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Lista de obras de David J Craik

133Cs relaxation times in rat tissues

artículo científico publicado en 1995

13C NMR relaxation and conformational flexibility of the deoxyribose ring.

artículo científico publicado en 1982

13C NMR relaxation studies of molecular motion in peptide fragments from human transthyretin

artículo científico publicado en 1995

15N cyclotides by whole plant labeling

scientific article published on 01 January 2008

1H NMR analysis of fibril-forming peptide fragments of transthyretin.

artículo científico publicado en 1994

1H and 13C NMR relaxation studies of molecular dynamics of the thyroid hormones thyroxine, 3,5,3'-triiodothyronine, and 3,5-diiodothyronine.

artículo científico publicado en 1996

1H-NMR structural studies of a cystine-linked peptide containing residues 71-93 of transthyretin and effects of a Ser84 substitution implicated in familial amyloidotic polyneuropathy

scientific article published on 01 June 1999

888 α-Conotoxin Vc1.1 Targets GABAB Receptors Modulating CaV2.2 and CaV2.3 Calcium Channels in Sensory Pathways Mediating Chronic Visceral Pain

A 1H-NMR determination of the solution structure of the A-chain of insulin: comparison with the crystal structure and an examination of the role of solvent.

artículo científico publicado en 1994

A Centipede Toxin Family Defines an Ancient Class of CSαβ Defensins ⬇️

artículo científico publicado en 2018

A Synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptor

artículo científico publicado en 2011

A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors

scientific article published on 27 March 2020

A comparative study of extraction methods reveals preferred solvents for cystine knot peptide isolation from Momordica cochinchinensis seeds

artículo científico publicado en 2014

A comparison of the self-association behavior of the plant cyclotides kalata B1 and kalata B2 via analytical ultracentrifugation.

artículo científico publicado en 2003

A computationally designed peptide derived from Escherichia colias a potential drug template for antibacterial and antibiofilm therapies

article

A conformational study by 1H NMR of a cyclic pentapeptide antagonist of endothelin

artículo científico publicado en 1993

A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202

artículo científico publicado en 1996

A continent of plant defense peptide diversity: cyclotides in Australian Hybanthus (Violaceae)

artículo científico publicado en 2005

A critical evaluation of models for complex molecular dynamics: application of NMR studies of double- and single-stranded DNA

scientific article published on 01 December 1983

A nearly idealized 6'-O-methylated iota-carrageenan from the Australian red alga Claviclonium ovatum (Acrotylaceae, Gigartinales).

artículo científico publicado en 2004

A new "era" for cyclotide sequencing.

artículo científico publicado en 2010

A new family of cystine knot peptides from the seeds of Momordica cochinchinensis.

artículo científico publicado en 2012

A new level of conotoxin diversity, a non-native disulfide bond connectivity in alpha-conotoxin AuIB reduces structural definition but increases biological activity

artículo científico publicado en 2002

A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins.

artículo científico publicado en 2006

A novel plant protein-disulfide isomerase involved in the oxidative folding of cystine knot defense proteins

artículo científico publicado en 2007

A novel quantitative kinase assay using bacterial surface display and flow cytometry

artículo científico publicado en 2013

A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability.

artículo científico publicado en 2006

A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein

artículo científico publicado en 1999

A novel  4/7-conotoxin LvIA from Conus lividus that selectively blocks  3 2 vs.  6/ 3 2 3 nicotinic acetylcholine receptors

artículo científico publicado en 2014

A peptide corresponding to the N-terminal 13 residues of T4 lysozyme forms an alpha-helix

artículo científico publicado en 1993

A radish seed antifungal peptide with a high amyloid fibril-forming propensity

artículo científico publicado en 2013

A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein

scientific article published on 25 July 2019

A systematic approach to document cyclotide distribution in plant species from genomic, transcriptomic, and peptidomic analysis

artículo científico publicado en 2013

Accurate de novo design of hyperstable constrained peptides

artículo científico publicado en 2016

Acyclic permutants of naturally occurring cyclic proteins. Characterization of cystine knot and beta-sheet formation in the macrocyclic polypeptide kalata B1.

artículo científico publicado en 2000

Alanine scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity.

artículo científico publicado en 2008

Albumins and their processing machinery are hijacked for cyclic peptides in sunflower

artículo científico publicado en 2011

Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists

artículo científico publicado en 2006

Altered metabolism of growth hormone receptor mutant mice: a combined NMR metabonomics and microarray study

scientific journal article

Amino Acid Scanning at P5' within the Bowman-Birk Inhibitory Loop Reveals Specificity Trends for Diverse Serine Proteases

scientific article published on 29 March 2019

An NMR and theoretical study of the conformation and internal flexibility of butaclamol hydrochloride

artículo científico publicado en 1991

An asparaginyl endopeptidase mediates in vivo protein backbone cyclization

artículo científico publicado en 2007

Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation.

artículo científico publicado en 2008

Analysis and classification of circular proteins in CyBase

artículo científico publicado en 2010

Anchor Residues Guide Form and Function in Grafted Peptides

scientific article published on 02 May 2019

Anthelminthic activity of the cyclotides (kalata B1 and B2) against schistosome parasites

artículo científico publicado en 2013

Anthelmintic activity of cyclotides: In vitro studies with canine and human hookworms.

artículo científico publicado en 2008

Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis. ⬇️

artículo científico publicado en 2007

Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting

artículo científico publicado en 2014

Antimicrobial and Anticancer Properties of Synthetic Peptides Derived from the Wasp Parachartergus fraternus

scientific article published on 26 November 2020

Antimicrobial peptide mimetics based on a diphenylacetylene scaffold: synthesis, conformational analysis and activity

artículo científico publicado en 2020

Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides

scientific article published on 08 April 2020

Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization.

artículo científico publicado en 2015

Are 9 10 Nicotinic Acetylcholine Receptors a Pain Target for -Conotoxins?

artículo científico publicado en 2007

Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor

artículo científico publicado en 2010

Backbone cyclised peptides from plants show molluscicidal activity against the rice pest Pomacea canaliculata (golden apple snail).

