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Lista de obras de Taisuke Tomita

A faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substrates

artículo científico publicado en 2006

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

artículo científico publicado en 1999

A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease.

artículo científico publicado en 2010

A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons.

artículo científico publicado en 2016

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

artículo científico publicado en 2003

A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface

artículo científico publicado en 2002

AP180 N-Terminal Homology (ANTH) and Epsin N-Terminal Homology (ENTH) Domains: Physiological Functions and Involvement in Disease

artículo científico publicado en 2019

APP processing and synaptic function

artículo científico publicado en 2003

Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease

artículo científico publicado en 2017

Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate

artículo científico publicado en 2007

Activation of γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 1.

artículo científico publicado en 2017

Activity-dependent proteolytic cleavage of neuroligin-1.

artículo científico publicado en 2012

Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator

artículo científico publicado en 2014

Alzheimer's disease treatment by inhibition/modulation of the gamma-secretase activity

artículo científico publicado en 2009

Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease

artículo científico publicado en 2000

Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

artículo científico publicado en 2005

Association of active gamma-secretase complex with lipid rafts.

artículo científico publicado en 2005

Attenuation of the aggregation and neurotoxicity of amyloid-β peptides by catalytic photooxygenation

artículo científico publicado en 2013

Autism-associated variants of neuroligin 4X impair synaptogenic activity by various molecular mechanisms

artículo científico publicado en 2020

BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.

artículo científico publicado en 2011

BIN1 regulates BACE1 intracellular trafficking and amyloid-β production

artículo científico publicado en 2016

BetaAPP gamma-secretase and SREBP site 2 protease are two different enzymes

artículo científico publicado en 1998

Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation

artículo científico publicado en 2014

Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference

artículo científico publicado en 2004

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

artículo científico publicado en 2006

CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway

artículo científico publicado en 2019

Cell-free methods to produce structurally intact mammalian membrane proteins.

artículo científico publicado en 2016

Cerebrospinal fluid levels of amyloid beta-peptide1-42, but not tau have positive correlation with brain glucose metabolism in humans

artículo científico publicado en 1999

Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system

artículo científico publicado en 2011

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

artículo científico publicado en 2002

Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production

artículo científico publicado en 2016

Conformational Dynamics of Transmembrane Domain 3 of Presenilin 1 Is Associated with the Trimming Activity of γ-Secretase

artículo científico publicado en 2019

Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein

artículo científico publicado en 2012

Convenient Synthesis of Photoaffinity Probes and Evaluation of Their Labeling Abilities

artículo científico publicado en 2007

Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase.

artículo científico publicado en 2015

Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase

artículo científico publicado en 2014

Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker

artículo científico publicado en 2009

Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling

artículo científico publicado en 2014

Distinct Neurotoxic Effects of Extracellular Tau Species in Primary Neuronal-Glial Cultures

artículo científico publicado en 2020

Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors

Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model.

artículo científico publicado en 2009

Dysregulated Metabolism of the Amyloid-β Protein and Therapeutic Approaches in Alzheimer Disease

artículo científico publicado en 2017

Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition.

artículo científico publicado en 2013

Effects of PS1 deficiency on membrane protein trafficking in neurons

artículo científico publicado en 1998

Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease

artículo científico publicado en 2010

Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease

artículo científico publicado en 1999

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

artículo científico publicado en 1999

Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana.

artículo científico publicado en 2013

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

artículo científico publicado en 2013

Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).

artículo científico publicado en 1996

Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.

artículo científico publicado en 2010

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.

artículo científico publicado en 1998

High performance plasma amyloid-β biomarkers for Alzheimer's disease

artículo científico publicado en 2018

Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger–aza-Wittig reaction of ω-azido pentafluorophenyl ester: synthesis and biological evaluation of LY411575 analogues

Histidine 131 in presenilin 1 is the pH-sensitive residue that causes the increase in Aβ42 level in acidic pH

scientific article published on 09 December 2019

Human tauopathy-derived tau strains determine the substrates recruited for templated amplification

scientific article published on 01 September 2021

Imbalance of Clara cell-mediated homeostatic inflammation is involved in lung metastasis.

artículo científico publicado en 2011

Inhibition of gamma-secretase activity by helical beta-peptide foldamers.

artículo científico publicado en 2009

Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1.

artículo científico publicado en 2012

Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice

artículo científico publicado en 2018

Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.

artículo científico publicado en 2008

Memantine inhibits β-amyloid aggregation and disassembles preformed β-amyloid aggregates.

artículo científico publicado en 2017

Memantine reduces the production of amyloid-β peptides through modulation of amyloid precursor protein trafficking.

