in the human UDP-galactose 4'-epimerase gene: towards a predictive framework for type III galactosemia

artículo científico publicado en 2013

In silico prediction of the effects of mutations in the human triose phosphate isomerase gene: Towards a predictive framework for TPI deficiency

artículo científico publicado en 2017

In vivo and in vitro function of human UDP-galactose 4'-epimerase variants.

artículo científico publicado en 2011

Increased promiscuity of human galactokinase following alteration of a single amino acid residue distant from the active site

artículo científico publicado en 2011

Insight into the mechanism of galactokinase: Role of a critical glutamate residue and helix/coil transitions

artículo científico publicado en 2016

Interaction of prothrombin with a phospholipid surface: evidence for a membrane-induced conformational change

article

Interactions between the budding yeast IQGAP homologue Iqg1p and its targets revealed by a split-EGFP bimolecular fluorescence complementation assay.

artículo científico publicado en 2008

Is there a common water-activity limit for the three domains of life?

artículo científico publicado en 2014

Kinetic analysis of yeast galactokinase: implications for transcriptional activation of the GAL genes

artículo científico publicado en 2002

LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway.

artículo científico publicado en 2017

LIAD-fs scheme for studies of ultrafast laser interactions with gas phase biomolecules.

artículo científico publicado en 2012

Liver fluke β-tubulin isotype 2 binds albendazole and is thus a probable target of this drug

artículo científico publicado en 2010

Mechanistic studies on human N-acetylgalactosamine kinase

artículo científico publicado en 2010

Metabolic Enzymes of Helminth Parasites: Potential as Drug Targets

artículo científico publicado en 2016

Misfolding of galactose 1-phosphate uridylyltransferase can result in type I galactosemia.

artículo científico publicado en 2013

Modulating Mobility: a Paradigm for Protein Engineering?

artículo científico publicado en 2016

Modulation of the mobility of a key region in human galactokinase: Impacts on catalysis and stability

article

Molecular structure of Saccharomyces cerevisiae Gal1p, a bifunctional galactokinase and transcriptional inducer

artículo científico publicado en 2005

Molecular structure of human galactokinase: implications for type II galactosemia

artículo científico publicado en 2004

Molecular structure of human galactose mutarotase

artículo científico publicado en 2004

Multiplication of microbes below 0.690 water activity: implications for terrestrial and extraterrestrial life ⬇️

artículo científico publicado en 2014

Myosin Va and spermine synthase: partners in exosome transport

artículo científico publicado en 2019

N-acetylgalactosamine Kinase: A Naturally Promiscuous Small Molecule Kinase

artículo científico publicado en 2011

NAD(P)H quinone oxidoreductase (NQO1): an enzyme which needs just enough mobility, in just the right places

article

NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms

scientific article published on 12 May 2019

Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer.

artículo científico publicado en 2017

Natural Small Molecules as Stabilizers and Activators of Cancer-Associated NQO1 Polymorphisms

artículo científico

Negative Cooperativity in NAD(P)H Quinone Oxidoreductase 1 (NQO1)

artículo científico publicado en 2019

New model for the interaction of IQGAP1 with CDC42 and RAC1.

artículo científico publicado en 2017

Novel and selective inactivators of Triosephosphate isomerase with anti-trematode activity

artículo científico publicado en 2020

Nucleotide sequence, heterologous expression and novel purification of DNA ligase from Bacillus stearothermophilus(1).

artículo científico publicado en 1999

Phosphorylation Mechanism of N-Acetyl-l-glutamate Kinase, a QM/MM Study

scientific article published on 21 March 2019

Phosphorylation Mechanism of Phosphomevalonate Kinase: Implications for Rational Engineering of Isoprenoid Biosynthetic Pathway Enzymes

artículo científico publicado en 2016

Pilot Evaluation of Two Fasciola hepatica Biomarkers for Supporting Triclabendazole (TCBZ) Efficacy Diagnostics

artículo científico publicado en 2020

Plume characteristics and dynamics of UV and IR laser-desorbed oligonucleotides ⬇️

artículo científico publicado el 19 de marzo de 2012

Purple sweet potato colour--a potential therapy for galactosemia?

artículo científico publicado en 2013

Reaction Mechanism of Isopentenyl Phosphate Kinase: A QM/MM Study.

artículo científico publicado en 2017

Role of Arg228 in the phosphorylation of galactokinase: the mechanism of GHMP kinases by quantum mechanics/molecular mechanics studies

artículo científico publicado en 2013

Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism.