artículo científico publicado en 2008

Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer

artículo científico publicado en 2017

Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survival

artículo científico publicado en 2009

Binding Loop Substitutions in the Cyclic Peptide SFTI-1 Generate Potent and Selective Chymase Inhibitors

artículo científico publicado en 2020

Binding mode of alpha-conotoxins to an acetylcholine binding protein determined by saturation transfer difference NMR.

artículo científico publicado en 2008

Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods.

artículo científico publicado en 2018

Bioactive Cyclization Optimizes the Affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Peptide Inhibitor

artículo científico publicado en 2020

Bioactive cystine knot proteins ⬇️

artículo científico publicado el 27 de febrero de 2011

Biochemical and biophysical characterization of a novel plant protein disulfide isomerase

article

Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold.

artículo científico publicado en 2016

Bioinformatics-Aided Venomics

artículo científico publicado en 2015

Biosynthesis and insecticidal properties of plant cyclotides: the cyclic knotted proteins from Oldenlandia affinis

artículo científico publicado en 2001

Biosynthesis of circular proteins in plants

artículo científico publicado en 2007

Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations

artículo científico publicado el 3 de marzo de 2011

Butterfly Pea (Clitoria ternatea), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine.

artículo científico publicado en 2019

C-13 NMR spectral studies of the thyroid hormone transport protein, transthyretin and the pancreatic insulin storage moiety, the zinc-insulin hexamer

artículo científico publicado en 1987

CD and NMR determination of the solution structure of a peptide corresponding to T4 lysozyme residues 38-51

artículo científico publicado en 1995

Calcium-Mediated Allostery of the EGF Fold

artículo científico publicado en 2018

Capped acyclic permutants of the circular protein kalata B1.

artículo científico publicado en 2004

Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix-Loop-Helix Peptides with Cell Penetrating and Tumor Suppressor Properties

artículo científico publicado en 2019

Cellular Uptake and Cytosolic Delivery of a Cyclic Cystine Knot Scaffold

artículo científico publicado en 2020

Cellular Uptake and Cytosolic Delivery of a Cyclic Cystine Knot Scaffold

Characterising the Subsite Specificity of Urokinase-Type Plasminogen Activator and Tissue-Type Plasminogen Activator using a Sequence-Defined Peptide Aldehyde Library

scientific article published on 24 October 2018

Characterization of Synthetic Tf2 as a NaV1.3 Selective Pharmacological Probe

artículo científico publicado en 2020

Characterization of Tachyplesin Peptides and Their Cyclized Analogues to Improve Antimicrobial and Anticancer Properties ⬇️

artículo científico publicado en 2019

Characterization of a Bioactive Acyclotide from Palicourea rigida

artículo científico publicado en 2016

Characterization of a Novel  -Conotoxin from Conus textile That Selectively Targets  6/ 3 2 3 Nicotinic Acetylcholine Receptors

artículo científico publicado en 2013

Characterization of a Novel α-Conotoxin TxID from Conus textile That Potently Blocks Rat α3β4 Nicotinic Acetylcholine Receptors

artículo científico publicado en 2013

Characterization of the sequential non-covalent and covalent interactions of the antitumour antibiotic hedamycin with double stranded DNA by NMR spectroscopy

artículo científico publicado en 1999

Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1

scientific article published on 21 June 2019

Chemical modification of conotoxins to improve stability and activity

artículo científico publicado en 2007

Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy

artículo científico publicado en 2011

Chemical synthesis and biosynthesis of the cyclotide family of circular proteins

artículo científico publicado en 2006

Chemical synthesis and structure elucidation of bovine kappa-casein (1-44).

artículo científico publicado en 2005

Chemical synthesis and structure of the prokineticin Bv8

artículo científico publicado en 2010

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

artículo científico publicado en 2014

Chemistry. Seamless proteins tie up their loose ends

artículo científico publicado en 2006

Chlorotoxin: Structure, activity, and potential uses in cancer therapy

artículo científico

Circling the enemy: cyclic proteins in plant defence

scientific article published on 06 May 2009

Circular Permutation of the Native Enzyme-Mediated Cyclization Position in Cyclotides

artículo científico publicado en 2020

Circular proteins and mechanisms of cyclization

artículo científico publicado en 2010

Circular proteins from Melicytus (Violaceae) refine the conserved protein and gene architecture of cyclotides

artículo científico publicado en 2009

Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist.

artículo científico publicado en 2015

Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta

artículo científico publicado en 2017

Combined X-ray and NMR Analysis of the Stability of the Cyclotide Cystine Knot Fold That Underpins Its Insecticidal Activity and Potential Use as a Drug Scaffold

artículo científico publicado en 2009

Computer-Aided Design of Mastoparan-like Peptides Enables the Generation of Nontoxic Variants with Extended Antibacterial Properties

scientific article published on 26 August 2019

Conformation of a peptide corresponding to T4 lysozyme residues 59-81 by NMR and CD spectroscopy

artículo científico publicado en 1994

Conformational Dynamics of Thyroid Hormones by Variable Temperature Nuclear Magnetic Resonance: The Role of Side Chain Rotations and Cisoid/Transoid Interconversions ⬇️

artículo científico publicado el 4 de julio de 1997

Conformational Flexibility Is a Determinant of Permeability for Cyclosporin.

artículo científico publicado en 2018

Conformational analysis of LYS(11-36), a peptide derived from the beta-sheet region of T4 lysozyme, in TFE and SDS

artículo científico publicado en 1997

Conformational analysis of cyproheptadine hydrochloride

scientific article published on 01 April 1990

Conformational studies by NMR of the antimicrobial peptide, drosocin, and its non-glycosylated derivative: effects of glycosylation on solution conformation

scientific article published on 01 January 1999

ConoServer, a database for conopeptide sequences and structures

artículo científico publicado en 2007

ConoServer: updated content, knowledge, and discovery tools in the conopeptide database

artículo científico publicado en 2012

Conopeptide characterization and classifications: an analysis using ConoServer

artículo científico publicado en 2010

Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides

artículo científico publicado en 2008

Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa

artículo científico publicado en 2000

Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa 2. Three-dimensional solution structure

artículo científico publicado en 2000

Conotoxins: Chemistry and Biology

scientific article published on 21 October 2019

Conotoxins: natural product drug leads

artículo científico publicado en 2009

Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins

artículo científico publicado en 2004

Constrained Cyclic Peptides as Immunomodulatory Inhibitors of the CD2:CD58 Protein-Protein Interaction

artículo científico publicado en 2016

Corrigendum to "Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7" [Biochim. Biophys. Acta 1859(5) (2017) 835-844].

artículo científico publicado en 2017

Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat

artículo científico publicado en 2015

Critical Residue Properties for Potency and Selectivity of α-Conotoxin RgIA Towards α9α10 Nicotinic Acetylcholine Receptors

artículo científico publicado en 2020

Crystal Structure at 1.1 Å Resolution of α-Conotoxin PnIB: Comparison with α-Conotoxins PnIA and GI ⬇️

artículo científico publicado el 23 de septiembre de 1997

CyBase: a database of cyclic protein sequence and structure

artículo científico publicado en 2006

CyBase: a database of cyclic protein sequences and structures, with applications in protein discovery and engineering

artículo científico publicado en 2007

Cyclic Analogues of Horseshoe Crab Peptide Tachyplesin I with Anticancer and Cell Penetrating Properties

scientific article published on 27 November 2019

Cyclic MrIA: a stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter

scientific article published on 01 November 2006

Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally Absorbed

artículo científico publicado en 2014

Cyclic Peptides Arising by Evolutionary Parallelism via Asparaginyl-Endopeptidase-Mediated Biosynthesis

artículo científico publicado en 2012

Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists

artículo científico publicado en 2015

Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain

artículo científico publicado en 2017

Cyclic gomesin, a stable redesigned spider peptide able to enter cancer cells

scientific article published on 23 September 2020

Cyclic peptide oral bioavailability: Lessons from the past.

artículo científico publicado en 2016

Cyclic thrombospondin-1 mimetics: grafting of a thrombospondin sequence into circular disulfide-rich frameworks to inhibit endothelial cell migration

artículo científico publicado en 2015

Cyclization of conotoxins to improve their biopharmaceutical properties.

artículo científico publicado en 2010

Cyclization of pyrrhocoricin retains structural elements crucial for the antimicrobial activity of the native peptide.

artículo científico publicado en 2004

Cyclization of the antimicrobial peptide gomesin with native chemical ligation: influences on stability and bioactivity

artículo científico publicado en 2013

Cyclizing Disulfide-Rich Peptides Using Sortase A

artículo científico publicado en 2019

Cyclotide Structure and Function: The Role of Membrane Binding and Permeation

artículo científico publicado en 2017

Cyclotide biosynthesis

artículo científico

Cyclotide interactions with the nematode external surface.

artículo científico publicado en 2010

Cyclotide isolation and characterization

artículo científico publicado en 2012

Cyclotide proteins and precursors from the genus Gloeospermum: filling a blank spot in the cyclotide map of Violaceae

artículo científico publicado en 2009

Cyclotide structures revealed by NMR, with a little help from X-ray crystallography

artículo científico publicado en 2020

Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism

artículo científico publicado en 2013

Cyclotides are a component of the innate defense of Oldenlandia affinis

artículo científico publicado en 2010

Cyclotides as Tools in Chemical Biology.

artículo científico publicado en 2017

Cyclotides as a basis for drug design

artículo científico

Cyclotides as grafting frameworks for protein engineering and drug design applications.

artículo científico

Cyclotides as natural anti-HIV agents.

artículo científico publicado en 2008

Cyclotides as templates in drug design

artículo científico publicado en 2009

Cyclotides associate with leaf vasculature and are the products of a novel precursor in petunia (Solanaceae)

artículo científico publicado en 2012

Cyclotides from Brazilian <i>Palicourea sessilis</i> and Their Effects on Human Lymphocytes

scientific article published on 04 January 2021

Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactions

artículo científico publicado en 2012

Cyclotides: Disulfide-rich peptide toxins in plants

scientific article published on 01 October 2019

Cyclotides: From Structure to Function

scientific article published on 12 December 2019

Cyclotides: a patent review

artículo científico publicado en 2011

Cyclotides: macrocyclic peptides with applications in drug design and agriculture

artículo científico publicado en 2009

Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep.

artículo científico publicado en 2008

Cycloviolacin H4, a hydrophobic cyclotide from Viola hederaceae

artículo científico publicado en 2006

Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities

artículo científico publicado en 2011

Defense Peptides Engineered from Human Platelet Factor 4 Kill Plasmodium by Selective Membrane Disruption

artículo científico publicado en 2018

Delineation of the Unbinding Pathway of α-Conotoxin ImI from the α7 Nicotinic Acetylcholine Receptor ⬇️

artículo científico publicado el 18 de mayo de 2012

Dermatophytic defensin with antiinfective potential

artículo científico publicado en 2012

Design and Therapeutic Applications of Cyclotides ⬇️

artículo científico publicado el 1 de diciembre de 2009

Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria.

artículo científico publicado en 2012

Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro

artículo científico publicado en 2014

Design of Potent and Selective Cathepsin G Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold

artículo científico publicado en 2017

Design of a cyclotide antagonist of neuropilin-1 and -2 that potently inhibits endothelial cell migration.

artículo científico publicado en 2013

Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold

artículo científico publicado en 2015

Design, Synthesis, Structural and Functional Characterization of Novel Melanocortin Agonists Based on the Cyclotide Kalata B1

artículo científico publicado en 2012

Design, synthesis, and characterization of a single-chain peptide antagonist for the relaxin-3 receptor RXFP3.

artículo científico publicado en 2011

Design, synthesis, and characterization of cyclic analogues of the iron regulatory peptide hormone hepcidin

artículo científico publicado en 2013

Designing macrocyclic disulfide-rich peptides for biotechnological applications

artículo científico publicado en 2018

Despite a Conserved Cystine Knot Motif, Different Cyclotides Have Different Membrane Binding Modes

artículo científico publicado en 2009

Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy

artículo científico publicado en 1997

Determination of the α-Conotoxin Vc1.1 Binding Site on the α9α10 Nicotinic Acetylcholine Receptor

scientific article published on 29 April 2013

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.

