Filtros de búsqueda

Lista de obras de Omar Abdel-Wahab

2-Hydroxyglutarate in IDH mutant acute myeloid leukemia: predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylcytosine levels.

artículo científico publicado en 2012

A mathematical framework to determine the temporal sequence of somatic genetic events in cancer

artículo científico publicado en 2010

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

artículo científico publicado en 2011

ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine

artículo científico publicado en 2021

ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression

artículo científico publicado en 2012

ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.

artículo científico publicado en 2017

Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q

artículo científico publicado en 2011

Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms

scientific article published on 25 November 2019

Acute myeloid leukemia with translocation t(8;16) presents with features which mimic acute promyelocytic leukemia and is associated with poor prognosis

scientific article published on 24 October 2012

BRAF-mutant hematopoietic malignancies

artículo científico publicado en 2014

Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma

artículo científico publicado en 2012

Clinical effect of point mutations in myelodysplastic syndromes

artículo científico publicado en 2011

Clinical implications of novel mutations in epigenetic modifiers in AML.

artículo científico publicado en 2011

Collaborating constitutive and somatic genetic events in myeloid malignancies: ASXL1 mutations in patients with germline GATA2 mutations

artículo científico publicado en 2014

Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms ⬇️

artículo científico publicado el 1 de abril de 2011

Consensus guidelines for the diagnosis and clinical management of Erdheim-Chester disease

artículo científico publicado en 2014

Current pre-clinical and clinical advances in the BCR-ABL1-positive and -negative chronic myeloproliferative neoplasms

artículo científico publicado en 2014

D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice

scientific article published on March 2014

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia

artículo científico publicado en 2014

DNA methylation disruption reshapes the hematopoietic differentiation landscape

artículo científico publicado en 2020

DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms ⬇️

artículo científico publicado el 26 de abril de 2011

Data from Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation

Data from Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation

Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML.

artículo científico publicado en 2011

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

artículo científico publicado en 2013

Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera

artículo científico publicado en 2010

Detection of an NRAS mutation in Erdheim-Chester disease.

artículo científico publicado en 2013

Diagnosis and classification of hematologic malignancies on the basis of genetics.

artículo científico publicado en 2017

Disordered epigenetic regulation in the pathophysiology of myeloproliferative neoplasms

artículo científico

ETV6-ABL1-positive "chronic myeloid leukemia": clinical and molecular response to tyrosine kinase inhibition.

artículo científico publicado en 2010

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

artículo científico publicado en 2013

Efficacy of intermittent combined RAF and MEK inhibition in a patient with concurrent BRAF- and NRAS-mutant malignancies

artículo científico publicado en 2014

Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis

artículo científico publicado en 2010

Emerging therapeutic paradigms to target the dysregulated Janus kinase/signal transducer and activator of transcription pathway in hematological malignancies

artículo científico publicado en 2014

Epigenetic alterations in hematopoietic malignancies

artículo científico publicado en 2012

FISHing for TET2: Utility of FISH for TET2 deletions detection in clinical samples

artículo científico publicado en 2011

Femoral bone marrow aspiration in live mice

artículo científico publicado en 2014

Focus on the epigenome in the myeloproliferative neoplasms

artículo científico

Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations.

artículo científico publicado en 2014

Functional evidence for derivation of systemic histiocytic neoplasms from hematopoietic stem/progenitor cells

artículo científico publicado en 2017

GM-CSF-dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia.

artículo científico publicado en 2013

Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome

artículo científico publicado en 2012

Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias

artículo científico publicado en 2010

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

artículo científico publicado en 2009

Genetics of the myeloproliferative neoplasms

scientific article published on March 2011

Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations

artículo científico

Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms.

artículo científico publicado en 2014

HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.

artículo científico publicado en 2013

HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans

artículo científico publicado en 2010

Hematopoietic stem cell origin of BRAFV600E mutations in hairy cell leukemia

artículo científico publicado en 2014

Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy

artículo científico publicado en 2012

How do messenger RNA splicing alterations drive myelodysplasia?

artículo científico publicado en 2017

IDH mutation impairs histone demethylation and results in a block to cell differentiation

artículo científico publicado en 2012

IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis.

artículo científico publicado en 2010

Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene

article published in the Proceedings of the National Academy of Sciences of the United States of America

Importance of genetics in the clinical management of chronic myelomonocytic leukemia

artículo científico publicado en 2013

Interpreting new molecular genetics in myelodysplastic syndromes

artículo científico

JAK-STAT pathway activation in malignant and nonmalignant cells contributes to MPN pathogenesis and therapeutic response

artículo científico publicado en 2015

JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation

artículo científico publicado en 2011

Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell-stimulated T cells yet preserves immunity to recall antigen

artículo científico publicado en 2011

Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127

scientific article published on 01 February 2024

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

artículo científico publicado en 2010

Loss of the tumor suppressor BAP1 causes myeloid transformation

artículo científico publicado en 2012

Metabolism and the leukemic stem cell.