artículo científico publicado en 2017

Split-EGFP screens for the detection and localisation of protein-protein interactions in living yeast cells

artículo científico publicado en 2010

Structural and molecular biology of type I galactosemia: disease-associated mutations

artículo científico

Structure of the adenylation domain of an NAD+-dependent DNA ligase

artículo científico publicado en 1999

The 67 kDa laminin receptor: structure, function and role in disease

artículo científico publicado en 2008

The Catalytic Cycle of the Antioxidant and Cancer-Associated Human NQO1 Enzyme: Hydride Transfer, Conformational Dynamics and Functional Cooperativity

artículo científico publicado en 2020

The GAL genetic switch: visualisation of the interacting proteins by split-EGFP bimolecular fluorescence complementation

artículo científico publicado en 2011

The Mechanism of Action of Praziquantel: Can New Drugs Exploit Similar Mechanisms?

artículo científico publicado en 2020

The N-terminus of A1-type myosin essential light chains binds actin and modulates myosin motor function

artículo científico publicado en 1998

The Schistosoma mansoni tegumental allergen protein, SmTAL1: Binding to an IQ-motif from a voltage-gated ion channel and effects of praziquantel

artículo científico publicado en 2020

The biology of habitat dominance; can microbes behave as weeds?

artículo científico publicado en 2013

The contribution of key hydrophobic residues in ecotin to enzyme-inhibitor complex stability

artículo científico publicado en 2009

The interaction of IQGAPs with calmodulin-like proteins

artículo científico publicado en 2011

The mechanism of action of praziquantel: six hypotheses

artículo científico publicado en 2018

The metastability of human UDP-galactose 4'-epimerase (GALE) is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding

artículo científico publicado en 2014

The molecular basis of galactosemia - Past, present and future

artículo científico

The molecular dynamics of Trypanosoma brucei UDP-galactose 4'-epimerase: a drug target for African sleeping sickness

artículo científico publicado en 2012

The role of the active site residues in human galactokinase: implications for the mechanisms of GHMP kinases.

artículo científico publicado en 2011

The roles and applications of chaotropes and kosmotropes in industrial fermentation processes

artículo científico publicado en 2020

The rôle of the proline-rich region in A1-type myosin essential light chains: implications for information transmission in the actomyosin complex

artículo científico publicado en 1997

The structural and molecular biology of type I galactosemia: Enzymology of galactose 1-phosphate uridylyltransferase

artículo científico

The structural and molecular biology of type III galactosemia.

artículo científico publicado en 2006

The structural and molecular biology of type IV galactosemia

scientific article published on 09 November 2020

The tegumental allergen-like proteins of Schistosoma mansoni: a biochemical study of SmTAL4-TAL13.

artículo científico publicado en 2018

The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties

artículo científico publicado en 2014

TheSaccharomyces cerevisiaequinone oxidoreductase Lot6p: stability, inhibition and cooperativity

scientific article published on 19 June 2014

Therapies for galactosemia: a patent landscape

scientific article published on 21 April 2020

Triose phosphate isomerase from the blood fluke Schistosoma mansoni: biochemical characterisation of a potential drug and vaccine target

artículo científico publicado en 2013

Type IV galactosemia

scientific article published on 21 November 2018

UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase- 6 (pp-GalNAc-T6): Role in Cancer and Prospects as a Drug Target.

artículo científico publicado en 2016

UDP-galactose 4'-epimerase from the liver fluke, Fasciola hepatica: biochemical characterization of the enzyme and identification of inhibitors.

artículo científico publicado en 2014

Water-mediated network in the resistance mechanism of fosfomycin

scientific article published on 01 August 2018

Lista de obras de David J. Timson

<i>Escherichia coli</i>Modulator of Drug Activity B (MdaB) Has Different Enzymological Properties to Eukaryote Quinone Oxidoreductases

A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer

A calcium-dependent interaction between calmodulin and the calponin homology domain of human IQGAP1.

A galactokinase-like protein from the liver fluke Fasciola hepatica

A ligand predication tool based on modeling and reasoning with imprecise probabilistic knowledge

A mysterious family of calcium-binding proteins from parasitic worms

A novel calmodulin-like protein from the liver fluke, Fasciola hepatica

A plasma membrane Ca(2+)-ATPase (PMCA) from the liver fluke, Fasciola hepatica.

A universal measure of chaotropicity and kosmotropicity.

Altered cofactor binding affects stability and activity of human UDP-galactose 4′-epimerase: Implications for type III galactosemia ⬇️

Analysis of UDP-galactose 4'-epimerase mutations associated with the intermediate form of type III galactosaemia

Antioxidant properties and global metabolite screening of the probiotic yeast Saccharomyces cerevisiae var. boulardii

Antiproton induced DNA damage: proton like in flight, carbon-ion like near rest.

Artemisinins act through at least two targets in a yeast model

Binding of serum albumin to the anthelmintic drugs albendazole, triclabendazole and their sulphoxides

Biochemical analysis of the interactions of IQGAP1 C-terminal domain with CDC42

Biochemical characterisation of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) from the liver fluke, Fasciola hepatica

Calmodulin disruption impacts growth and motility in juvenile liver fluke

Calmodulins from Schistosoma mansoni: Biochemical analysis and interaction with IQ-motifs from voltage-gated calcium channels

Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity

Catalytic mechanism of mevalonate kinase revisited, a QM/MM study

Chaotropicity: a key factor in product tolerance of biofuel-producing microorganisms.