artículo científico publicado en 2018

Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.

artículo científico publicado en 2016

Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions

artículo científico publicado en 2016

Difficult Macrocyclizations:  New Strategies for Synthesizing Highly Strained Cyclic Tetrapeptides

artículo científico publicado en 2003

Discovery and Characterization of Cyclic and Acyclic Trypsin Inhibitors from Momordica dioica

scientific article published on 23 January 2019

Discovery and Characterization of Cyclotides from Rinorea Species

artículo científico publicado en 2018

Discovery and applications of disulfide-rich cyclic peptides

artículo científico

Discovery and applications of the plant cyclotides

artículo científico publicado en 2010

Discovery and characterization of a linear cyclotide from Viola odorata: implications for the processing of circular proteins

artículo científico publicado en 2006

Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus

artículo científico publicado en 2020

Discovery and optimization of peptide macrocycles

artículo científico publicado en 2016

Discovery of Peptide Drugs from Natural Sources

Discovery of an unusual biosynthetic origin for circular proteins in legumes

artículo científico publicado en 2011

Discovery of cyclotide-like protein sequences in graminaceous crop plants: ancestral precursors of circular proteins?

artículo científico publicado en 2006

Discovery of cyclotides in the fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins.

artículo científico publicado en 2011

Discovery, isolation, and structural characterization of cyclotides from Viola sumatrana Miq.

artículo científico publicado en 2016

Discovery, structural determination, and putative processing of the precursor protein that produces the cyclic trypsin inhibitor sunflower trypsin inhibitor 1.

artículo científico publicado en 2005

Discovery, structure and biological activities of cyclotides.

scientific article published on 23 May 2009

Discovery, structure and biological activities of the cyclotides

artículo científico publicado en 2004

Discovery, structure, function, and applications of cyclotides: circular proteins from plants

artículo científico publicado en 2016

Discovery, synthesis, and structure-activity relationships of conotoxins.

artículo científico publicado en 2014

Dissecting the oxidative folding of circular cystine knot miniproteins

artículo científico publicado en 2009

Distribution and evolution of circular miniproteins in flowering plants

article

Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae.

artículo científico publicado en 2015

Disulfide bond mutagenesis and the structure and function of the head-to-tail macrocyclic trypsin inhibitor SFTI-1.

artículo científico publicado en 2005

Disulfide folding pathways of cystine knot proteins. Tying the knot within the circular backbone of the cyclotides

artículo científico publicado en 2003

Disulfide mapping of the cyclotide kalata B1. Chemical proof of the cystic cystine knot motif.

artículo científico publicado en 2003

Disulfide-rich macrocyclic peptides as templates in drug design

artículo científico

Drug competition for thyroxine binding to transthyretin (prealbumin): comparison with effects on thyroxine-binding globulin

scientific article published on 01 June 1989

Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy

artículo científico publicado en 2016

EGF-like and Other Disulfide-rich Microdomains as Therapeutic Scaffolds

scientific article published on 22 December 2019

Editorial Overview

artículo científico publicado en 2017

Effect of magnesium depletion and potassium depletion and chlorothiazide on intracellular pH in the rat, studied by 31P NMR

artículo científico publicado en 1989

Effects of Chirality at Tyr13 on the Structure−Activity Relationships of ω-Conotoxins fromConus magus†

artículo científico publicado en 1999

Effects of Cyclization on Peptide Backbone Dynamics.

artículo científico publicado en 2015

Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID

artículo científico publicado en 2012

Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels.

artículo científico publicado en 2014

Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA(B) receptor

artículo científico publicado en 2011

Effects of cyclotides against cutaneous infections caused by Staphylococcus aureus.

artículo científico publicado en 2014

Effects of linker sequence modifications on the structure, stability, and biological activity of a cyclic α-conotoxin

scientific article published on 01 November 2016

Efficient Enzymatic Ligation of Inhibitor Cystine Knot Spider Venom Peptides: Using Sortase A To Form Double-Knottins That Probe Voltage-Gated Sodium Channel NaV1.7.

scientific article published on 12 September 2018

Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

artículo científico publicado en 2015

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

artículo científico publicado en 2016

Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition.

artículo científico publicado en 2015

Engineering Cyclic Peptide Toxins

artículo científico publicado el 1 de enero de 2012

Engineering of conotoxins for the treatment of pain

artículo científico publicado en 2011

Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1

artículo científico publicado en 2018

Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds

artículo científico publicado en 2011

Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides

artículo científico publicado en 2008

Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII.

artículo científico publicado en 2005

Enhanced Activity against Multidrug-Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling Pathway

artículo científico publicado en 2020

Enzymatic cyclization of a potent bowman-birk protease inhibitor, sunflower trypsin inhibitor-1, and solution structure of an acyclic precursor peptide

artículo científico publicado en 2003

Establishing regiocontrol of disulfide bond isomers of alpha-conotoxin ImI via the synthesis of N-to-C cyclic analogs

artículo científico publicado en 2010

Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity

scientific article published on 17 October 2019

Evaluation of the <i>in Vivo</i> Aphrodisiac Activity of a Cyclotide Extract from <i>Hybanthus enneaspermus</i>

artículo científico publicado en 2020

Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice

artículo científico publicado en 2010

Evolutionary Origins of a Bioactive Peptide Buried within Preproalbumin

artículo científico publicado en 2014

Exploring experimental and computational markers of cyclic peptides: Charting islands of permeability

artículo científico publicado en 2015

Factors affecting 133Cs chemical shifts in erythrocytes from cesium-fed rats

artículo científico publicado en 1994

Factors affecting 39K NMR detectability in rat tissue

artículo científico publicado en 1991

Fmoc-based synthesis of disulfide-rich cyclic peptides

artículo científico publicado en 2014

Foreword for ICCP2012 Issue of Biopolymers Peptide Science Circular Proteins: Never Ending Possibilities

artículo científico publicado en 2013

Formation of cyclotides and variations in cyclotide expression in Oldenlandia affinis suspension cultures

artículo científico publicado en 2007

Forward for ICCP2015 issue of Biopolymers Peptide Science

artículo científico publicado en 2016

Functional evolution of scorpion venom peptides with an inhibitor cystine knot fold

artículo científico publicado en 2013

Functional group contributions to drug-receptor interactions.

artículo científico publicado en 1984

Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes

artículo científico publicado en 2018

Gene coevolution and regulation lock cyclic plant defence peptides to their targets

artículo científico publicado en 2015

Gly(6) of kalata B1 is critical for the selective binding to phosphatidylethanolamine membranes

artículo científico publicado en 2012

High level of aspartic acid-bond isomerization during the synthesis of an N-linked tau glycopeptide

scientific article published on 01 October 1999

High-affinity cyclic peptide matriptase inhibitors

artículo científico publicado en 2013

Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma

scientific article published on 26 December 2018

Histidine-Rich Defensins from the Solanaceae and Brasicaceae Are Antifungal and Metal Binding Proteins ⬇️

journal article from 'Journal of Fungi' published in 2020

Holocyclotoxin-1, a cystine knot toxin from Ixodes holocyclus

artículo científico publicado en 2014

Host-Defense Activities of Cyclotides ⬇️

artículo científico publicado el 15 de febrero de 2012

How bugs make lassos

artículo científico publicado en 2009

Identification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides

artículo científico publicado en 2011

Identification and structural characterization of novel cyclotide with activity against an insect pest of sugar cane

artículo científico publicado en 2011

Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis

artículo científico publicado en 2010

Identification of initiation sites for T4 lysozyme folding using CD and NMR spectroscopy of peptide fragments.

artículo científico publicado en 2000

Identification of survival-promoting OSIP108 peptide variants and their internalization in human cells

artículo científico publicado en 2016

Identification of two suites of cyclotide precursor genes from metallophyte Viola baoshanensis: cDNA sequence variation, alternative RNA splicing and potential cyclotide diversity

artículo científico publicado en 2008

Identification, Characterization, and Three-Dimensional Structure of the Novel Circular Bacteriocin, Enterocin NKR-5-3B, from Enterococcus faecium

artículo científico publicado en 2015

Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors.

artículo científico publicado en 2013

Importance of the cell membrane on the mechanism of action of cyclotides

artículo científico publicado en 2012

Improved Asparaginyl Ligase-catalyzed Transpeptidation via Selective Nucleophile Quenching

artículo científico publicado en 2020

Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable

artículo científico publicado en 2014

Improving the Selectivity of Engineered Protease Inhibitors: Optimizing the P2 Prime Residue Using a Versatile Cyclic Peptide Library

artículo científico publicado en 2015

In Silico Design of MDM2-Targeting Peptides from a Naturally Occurring Constrained Peptide

artículo científico publicado en 2019

In vivo efficacy of anuran trypsin inhibitory peptides against staphylococcal skin infection and the impact of peptide cyclization

artículo científico publicado en 2015

Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues

artículo científico publicado en 2008

Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold.

artículo científico publicado en 2016

Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site

artículo científico publicado en 2000

Insecticidal plant cyclotides and related cystine knot toxins

artículo científico publicado en 2006

Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor

artículo científico publicado en 2019

Insights into processing and cyclization events associated with biosynthesis of the cyclic Peptide kalata B1.

artículo científico publicado en 2012

Insights into the molecular flexibility of θ-defensins by NMR relaxation analysis

artículo científico publicado en 2014

Interaction of Hoechst 33258 with the minor groove of the A + T‐rich DNA duplex d(GGTAATTACC)2 studied in solution by NMR spectroscopy ⬇️

artículo científico publicado el 1 de febrero de 1993

Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors.

artículo científico publicado en 2017

Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.

artículo científico publicado en 2016

Interlocking disulfides in circular proteins: toward efficient oxidative folding of cyclotides

artículo científico publicado en 2010

Is the Mirror Image a True Reflection? Intrinsic Membrane Chirality Modulates Peptide Binding

artículo científico publicado en 2019

Isolation and Characterization of Antimicrobial Peptides with Unusual Disulfide Connectivity from the Colonial Ascidian Synoicum turgens

scientific article published on 12 January 2020

Isolation and Characterization of Cyclotides from Brazilian Psychotria: Significance in Plant Defense and Co-occurrence with Antioxidant Alkaloids.

artículo científico publicado en 2016

Isolation and characterization of cytotoxic cyclotides from Viola philippica.

artículo científico publicado en 2011

Isolation and characterization of cytotoxic cyclotides from Viola tricolor

artículo científico publicado en 2010

Isolation and characterization of novel cyclotides from Viola hederaceae: solution structure and anti-HIV activity of vhl-1, a leaf-specific expressed cyclotide.

artículo científico publicado en 2005

Isolation and characterization of peptides from Momordica cochinchinensis seeds

artículo científico publicado en 2009

Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors

artículo científico publicado en 2013

Isolation, sequencing, and structure-activity relationships of cyclotides.

artículo científico publicado en 2010

Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature?

artículo científico publicado en 2005

Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence

artículo científico publicado en 2003

Iterative Optimization of the Cyclic Peptide SFTI-1 Yields Potent Inhibitors of Neutrophil Proteinase 3

scientific article published on 19 July 2019

Joseph Rudinger memorial lecture: Discovery and applications of cyclotides ⬇️

artículo científico publicado el 5 de junio de 2013

Kalata B1 and Kalata B2 Have a Surfactant-Like Activity in Phosphatidylethanolomine-Containing Lipid Membranes

artículo científico publicado en 2017

Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif

artículo científico publicado en 2006

Key challenges for the creation and maintenance of specialist protein resources

artículo científico publicado en 2015

Key residues in the nicotinic acetylcholine receptor β2 subunit contribute to α-conotoxin LvIA binding.

artículo científico publicado en 2015

Knots in rings. The circular knotted protein Momordica cochinchinensis trypsin inhibitor-II folds via a stable two-disulfide intermediate.

artículo científico publicado en 2006

Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins

artículo científico publicado en 2017

Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1.

