Lista de obras - Dominic J Wells - Dominio Público Uruguay

"Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic

artículo científico publicado en 2018

A New Extensively Characterised Conditionally Immortal Muscle Cell-Line for Investigating Therapeutic Strategies in Muscular Dystrophies ⬇️

artículo científico publicado el 14 de septiembre de 2011

Adeno-associated virus vector gene transfer and sarcolemmal expression of a 144 kDa micro-dystrophin effectively restores the dystrophin-associated protein complex and inhibits myofibre degeneration in nude/mdx mice

artículo científico publicado en 2002

Adenoviral vectors for gene transfer of full-length human dystrophin cDNAs

article

Age and sex influence expression of plasmid DNA directly injected into mouse skeletal muscle

artículo científico publicado en 1992

Altered secondary myogenesis in transgenic animals expressing the neural cell adhesion molecule under the control of a skeletal muscle alpha-actin promoter

artículo científico publicado en 1996

An IL-7 fusion protein that shows increased thymopoietic ability

artículo científico publicado en 2005

Analysis of a 70 kb segment of DNA containing the human zeta and alpha-globin genes linked to their regulatory element (HS-40) in transgenic mice

artículo científico publicado en 1994

Analysis of the human alpha-globin gene cluster in transgenic mice

artículo científico publicado en 1993

Animal welfare and the 3Rs in European biomedical research ⬇️

artículo científico publicado el 1 de diciembre de 2011

Animals with Novel Genes

artículo científico publicado en 1995

Assessing the welfare of genetically altered mice.

artículo científico publicado en 2006

Beyond the vertebrates: achieving maximum power during flight in insects and hummingbirds

artículo científico publicado en 1994

Characterisation of expression of mDMAHP, a homeodomain-encoding gene at the murine DM locus

artículo científico publicado en 1997

Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons

artículo científico publicado en 2017

Characterization of an evolutionarily conserved far-upstream enhancer in the human alpha 2(I) collagen (COL1A2) gene

artículo científico publicado en 2001

Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome

artículo científico publicado en 2005

Chronic systemic therapy with low-dose morpholino oligomers ameliorates the pathology and normalizes locomotor behavior in mdx mice

artículo científico publicado en 2010

Codon and mRNA Sequence Optimization of Microdystrophin Transgenes Improves Expression and Physiological Outcome in Dystrophic mdx Mice Following AAV2/8 Gene Transfer

article

Cold exposure increases running VO(2max) and cost of transport in goats

artículo científico publicado en 2001

Cooperativity between far upstream enhancer and proximal promoter elements of the human {alpha}2(I) collagen (COL1A2) gene instructs tissue specificity in transgenic mice

scientific article published on 29 October 2004

Designing translationally relevant preclinical studies of new therapeutics

artículo científico publicado en 2017

Determination of qPCR Reference Genes Suitable for Normalizing Gene Expression in a Canine Model of Duchenne Muscular Dystrophy.

artículo científico publicado en 2018

Differential expression and secretion of alpha 1 anti-trypsin between direct DNA injection and implantation of transfected myoblast

artículo científico publicado en 1999

Direct retroviral-mediated transfer of a dystrophin minigene into mdx mouse muscle in vivo

scientific article published on 01 June 1993

Ectopic expression of NCAM in skeletal muscle of transgenic mice results in terminal sprouting at the neuromuscular junction and altered structure but not function

artículo científico publicado en 2000

Effect of albumin and dextrose concentration on ultrasound and microbubble mediated gene transfection in vivo.

artículo científico publicado en 2012

Efficiency of in vivo gene transfer using murine retroviral vectors is strain-dependent in mice

scientific article published on 01 September 1995

Electroporation and ultrasound enhanced non-viral gene delivery in vitro and in vivo

artículo científico publicado en 2009

Enhanced expression of recombinant dystrophin following intramuscular injection of Epstein-Barr virus (EBV)-based mini-chromosome vectors in mdx mice

artículo científico publicado en 1999

Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

artículo científico publicado en 2011

Expression of opsin genes early in ocular development of humans and mice.

artículo científico publicado en 2003

Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A.

artículo científico publicado en 2008

Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS).

artículo científico publicado en 2018

Gene doping: possibilities and practicalities

artículo científico publicado en 2009

Gene doping: the hype and the reality.

artículo científico publicado en 2008

Gene expression in skeletal muscle in response to stretch and force generation

artículo científico publicado el 1 de marzo de 1992

Gene therapy progress and prospects: electroporation and other physical methods.

artículo científico publicado en 2004

Genetic correction of dystrophin deficiency and skeletal muscle remodeling in adult MDX mouse via transplantation of retroviral producer cells.

scientific article published on August 1997

Genetic engineering in athletes

artículo científico publicado en 2008

Genetic treatments in muscular dystrophies

artículo científico publicado en 2007

Genetically modified animals and pharmacological research

artículo científico publicado en 2010

Heat shock protein 27 overexpression mitigates cytokine-induced islet apoptosis and streptozotocin-induced diabetes

artículo científico publicado en 2009

Heat shock protein 27 protects against atherogenesis via an estrogen-dependent mechanism: role of selective estrogen receptor beta modulation.

artículo científico publicado en 2009

Heat shock protein 27 protects the heart against myocardial infarction

artículo científico publicado en 2004

Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration

artículo científico publicado en 2001

Histopathological Evaluation of Skeletal Muscle with Specific Reference to Mouse Models of Muscular Dystrophy.

artículo científico publicado en 2016

Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation

artículo científico publicado en 2007

Identification and validation of quantitative PCR reference genes suitable for normalizing expression in normal and dystrophic cell culture models of myogenesis

artículo científico publicado en 2014

Identification of a repressor in the first intron of the human alpha2(I) collagen gene (COL1A2).

artículo científico publicado en 2005

Identification of qPCR reference genes suitable for normalizing gene expression in the mdx mouse model of Duchenne muscular dystrophy

artículo científico publicado en 2019

Identification of the key regions within the mouse pro-alpha 2(I) collagen gene far-upstream enhancer

artículo científico publicado en 2001

Improved gene transfer by direct plasmid injection associated with regeneration in mouse skeletal muscle

artículo científico publicado en 1993

In silico characterisation and chromosomal localisation of human RRH (peropsin)--implications for opsin evolution

artículo científico publicado en 2003

Independent regulation of the myotonic dystrophy 1 locus genes postnatally and during adult skeletal muscle regeneration

artículo científico publicado en 2000

Influence of needle gauge on in vivo ultrasound and microbubble-mediated gene transfection.

artículo científico publicado en 2011

Insertion of two independent enhancers in the long terminal repeat of a self-inactivating vector results in high-titer retroviral vectors with tissue-specific expression

artículo científico publicado en 1998

Intramuscular injection of plasmid DNA ⬇️

artículo científico publicado el 1 de enero de 1995

Investigating Synthetic Oligonucleotide Targeting of Mir31 in Duchenne Muscular Dystrophy

artículo científico publicado en 2016

Investigation of a transgenic mouse model of familial dilated cardiomyopathy.

artículo científico publicado en 2010

Limitations to aerobic performance in mammals: interaction of structure and demand

scientific article published on 01 June 1988

Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study

artículo científico publicado en 2009

Measuring clinical effectiveness of medicinal products for the treatment of Duchenne muscular dystrophy

artículo científico publicado en 2014

Metformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice

artículo científico publicado en 2011

Microbubble stability is a major determinant of the efficiency of ultrasound and microbubble mediated in vivo gene transfer.

artículo científico publicado en 2009

Molecular Mechanism of the E99K Mutation in Cardiac Actin (ACTC Gene) That Causes Apical Hypertrophy in Man and Mouse ⬇️

artículo científico publicado el 26 de mayo de 2011

Muscle moment arms and sensitivity analysis of a mouse hindlimb musculoskeletal model

artículo científico publicado en 2016

Muscular dystrophies due to glycosylation defects: diagnosis and therapeutic strategies

artículo científico

Musculoskeletal Geometry, Muscle Architecture and Functional Specialisations of the Mouse Hindlimb

artículo científico publicado en 2016

Mutated fukutin-related protein (FKRP) localises as wild type in differentiated muscle cells

artículo científico publicado en 2005

Olfaction variation in mouse husbandry and its implications for refinement and standardization: UK survey of animal scents.

artículo científico publicado en 2015

Olfactory variation in mouse husbandry and its implications for refinement and standardization: UK survey of non-animal scents

artículo científico publicado en 2015

Opening the floodgates: clinically applicable hydrodynamic delivery of plasmid DNA to skeletal muscle.

artículo científico publicado en 2004

Overexpression of heat shock protein 27 reduces cortical damage after cerebral ischemia

artículo científico publicado en 2009

Peptide-conjugated antisense therapy takes a skip ahead

scientific article published on 01 September 2008

Physiological characterization of muscle strength with variable levels of dystrophin restoration in mdx mice following local antisense therapy.

artículo científico publicado en 2010

Poloxamer [corrected] 188 has a deleterious effect on dystrophic skeletal muscle function.

artículo científico publicado en 2014

Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse

artículo científico publicado en 2012

Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression

artículo científico publicado en 2007

Relocalization of neuronal nitric oxide synthase (nNOS) as a marker for complete restoration of the dystrophin associated protein complex in skeletal muscle

artículo científico publicado en 2003

Restoration of dystrophin expression using the Sleeping Beauty transposon.

artículo científico publicado en 2011

Retroviral-mediated gene transfer into murine and human skeletal muscle for the correction of dystrophin deficiency

artículo científico publicado en 1996

Role of a 5'-enhancer in the transcriptional regulation of the human endothelial cell protein C receptor gene

artículo científico publicado en 2006

Running energetics in the pronghorn antelope

artículo científico publicado en 1991

Skeletal muscle mitochondria: the aerobic gate?

artículo científico publicado en 1988

Stable micro-dystrophin gene transfer using an integrating adeno-retroviral hybrid vector ameliorates the dystrophic pathology in mdx mouse muscle.

artículo científico publicado en 2002

Structure and evolution of the teleost extraretinal rod-like opsin (errlo) and ocular rod opsin (rho) genes: is teleost rho a retrogene?

artículo científico publicado en 2003

Sustained transgene expression using non-viral enzymatic systems for stable chromosomal integration.

artículo científico publicado en 2008

The TREAT-NMD advisory committee for therapeutics (TACT): an innovative de-risking model to foster orphan drug development

artículo científico publicado en 2015

The human ClC-4 protein, a member of the CLC chloride channel/transporter family, is localized to the endoplasmic reticulum by its N-terminus

scientific journal article

The skeletal muscle phenotype of the DE50-MD dog model of Duchenne muscular dystrophy

artículo científico publicado en 2022

The transgenic expression of LARGE exacerbates the muscle phenotype of dystroglycanopathy mice

artículo científico publicado en 2013

Therapeutic restoration of dystrophin expression in Duchenne muscular dystrophy.

artículo científico publicado en 2006

Tracking progress: an update on animal models for Duchenne muscular dystrophy

artículo científico publicado en 2018

Transgenic Rescue of the LARGEmyd Mouse: A LARGE Therapeutic Window?

artículo científico publicado en 2016

Transgenic overexpression of LARGE induces α-dystroglycan hyperglycosylation in skeletal and cardiac muscle

artículo científico publicado en 2010

Translational and regulatory challenges for exon skipping therapies

artículo científico

Transplantation of retroviral producer cells for in vivo gene transfer into mouse skeletal muscle

artículo científico publicado en 1996

Treatments for muscular dystrophy: increased treatment options for Duchenne and related muscular dystropies

artículo científico publicado en 2008

What is the level of dystrophin expression required for effective therapy of Duchenne muscular dystrophy?

scientific article published on 01 June 2019

Zebrafish melanopsin: isolation, tissue localisation and phylogenetic position

artículo científico publicado en 2002

Lista de obras de Dominic J Wells

"Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic

A New Extensively Characterised Conditionally Immortal Muscle Cell-Line for Investigating Therapeutic Strategies in Muscular Dystrophies ⬇️

Adeno-associated virus vector gene transfer and sarcolemmal expression of a 144 kDa micro-dystrophin effectively restores the dystrophin-associated protein complex and inhibits myofibre degeneration in nude/mdx mice

Adenoviral vectors for gene transfer of full-length human dystrophin cDNAs

Age and sex influence expression of plasmid DNA directly injected into mouse skeletal muscle

Altered secondary myogenesis in transgenic animals expressing the neural cell adhesion molecule under the control of a skeletal muscle alpha-actin promoter

An IL-7 fusion protein that shows increased thymopoietic ability

Analysis of a 70 kb segment of DNA containing the human zeta and alpha-globin genes linked to their regulatory element (HS-40) in transgenic mice

Analysis of the human alpha-globin gene cluster in transgenic mice

Animal welfare and the 3Rs in European biomedical research ⬇️

Animals with Novel Genes

Assessing the welfare of genetically altered mice.

Beyond the vertebrates: achieving maximum power during flight in insects and hummingbirds

Characterisation of expression of mDMAHP, a homeodomain-encoding gene at the murine DM locus

Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons

Characterization of an evolutionarily conserved far-upstream enhancer in the human alpha 2(I) collagen (COL1A2) gene

Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome

Chronic systemic therapy with low-dose morpholino oligomers ameliorates the pathology and normalizes locomotor behavior in mdx mice

Codon and mRNA Sequence Optimization of Microdystrophin Transgenes Improves Expression and Physiological Outcome in Dystrophic mdx Mice Following AAV2/8 Gene Transfer

Cold exposure increases running VO(2max) and cost of transport in goats

Cooperativity between far upstream enhancer and proximal promoter elements of the human {alpha}2(I) collagen (COL1A2) gene instructs tissue specificity in transgenic mice

Designing translationally relevant preclinical studies of new therapeutics

Determination of qPCR Reference Genes Suitable for Normalizing Gene Expression in a Canine Model of Duchenne Muscular Dystrophy.

Differential expression and secretion of alpha 1 anti-trypsin between direct DNA injection and implantation of transfected myoblast

Direct retroviral-mediated transfer of a dystrophin minigene into mdx mouse muscle in vivo

Ectopic expression of NCAM in skeletal muscle of transgenic mice results in terminal sprouting at the neuromuscular junction and altered structure but not function

Effect of albumin and dextrose concentration on ultrasound and microbubble mediated gene transfection in vivo.

Efficiency of in vivo gene transfer using murine retroviral vectors is strain-dependent in mice

Electroporation and ultrasound enhanced non-viral gene delivery in vitro and in vivo

Enhanced expression of recombinant dystrophin following intramuscular injection of Epstein-Barr virus (EBV)-based mini-chromosome vectors in mdx mice

Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

Expression of opsin genes early in ocular development of humans and mice.

Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A.

Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS).

Gene doping: possibilities and practicalities

Gene doping: the hype and the reality.

Gene expression in skeletal muscle in response to stretch and force generation

Gene therapy progress and prospects: electroporation and other physical methods.

Genetic correction of dystrophin deficiency and skeletal muscle remodeling in adult MDX mouse via transplantation of retroviral producer cells.

Genetic engineering in athletes

Genetic treatments in muscular dystrophies

Genetically modified animals and pharmacological research

Heat shock protein 27 overexpression mitigates cytokine-induced islet apoptosis and streptozotocin-induced diabetes

Heat shock protein 27 protects against atherogenesis via an estrogen-dependent mechanism: role of selective estrogen receptor beta modulation.

Heat shock protein 27 protects the heart against myocardial infarction

Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration

Histopathological Evaluation of Skeletal Muscle with Specific Reference to Mouse Models of Muscular Dystrophy.

Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation

Identification and validation of quantitative PCR reference genes suitable for normalizing expression in normal and dystrophic cell culture models of myogenesis

Identification of a repressor in the first intron of the human alpha2(I) collagen gene (COL1A2).

Identification of qPCR reference genes suitable for normalizing gene expression in the mdx mouse model of Duchenne muscular dystrophy

Identification of the key regions within the mouse pro-alpha 2(I) collagen gene far-upstream enhancer

Improved gene transfer by direct plasmid injection associated with regeneration in mouse skeletal muscle

In silico characterisation and chromosomal localisation of human RRH (peropsin)--implications for opsin evolution

Independent regulation of the myotonic dystrophy 1 locus genes postnatally and during adult skeletal muscle regeneration

Influence of needle gauge on in vivo ultrasound and microbubble-mediated gene transfection.

Insertion of two independent enhancers in the long terminal repeat of a self-inactivating vector results in high-titer retroviral vectors with tissue-specific expression

Intramuscular injection of plasmid DNA ⬇️

Investigating Synthetic Oligonucleotide Targeting of Mir31 in Duchenne Muscular Dystrophy

Investigation of a transgenic mouse model of familial dilated cardiomyopathy.

Limitations to aerobic performance in mammals: interaction of structure and demand

Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study

Measuring clinical effectiveness of medicinal products for the treatment of Duchenne muscular dystrophy

Metformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice

Microbubble stability is a major determinant of the efficiency of ultrasound and microbubble mediated in vivo gene transfer.

Molecular Mechanism of the E99K Mutation in Cardiac Actin (ACTC Gene) That Causes Apical Hypertrophy in Man and Mouse ⬇️

Muscle moment arms and sensitivity analysis of a mouse hindlimb musculoskeletal model

Muscular dystrophies due to glycosylation defects: diagnosis and therapeutic strategies

Musculoskeletal Geometry, Muscle Architecture and Functional Specialisations of the Mouse Hindlimb

Mutated fukutin-related protein (FKRP) localises as wild type in differentiated muscle cells

Olfaction variation in mouse husbandry and its implications for refinement and standardization: UK survey of animal scents.

Olfactory variation in mouse husbandry and its implications for refinement and standardization: UK survey of non-animal scents

Opening the floodgates: clinically applicable hydrodynamic delivery of plasmid DNA to skeletal muscle.

Overexpression of heat shock protein 27 reduces cortical damage after cerebral ischemia

Peptide-conjugated antisense therapy takes a skip ahead

Physiological characterization of muscle strength with variable levels of dystrophin restoration in mdx mice following local antisense therapy.

Poloxamer [corrected] 188 has a deleterious effect on dystrophic skeletal muscle function.

Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse

Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression