Lista de obras - Aaron J Oakley - Dominio Público Uruguay

A molecular mousetrap determines polarity of termination of DNA replication in E. coli

artículo científico publicado en 2006

A structural view of bacterial DNA replication

scientific article published on 17 April 2019

Anisotropic atomic motions in high-resolution protein crystallography molecular dynamics simulations

artículo científico publicado en 2007

Atomistic Insights into Photoprotein Formation: Computational Prediction of the Properties of Coelenterazine and Oxygen Binding in Obelin

scientific article published on 16 December 2019

Bacterial Sliding Clamp Inhibitors that Mimic the Sequential Binding Mechanism of Endogenous Linear Motifs

artículo científico publicado en 2015

Binding inhibitors of the bacterial sliding clamp by design

artículo científico publicado en 2011

Characterization of a family 11 xylanase from Bacillus subtillis B230 used for paper bleaching

artículo científico publicado en 2003

Comparison of negative and positive ion electrospray ionization mass spectra of calmodulin and its complex with trifluoperazine

scientific article published on 01 January 2005

Crystal and solution structures of the helicase-binding domain of Escherichia coli primase

artículo científico publicado en 2005

Crystal structures and biochemical characterization of DNA sliding clamps from three Gram-negative bacterial pathogens

artículo científico publicado en 2018

Crystallization and diffraction data of 1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase: a cofactor-free oxygenase of the alpha/beta-hydrolase family.

artículo científico publicado en 2007

Crystallization of two glutathione S-transferases from an unusual gene family

artículo científico publicado en 2001

DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs

artículo científico publicado en 2014

Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach

artículo científico publicado en 2014

Dynamics of Open DNA Sliding Clamps

artículo científico publicado en 2016

Exploring the structure and activity of haloalkane dehalogenase from Sphingomonas paucimobilis UT26: evidence for product- and water-mediated inhibition

artículo científico publicado en 2002

Expression, purification, crystallization, and NMR studies of the helicase interaction domain of Escherichia coli DnaG primase

artículo científico publicado en 2004

Flexibility revealed by the 1.85 A crystal structure of the beta sliding-clamp subunit of Escherichia coli DNA polymerase III

artículo científico publicado en 2003

Fragment-Based Discovery of Inhibitors of the Bacterial DnaG-SSB Interaction

artículo científico publicado en 2018

Fragment-based screening by protein crystallography: successes and pitfalls

artículo científico publicado en 2012

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.

artículo científico publicado en 2017

Glutathione transferases: a structural perspective ⬇️

artículo científico publicado el 23 de marzo de 2011

Glutathione transferases: new functions.

artículo científico publicado en 2005

Haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26: X-ray crystallographic studies of dehalogenation of brominated substrates

artículo científico publicado en 2003

Hotspots of age-related protein degradation: the importance of neighboring residues for the formation of non-disulfide crosslinks derived from cysteine

artículo científico publicado en 2017

Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase

artículo científico publicado en 2010

Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism

artículo científico publicado en 2010

Identification of a novel tetrameric structure for human apolipoprotein-D

artículo científico publicado en 2018

Identification, characterization and structure of a new Delta class glutathione transferase isoenzyme

artículo científico publicado en 2005

Intramolecular binding mode of the C-terminus of Escherichia coli single-stranded DNA binding protein determined by nuclear magnetic resonance spectroscopy

artículo científico publicado en 2014

Macromolecular crystallography as a tool for investigating drug, enzyme and receptor interactions.

artículo científico publicado en 2000

Magneto-optic spectroscopy of a protein tetramer binding two exciton-coupled chlorophylls

artículo científico publicado en 2006

Malonate-bound structure of the glycerophosphodiesterase fromEnterobacter aerogenes(GpdQ) and characterization of the native Fe2+metal-ion preference

artículo científico publicado en 2008

Mechanism and putative structure of B(0)-like neutral amino acid transporters.

artículo científico publicado en 2006

Molecular dynamics analysis of apolipoprotein-D-lipid hydroperoxide interactions: mechanism for selective oxidation of Met-93.

artículo científico publicado en 2012

Multifunctional role of Tyr 108 in the catalytic mechanism of human glutathione transferase P1-1. Crystallographic and kinetic studies on the Y108F mutant enzyme

artículo científico publicado en 1997

Multiple classes and isoforms of the RNA polymerase recycling motor protein HelD

artículo científico publicado en 2021

Mutations of Gly to Ala in human glutathione transferase P1-1 affect helix 2 (G-site) and induce positive cooperativity in the binding of glutathione.