artículo científico publicado en 2010

Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition

artículo científico publicado en 2021

Modeling CBL activating mutations in vivo

artículo científico publicado en 2017

Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins

artículo científico publicado en 2016

Molecular analysis of patients with polycythemia vera or essential thrombocythemia receiving pegylated interferon α-2a

artículo científico publicado en 2013

Molecular genetics of acute myeloid leukemia: clinical implications and opportunities for integrating genomics into clinical practice

artículo científico publicado en 2012

Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors

artículo científico publicado en 2019

Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia ⬇️

artículo científico publicado el 24 de enero de 2013

Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy

artículo científico publicado en 2011

Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia.

artículo científico publicado en 2013

Mutations with epigenetic effects in myeloproliferative neoplasms and recent progress in treatment: Proceedings from the 5th International Post-ASH Symposium

artículo científico publicado en 2011

Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations

scientific journal article

Oncogenic TRK fusions are amenable to inhibition in hematologic malignancies

artículo científico publicado en 2018

Oncogenic splicing regulated by phase separation

artículo científico publicado en 2020

PHF6 mutations in adult acute myeloid leukemia

artículo científico publicado en 2010

PTEN isoforms with dual and opposing function

scientific article published on 01 November 2019

Partial loss of genes might open therapeutic window

artículo científico publicado en 2017

Primary myelofibrosis: update on definition, pathogenesis, and treatment.

scientific article published on January 2009

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

artículo científico publicado en 2012

Progression of RAS-mutant leukemia during RAF inhibitor treatment

artículo científico publicado en 2012

Proposed criteria for response assessment in patients treated in clinical trials for myeloproliferative neoplasms in blast phase (MPN-BP): formal recommendations from the post-myeloproliferative neoplasm acute myeloid leukemia consortium

artículo científico publicado en 2012

Recent advances in the treatment of acute myeloid leukemia.

artículo científico publicado en 2010

Recent discoveries in molecular characterization of acute myeloid leukemia

artículo científico

Recurrent RAS and PIK3CA mutations in Erdheim-Chester disease

artículo científico publicado en 2014

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

artículo científico publicado en 2012

Refining the prognostic importance of the diversity of FLT3 internal tandem duplications

artículo científico publicado en 2012

Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression.

artículo científico publicado en 2013

Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML.

artículo científico publicado en 2017

Role of TET2 and ASXL1 mutations in the pathogenesis of myeloproliferative neoplasms

artículo científico publicado en 2012

Safety, efficacy and biological predictors of response to sequential azacitidine and lenalidomide for elderly patients with acute myeloid leukemia

artículo científico publicado en 2011

Selective activity of the histone deacetylase inhibitor AR-42 against leukemia stem cells: a novel potential strategy in acute myelogenous leukemia

artículo científico publicado en 2014

Sequential azacitidine plus lenalidomide combination for elderly patients with untreated acute myeloid leukemia ⬇️

artículo científico publicado el 14 de diciembre de 2012

Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia ⬇️

artículo científico publicado el 2 de mayo de 2013

Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.

artículo científico publicado en 2012

Somatic alterations and dysregulation of epigenetic modifiers in cancers.

artículo científico publicado en 2014

Somatic gene mutations expose cytoplasmic DNA to co-opt the cGAS/STING/NLRP3 axis in myelodysplastic syndromes

artículo científico publicado en 2022

Somatic mutations and cell identity linked by Genotyping of Transcriptomes

artículo científico publicado en 2019

Supplementary Figure from Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation

Supplementary Figure from Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations

article

TET family proteins and their role in stem cell differentiation and transformation.

artículo científico publicado en 2011

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

scientific journal article

The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigenetics

artículo científico

The JAK2V617F oncogene requires expression of inducible phosphofructokinase/fructose-bisphosphatase 3 for cell growth and increased metabolic activity

artículo científico publicado en 2011

The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.

artículo científico publicado en 2010

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

artículo científico publicado en 2010

The importance of subclonal genetic events in MDS.

artículo científico publicado en 2013

The most commonly reported variant in ASXL1 (c.1934dupG;p.Gly646TrpfsX12) is not a somatic alteration

artículo científico publicado en 2010

The mutational landscape of paroxysmal nocturnal hemoglobinuria revealed: new insights into clonal dominance

artículo científico publicado en 2014

The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization.

artículo científico publicado en 2012

The role of mutations in epigenetic regulators in myeloid malignancies

artículo científico publicado en 2012

The spliceosome as an indicted conspirator in myeloid malignancies

artículo científico publicado en 2011

Toll-like receptor alterations in myelodysplastic syndrome

artículo científico publicado en 2013

Translocation t(11;17) in de novo myelodysplastic syndrome not associated with acute myeloid or acute promyelocytic leukemia

artículo científico publicado en 2012

Unraveling the genetic underpinnings of myeloproliferative neoplasms and understanding their effect on disease course and response to therapy: proceedings from the 6th International Post-ASH Symposium

artículo científico publicado en 2012

Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes

artículo científico publicado en 2012

Warfarin-induced skin necrosis in a patient with heparin-induced thrombocytopenia: two diseases or one?

artículo científico publicado en 2008

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda