Lista de obras - Petr Broz - Dominio Público Uruguay

AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity

artículo científico publicado en 2016

ASC filament formation serves as a signal amplification mechanism for inflammasomes

artículo científico publicado en 2016

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.

artículo científico publicado en 2010

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages

artículo científico publicado en 2018

Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis

scientific article published on 03 December 2019

Caspase target drives pyroptosis

scientific article published in Nature

Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop

artículo científico publicado en 2013

Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection.

artículo científico publicado en 2012

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

artículo científico publicado en 2020

Caspase-11 activates a canonical NLRP3 inflammasome by promoting K(+) efflux

artículo científico publicado en 2015

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

artículo científico publicado en 2014

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

artículo científico publicado en 2012

Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

scientific article published on 18 November 2020

Corrigendum: ASC filament formation serves as a signal amplification mechanism for inflammasomes

artículo científico publicado en 2017

Cross talk between intracellular pathogens and cell death

scientific article published on 22 June 2020

Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways

scientific article published on 01 March 2020

Detecting Release of Bacterial dsDNA into the Host Cytosol Using Fluorescence Microscopy

artículo científico publicado en 2018

Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing

artículo científico publicado en 2010

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

scientific article published on 01 November 2018

Elevated AIM2-mediated pyroptosis triggered by hypercytotoxic Francisella mutant strains is attributed to increased intracellular bacteriolysis

artículo científico

Evolutionary Convergence and Divergence in NLR Function and Structure

artículo científico publicado en 2017

Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly

scientific article published on 22 March 2019

Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape

artículo científico publicado en 2017

Function and mechanism of the pyrin inflammasome

artículo científico publicado en 2017

Function and molecular architecture of the Yersinia injectisome tip complex

artículo científico publicado en 2007

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

artículo científico publicado en 2016

Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection

artículo científico publicado en 2021

Getting rid of the bad apple: inflammasome-induced extrusion of Salmonella-infected enterocytes

artículo científico publicado en 2014

Global Ion Suppression Limits the Potential of Mass Spectrometry Based Phosphoproteomics

artículo científico publicado en 2018

Guanylate-Binding Protein-Dependent Noncanonical Inflammasome Activation Prevents Burkholderia thailandensis-Induced Multinucleated Giant Cell Formation

artículo científico publicado en 2021

Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection

scientific article published on 27 December 2018

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

artículo científico publicado en 2015

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

artículo científico publicado en 2020

IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection.

artículo científico publicado en 2017

Immune Response: Intracellular pathogens under attack

artículo científico publicado en 2016

Inflammasome assembly: The wheels are turning

artículo científico publicado en 2015

Inflammasomes in Host Defense and Autoimmunity

artículo científico publicado en 2016

Inflammasomes: Intracellular detection of extracellular bacteria

artículo científico publicado en 2016

Inflammasomes: mechanism of assembly, regulation and signalling

artículo científico publicado en 2016

Innate Immune Recognition of Francisella Tularensis: Activation of Type-I Interferons and the Inflammasome ⬇️

artículo científico publicado el 3 de febrero de 2011

Interferon-induced guanylate-binding proteins promote cytosolic lipopolysaccharide detection by caspase-11.

artículo científico publicado en 2015

Interferon-inducible GTPases in cell autonomous and innate immunity

artículo científico publicado en 2015

K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

artículo científico publicado en 2016

LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.

artículo científico publicado en 2018

Measuring inflammasome activation in response to bacterial infection

artículo científico publicado en 2013

Mechanisms and Consequences of Inflammasome Activation

artículo científico publicado en 2017

Mobilizable Plasmids for Tunable Gene Expression in

article

Molecular mechanisms of inflammasome activation during microbial infections ⬇️

artículo científico publicado el 1 de septiembre de 2011

Newly described pattern recognition receptors team up against intracellular pathogens

artículo científico

Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps

artículo científico publicado en 2018

Noncanonical inflammasomes: caspase-11 activation and effector mechanisms

artículo científico publicado en 2013

Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation

artículo científico publicado en 2019

Pannexin-1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation

artículo científico publicado en 2019

Protective anti-V antibodies inhibit Pseudomonas and Yersinia translocon assembly within host membranes

artículo científico publicado en 2005

Quantification of Cytosolic vs. Vacuolar Salmonella in Primary Macrophages by Differential Permeabilization

artículo científico publicado en 2015

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella

artículo científico publicado en 2010

Sensing of invading pathogens by GBPs: At the crossroads between cell-autonomous and innate immunity

scholarly article by José Carlos Santos & Petr Broz published 18 July 2018 in Journal of Leukocyte Biology

