Lista de obras - Roberto Sitia - Dominio Público Uruguay

A RIDDle solved: why an intact IRE1α/XBP-1 signaling relay is key for humoral immune responses.

artículo científico publicado en 2014

A computer-driven approach to PCR-based differential screening, alternative to differential display

artículo científico publicado en 1999

A dynamic study of protein secretion and aggregation in the secretory pathway.

artículo científico publicado en 2014

A new fluorogenic peptide determines proteasome activity in single cells.

artículo científico publicado en 2010

A novel pathway for secretory proteins?

artículo científico publicado en 1990

A novel way to get out of the cell

artículo científico publicado en 1993

A pH-regulated quality control cycle for surveillance of secretory protein assembly

artículo científico publicado en 2013

A peptide extension dictates IgM assembly

artículo científico publicado en 2017

A persulfidation-based mechanism controls aquaporin-8 conductance.

artículo científico publicado en 2018

AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells.

artículo científico publicado en 2016

Aberrant disulphide bonding contributes to the ER retention of alpha1-antitrypsin deficiency variants.

artículo científico publicado en 2015

Aspects of gene regulation during the UPR in human cells

artículo científico publicado en 2000

Assessing Heterogeneity of Osteolytic Lesions in Multiple Myeloma by ¹H HR-MAS NMR Metabolomics

scientific article published on 31 October 2016

Atypical IgM on T cells predict relapse and steroid dependence in idiopathic nephrotic syndrome

artículo científico publicado en 2019

B- to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses

artículo científico publicado en 2010

Biochemical nature of Russell Bodies

artículo científico publicado en 2015

Biogenesis and function of IgM: the role of the conserved mu-chain tailpiece glycans

artículo científico publicado en 1998

Biosynthesis of membrane and secreted epsilon-chains during lipopolysaccharide-induced differentiation of an IgE+ murine B-lymphoma

scientific article published on 01 November 1985

Bortezomib in the treatment of AL amyloidosis: targeted therapy?

artículo científico publicado en 2007

Building and operating an antibody factory: redox control during B to plasma cell terminal differentiation.

artículo científico publicado en 2008

CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells

artículo científico publicado en 2009

Chemo-metabolic regulation of immune responses by Tregs

artículo científico publicado en 2009

Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein

artículo científico publicado en 2006

Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention

artículo científico publicado en 2016

Crystal structure of human ERp44 shows a dynamic functional modulation by its carboxy-terminal tail

artículo científico publicado en 2008

Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI

artículo científico publicado en 2010

Cysteine and glutathione secretion in response to protein disulfide bond formation in the ER.

artículo científico publicado en 1997

Cysteines as Redox Molecular Switches and Targets of Disease

artículo científico publicado en 2017

Dampening Ab responses using proteasome inhibitors following in vivo B cell activation

artículo científico publicado en 2008

Different redox sensitivity of endoplasmic reticulum associated degradation clients suggests a novel role for disulphide bonds in secretory proteins.

artículo científico publicado en 2014

Differential expression of Galalpha1,3Gal epitope in polymeric and monomeric IgM secreted by mouse myeloma cells deficient in alpha2, 6-sialyltransferase

artículo científico publicado en 1998

Differentiation in the murine B cell lymphoma I.29: individual mu + clones may be induced by lipopolysaccharide to both IgM secretion and isotype switching.

artículo científico publicado en 1987

Differentiation in the murine B cell lymphoma I.29: inductive capacities of lipopolysaccharide and Mycoplasma fermentans products

artículo científico publicado en 1985

Diseases originating from altered protein quality control in the endoplasmic reticulum.

artículo científico publicado en 2007

Dynamic regulation of Ero1α and peroxiredoxin 4 localization in the secretory pathway

scientific article published on 26 August 2013

Dynamic retention of Ero1alpha and Ero1beta in the endoplasmic reticulum by interactions with PDI and ERp44.

artículo científico publicado en 2006

Dysregulated IL-1β Secretion in Autoinflammatory Diseases: A Matter of Stress?

artículo científico publicado en 2017

ER storage diseases: a role for ERGIC-53 in controlling the formation and shape of Russell bodies

artículo científico publicado en 2006

ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum

artículo científico publicado en 2000

ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress

artículo científico publicado en 2003

ERp44 and ERGIC-53 synergize in coupling efficiency and fidelity of IgM polymerization and secretion

artículo científico

ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family

artículo científico publicado en 2002

Endoplasmic reticulum stress.

artículo científico publicado en 2007

Entry of exogenous polypeptides into the nucleus of living cells: facts and speculations.

artículo científico publicado en 1995

Ero1-PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum

artículo científico publicado en 2013

Ero1α regulates Ca(2+) fluxes at the endoplasmic reticulum-mitochondria interface (MAM).

artículo científico publicado en 2011

Evolution, role in inflammation, and redox control of leaderless secretory proteins

scientific article published on 24 April 2020

Exposed Thiols Confer Localization in the Endoplasmic Reticulum by Retention Rather than Retrieval

scientific article published in Journal of Biological Chemistry

Expression of KIF3C kinesin during neural development and in vitro neuronal differentiation.

artículo científico publicado en 2001

Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunction

artículo científico publicado en 2011

Fibroblasts from FAD-linked presenilin 1 mutations display a normal unfolded protein response but overproduce Abeta42 in response to tunicamycin

artículo científico publicado en 2004

Formation, isomerisation and reduction of disulphide bonds during protein quality control in the endoplasmic reticulum

artículo científico publicado en 2002

From antibodies to adiponectin: role of ERp44 in sizing and timing protein secretion ⬇️

artículo científico publicado el 1 de octubre de 2010

Genomic organization and transcriptional analysis of the human genes coding for caveolin-1 and caveolin-2

artículo científico publicado en 2000

Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum.

artículo científico publicado en 2004

Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1α to promote oxidative protein folding

scientific article published on 17 September 2013

Glycoprotein quality control in the endoplasmic reticulum. Mannose trimming by endoplasmic reticulum mannosidase I times the proteasomal degradation of unassembled immunoglobulin subunits

artículo científico publicado en 2001

HIV-1 Tat: immunosuppression via TGF-beta1 induction

artículo científico publicado en 1999

HIV-I Tat: a polypeptide for all seasons

scientific article published on 01 December 1998

Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane

artículo científico publicado en 2019

IgM polymerization inhibits the Golgi-mediated processing of the mu-chain carboxy-terminal glycans

artículo científico publicado en 1996

Inadequate BiP availability defines endoplasmic reticulum stress

artículo científico publicado en 2019

Iron increases the susceptibility of multiple myeloma cells to bortezomib.

artículo científico publicado en 2012

KIF3C, a Novel Member of the Kinesin Superfamily: Sequence, Expression, and Mapping to Human Chromosome 2 at 2p23 ⬇️

artículo científico publicado el 1 de febrero de 1998

Lymphocyte membrane immunoglobulins: similarities between human IgD and mouse IgD-like molecules ⬇️

artículo científico publicado el 1 de agosto de 1977

MHC class II transactivator is an in vivo regulator of osteoclast differentiation and bone homeostasis co-opted from adaptive immunity.

artículo científico publicado en 2014

Managing and exploiting stress in the antibody factory.

artículo científico publicado en 2007

Maturation of chronic lymphocytic leukemia B cells: correlation between the capacity of responding to T-cell factors in vitro and the stage of maturation reached in vivo.

artículo científico publicado en 1985

Metabolomics of B to plasma cell differentiation

artículo científico publicado en 2011

Molecular bases of cyclic and specific disulfide interchange between human ERO1alpha protein and protein-disulfide isomerase (PDI).

artículo científico publicado en 2011

Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity

scientific article published on 04 October 2019

Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44.

artículo científico publicado en 2008

On the redox control of B lymphocyte differentiation and function

artículo científico

Oxidative protein folding in the secretory pathway and redox signaling across compartments and cells

artículo científico publicado en 2010

Pathogenesis of ER storage disorders: modulating Russell body biogenesis by altering proximal and distal quality control.

artículo científico publicado en 2010

Peroxides and peroxidases in the endoplasmic reticulum: integrating redox homeostasis and oxidative folding

artículo científico

Physiology and pathology of proteostasis in the early secretory compartment

artículo científico publicado en 2010

Pivotal Advance: Protein synthesis modulates responsiveness of differentiating and malignant plasma cells to proteasome inhibitors

artículo científico publicado en 2012

Plasma cells require autophagy for sustainable immunoglobulin production.

artículo científico publicado en 2013

Post-translational regulation of interleukin 1 beta secretion

scientific article published on 01 March 1993

Production of H₂O₂ in the endoplasmic reticulum promotes in vivo disulfide bond formation

artículo científico publicado en 2012

Progressive quality control of secretory proteins in the early secretory compartment by ERp44

artículo científico publicado en 2014

Progressive waves of IL-1β release by primary human monocytes via sequential activation of vesicular and gasdermin D-mediated secretory pathways

scientific article published on 23 October 2018

Progressively impaired proteasomal capacity during terminal plasma cell differentiation

artículo científico publicado en 2006

Protein degradation in the endoplasmic reticulum

artículo científico

Protein quality control in the early secretory pathway

artículo científico publicado en 2008

Proteostasis and "redoxtasis" in the secretory pathway: Tales of tails from ERp44 and immunoglobulins

artículo científico publicado en 2015

Proteostenosis and plasma cell pathophysiology

artículo científico publicado en 2010

Proteotoxic stress and cell lifespan control.

scientific article published on 23 July 2008

Quality control in the endoplasmic reticulum protein factory

artículo científico publicado en 2003

Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its signaling amplitude.

artículo científico publicado en 2017

Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages

artículo científico publicado en 2018

Redox homeostasis modulates the sensitivity of myeloma cells to bortezomib

artículo científico publicado en 2008

Redox remodeling allows and controls B-cell activation and differentiation

artículo científico publicado en 2010

Reduction of interchain disulfide bonds precedes the dislocation of Ig-mu chains from the endoplasmic reticulum to the cytosol for proteasomal degradation

artículo científico publicado en 2001

Regulation of Calcium Fluxes by GPX8, a Type-II Transmembrane Peroxidase Enriched at the Mitochondria-Associated Endoplasmic Reticulum Membrane

artículo científico publicado en 2017

Regulation of IgM biosynthesis in human chronic lymphocytic leukemia. Normal and neoplastic B cells respond differently to TPA

scientific article published on 01 January 1989

Response to Marinelli and Marchissio.

artículo científico publicado en 2013

Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins.

artículo científico publicado en 2018

Roles of N-glycans in the polymerization-dependent aggregation of mutant Ig-μ chains in the early secretory pathway

artículo científico publicado en 2017

SEL1L and HRD1 are involved in the degradation of unassembled secretory Ig-mu chains

artículo científico publicado en 2008

Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis

artículo científico publicado en 2007

Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion

artículo científico publicado en 2003

Sialylation of N-linked glycans influences the immunomodulatory effects of IgM on T cells

artículo científico publicado en 2014

Stress Regulates Aquaporin-8 Permeability to Impact Cell Growth and Survival

artículo científico publicado en 2016

Structural basis of pH-dependent client binding by ERp44, a key regulator of protein secretion at the ER-Golgi interface.

artículo científico publicado en 2017

Synthesis, processing, and intracellular transport of CD36 during monocytic differentiation

artículo científico publicado en 1996

The Association of HIV-1 Tat with Nuclei Is Regulated by Ca2+Ions and Cytosolic Factors

artículo científico publicado en 1997

The C-terminal domain of yeast Ero1p mediates membrane localization and is essential for function

artículo científico publicado en 2001

The Diversity of Oxidative Protein Folding

artículo científico publicado en 2006

The Importance Of Naturally Attenuated Sars-Cov-2 In The Fight Against Covid-19

scientific article published on 28 April 2020

The making of a professional secretory cell: architectural and functional changes in the ER during B lymphocyte plasma cell differentiation

artículo científico publicado en 2003

The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition.

artículo científico publicado en 2009

The role of glycosylation in secretion and membrane expression of immunoglobulins M and A

scientific article published on 01 August 1984

The unconventional secretion of IL-1β: Handling a dangerous weapon to optimize inflammatory responses

artículo científico publicado en 2018

The unfolded protein response switches from pro-survival to pro-apoptotic to cap the extent of endoplasmic reticulum expansion

artículo científico publicado en 2017

Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44

artículo científico publicado en 2003

Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish

artículo científico publicado en 2016

Two conserved cysteine triads in human Ero1alpha cooperate for efficient disulfide bond formation in the endoplasmic reticulum

artículo científico publicado en 2004

Tyrosine kinase signal modulation: a matter of H2O2 membrane permeability?

artículo científico publicado en 2013

Zinc regulates ERp44-dependent protein quality control in the early secretory pathway

artículo científico publicado en 2019

Lista de obras de Roberto Sitia

A RIDDle solved: why an intact IRE1α/XBP-1 signaling relay is key for humoral immune responses.

A computer-driven approach to PCR-based differential screening, alternative to differential display

A dynamic study of protein secretion and aggregation in the secretory pathway.

A new fluorogenic peptide determines proteasome activity in single cells.

A novel pathway for secretory proteins?

A novel way to get out of the cell

A pH-regulated quality control cycle for surveillance of secretory protein assembly

A peptide extension dictates IgM assembly

A persulfidation-based mechanism controls aquaporin-8 conductance.

AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells.

Aberrant disulphide bonding contributes to the ER retention of alpha1-antitrypsin deficiency variants.

Aspects of gene regulation during the UPR in human cells

Assessing Heterogeneity of Osteolytic Lesions in Multiple Myeloma by ¹H HR-MAS NMR Metabolomics

Atypical IgM on T cells predict relapse and steroid dependence in idiopathic nephrotic syndrome

B- to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses

Biochemical nature of Russell Bodies

Biogenesis and function of IgM: the role of the conserved mu-chain tailpiece glycans

Biosynthesis of membrane and secreted epsilon-chains during lipopolysaccharide-induced differentiation of an IgE+ murine B-lymphoma

Bortezomib in the treatment of AL amyloidosis: targeted therapy?