artículo científico publicado en 1998

Novel Folding and Stability Defects Cause a Deficiency of Human Glutathione Transferase Omega 1

artículo científico publicado en 2011

Polymorphism of glutathione transferase Omega 1 in a population exposed to a high environmental arsenic burden

artículo científico publicado en 2008

Preliminary X-ray crystallographic studies of a newly defined human theta-class glutathione transferase.

artículo científico publicado en 1998

Proofreading exonuclease on a tether: the complex between the E. coli DNA polymerase III subunits α, epsilon, θ and β reveals a highly flexible arrangement of the proofreading domain

artículo científico publicado en 2013

Rational Design of a 310 -Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp

artículo científico publicado en 2018

Replisome speed determines the efficiency of the Tus-Ter replication termination barrier

artículo científico publicado en 2015

Reviewing hit discovery literature for difficult targets: glutathione transferase omega-1 as an example.

artículo científico publicado en 2018

S-(4-Nitrophenacyl)glutathione is a specific substrate for glutathione transferase omega 1-1.

artículo científico publicado en 2007

Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: implications for lipid antioxidant activity and Alzheimer's disease.

artículo científico publicado en 2012

Sodium translocation by the iminoglycinuria associated imino transporter (SLC6A20).

artículo científico publicado en 2009

Solution Structure of Glutathione Bound to Human Glutathione Transferase P1-1: Comparison of NMR Measurements with the Crystal Structure†

scientific article published on 01 March 1998

Structural Insights into Omega-Class Glutathione Transferases: A Snapshot of Enzyme Reduction and Identification of a Non-Catalytic Ligandin Site

artículo científico publicado en 2013

Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses

artículo científico publicado en 2010

Structural and biophysical analyses of the skeletal dihydropyridine receptor β subunit β1a reveal critical roles of domain interactions for stability.

artículo científico publicado en 2017

Structural and thermodynamic dissection of linear motif recognition by the E. coli sliding clamp

artículo científico publicado en 2013

Structural basis for cofactor-independent dioxygenation of N-heteroaromatic compounds at the / -hydrolase fold

artículo científico publicado en 2010

Structural flexibility modulates the activity of human glutathione transferase P1-1. Influence of a poor co-substrate on dynamics and kinetics of human glutathione transferase

artículo científico publicado en 1996

Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases

artículo científico publicado en 2012

Structure and function of a spectrin-like regulator of bacterial cytokinesis

artículo científico publicado en 2014

Structures of thermolabile mutants of human glutathione transferase P1-1

artículo científico publicado en 2000

Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential.

artículo científico publicado en 2004

The 2.0-A crystal structure of eqFP611, a far red fluorescent protein from the sea anemone Entacmaea quadricolor

artículo científico publicado en 2003

The 2.2 A crystal structure of a pocilloporin pigment reveals a nonplanar chromophore conformation

artículo científico publicado en 2003

The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants

artículo científico publicado en 2008

The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1-1 in two different modes

artículo científico publicado en 1997

The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site)

artículo científico publicado en 1999

Thermodynamic description of the effect of the mutation Y49F on human glutathione transferase P1-1 in binding with glutathione and the inhibitor S-hexylglutathione

artículo científico publicado en 2003

Three-dimensional structure of (1,4)-beta-D-mannan mannanohydrolase from tomato fruit

artículo científico publicado en 2005

Time to face the fats: what can mass spectrometry reveal about the structure of lipids and their interactions with proteins?

artículo científico publicado en 2012

Valine 10 May Act as a Driver for Product Release from the Active Site of Human Glutathione Transferase P1-1

artículo científico publicado en 2000

Lista de obras de Aaron J Oakley

A molecular mousetrap determines polarity of termination of DNA replication in E. coli

A structural view of bacterial DNA replication

Anisotropic atomic motions in high-resolution protein crystallography molecular dynamics simulations

Atomistic Insights into Photoprotein Formation: Computational Prediction of the Properties of Coelenterazine and Oxygen Binding in Obelin

Bacterial Sliding Clamp Inhibitors that Mimic the Sequential Binding Mechanism of Endogenous Linear Motifs

Binding inhibitors of the bacterial sliding clamp by design

Characterization of a family 11 xylanase from Bacillus subtillis B230 used for paper bleaching

Comparison of negative and positive ion electrospray ionization mass spectra of calmodulin and its complex with trifluoperazine

Crystal and solution structures of the helicase-binding domain of Escherichia coli primase

Crystal structures and biochemical characterization of DNA sliding clamps from three Gram-negative bacterial pathogens

Crystallization and diffraction data of 1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase: a cofactor-free oxygenase of the alpha/beta-hydrolase family.