Sequence-specific solid-state NMR assignments of the mouse ASC PYRIN domain in its filament form

artículo científico publicado en 2015

Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy.

artículo científico publicado en 2015

The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice

artículo científico publicado en 2017

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

artículo científico publicado en 2017

The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles

artículo científico publicado en 2005

The gasdermin-D pore: Executor of pyroptotic cell death

artículo científico publicado en 2016

The gasdermins, a protein family executing cell death and inflammation

artículo científico publicado en 2019

The needle length of bacterial injectisomes is determined by a molecular ruler.

artículo científico publicado en 2003

The type III secretion system tip complex and translocon.

artículo científico publicado en 2008

Toll-like receptor and inflammasome signals converge to amplify the innate bactericidal capacity of T helper 1 cells.

scientific article published on 06 February 2014

Lista de obras de Petr Broz

AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity

ASC filament formation serves as a signal amplification mechanism for inflammasomes

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages

Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis

Caspase target drives pyroptosis

Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop

Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection.

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

Caspase-11 activates a canonical NLRP3 inflammasome by promoting K(+) efflux

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

Corrigendum: ASC filament formation serves as a signal amplification mechanism for inflammasomes

Cross talk between intracellular pathogens and cell death

Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways

Detecting Release of Bacterial dsDNA into the Host Cytosol Using Fluorescence Microscopy

Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

Elevated AIM2-mediated pyroptosis triggered by hypercytotoxic Francisella mutant strains is attributed to increased intracellular bacteriolysis

Evolutionary Convergence and Divergence in NLR Function and Structure

Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly

Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape

Function and mechanism of the pyrin inflammasome

Function and molecular architecture of the Yersinia injectisome tip complex

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection

Getting rid of the bad apple: inflammasome-induced extrusion of Salmonella-infected enterocytes

Global Ion Suppression Limits the Potential of Mass Spectrometry Based Phosphoproteomics

Guanylate-Binding Protein-Dependent Noncanonical Inflammasome Activation Prevents Burkholderia thailandensis-Induced Multinucleated Giant Cell Formation

Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection.

Immune Response: Intracellular pathogens under attack

Inflammasome assembly: The wheels are turning

Inflammasomes in Host Defense and Autoimmunity

Inflammasomes: Intracellular detection of extracellular bacteria

Inflammasomes: mechanism of assembly, regulation and signalling

Innate Immune Recognition of Francisella Tularensis: Activation of Type-I Interferons and the Inflammasome ⬇️

Interferon-induced guanylate-binding proteins promote cytosolic lipopolysaccharide detection by caspase-11.

Interferon-inducible GTPases in cell autonomous and innate immunity

K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.

Measuring inflammasome activation in response to bacterial infection

Mechanisms and Consequences of Inflammasome Activation

Mobilizable Plasmids for Tunable Gene Expression in

Molecular mechanisms of inflammasome activation during microbial infections ⬇️

Newly described pattern recognition receptors team up against intracellular pathogens

Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps

Noncanonical inflammasomes: caspase-11 activation and effector mechanisms

Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation

Pannexin-1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation

Protective anti-V antibodies inhibit Pseudomonas and Yersinia translocon assembly within host membranes

Quantification of Cytosolic vs. Vacuolar Salmonella in Primary Macrophages by Differential Permeabilization

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella

Sensing of invading pathogens by GBPs: At the crossroads between cell-autonomous and innate immunity

Sequence-specific solid-state NMR assignments of the mouse ASC PYRIN domain in its filament form

Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy.

The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles

The gasdermin-D pore: Executor of pyroptotic cell death

The gasdermins, a protein family executing cell death and inflammation

The needle length of bacterial injectisomes is determined by a molecular ruler.

The type III secretion system tip complex and translocon.

Toll-like receptor and inflammasome signals converge to amplify the innate bactericidal capacity of T helper 1 cells.