Lista de obras - Xavier Morelli - Dominio Público Uruguay

15N-labelling and preliminary heteronuclear NMR study of Desulfovibrio vulgaris Hildenborough cytochrome c553

artículo científico publicado en 1999

2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine.

artículo científico publicado en 2013

2P2Ichem: focused chemical libraries dedicated to orthosteric modulation of protein–protein interactions

article

2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein-protein interactions.

artículo científico publicado en 2016

2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions.

artículo científico publicado en 2012

A Biochemical/Biophysical Assay Dyad for HTS-Compatible Triaging of Inhibitors of the HIV-1 Nef/Hck SH3 Interaction

artículo científico publicado en 2013

A novel approach for assessing macromolecular complexes combining soft-docking calculations with NMR data.

artículo científico publicado en 2001

A peptide mimic of an antigenic loop of alpha-human chorionic gonadotropin hormone: solution structure and interaction with a llama V(HH) domain

artículo científico publicado en 2002

A specific protein disorder catalyzer of HIV-1 Nef

article

Acceleration of the Drug Discovery Process: A Combinatorial Approach Using NMR Spectroscopy and Virtual Screening

Alteration of a single tryptophan residue of the cellulose-binding domain blocks secretion of the Erwinia chrysanthemi Cel5 cellulase (ex-EGZ) via the type II system.

artículo científico publicado en 2000

Aminoacylase 1-catalysed deacetylation of bioactives epoxides mycotoxin-derived mercapturates; 3,4-epoxyprecocenes as models of cytotoxic epoxides

artículo científico publicado en 2012

An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity

artículo científico publicado en 2010

Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database

artículo científico publicado en 2010

Chemical and structural lessons from recent successes in protein-protein interaction inhibition (2P2I).

artículo científico publicado en 2011

Chemical libraries dedicated to protein-protein interactions

artículo científico publicado en 2015

Chemistry-driven Hit-to-lead Optimization Guided by Structure-based Approaches

artículo científico publicado en 2018

Comparative Virtual and Experimental Medium Throughput Screening for Hepatitis C Virus Polymerase Inhibitors

article published in 2008

Conotoxins and structural biology: a prospective paradigm for drug discovery.

artículo científico publicado en 2004

Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes

artículo científico publicado en 2014

CovaDOTS: In Silico Chemistry-Driven Tool to Design Covalent Inhibitors Using a Linking Strategy

scientific article published on 05 April 2019

Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminal domain

artículo científico publicado en 2014

Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.

artículo científico publicado en 2017

Editorial

scholarly article by Francoise Ochsenbein published in October 2015

Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins

artículo científico publicado en 2016

Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space

artículo científico publicado en 2014

GFscore: a general nonlinear consensus scoring function for high-throughput docking

artículo científico publicado en 2006

Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis.

artículo científico publicado en 2017

Heteronuclear NMR and soft docking: an experimental approach for a structural model of the cytochrome c553-ferredoxin complex

artículo científico publicado en 2000

Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X

artículo científico publicado en 2010

Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase

artículo científico publicado en 2014

Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step

artículo científico publicado en 2009

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach

artículo científico publicado en 2018

Interaction between the C-terminal domains of N and P proteins of measles virus investigated by NMR

artículo científico publicado en 2009

Mapping the cytochrome c 553 interacting site using 1 H and 15 N NMR

artículo científico publicado en 1999

Modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity.

artículo científico publicado en 2010

Molecular mapping of the RNA Cap 2'-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16.

artículo científico publicado en 2010

Multiple orientations in a physiological complex: the pyruvate-ferredoxin oxidoreductase-ferredoxin system

artículo científico publicado en 2004

Mutational analysis of the DOK2 haploinsufficient tumor suppressor gene in chronic myelomonocytic leukemia (CMML)

article

Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors

artículo científico publicado en 2018

Prevalence, specificity and determinants of lipid-interacting PDZ domains from an in-cell screen and in vitro binding experiments

artículo científico publicado en 2013

Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein

artículo científico publicado en 2007

Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery

artículo científico publicado en 2016

Protein-protein interaction inhibition (2P2I): fewer and fewer undruggable targets.

artículo científico publicado en 2009

Searching for the Holy Grail; protein-protein interaction analysis and modulation

artículo científico publicado en 2012

Sequential NMR assignment of the ferri-cytochrome c3 from Desulfovibrio vulgaris Hildenborough

artículo científico publicado en 2002

Solution structure of HndAc: a thioredoxin-like domain involved in the NADP-reducing hydrogenase complex

artículo científico publicado en 2006

Stereoselective synthesis of original spirolactams displaying promising folded structures.

artículo científico publicado en 2013

Structural Basis for the Interaction between Golgi Reassembly-stacking Protein GRASP55 and Golgin45.

artículo científico publicado en 2017

Structural and genetic analyses reveal a key role in prophage excision for the TorI response regulator inhibitor

artículo científico publicado en 2005

Structural basis for the interaction between the Golgi reassembly-stacking protein GRASP65 and the Golgi matrix protein GM130.

