Lista de obras - Hansruedi Glatt - Dominio Público Uruguay

1-Hydroxymethylpyrene and its sulfuric acid ester: toxicological effects in vitro and in vivo, and metabolic aspects

artículo científico publicado en 1994

1-Methoxy-3-indolylmethyl DNA adducts in six tissues, and blood protein adducts, in mice under pak choi diet: time course and persistence

scientific article published on 15 April 2019

1-Methoxy-3-indolylmethyl glucosinolate; a potent genotoxicant in bacterial and mammalian cells: Mechanisms of bioactivation.

artículo científico publicado en 2010

Abundance of DNA adducts of methyleugenol, a rodent hepatocarcinogen, in human liver samples

artículo científico publicado en 2013

Activation of Polycyclic Aromatic Compounds by cDNA-Expressed Phase I and Phase II Enzymes

Activation of benzylic alcohols to mutagens by human hepatic sulphotransferases.

artículo científico publicado en 1994

Activation of promutagens by endogenous and heterologous sulfotransferases expressed in continuous cell cultures

artículo científico publicado en 1994

Activation of propane 2-nitronate to a genotoxicant in V79-derived cell lines engineered for the expression of rat hepatic sulfotransferases

artículo científico publicado en 1999

Altered tissue distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adducts in mice transgenic for human sulfotransferases 1A1 and 1A2.

artículo científico publicado en 2011

Aneuploidy induction by benzo[a]pyrene and polyploidy induction by 7,12-dimethylbenz[a]anthracene in Chinese hamster cell lines V79-MZ and V79.

artículo científico publicado en 1997

Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2

artículo científico publicado en 2000

Benzylic hydroxylation of 1-methylpyrene and 1-ethylpyrene by human and rat cytochromes P450 individually expressed in V79 Chinese hamster cells

artículo científico publicado en 1999

Bioactivation of the heterocyclic aromatic amine 2-amino-3-methyl-9H-pyrido [2,3-b]indole (MeAalphaC) in recombinant test systems expressing human xenobiotic-metabolizing enzymes

artículo científico publicado en 2004

Biomarkers of exposure, effect, and susceptibility in workers exposed to nitrotoluenes

artículo científico publicado en 2006

Biphenyl and fluorinated derivatives: liver enzyme-mediated mutagenicity detected in Salmonella typhimurium and Chinese hamster V79 cells

artículo científico publicado en 1992

Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products

artículo científico publicado en 2010

Cell culture system for the controlled intracellular generation of reactive oxygen species

artículo científico publicado en 1997

Characterization of an epithelial, nearly diploid liver cell strain, from Chinese hamster, able to activate promutagens

artículo científico publicado en 1987

Characterization of thyroid hormone sulfotransferases

scientific article published on 01 February 1998

Chiral inversion of 1-hydroxyethylpyrene enantiomers mediated by enantioselective sulfotransferases

artículo científico publicado en 1998

Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6).

artículo científico publicado en 2007

Coffee diterpenes prevent the genotoxic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N-nitrosodimethylamine in a human derived liver cell line (HepG2).

artículo científico publicado en 2005

Comparison of common gene mutation tests in mammalian cells in culture: a position paper of the GUM Commission for the Development of Guidelines for Genotoxicity Testing

artículo científico publicado en 1994

Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico--implications for differences in activity, subunit dimerization and substrate inhibition

artículo científico publicado en 2009

Conjugation of 4-nitrophenol and 4-hydroxylonazolac in V79-derived cells expressing individual forms of human sulphotransferases

artículo científico publicado en 2002

Constitutive expression of bioactivating enzymes in normal human prostate suggests a capability to activate pro-carcinogens to DNA-damaging metabolites.

artículo científico publicado en 2010

Consumption of Brussels sprouts protects peripheral human lymphocytes against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and oxidative DNA-damage: results of a controlled human intervention trial

artículo científico publicado en 2008

Conversion of the common food constituent 5-hydroxymethylfurfural into a mutagenic and carcinogenic sulfuric acid ester in the mouse in vivo

artículo científico publicado en 2009

DNA strand break induction, mutagenicity, and cytotoxicity of the mycotoxins 11-β-hydroxy-7-deoxy-rosenonolactone, rosenonolactone, and trichothecin

artículo científico publicado en 1992

Detection of DNA adducts originating from 1-methoxy-3-indolylmethyl glucosinolate using isotope-dilution UPLC-ESI-MS/MS.

