Lista de obras - Nicoletta Pedemonte - Dominio Público Uruguay

Antihypertensive 1,4-dihydropyridines as correctors of the cystic fibrosis transmembrane conductance regulator channel gating defect caused by cystic fibrosis mutations.

artículo científico publicado en 2005

Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia.

artículo científico publicado en 2012

Asymmetric 4-aryl-1,4-dihydropyridines potentiate mutant cystic fibrosis transmembrane conductance regulator (CFTR).

artículo científico publicado en 2012

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity

scientific article published on 16 July 2019

Block of CFTR-dependent chloride currents by inhibitors of multidrug resistance-associated proteins.

artículo científico publicado en 2007

CFTR processing, trafficking and interactions

scientific article published on 31 October 2019

Chemically modified hCFTR mRNAs recuperate lung function in a mouse model of cystic fibrosis

scientific article published in Scientific Reports

Corrigendum: Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium

scientific article published on 27 August 2019

Cystic fibrosis: a new target for 4-Imidazo[2,1-b]thiazole-1,4-dihydropyridines.

artículo científico publicado en 2011

Development of the Olfactory Epithelium and Nasal Glands in TMEM16A-/- and TMEM16A+/+ Mice

artículo científico publicado en 2015

Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel

scientific article published on 21 February 2020

Dual activity of aminoarylthiazoles on the trafficking and gating defects of the cystic fibrosis transmembrane conductance regulator chloride channel caused by cystic fibrosis mutations.

artículo científico publicado en 2011

Editorial: Special Issue on "Therapeutic Approaches for Cystic Fibrosis"

scientific article published on 11 September 2020

Effect of inflammatory stimuli on airway ion transport.

artículo científico publicado en 2004

Epithelial sodium channel inhibition in primary human bronchial epithelia by transfected siRNA.

artículo científico publicado en 2008

Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models.

artículo científico publicado en 2004

GM1 as Adjuvant of Innovative Therapies for Cystic Fibrosis Disease

artículo científico publicado en 2020

Gelsolin Secretion in Interleukin-4–treated Bronchial Epithelia and in Asthmatic Airways

artículo científico publicado en 2005

Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation.

artículo científico publicado en 2015

High-Content Screening Identifies Vanilloids as a Novel Class of Inhibitors of NET Formation

scientific article published on 30 April 2019

High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs.

artículo científico publicado en 2019

High-throughput screening identifies FAU protein as a regulator of mutant cystic fibrosis transmembrane conductance regulator channel.

artículo científico publicado en 2017

High-throughput screening of libraries of compounds to identify CFTR modulators.

artículo científico publicado en 2011

Identification, Structure-Activity Relationship, and Biological Characterization of 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indoles as a Novel Class of CFTR Potentiators

scientific article published on 18 September 2020

In type 1 diabetes a subset of anti-coxsackievirus B4 antibodies recognize autoantigens and induce apoptosis of pancreatic beta cells

artículo científico publicado en 2013

In vitro recapitulation of the site-specific editing (to wild-type) of mutant IDS mRNA transcripts, and the characterization of IDS protein translated from the edited mRNAs

artículo científico publicado en 2017

Ligand-based design, in silico ADME-Tox filtering, synthesis and biological evaluation to discover new soluble 1,4-DHP-based CFTR activators

artículo científico publicado en 2012

Molecular Docking and QSAR Studies as Computational Tools Exploring the Rescue Ability of F508del CFTR Correctors

artículo científico publicado en 2020

Mutation-specific potency and efficacy of cystic fibrosis transmembrane conductance regulator chloride channel potentiators.

artículo científico publicado en 2009

Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating.

artículo científico publicado en 2003

New Insights into the Binding Features of F508del CFTR Potentiators: A Molecular Docking, Pharmacophore Mapping and QSAR Analysis Approach

scientific article published on 04 December 2020

Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium

scientific article published on 13 June 2019

Novel Hits in the Correction of ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein: Synthesis, Pharmacological, and ADME Evaluation of Tetrahydropyrido[4,3-d]pyrimidines for the Potential Treatment of Cystic Fibrosis.

artículo científico publicado en 2015

Pharmacological Correctors of Mutant CFTR Mistrafficking

artículo científico publicado en 2012

Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia

artículo científico publicado en 2018

Phenylhydrazones as Correctors of a Mutant Cystic Fibrosis Transmembrane Conductance Regulator.

artículo científico publicado en 2015

Proteomic analysis of the airway surface liquid: modulation by proinflammatory cytokines

article

Proteomics and Metabolomics for Cystic Fibrosis Research

artículo científico publicado en 2020

RNF5, DAB2 and Friends: Novel Drug Targets for Cystic Fibrosis

artículo científico publicado en 2016

Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions.

artículo científico publicado en 2006

Recent Strategic Advances in CFTR Drug Discovery: An Overview

scientific article published on 31 March 2020

Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling.

artículo científico publicado en 2011

Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

artículo científico publicado en 2010

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

artículo científico publicado en 2005

Spatial organization of displaced ganglion cells in the chick retina ⬇️

artículo científico publicado el 1 de noviembre de 2002

Structure and function of TMEM16 proteins (anoctamins)

artículo científico publicado en 2014

Structure-activity relationship of 1,4-dihydropyridines as potentiators of the cystic fibrosis transmembrane conductance regulator chloride channel

artículo científico publicado en 2007

Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools.