artículo científico publicado en 2015

Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity

artículo científico publicado en 2003

Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a.

artículo científico publicado en 1999

Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptake

artículo científico publicado en 2017

Lysine-rich Cyclotides: A New Subclass of Circular Knotted Proteins from Violaceae

artículo científico publicado en 2015

Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity

artículo científico publicado en 2010

Make it or break it: Plant AEPs on stage in biotechnology

artículo científico publicado en 2020

Making ends meet: chemically mediated circularization of recombinant proteins

artículo científico publicado en 2013

Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7.

artículo científico publicado en 2020

Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET.

scientific article published on 15 February 2017

Mechanisms of bacterial membrane permeabilization by crotalicidin (Ctn) and its fragment Ctn(15-34), antimicrobial peptides from rattlesnake venom

artículo científico publicado en 2017

Membrane-binding properties of gating modifier and pore-blocking toxins: Membrane interaction is not a prerequisite for modification of channel gating

artículo científico publicado en 2016

MiAMP1, a novel protein from Macadamia integrifolia adopts a Greek key beta-barrel fold unique amongst plant antimicrobial proteins

artículo científico publicado en 1999

Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone

artículo científico publicado en 2003

Microwave-assisted Boc-solid phase peptide synthesis of cyclic cysteine-rich peptides

artículo científico publicado en 2008

Mining the genome of Arabidopsis thaliana as a basis for the identification of novel bioactive peptides involved in oxidative stress tolerance

artículo científico publicado en 2013

Mirror Images of Antimicrobial Peptides Provide Reflections on Their Functions and Amyloidogenic Properties

artículo científico publicado en 2016

Models for the binding of amiodarone to the thyroid hormone receptor

scientific article published on 01 February 1992

Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases.

artículo científico publicado en 2018

Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors

scientific article published on 24 September 2018

Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor

scientific article published on 07 June 2019

Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function

artículo científico publicado en 2008

Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis.

artículo científico publicado en 2013

NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced Na Channel Potency

scientific article published on 22 October 2018

NMR and molecular modelling based conformational analysis of some N-alkyl 1- and 2-benzazepinones: useful central nervous system agent design motifs

scientific article published on 01 November 1994

NMR and protein structure in drug design: application to cyclotides and conotoxins

artículo científico publicado en 2011

NMR as a tool for elucidating the structures of circular and knotted proteins.

artículo científico publicado en 2007

NMR in peptide drug development

scientific article published on 01 January 2008

NMR measurement of 39K detectability and relaxation constants in rat tissue

artículo científico publicado en 1993

NMR of conotoxins: structural features and an analysis of chemical shifts of post-translationally modified amino acids.

artículo científico publicado en 2006

NMR of plant proteins ⬇️

artículo científico publicado el 31 de enero de 2013

NMR studies of the conformational interconversion of butaclamol in solution

artículo científico publicado en 1991

NMRDyn: a program for NMR relaxation studies of protein association

artículo científico publicado en 2008

NaV 1.6 regulates excitability of mechanosensitive sensory neurons

artículo científico publicado en 2019

Native chemical ligation applied to the synthesis and bioengineering of circular peptides and proteins

artículo científico publicado en 2010

Natural structural diversity within a conserved cyclic peptide scaffold

artículo científico publicado en 2016

Naturally occurring circular proteins: distribution, biosynthesis and evolution.

artículo científico publicado en 2010

Neurotoxic peptides from the venom of the giant Australian stinging tree

scientific article published on 16 September 2020

New alkaloids from Pandanus amaryllifolius.

artículo científico publicado en 2004

Nicotiana alata Defensin Chimeras Reveal Differences in the Mechanism of Fungal and Tumor Cell Killing and an Enhanced Antifungal Variant ⬇️

artículo científico publicado en 2016

Nomenclature of homodetic cyclic peptides produced from ribosomal precursors: An IUPAC task group interim report.

artículo científico publicado en 2016

Novel inhibitor cystine knot peptides from Momordica charantia

artículo científico publicado en 2013

Optimization of the cyclotide framework to improve cell penetration properties

artículo científico publicado en 2015

Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR.

artículo científico publicado en 2017

Oxidative folding of cyclic cystine knot proteins.

artículo científico publicado en 2008

Oxidative folding of the cystine knot motif in cyclotide proteins.

artículo científico publicado en 2005

Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design

artículo científico publicado en 2013

PTRF/cavin-1 neutralizes non-caveolar caveolin-1 microdomains in prostate cancer

artículo científico

Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization

scientific article published on 03 April 2019

Peptide macrocyclization by a bifunctional endoprotease.

artículo científico publicado en 2015

Peptide quantification by matrix-assisted laser desorption ionisation time-of-flight mass spectrometry: investigations of the cyclotide kalata B1 in biological fluids.

artículo científico publicado en 2005

Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx-1

artículo científico publicado en 2018

Peptides from Mamba Venom as Pain Killers

artículo científico publicado en 2013

Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation - Suggestion of a Binding Mode at the α7 nAChR

artículo científico publicado en 2019

Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold

scientific article published on 04 May 2019

Phosphatidylethanolamine binding is a conserved feature of cyclotide-membrane interactions

artículo científico publicado en 2012

Phosphorylation of the C-Terminal Sites of Human p53 Reduces Non-Sequence-Specific DNA Binding as Modeled with Synthetic Peptides ⬇️

artículo científico publicado el 29 de septiembre de 1998

Photodegradation of irinotecan (CPT-11) in aqueous solutions: identification of fluorescent products and influence of solution composition.

artículo científico publicado en 1997

Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae

artículo científico publicado en 2008

Plant cyclotides: circular, knotted peptide toxins.

artículo científico publicado en 2001

Plant-derived decapeptide OSIP108 interferes with Candida albicans biofilm formation without affecting cell viability

artículo científico publicado en 2014

Potent, Selective, and Cell-Penetrating Inhibitors of Kallikrein-Related Peptidase 4 Based on the Cyclic Peptide MCoTI-II

scientific article published on 21 November 2018

Potential therapeutic applications of the cyclotides and related cystine knot mini-proteins

artículo científico publicado en 2007

Prediction and characterization of cyclic proteins from sequences in three domains of life

artículo científico publicado en 2013

Problems in the assessment of magnesium depletion in the rat by in vivo 31P NMR

artículo científico publicado en 1988

Processing of a 22 kDa precursor protein to produce the circular protein tricyclon A.