artículo científico publicado en 2012

Detection of genotoxicants in Brassicales using endogenous DNA as a surrogate target and adducts determined by 32P-postlabelling as an experimental end point

artículo científico publicado en 2010

Determination of DNA single strand breaks and selective DNA amplification by N-nitrodimethylamine and analogs, and estimation of the indicator cells' metabolic capacities

artículo científico publicado en 1986

Detoxification of promutagenic aldehydes derived from methylpyrenes by human aldehyde dehydrogenases ALDH2 and ALDH3A1.

artículo científico publicado en 2008

Development and validation of a fluorescence HPLC-based screening assay for inhibition of human estrogen sulfotransferase.

artículo científico publicado en 2006

Development and validation of alternative metabolic systems for mutagenicity testing in short-term assays

artículo científico publicado en 1996

Dietary exposure to 5-hydroxymethylfurfural from Norwegian food and correlations with urine metabolites of short-term exposure

artículo científico publicado en 2008

Dietary resistant starch type 3 prevents tumor induction by 1,2-dimethylhydrazine and alters proliferation, apoptosis and dedifferentiation in rat colon

artículo científico publicado en 2006

Differential activation of promutagens by alloenzymes of human sulfotransferase 1A2 expressed in Salmonella typhimurium.

artículo científico publicado en 2002

Direct optical resolution of trans-dihydrodiol enantiomers of fjord-region polycyclic aromatic hydrocarbons by high-performance liquid chromatography on a modified cellulose phase

Directing role of organic anion transporters in the excretion of mercapturic acids of alkylated polycyclic aromatic hydrocarbons

artículo científico publicado en 2007

Dual role of epoxide hydratase in both activation and inactivation of benzo(a)pyrene

artículo científico publicado en 1977

Effect of SULT1A1 and NAT2 genetic polymorphism on the association between cigarette smoking and colorectal adenomas

artículo científico publicado en 2004

Effect of pentachlorophenol and 2,6-dichloro-4-nitrophenol on the activity of cDNA-expressed human alcohol and aldehyde dehydrogenases

artículo científico publicado en 2009

Effects of various enzyme inducers on monooxygenase, glutathione S-transferase and epoxide hydrolase activities in cultured hepatoma cells

scientific article published on 01 October 1982

Efficient oxidation of promutagenic hydroxymethylpyrenes by cDNA-expressed human alcohol dehydrogenase ADH2 and its inhibition by various agents

artículo científico publicado en 2007

Endogenous mutagens derived from amino acids

artículo científico publicado en 1990

Ethanol Enhances the Activation of 1-Hydroxymethylpyrene to DNA Adduct-Forming Species in the Rat

Expression of human estrogen sulfotransferase in Salmonella typhimurium: differences between hHST and hEST in the enantioselective activation of 1-hydroxyethylpyrene to a mutagen

artículo científico publicado en 1998

Extractionless method for the determination of urinary caffeine metabolites using high-performance liquid chromatography coupled with tandem mass spectrometry

artículo científico publicado en 2003

First Chemical Synthesis and in Vitro Characterization of the Potential Human Metabolites 5-O-Feruloylquinic Acid 4′-Sulfate and 4′-O-Glucuronide

article

Fjord-region diol-epoxides of benzo[c]chrysene are potent inducers of micronuclei in murine bone marrow

artículo científico publicado en 1994

Fruits and vegetables protect against the genotoxicity of heterocyclic aromatic amines activated by human xenobiotic-metabolizing enzymes expressed in immortal mammalian cells

artículo científico publicado en 2010

Genotoxicity assessment of aromatic amines and amides in genetically engineered V79 cells.

artículo científico publicado en 1994

Genotypic variation of the glucosinolate profile in pak choi (Brassica rapa ssp. chinensis).

artículo científico publicado en 2013

Heterologous expression of human N-acetyltransferases 1 and 2 and sulfotransferase 1A1 in Salmonella typhimurium for mutagenicity testing of heterocyclic amines

artículo científico publicado en 2002

How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop

artículo científico publicado en 2007

Human CYP3A4-mediated toxification of the pyrrolizidine alkaloid lasiocarpine

scientific article published on 16 May 2019

Human Platelet Phenolsulfotransferases: cDNA Cloning, Stable Expression in V79 Cells, and Identification of a Novel Allelic Variant of the Phenol-Sulfating Form ⬇️

artículo científico publicado el 17 de marzo de 1995

Human cytochrome P450 2E1 and sulfotransferase 1A1 coexpressed in Chinese hamster V79 cells enhance spontaneous mutagenesis

artículo científico publicado en 2010

Human cytochrome P450 reductase can act as a source of endogenous oxidative DNA damage and genetic instability

artículo científico publicado en 2005

Human dehydroepiandrosterone sulfotransferase. Purification, molecular cloning, and characterization.

artículo científico publicado en 1995

Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme.

artículo científico publicado en 1995

Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue

artículo científico publicado en 2006

Hydroxymethyl-substituted furans: mutagenicity in Salmonella typhimurium strains engineered for expression of various human and rodent sulphotransferases

artículo científico publicado en 2011

Identification and localization of soluble sulfotransferases in the human gastrointestinal tract.

artículo científico publicado en 2007

Identification of glucosinolate congeners able to form DNA adducts and to induce mutations upon activation by myrosinase.

artículo científico publicado en 2011

Identification of human and murine sulfotransferases able to activate hydroxylated metabolites of methyleugenol to mutagens in Salmonella typhimurium and detection of associated DNA adducts using UPLC-MS/MS methods

artículo científico publicado en 2012

Impact of gut microbiota on intestinal and hepatic levels of phase 2 xenobiotic-metabolizing enzymes in the rat.

artículo científico publicado en 2009

Inactivation of electrophilic metabolites by glutathione S-transferases and limitation of the system due to subcellular localization

artículo científico publicado en 1977

Induction of Cytochrome P4501A1 in Haemopoietic Stem Cells by Hydroxylated Metabolites of Benzene

artículo científico publicado en 1995

Influence of the level of cytosolic epoxide hydrolase on the induction of sister chromatid exchanges by trans-β-ethylstyrene 7,8-oxide in human lymphocytes

scientific article published on 01 November 1991

Inhibitors of mammalian melanocyte tyrosinase: in vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors

artículo científico publicado en 1999

Intestinal carcinogenesis of two food processing contaminants, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 5-hydroxymethylfurfural, in transgenic FVB min mice expressing human sulfotransferases

artículo científico publicado en 2011

Investigation of the genotoxic effects of 2-amino-9H-pyrido[2,3-b]indole in different organs of rodents and in human derived cells

artículo científico publicado en 2004

Mammalian cell gene mutation assays working group report

artículo científico publicado en 1994

Metabolic activation of furfuryl alcohol: formation of 2-methylfuranyl DNA adducts in Salmonella typhimurium strains expressing human sulfotransferase 1A1 and in FVB/N mice ⬇️

artículo científico publicado el 5 de julio de 2011

Metabolic activation of the (+)-S,S- and (-)-R,R-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene: stereoselectivity, DNA adduct formation, and mutagenicity in Chinese hamster V79 cells.

artículo científico publicado en 1997

Metabolic activation to a mutagen of 3-hydroxy-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene, a secondary metabolite of benzo[a]pyrene

artículo científico publicado en 1987

Metabolism of methyleugenol in liver microsomes and primary hepatocytes: pattern of metabolites, cytotoxicity, and DNA-adduct formation.

artículo científico publicado en 2012

Metabolism of the bay-region diol-epoxide of chrysene to a triol-epoxide and the enzyme-catalysed conjugation of these epoxides with glutathione

artículo científico publicado en 1986

Microsomal epoxide hydrolase in different rat strains

artículo científico publicado en 1983

Molecular and cellular basis for adequate metabolic design of genotoxicity studies

artículo científico publicado en 1992

Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy.

artículo científico publicado en 2009

Molecular studies on the toxifying effects by genetically engineered cytochromes P450.