Building and operating an antibody factory: redox control during B to plasma cell terminal differentiation.

CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells

Chemo-metabolic regulation of immune responses by Tregs

Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein

Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention

Crystal structure of human ERp44 shows a dynamic functional modulation by its carboxy-terminal tail

Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI

Cysteine and glutathione secretion in response to protein disulfide bond formation in the ER.

Cysteines as Redox Molecular Switches and Targets of Disease

Dampening Ab responses using proteasome inhibitors following in vivo B cell activation

Different redox sensitivity of endoplasmic reticulum associated degradation clients suggests a novel role for disulphide bonds in secretory proteins.

Differential expression of Galalpha1,3Gal epitope in polymeric and monomeric IgM secreted by mouse myeloma cells deficient in alpha2, 6-sialyltransferase

Differentiation in the murine B cell lymphoma I.29: individual mu + clones may be induced by lipopolysaccharide to both IgM secretion and isotype switching.

Differentiation in the murine B cell lymphoma I.29: inductive capacities of lipopolysaccharide and Mycoplasma fermentans products

Diseases originating from altered protein quality control in the endoplasmic reticulum.

Dynamic regulation of Ero1α and peroxiredoxin 4 localization in the secretory pathway

Dynamic retention of Ero1alpha and Ero1beta in the endoplasmic reticulum by interactions with PDI and ERp44.

Dysregulated IL-1β Secretion in Autoinflammatory Diseases: A Matter of Stress?

ER storage diseases: a role for ERGIC-53 in controlling the formation and shape of Russell bodies

ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum

ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress

ERp44 and ERGIC-53 synergize in coupling efficiency and fidelity of IgM polymerization and secretion

ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family

Endoplasmic reticulum stress.

Entry of exogenous polypeptides into the nucleus of living cells: facts and speculations.

Ero1-PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum

Ero1α regulates Ca(2+) fluxes at the endoplasmic reticulum-mitochondria interface (MAM).

Evolution, role in inflammation, and redox control of leaderless secretory proteins

Exposed Thiols Confer Localization in the Endoplasmic Reticulum by Retention Rather than Retrieval

Expression of KIF3C kinesin during neural development and in vitro neuronal differentiation.

Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunction

Fibroblasts from FAD-linked presenilin 1 mutations display a normal unfolded protein response but overproduce Abeta42 in response to tunicamycin

Formation, isomerisation and reduction of disulphide bonds during protein quality control in the endoplasmic reticulum

From antibodies to adiponectin: role of ERp44 in sizing and timing protein secretion ⬇️

Genomic organization and transcriptional analysis of the human genes coding for caveolin-1 and caveolin-2

Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum.

Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1α to promote oxidative protein folding

Glycoprotein quality control in the endoplasmic reticulum. Mannose trimming by endoplasmic reticulum mannosidase I times the proteasomal degradation of unassembled immunoglobulin subunits

HIV-1 Tat: immunosuppression via TGF-beta1 induction

HIV-I Tat: a polypeptide for all seasons

Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane

IgM polymerization inhibits the Golgi-mediated processing of the mu-chain carboxy-terminal glycans

Inadequate BiP availability defines endoplasmic reticulum stress

Iron increases the susceptibility of multiple myeloma cells to bortezomib.

KIF3C, a Novel Member of the Kinesin Superfamily: Sequence, Expression, and Mapping to Human Chromosome 2 at 2p23 ⬇️

Lymphocyte membrane immunoglobulins: similarities between human IgD and mouse IgD-like molecules ⬇️

MHC class II transactivator is an in vivo regulator of osteoclast differentiation and bone homeostasis co-opted from adaptive immunity.

Managing and exploiting stress in the antibody factory.

Maturation of chronic lymphocytic leukemia B cells: correlation between the capacity of responding to T-cell factors in vitro and the stage of maturation reached in vivo.

Metabolomics of B to plasma cell differentiation

Molecular bases of cyclic and specific disulfide interchange between human ERO1alpha protein and protein-disulfide isomerase (PDI).

Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity

Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44.

On the redox control of B lymphocyte differentiation and function

Oxidative protein folding in the secretory pathway and redox signaling across compartments and cells

Pathogenesis of ER storage disorders: modulating Russell body biogenesis by altering proximal and distal quality control.

Peroxides and peroxidases in the endoplasmic reticulum: integrating redox homeostasis and oxidative folding

Physiology and pathology of proteostasis in the early secretory compartment

Pivotal Advance: Protein synthesis modulates responsiveness of differentiating and malignant plasma cells to proteasome inhibitors

Plasma cells require autophagy for sustainable immunoglobulin production.