artículo científico publicado en 2005

Production of a structurally validated cyclotide in rice suspension cells is enabled by a supporting biosynthetic enzyme

artículo científico publicado en 2020

Protease-catalysed protein splicing: a new post-translational modification?

scientific article published on 01 July 2008

Protein folding: Turbo-charged crosslinking

artículo científico publicado en 2012

Proteome analysis of the hyaluronic acid-producing bacterium, Streptococcus zooepidemicus.

artículo científico publicado en 2009

Purification and characterization of a plant antimicrobial peptide expressed in Escherichia coli

artículo científico publicado en 1999

Qualitative analysis of the stability of the oxazine ring of various benzoxazine and pyridooxazine derivatives with proton nuclear magnetic resonance spectroscopy

artículo científico publicado en 1992

Quantification of small cyclic disulfide‐rich peptides ⬇️

artículo científico publicado el 1 de enero de 2012

Quantitative analysis of backbone-cyclised peptides in plants

artículo científico publicado en 2008

Racemic and quasi-racemic X-ray structures of cyclic disulfide-rich peptide drug scaffolds

artículo científico publicado en 2014

Rapid and Scalable Plant-Based Production of a Potent Plasmin Inhibitor Peptide

artículo científico publicado en 2019

Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients

artículo científico publicado en 2014

Recent Progress Towards Pharmaceutical Applications of Disulfide-Rich Cyclic Peptides ⬇️

artículo científico publicado el 1 de septiembre de 2013

Recent developments in nuclear magnetic resonance spectroscopy

artículo científico publicado en 1981

Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties

artículo científico publicado en 2017

RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs.

artículo científico publicado en 2011

Relationship between ATP resynthesis and calcium accumulation in the reperfused rat heart

artículo científico publicado en 1992

Retrocyclin-2: a potent anti-HIV theta-defensin that forms a cyclic cystine ladder structural motif.

artículo científico publicado en 2009

Retrocyclin-2: structural analysis of a potent anti-HIV theta-defensin

artículo científico publicado en 2007

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

artículo científico publicado en 2013

Ribosomally-synthesised cyclic peptides from plants as drug leads and pharmaceutical scaffolds

artículo científico publicado en 2017

Ring flexibility within tricyclic antidepressant drugs

artículo científico publicado en 2001

Role of phosphorylation in the conformation of tau peptides implicated in Alzheimer's disease.

artículo científico publicado en 2000

Safer In Vitro Drug Screening Models for Melioidosis Therapy Development

scientific article published on 21 September 2020

Salt-Tolerant Antifungal and Antibacterial Activities of the Corn Defensin ZmD32

artículo científico publicado en 2019

Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor

artículo científico publicado en 2009

Secondary structure of the third extracellular loop responsible for ligand selectivity of a mammalian gonadotropin-releasing hormone receptor

artículo científico publicado en 2002

Selective removal of individual disulfide bonds within a potato type II serine proteinase inhibitor from Nicotiana alata reveals differential stabilization of the reactive-site loop

artículo científico publicado en 2009

Semienzymatic Cyclization of Disulfide-rich Peptides Using Sortase A

artículo científico publicado en 2014

Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential

artículo científico publicado en 2019

Single Amino Acid Substitution in α-Conotoxin TxID Reveals a Specific α3β4 Nicotinic Acetylcholine Receptor Antagonist

artículo científico publicado en 2018

Single Amino Acid Substitutions in α-Conotoxin PnIA Shift Selectivity for Subtypes of the Mammalian Neuronal Nicotinic Acetylcholine Receptor

artículo científico publicado en 1999

Site-Specific Sequential Protein Labeling Catalyzed by a Single Recombinant Ligase

artículo científico publicado en 2019

Small cyclic sodium channel inhibitors

artículo científico publicado en 2020

Small molecular probes for G-protein-coupled C5a receptors: conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a.

artículo científico publicado en 1998

Solution Structure, Membrane Interactions, and Protein Binding Partners of the Tetraspanin Sm-TSP-2, a Vaccine Antigen from the Human Blood FlukeSchistosoma mansoni

artículo científico publicado en 2014

Solution conformation of endothelin, a potent vaso-constricting bicyclic peptide. A combined use of 1H NMR spectroscopy and distance geometry calculations

artículo científico publicado en 1991

Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3.

artículo científico publicado en 2006

Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3.

artículo científico publicado en 2005

Solution structure and proposed binding mechanism of a novel potassium channel toxin κ-conotoxin PVIIA ⬇️

artículo científico publicado el 15 de diciembre de 1997

Solution structure by NMR of circulin A: a macrocyclic knotted peptide having anti-HIV activity

artículo científico publicado en 1999

Solution structure of BSTI: a new trypsin inhibitor from skin secretions of Bombina bombina

artículo científico publicado en 2001

Solution structure of alpha-conotoxin ImI by 1H nuclear magnetic resonance

artículo científico publicado en 1999

Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?

artículo científico publicado en 1998

Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter

artículo científico publicado en 2005

Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels

artículo científico publicado en 2002

Solution structure of the B-chain of insulin as determined by 1H NMR spectroscopy. Comparison with the crystal structure of the insulin hexamer and with the solution structure of the insulin monomer

artículo científico publicado en 1995

Solution structure of the acetylated and noncleavable mitochondrial targeting signal of rat chaperonin 10

scientific article published on 01 January 1995

Solution structure of the cyclotide palicourein: implications for the development of a pharmaceutical framework

artículo científico publicado en 2004

Solution structure of the sodium channel antagonist conotoxin GS: a new molecular caliper for probing sodium channel geometry

artículo científico publicado en 1997

Solution structure, aggregation behavior, and flexibility of human relaxin-2

artículo científico publicado en 2015

Solution structures by 1H NMR of the novel cyclic trypsin inhibitor SFTI-1 from sunflower seeds and an acyclic permutant

artículo científico publicado en 2001

Solution structures of the cis- and trans-Pro30 isomers of a novel 38-residue toxin from the venom of Hadronyche Infensa sp. that contains a cystine-knot motif within its four disulfide bonds

artículo científico publicado en 2002

Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists.