artículo científico publicado en 2017

Membrane trafficking and proteolytic activity of γ-secretase in Alzheimer's disease

artículo científico publicado en 2016

Molecular cell biology of presenilins

scientific article published on 01 December 1999

Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4

artículo científico publicado en 2002

Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2

artículo científico publicado en 2001

Molecular cloning of a novel basic helix-loop-helix protein from the rat brain

artículo científico publicado en 1996

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

artículo científico publicado en 1998

Molecular mechanism of intramembrane proteolysis by γ-secretase

artículo científico publicado en 2014

Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human beta-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays.

artículo científico publicado en 2006

Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid Peptide

Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

scientific journal article

Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.

artículo científico publicado en 2011

New photocleavable linker: α-Thioacetophenone-type linker

scientific article published on 09 May 2014

Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord

artículo científico publicado en 2006

Novel Notch-sparing gamma-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library.

artículo científico publicado en 2010

Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates

artículo científico publicado en 2006

NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease

artículo científico publicado en 2019

ORIGINAL ARTICLE: Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis

artículo científico publicado en 2008

Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity

artículo científico publicado en 2004

Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo.

artículo científico publicado en 2016

Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase

artículo científico publicado en 2010

Peptide-based short single β-strand mimics without hydrogen bonding or aggregation

scientific article published on 01 February 2020

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1 ⬇️

artículo científico publicado el 14 de octubre de 2011

Photo-oxygenation inhibits tau amyloid formation

scientific article published on 01 May 2019

Physiological and pathological functions of LRRK2: implications from substrate proteins

artículo científico publicado en 2018

Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling

scientific journal article

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

artículo científico publicado en 2003

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

artículo científico publicado en 2002

Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid β peptides ending at Aβ40 and Aβ42

article

Probing the Structure and Function Relationships of Presenilin by Substituted-Cysteine Accessibility Method.

artículo científico publicado en 2016

Protein trafficking and maturation regulate intramembrane proteolysis

artículo científico publicado en 2013

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag.

artículo científico publicado en 2017

Rescue of Hypovitaminosis A Induces Non-Amyloidogenic Amyloid Precursor Protein (APP) Processing.

artículo científico publicado en 2016

Retrograde transport of γ-secretase from endosomes to the trans-Golgi network regulates Aβ42 production

artículo científico publicado en 2018

Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance

artículo científico publicado en 2016

S-palmitoylation of gamma-secretase subunits nicastrin and APH-1

artículo científico publicado en 2008

Secretase inhibitors and modulators for Alzheimer's disease treatment

scientific article published on May 2009

Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles

artículo científico publicado en 2004

Selectivity to amyloid-β precursor protein cleavage provides hope against Alzheimer's

artículo científico publicado en 2011

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

artículo científico publicado en 2009

Slater to Mott Crossover in the Metal to Insulator Transition ofNd2Ir2O7 ⬇️

artículo científico publicado en 2016

Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups

artículo científico publicado en 2003

Specific mutations in presenilin 1 cause conformational changes in γ-secretase to modulate amyloid beta trimming

artículo científico publicado en 2019

Structural biology of presenilins and signal peptide peptidases

artículo científico publicado en 2013

Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes

artículo científico publicado en 2013

Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.

artículo científico publicado en 2006

Structure-function relationship of γ-secretase

artículo científico publicado en 2012

Structures of α-synuclein filaments from multiple system atrophy

artículo científico publicado en 2020

Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.

artículo científico publicado en 2001

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

artículo científico publicado en 2003

Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities

artículo científico publicado en 2015

Synthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Aβ-peptide production inhibitors

article

Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors

scientific article published in 2006

Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity

artículo científico publicado en 2014

Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.

artículo científico publicado en 2004

The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.

artículo científico publicado en 2008

The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif

artículo científico publicado en 2017

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

artículo científico publicado en 2001

The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis

artículo científico publicado en 2006

The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals

artículo científico publicado en 2002

The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.

artículo científico publicado en 2000

The presenilin 1 mutation (M146V) linked to familial Alzheimer's disease attenuates the neuronal differentiation of NTera 2 cells

artículo científico publicado en 1998

The role of presenilin cofactors in the gamma-secretase complex

artículo científico publicado en 2003

Three-dimensional structure of the signal peptide peptidase

artículo científico publicado en 2011

Three-dimensional structure of the γ-secretase complex

artículo científico publicado en 2006

Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations

scientific article published on 01 November 2000

[Alzheimer disease: experimental approaches to genetic and environmental risk factors].

artículo científico publicado en 2013

[Development of Alzheimer's disease treatment based on the molecular mechanism of γ-secretase activity].

artículo científico publicado en 2012

[Targeting the structure and function relationships of the gamma-secretase for the development of Alzheimer's disease].

artículo científico publicado en 2008

γ -Secretase Pharmacology: What Pharmacology Will Work for Alzheimer's Disease?

artículo científico publicado en 2013

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