artículo científico publicado en 1999

Mutagenic potential of DNA adducts formed by diol-epoxides, triol-epoxides and the K-region epoxide of chrysene in mammalian cells

artículo científico publicado en 1986

Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone

artículo científico publicado en 2007

Mutagenicity of 5-hydroxymethylfurfural in V79 cells expressing human SULT1A1: identification and mass spectrometric quantification of DNA adducts formed

artículo científico publicado en 2012

Mutagenicity of K-region oxides and imines of chrysene, benzo[c]phenanthrene and benzo[g]chrysene in Salmonella typhimurium

artículo científico publicado en 1994

Mutagenicity of N-nitrosodiethanolamine in a V79-derived cell line expressing two human biotransformation enzymes

artículo científico publicado en 2008

Mutagenicity of N-substituted phenanthrene 9,10-imines in Salmonella typhimurium and Chinese hamster V79 cells

artículo científico publicado en 1986

Mutagenicity of arbutin in mammalian cells after activation by human intestinal bacteria

artículo científico publicado en 2006

Mutagenicity of cysteine and penicillamine and its enantiomeric selectivity

artículo científico publicado en 1985

Mutagenicity spectra in Salmonella typhimurium strains of glutathione, L-cysteine and active oxygen species

artículo científico publicado en 1989

N-Acetyltransferase and sulfotransferase activity in human prostate: potential for carcinogen activation

artículo científico publicado en 2006

N-Acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast.

artículo científico publicado en 2001

Optimized enzymatic hydrolysis of DNA for LC-MS/MS analyses of adducts of 1-methoxy-3-indolylmethyl glucosinolate and methyleugenol.

artículo científico publicado en 2012

Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases

artículo científico publicado en 2007

Pharmacogenetics of soluble sulfotransferases (SULTs) ⬇️

artículo científico publicado el 5 de noviembre de 2003

Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples

artículo científico publicado en 2010

Phytoestrogens and xenoestrogens: the contribution of diet and environment to endocrine disruption.

artículo científico publicado en 2007

Polymorphisms in sulfotransferasesSULT1A1 andSULT1A2 are not related to colorectal cancer

scientific article published on 01 February 2005

Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs

artículo científico publicado en 2000

Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters

artículo científico publicado en 2002

Probenecid, an inhibitor of transmembrane organic anion transporters, alters tissue distribution of DNA adducts in 1-hydroxymethylpyrene-treated rats.

artículo científico publicado en 2009

Proliferation and differentiation of murine haemopoietic progenitor cells in stroma-free culture in the presence of metabolites of chlorinated pesticides

artículo científico publicado en 2001

Protection by beverages, fruits, vegetables, herbs, and flavonoids against genotoxicity of 2-acetylaminofluorene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in metabolically competent V79 cells

artículo científico publicado en 2002

Rat, but not human, sulfotransferase activates a tamoxifen metabolite to produce DNA adducts and gene mutations in bacteria and mammalian cells in culture

artículo científico publicado en 1998

Renal organic anion transporters OAT1 and OAT3 mediate the cellular accumulation of 5-sulfooxymethylfurfural, a reactive, nephrotoxic metabolite of the Maillard product 5-hydroxymethylfurfural.

artículo científico publicado en 2009

Risk of Colorectal Adenomas in Relation to Meat Consumption, Meat Preparation, and Genetic Susceptibility in a Dutch Population

artículo científico publicado en 2004

SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens

artículo científico publicado en 2008

Salmonella strains and mammalian cells genetically engineered for expression of sulfotransferases

artículo científico publicado en 1995

Some substrates and inhibitors of cytosolic epoxide hydrolase induce sister-chromatid exchanges in mammalian cells, but do not induce gene mutations in Salmonella typhimurium and V79 cells

artículo científico publicado en 1993

Species differences in activating and inactivating enzymes related to the control of mutagenic metabolites

artículo científico publicado en 1977

Stable heterologous expression of hydroxysteroid sulphotransferase in Chinese hamster V79 cells and their use for toxicological investigations

artículo científico publicado en 1994

Strategy for genotoxicity testing--metabolic considerations

artículo científico publicado en 2006

Strong impact of sulfotransferases on DNA adduct formation by 4-aminobiphenyl in bladder and liver in mice

scientific article published on 10 October 2018

Structural elucidation of hydroxylated metabolites of the isoflavan equol by gas chromatography-mass spectrometry and high-performance liquid chromatography-mass spectrometry

artículo científico publicado en 2005

Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene

artículo científico publicado en 2001

Structure-activity relationship in the induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells by regioisomeric phenanthrene quinones.

artículo científico publicado en 1997

Study of 5-hydroxymethylfurfural and its metabolite 5-sulfooxymethylfurfural on induction of colonic aberrant crypt foci in wild-type mice and transgenic mice expressing human sulfotransferases 1A1 and 1A2.

artículo científico publicado en 2012

Sulfotransferase forms expressed in human intestinal Caco-2 and TC7 cells at varying stages of differentiation and role in benzo[a]pyrene metabolism

artículo científico publicado en 2007

Sulfotransferase-mediated activation of mutagens studied using heterologous expression systems

artículo científico publicado en 1998

Sulfotransferases and acetyltransferases in mutagenicity testing: technical aspects

artículo científico publicado en 2005

Sulfotransferases in the bioactivation of xenobiotics

artículo científico publicado en 2000

Sulfotransferases: genetics and role in toxicology

artículo científico publicado en 2000

Sulpho-conjugation of ethanol in humans in vivo and by individual sulphotransferase forms in vitro

artículo científico publicado en 2004

The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals

artículo científico publicado en 2010

The Role of Cytochrome P450 1B1 in Dibenzo[ a,l ]pyrene-induced Carcinogenesis

The apparent ubiquity of epoxide hydratase in rat organs

artículo científico publicado en 1977

The presence of KCl in the exposure medium strongly influences the mutagenicity of metabolites of polycyclic aromatic hydrocarbons in Escherichia coli

artículo científico publicado en 1994

The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans.

artículo científico publicado en 2008

Time course of hepatic 1-methylpyrene DNA adducts in rats determined by isotope dilution LC-MS/MS and 32P-postlabeling

artículo científico publicado en 2008

Toxicity studies with 5-hydroxymethylfurfural and its metabolite 5-sulphooxymethylfurfural in wild-type mice and transgenic mice expressing human sulphotransferases 1A1 and 1A2.

artículo científico publicado en 2012

Uptake of chemically reactive, DNA-damaging sulfuric acid esters into renal cells by human organic anion transporters

artículo científico publicado en 2006

V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals.

artículo científico publicado en 2005

Vitamin E activates gene expression via the pregnane X receptor

artículo científico publicado en 2003

Xenobiotic metabolizing enzymes of rat liver nonparenchymal cells

artículo científico publicado en 1986

cis- and trans-1,2-diphenylaziridines: induction of xenobiotic-metabolizing enzymes in rat liver and mutagenicity in Salmonella typhimurium

artículo científico publicado en 1986

Lista de obras de Hansruedi Glatt

1-Hydroxymethylpyrene and its sulfuric acid ester: toxicological effects in vitro and in vivo, and metabolic aspects

1-Methoxy-3-indolylmethyl DNA adducts in six tissues, and blood protein adducts, in mice under pak choi diet: time course and persistence

1-Methoxy-3-indolylmethyl glucosinolate; a potent genotoxicant in bacterial and mammalian cells: Mechanisms of bioactivation.

Abundance of DNA adducts of methyleugenol, a rodent hepatocarcinogen, in human liver samples

Activation of Polycyclic Aromatic Compounds by cDNA-Expressed Phase I and Phase II Enzymes

Activation of benzylic alcohols to mutagens by human hepatic sulphotransferases.

Activation of promutagens by endogenous and heterologous sulfotransferases expressed in continuous cell cultures

Activation of propane 2-nitronate to a genotoxicant in V79-derived cell lines engineered for the expression of rat hepatic sulfotransferases

Altered tissue distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adducts in mice transgenic for human sulfotransferases 1A1 and 1A2.

Aneuploidy induction by benzo[a]pyrene and polyploidy induction by 7,12-dimethylbenz[a]anthracene in Chinese hamster cell lines V79-MZ and V79.

Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2

Benzylic hydroxylation of 1-methylpyrene and 1-ethylpyrene by human and rat cytochromes P450 individually expressed in V79 Chinese hamster cells

Bioactivation of the heterocyclic aromatic amine 2-amino-3-methyl-9H-pyrido [2,3-b]indole (MeAalphaC) in recombinant test systems expressing human xenobiotic-metabolizing enzymes

Biomarkers of exposure, effect, and susceptibility in workers exposed to nitrotoluenes

Biphenyl and fluorinated derivatives: liver enzyme-mediated mutagenicity detected in Salmonella typhimurium and Chinese hamster V79 cells

Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products

Cell culture system for the controlled intracellular generation of reactive oxygen species

Characterization of an epithelial, nearly diploid liver cell strain, from Chinese hamster, able to activate promutagens

Characterization of thyroid hormone sulfotransferases

Chiral inversion of 1-hydroxyethylpyrene enantiomers mediated by enantioselective sulfotransferases

Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6).

Coffee diterpenes prevent the genotoxic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N-nitrosodimethylamine in a human derived liver cell line (HepG2).

Comparison of common gene mutation tests in mammalian cells in culture: a position paper of the GUM Commission for the Development of Guidelines for Genotoxicity Testing

Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico--implications for differences in activity, subunit dimerization and substrate inhibition

Conjugation of 4-nitrophenol and 4-hydroxylonazolac in V79-derived cells expressing individual forms of human sulphotransferases

Constitutive expression of bioactivating enzymes in normal human prostate suggests a capability to activate pro-carcinogens to DNA-damaging metabolites.

Consumption of Brussels sprouts protects peripheral human lymphocytes against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and oxidative DNA-damage: results of a controlled human intervention trial

Conversion of the common food constituent 5-hydroxymethylfurfural into a mutagenic and carcinogenic sulfuric acid ester in the mouse in vivo

DNA strand break induction, mutagenicity, and cytotoxicity of the mycotoxins 11-β-hydroxy-7-deoxy-rosenonolactone, rosenonolactone, and trichothecin

Detection of DNA adducts originating from 1-methoxy-3-indolylmethyl glucosinolate using isotope-dilution UPLC-ESI-MS/MS.

Detection of genotoxicants in Brassicales using endogenous DNA as a surrogate target and adducts determined by 32P-postlabelling as an experimental end point

Determination of DNA single strand breaks and selective DNA amplification by N-nitrodimethylamine and analogs, and estimation of the indicator cells' metabolic capacities

Detoxification of promutagenic aldehydes derived from methylpyrenes by human aldehyde dehydrogenases ALDH2 and ALDH3A1.

Development and validation of a fluorescence HPLC-based screening assay for inhibition of human estrogen sulfotransferase.

Development and validation of alternative metabolic systems for mutagenicity testing in short-term assays

Dietary exposure to 5-hydroxymethylfurfural from Norwegian food and correlations with urine metabolites of short-term exposure

Dietary resistant starch type 3 prevents tumor induction by 1,2-dimethylhydrazine and alters proliferation, apoptosis and dedifferentiation in rat colon

Differential activation of promutagens by alloenzymes of human sulfotransferase 1A2 expressed in Salmonella typhimurium.

Direct optical resolution of trans-dihydrodiol enantiomers of fjord-region polycyclic aromatic hydrocarbons by high-performance liquid chromatography on a modified cellulose phase

Directing role of organic anion transporters in the excretion of mercapturic acids of alkylated polycyclic aromatic hydrocarbons

Dual role of epoxide hydratase in both activation and inactivation of benzo(a)pyrene

Effect of SULT1A1 and NAT2 genetic polymorphism on the association between cigarette smoking and colorectal adenomas

Effect of pentachlorophenol and 2,6-dichloro-4-nitrophenol on the activity of cDNA-expressed human alcohol and aldehyde dehydrogenases

Effects of various enzyme inducers on monooxygenase, glutathione S-transferase and epoxide hydrolase activities in cultured hepatoma cells