artículo científico publicado en 2015

Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins

artículo científico publicado en 2003

Structural model of the Fe-hydrogenase/cytochrome c553 complex combining transverse relaxation-optimized spectroscopy experiments and soft docking calculations

artículo científico publicado en 2000

Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)

artículo científico publicado en 2012

Synergy and allostery in ligand binding by HIV-1 Nef

artículo científico publicado en 2021

The crystal structure of the hexadeca-heme cytochrome Hmc and a structural model of its complex with cytochrome c(3)

artículo científico publicado en 2002

The cytochrome c3-[Fe]-hydrogenase electron-transfer complex: structural model by NMR restrained docking

artículo científico publicado en 2003

The type I/type II cytochrome c3 complex: an electron transfer link in the hydrogen-sulfate reduction pathway

artículo científico publicado en 2005

Lista de obras de Xavier Morelli

15N-labelling and preliminary heteronuclear NMR study of Desulfovibrio vulgaris Hildenborough cytochrome c553

2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine.

2P2Ichem: focused chemical libraries dedicated to orthosteric modulation of protein–protein interactions

2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein-protein interactions.

2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions.

A Biochemical/Biophysical Assay Dyad for HTS-Compatible Triaging of Inhibitors of the HIV-1 Nef/Hck SH3 Interaction

A novel approach for assessing macromolecular complexes combining soft-docking calculations with NMR data.

A peptide mimic of an antigenic loop of alpha-human chorionic gonadotropin hormone: solution structure and interaction with a llama V(HH) domain

A specific protein disorder catalyzer of HIV-1 Nef

Acceleration of the Drug Discovery Process: A Combinatorial Approach Using NMR Spectroscopy and Virtual Screening

Alteration of a single tryptophan residue of the cellulose-binding domain blocks secretion of the Erwinia chrysanthemi Cel5 cellulase (ex-EGZ) via the type II system.

Aminoacylase 1-catalysed deacetylation of bioactives epoxides mycotoxin-derived mercapturates; 3,4-epoxyprecocenes as models of cytotoxic epoxides

An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity

Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database

Chemical and structural lessons from recent successes in protein-protein interaction inhibition (2P2I).

Chemical libraries dedicated to protein-protein interactions

Chemistry-driven Hit-to-lead Optimization Guided by Structure-based Approaches

Comparative Virtual and Experimental Medium Throughput Screening for Hepatitis C Virus Polymerase Inhibitors

Conotoxins and structural biology: a prospective paradigm for drug discovery.

Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes

CovaDOTS: In Silico Chemistry-Driven Tool to Design Covalent Inhibitors Using a Linking Strategy

Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminal domain

Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.

Editorial

Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins

Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space

GFscore: a general nonlinear consensus scoring function for high-throughput docking

Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis.

Heteronuclear NMR and soft docking: an experimental approach for a structural model of the cytochrome c553-ferredoxin complex

Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X

Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase

Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach

Interaction between the C-terminal domains of N and P proteins of measles virus investigated by NMR

Mapping the cytochrome c 553 interacting site using 1 H and 15 N NMR

Modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity.

Molecular mapping of the RNA Cap 2'-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16.

Multiple orientations in a physiological complex: the pyruvate-ferredoxin oxidoreductase-ferredoxin system

Mutational analysis of the DOK2 haploinsufficient tumor suppressor gene in chronic myelomonocytic leukemia (CMML)

Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors

Prevalence, specificity and determinants of lipid-interacting PDZ domains from an in-cell screen and in vitro binding experiments

Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein

Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery

Protein-protein interaction inhibition (2P2I): fewer and fewer undruggable targets.

Searching for the Holy Grail; protein-protein interaction analysis and modulation

Sequential NMR assignment of the ferri-cytochrome c3 from Desulfovibrio vulgaris Hildenborough

Solution structure of HndAc: a thioredoxin-like domain involved in the NADP-reducing hydrogenase complex

Stereoselective synthesis of original spirolactams displaying promising folded structures.

Structural Basis for the Interaction between Golgi Reassembly-stacking Protein GRASP55 and Golgin45.

Structural and genetic analyses reveal a key role in prophage excision for the TorI response regulator inhibitor

Structural basis for the interaction between the Golgi reassembly-stacking protein GRASP65 and the Golgi matrix protein GM130.

Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins

Structural model of the Fe-hydrogenase/cytochrome c553 complex combining transverse relaxation-optimized spectroscopy experiments and soft docking calculations

Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)

Synergy and allostery in ligand binding by HIV-1 Nef

The crystal structure of the hexadeca-heme cytochrome Hmc and a structural model of its complex with cytochrome c(3)

The cytochrome c3-[Fe]-hydrogenase electron-transfer complex: structural model by NMR restrained docking

The type I/type II cytochrome c3 complex: an electron transfer link in the hydrogen-sulfate reduction pathway