artículo científico publicado en 2017

Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis.

artículo científico publicado en 2015

Synthesis and structure-activity relationship of aminoarylthiazole derivatives as potential potentiators of the chloride transport defect in cystic fibrosis

artículo científico publicado en 2020

Synthesis of 4-thiophen-2'-yl-1,4-dihydropyridines as potentiators of the CFTR chloride channel

artículo científico publicado en 2009

The search for a common structural moiety among selected pharmacological correctors of the mutant CFTR chloride channel.

artículo científico publicado en 2014

Therapeutic approaches to CFTR dysfunction: From discovery to drug development.

artículo científico publicado en 2017

Thiocyanate transport in resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels

artículo científico publicado en 2007

Thymosin α-1 does not correct F508del-CFTR in cystic fibrosis airway epithelia

artículo científico publicado en 2019

Thymosin α-1 does not correct F508del-CFTR in cystic fibrosis airway epithelia.

artículo científico publicado en 2018

Lista de obras de Nicoletta Pedemonte

Antihypertensive 1,4-dihydropyridines as correctors of the cystic fibrosis transmembrane conductance regulator channel gating defect caused by cystic fibrosis mutations.

Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia.

Asymmetric 4-aryl-1,4-dihydropyridines potentiate mutant cystic fibrosis transmembrane conductance regulator (CFTR).

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity

Block of CFTR-dependent chloride currents by inhibitors of multidrug resistance-associated proteins.

CFTR processing, trafficking and interactions

Chemically modified hCFTR mRNAs recuperate lung function in a mouse model of cystic fibrosis

Corrigendum: Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium

Cystic fibrosis: a new target for 4-Imidazo[2,1-b]thiazole-1,4-dihydropyridines.

Development of the Olfactory Epithelium and Nasal Glands in TMEM16A-/- and TMEM16A+/+ Mice

Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel

Dual activity of aminoarylthiazoles on the trafficking and gating defects of the cystic fibrosis transmembrane conductance regulator chloride channel caused by cystic fibrosis mutations.

Editorial: Special Issue on "Therapeutic Approaches for Cystic Fibrosis"

Effect of inflammatory stimuli on airway ion transport.

Epithelial sodium channel inhibition in primary human bronchial epithelia by transfected siRNA.

Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models.

GM1 as Adjuvant of Innovative Therapies for Cystic Fibrosis Disease

Gelsolin Secretion in Interleukin-4–treated Bronchial Epithelia and in Asthmatic Airways

Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation.

High-Content Screening Identifies Vanilloids as a Novel Class of Inhibitors of NET Formation

High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs.

High-throughput screening identifies FAU protein as a regulator of mutant cystic fibrosis transmembrane conductance regulator channel.

High-throughput screening of libraries of compounds to identify CFTR modulators.

Identification, Structure-Activity Relationship, and Biological Characterization of 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indoles as a Novel Class of CFTR Potentiators

In type 1 diabetes a subset of anti-coxsackievirus B4 antibodies recognize autoantigens and induce apoptosis of pancreatic beta cells

In vitro recapitulation of the site-specific editing (to wild-type) of mutant IDS mRNA transcripts, and the characterization of IDS protein translated from the edited mRNAs

Ligand-based design, in silico ADME-Tox filtering, synthesis and biological evaluation to discover new soluble 1,4-DHP-based CFTR activators

Molecular Docking and QSAR Studies as Computational Tools Exploring the Rescue Ability of F508del CFTR Correctors

Mutation-specific potency and efficacy of cystic fibrosis transmembrane conductance regulator chloride channel potentiators.

Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating.

New Insights into the Binding Features of F508del CFTR Potentiators: A Molecular Docking, Pharmacophore Mapping and QSAR Analysis Approach

Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium

Novel Hits in the Correction of ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein: Synthesis, Pharmacological, and ADME Evaluation of Tetrahydropyrido[4,3-d]pyrimidines for the Potential Treatment of Cystic Fibrosis.

Pharmacological Correctors of Mutant CFTR Mistrafficking

Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia

Phenylhydrazones as Correctors of a Mutant Cystic Fibrosis Transmembrane Conductance Regulator.

Proteomic analysis of the airway surface liquid: modulation by proinflammatory cytokines

Proteomics and Metabolomics for Cystic Fibrosis Research

RNF5, DAB2 and Friends: Novel Drug Targets for Cystic Fibrosis

Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions.

Recent Strategic Advances in CFTR Drug Discovery: An Overview

Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling.

Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

Spatial organization of displaced ganglion cells in the chick retina ⬇️

Structure and function of TMEM16 proteins (anoctamins)

Structure-activity relationship of 1,4-dihydropyridines as potentiators of the cystic fibrosis transmembrane conductance regulator chloride channel

Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools.

Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis.

Synthesis and structure-activity relationship of aminoarylthiazole derivatives as potential potentiators of the chloride transport defect in cystic fibrosis

Synthesis of 4-thiophen-2'-yl-1,4-dihydropyridines as potentiators of the CFTR chloride channel

The search for a common structural moiety among selected pharmacological correctors of the mutant CFTR chloride channel.

Therapeutic approaches to CFTR dysfunction: From discovery to drug development.

Thiocyanate transport in resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels

Thymosin α-1 does not correct F508del-CFTR in cystic fibrosis airway epithelia

Thymosin α-1 does not correct F508del-CFTR in cystic fibrosis airway epithelia.