Crystallization of two glutathione S-transferases from an unusual gene family

DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs

Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach

Dynamics of Open DNA Sliding Clamps

Exploring the structure and activity of haloalkane dehalogenase from Sphingomonas paucimobilis UT26: evidence for product- and water-mediated inhibition

Expression, purification, crystallization, and NMR studies of the helicase interaction domain of Escherichia coli DnaG primase

Flexibility revealed by the 1.85 A crystal structure of the beta sliding-clamp subunit of Escherichia coli DNA polymerase III

Fragment-Based Discovery of Inhibitors of the Bacterial DnaG-SSB Interaction

Fragment-based screening by protein crystallography: successes and pitfalls

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.

Glutathione transferases: a structural perspective ⬇️

Glutathione transferases: new functions.

Haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26: X-ray crystallographic studies of dehalogenation of brominated substrates

Hotspots of age-related protein degradation: the importance of neighboring residues for the formation of non-disulfide crosslinks derived from cysteine

Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase

Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism

Identification of a novel tetrameric structure for human apolipoprotein-D

Identification, characterization and structure of a new Delta class glutathione transferase isoenzyme

Intramolecular binding mode of the C-terminus of Escherichia coli single-stranded DNA binding protein determined by nuclear magnetic resonance spectroscopy

Macromolecular crystallography as a tool for investigating drug, enzyme and receptor interactions.

Magneto-optic spectroscopy of a protein tetramer binding two exciton-coupled chlorophylls

Malonate-bound structure of the glycerophosphodiesterase fromEnterobacter aerogenes(GpdQ) and characterization of the native Fe2+metal-ion preference

Mechanism and putative structure of B(0)-like neutral amino acid transporters.

Molecular dynamics analysis of apolipoprotein-D-lipid hydroperoxide interactions: mechanism for selective oxidation of Met-93.

Multifunctional role of Tyr 108 in the catalytic mechanism of human glutathione transferase P1-1. Crystallographic and kinetic studies on the Y108F mutant enzyme

Multiple classes and isoforms of the RNA polymerase recycling motor protein HelD

Mutations of Gly to Ala in human glutathione transferase P1-1 affect helix 2 (G-site) and induce positive cooperativity in the binding of glutathione.

Novel Folding and Stability Defects Cause a Deficiency of Human Glutathione Transferase Omega 1

Polymorphism of glutathione transferase Omega 1 in a population exposed to a high environmental arsenic burden

Preliminary X-ray crystallographic studies of a newly defined human theta-class glutathione transferase.

Proofreading exonuclease on a tether: the complex between the E. coli DNA polymerase III subunits α, epsilon, θ and β reveals a highly flexible arrangement of the proofreading domain

Rational Design of a 310 -Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp

Replisome speed determines the efficiency of the Tus-Ter replication termination barrier

Reviewing hit discovery literature for difficult targets: glutathione transferase omega-1 as an example.

S-(4-Nitrophenacyl)glutathione is a specific substrate for glutathione transferase omega 1-1.

Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: implications for lipid antioxidant activity and Alzheimer's disease.

Sodium translocation by the iminoglycinuria associated imino transporter (SLC6A20).

Solution Structure of Glutathione Bound to Human Glutathione Transferase P1-1: Comparison of NMR Measurements with the Crystal Structure†

Structural Insights into Omega-Class Glutathione Transferases: A Snapshot of Enzyme Reduction and Identification of a Non-Catalytic Ligandin Site

Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses

Structural and biophysical analyses of the skeletal dihydropyridine receptor β subunit β1a reveal critical roles of domain interactions for stability.

Structural and thermodynamic dissection of linear motif recognition by the E. coli sliding clamp

Structural basis for cofactor-independent dioxygenation of N-heteroaromatic compounds at the / -hydrolase fold

Structural flexibility modulates the activity of human glutathione transferase P1-1. Influence of a poor co-substrate on dynamics and kinetics of human glutathione transferase

Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases

Structure and function of a spectrin-like regulator of bacterial cytokinesis

Structures of thermolabile mutants of human glutathione transferase P1-1

Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential.

The 2.0-A crystal structure of eqFP611, a far red fluorescent protein from the sea anemone Entacmaea quadricolor

The 2.2 A crystal structure of a pocilloporin pigment reveals a nonplanar chromophore conformation

The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants

The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1-1 in two different modes

The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site)

Thermodynamic description of the effect of the mutation Y49F on human glutathione transferase P1-1 in binding with glutathione and the inhibitor S-hexylglutathione

Three-dimensional structure of (1,4)-beta-D-mannan mannanohydrolase from tomato fruit

Time to face the fats: what can mass spectrometry reveal about the structure of lipids and their interactions with proteins?

Valine 10 May Act as a Driver for Product Release from the Active Site of Human Glutathione Transferase P1-1