Characterisation of eppin function: expression and activity in the lung

Characterisation of two calmodulin-like proteins from the liver fluke, Fasciola hepatica

Characterization of Calcium-Binding Proteins from Parasitic Worms

Characterization of the Saccharomyces cerevisiae galactose mutarotase/UDP-galactose 4-epimerase protein, Gal10p.

Citrate synthase from the liver fluke Fasciola hepatica

Comparative biochemical analysis of three members of the Schistosoma mansoni TAL family: Differences in ion and drug binding properties

Comparison of dynamics of wildtype and V94M human UDP-galactose 4-epimerase-A computational perspective on severe epimerase-deficiency galactosemia.

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands

Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity.

DNA damage by low-energy ions

Damage to plasmid DNA induced by low energy carbon ions

Destressing Yeast for Higher Biofuel Yields: Can Excess Chaotropicity Be Mitigated?

Detection and localisation of protein-protein interactions in Saccharomyces cerevisiae using a split-GFP method

Development and implementation of split-GFP-based bimolecular fluorescence complementation (BiFC) assays in yeast

Development of a novel mass spectrometric technique for studying DNA damage

Dicoumarol: A Drug which Hits at Least Two Very Different Targets in Vitamin K Metabolism

Different specificities of two aldehyde dehydrogenases from Saccharomyces cerevisiae var. boulardii

Differential expression of liver fluke β-tubulin isotypes at selected life cycle stages

Dynamic origins of substrate promiscuity in bacterial galactokinases

Effects of alcohols and compatible solutes on the activity of β-galactosidase.

Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

Evidence for chaotropicity/kosmotropicity offset in a yeast growth model

Expression, purification and crystallization of a novel metagenome-derived salicylaldehyde dehydrogenase from Alpine soil

FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1.

Fasciola hepatica calcium-binding protein FhCaBP2: structure of the dynein light chain-like domain

Fasciola hepatica expresses multiple alpha- and beta-tubulin isotypes.

FhCaBP1 (FH22): A Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains

FhCaBP2: a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains

FhCaBP3: a Fasciola hepatica calcium binding protein with EF-hand and dynein light chain domains.

FhCaBP4: a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains.

Fine tuning the myosin motor: the role of the essential light chain in striated muscle myosin.

Fragmentation of neutral amino acids and small peptides by intense, femtosecond laser pulses.

Fructose 1,6-phosphatase: getting the message across

Functional analysis of disease-causing mutations in human UDP-galactose 4-epimerase

Functional analysis of disease‐causing mutations in human galactokinase ⬇️

Functional domains of an NAD + -dependent DNA ligase 1 1Edited by A. R. Fersht

Functional domains of the human epididymal protease inhibitor, eppin

Galactokinase promiscuity: a question of flexibility?

Glycerol enhances fungal germination at the water-activity limit for life

Hydrophobic substances induce water stress in microbial cells.

IQ motif selectivity in human IQGAP1: binding of myosin essential light chain and S100B

IQ-motif peptides as novel anti-microbial agents

IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain

IQGAP1 Interaction with RHO Family Proteins Revisited: KINETIC AND EQUILIBRIUM EVIDENCE FOR MULTIPLE DISTINCT BINDING SITES.

Identification and characterisation of human aldose 1-epimerase

Improving the Activity and Stability of Human Galactokinase for Therapeutic and Biotechnological Applications.

In Silico Analysis of the Effects of Point Mutations on α-Globin: Implications for α-Thalassemia

In Silico Prediction of the Effects of Mutations in the Human Mevalonate Kinase Gene: Towards a Predictive Framework for Mevalonate Kinase Deficiency.

In silico identification and biochemical characterization of novel inhibitors of NQO1

In silico prediction of the effects of mutations in the human UDP-galactose 4'-epimerase gene: towards a predictive framework for type III galactosemia

In silico prediction of the effects of mutations in the human triose phosphate isomerase gene: Towards a predictive framework for TPI deficiency

In vivo and in vitro function of human UDP-galactose 4'-epimerase variants.

Increased promiscuity of human galactokinase following alteration of a single amino acid residue distant from the active site

Insight into the mechanism of galactokinase: Role of a critical glutamate residue and helix/coil transitions

Interaction of prothrombin with a phospholipid surface: evidence for a membrane-induced conformational change

Interactions between the budding yeast IQGAP homologue Iqg1p and its targets revealed by a split-EGFP bimolecular fluorescence complementation assay.

Is there a common water-activity limit for the three domains of life?