Efficient oxidation of promutagenic hydroxymethylpyrenes by cDNA-expressed human alcohol dehydrogenase ADH2 and its inhibition by various agents

Endogenous mutagens derived from amino acids

Ethanol Enhances the Activation of 1-Hydroxymethylpyrene to DNA Adduct-Forming Species in the Rat

Expression of human estrogen sulfotransferase in Salmonella typhimurium: differences between hHST and hEST in the enantioselective activation of 1-hydroxyethylpyrene to a mutagen

Extractionless method for the determination of urinary caffeine metabolites using high-performance liquid chromatography coupled with tandem mass spectrometry

First Chemical Synthesis and in Vitro Characterization of the Potential Human Metabolites 5-O-Feruloylquinic Acid 4′-Sulfate and 4′-O-Glucuronide

Fjord-region diol-epoxides of benzo[c]chrysene are potent inducers of micronuclei in murine bone marrow

Fruits and vegetables protect against the genotoxicity of heterocyclic aromatic amines activated by human xenobiotic-metabolizing enzymes expressed in immortal mammalian cells

Genotoxicity assessment of aromatic amines and amides in genetically engineered V79 cells.

Genotypic variation of the glucosinolate profile in pak choi (Brassica rapa ssp. chinensis).

Heterologous expression of human N-acetyltransferases 1 and 2 and sulfotransferase 1A1 in Salmonella typhimurium for mutagenicity testing of heterocyclic amines

How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop

Human CYP3A4-mediated toxification of the pyrrolizidine alkaloid lasiocarpine

Human Platelet Phenolsulfotransferases: cDNA Cloning, Stable Expression in V79 Cells, and Identification of a Novel Allelic Variant of the Phenol-Sulfating Form ⬇️

Human cytochrome P450 2E1 and sulfotransferase 1A1 coexpressed in Chinese hamster V79 cells enhance spontaneous mutagenesis

Human cytochrome P450 reductase can act as a source of endogenous oxidative DNA damage and genetic instability

Human dehydroepiandrosterone sulfotransferase. Purification, molecular cloning, and characterization.

Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme.

Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue

Hydroxymethyl-substituted furans: mutagenicity in Salmonella typhimurium strains engineered for expression of various human and rodent sulphotransferases

Identification and localization of soluble sulfotransferases in the human gastrointestinal tract.

Identification of glucosinolate congeners able to form DNA adducts and to induce mutations upon activation by myrosinase.

Identification of human and murine sulfotransferases able to activate hydroxylated metabolites of methyleugenol to mutagens in Salmonella typhimurium and detection of associated DNA adducts using UPLC-MS/MS methods

Impact of gut microbiota on intestinal and hepatic levels of phase 2 xenobiotic-metabolizing enzymes in the rat.

Inactivation of electrophilic metabolites by glutathione S-transferases and limitation of the system due to subcellular localization

Induction of Cytochrome P4501A1 in Haemopoietic Stem Cells by Hydroxylated Metabolites of Benzene

Influence of the level of cytosolic epoxide hydrolase on the induction of sister chromatid exchanges by trans-β-ethylstyrene 7,8-oxide in human lymphocytes

Inhibitors of mammalian melanocyte tyrosinase: in vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors

Intestinal carcinogenesis of two food processing contaminants, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 5-hydroxymethylfurfural, in transgenic FVB min mice expressing human sulfotransferases

Investigation of the genotoxic effects of 2-amino-9H-pyrido[2,3-b]indole in different organs of rodents and in human derived cells

Mammalian cell gene mutation assays working group report

Metabolic activation of furfuryl alcohol: formation of 2-methylfuranyl DNA adducts in Salmonella typhimurium strains expressing human sulfotransferase 1A1 and in FVB/N mice ⬇️

Metabolic activation of the (+)-S,S- and (-)-R,R-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene: stereoselectivity, DNA adduct formation, and mutagenicity in Chinese hamster V79 cells.

Metabolic activation to a mutagen of 3-hydroxy-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene, a secondary metabolite of benzo[a]pyrene

Metabolism of methyleugenol in liver microsomes and primary hepatocytes: pattern of metabolites, cytotoxicity, and DNA-adduct formation.