artículo científico publicado en 2010

Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7.

artículo científico publicado en 2017

Stability studies of oxazolidine-based compounds using 1H NMR spectroscopy

artículo científico publicado en 2010

Stabilization of α-Conotoxin AuIB: Influences of Disulfide Connectivity and Backbone Cyclization

scientific article published on 20 August 2010

Stage-specific proteophosphoglycan from Leishmania mexicana amastigotes. Structural characterization of novel mono-, di-, and triphosphorylated phosphodiester-linked oligosaccharides

scientific article published on 01 May 1998

Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB

scientific article published on 21 July 2018

Structural Insights into the Role of the Cyclic Backbone in a Squash Trypsin Inhibitor

artículo científico publicado en 2013

Structural analysis and molecular model of a self-incompatibility RNase from wild tomato.

artículo científico publicado en 1998

Structural analysis of peptide fragment 71-93 of transthyretin by NMR spectroscopy and electron microscopy: insight into amyloid fibril formation.

artículo científico publicado en 1994

Structural analysis of the N-linked glycan chains from a stylar glycoprotein associated with expression of self-incompatibility in Nicotiana alata

artículo científico publicado en 1992

Structural analysis of the carbohydrate moiety of arabinogalactan-proteins from stigmas and styles of Nicotiana alata

artículo científico publicado en 1995

Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis

artículo científico publicado en 2010

Structural and functional analysis of human liver-expressed antimicrobial peptide 2.

artículo científico publicado en 2010

Structural and functional characterization of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies

artículo científico publicado en 2016

Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4.

artículo científico publicado en 2006

Structural characterisation of galactoglucomannan secreted by suspension-cultured cells of Nicotiana plumbaginifolia

scientific article published on 01 August 1997

Structural characterisation of xyloglucan secreted by suspension-cultured cells of Nicotiana plumbaginifolia

scientific article published on 01 October 1996

Structural characterization of the 1:1 adduct formed between the antitumor antibiotic hedamycin and the oligonucleotide duplex d(CACGTG)2 by 2D NMR spectroscopy

artículo científico publicado en 1996

Structural characterization of the cyclic cystine ladder motif of θ-defensins

artículo científico publicado en 2012

Structural insights into the function of relaxins

artículo científico publicado en 2009

Structural parameters modulating the cellular uptake of disulfide-rich cyclic cell-penetrating peptides: MCoTI-II and SFTI-1

scientific article published on 24 June 2014

Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design.

artículo científico publicado en 2006

Structural properties of relaxin chimeras.

artículo científico publicado en 2009

Structural refinement of insecticidal plant proteinase inhibitors from Nicotiana alata

artículo científico publicado en 2008

Structural studies of conotoxins

artículo científico publicado en 2009

Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA

scientific article published on 07 February 2020

Structure and activity of alpha-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABA(B) receptor-coupled N-type calcium channels

artículo científico publicado en 2011

Structure and folding of disulfide-rich miniproteins: insights from molecular dynamics simulations and MM-PBSA free energy calculations

artículo científico publicado en 2008

Structure and folding of potato type II proteinase inhibitors: circular permutation and intramolecular domain swapping.

artículo científico publicado en 2005

Structure determination of extracellular fragments of amyloid proteins involved in Alzheimer's disease and Dutch-type hereditary cerebral haemorrhage with amyloidosis

artículo científico publicado en 1994

Structure determination of the three disulfide bond isomers of α-conotoxin GI: a model for the role of disulfide bonds in structural stability 1 1Edited by P. E. Wright ⬇️

artículo científico publicado el 1 de mayo de 1998

Structure of N-glycans on the S3- and S6-allele stylar self-incompatibility ribonucleases of Nicotiana alata

artículo científico publicado en 1996

Structure of Petunia hybrida defensin 1, a novel plant defensin with five disulfide bonds

artículo científico publicado en 2003

Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework

artículo científico publicado en 2009

Structure of the N-linked oligosaccharides from tridacnin, a lectin found in the haemolymph of the giant clam Hippopus hippopus

scientific article published on 01 September 1995

Structure of the R3/I5 Chimeric Relaxin Peptide, a Selective GPCR135 and GPCR142 Agonist

artículo científico publicado en 2008

Structure of thermolysin cleaved microcin J25: extreme stability of a two-chain antimicrobial peptide devoid of covalent links

artículo científico publicado en 2004

Structure of α-conotoxin BuIA: influences of disulfide connectivity on structural dynamics ⬇️

artículo científico publicado en 2007

Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif.

artículo científico publicado en 2016

Structure-activity analysis of truncated albumin-binding domains suggests new lead constructs for potential therapeutic delivery

scientific article published on 09 July 2020

Structure-activity relationship study of the plant-derived decapeptide OSIP108 inhibiting Candida albicans biofilm formation.

artículo científico publicado en 2014

Structure-activity studies of conantokins as human N-methyl-D-aspartate receptor modulators

artículo científico publicado en 1999

Structures of a series of 6-kDa trypsin inhibitors isolated from the stigma of Nicotiana alata

artículo científico publicado en 1995

Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons.

artículo científico publicado en 2004

Structures of naturally occurring circular proteins from bacteria

artículo científico publicado en 2003

Structure–Activity Studies Reveal the Molecular Basis for GABAB-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1

artículo científico publicado en 2018

Studies on the membrane interactions of the cyclotides kalata B1 and kalata B6 on model membrane systems by surface plasmon resonance

artículo científico publicado en 2005

Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold

artículo científico publicado en 2016

Sunflower Trypsin Inhibitor-1 (SFTI-1): Sowing Seeds in the Fields of Chemistry and Biology

artículo científico publicado en 2020

Sunflower trypsin inhibitor-1, proteolytic studies on a trypsin inhibitor peptide and its analogs.

artículo científico publicado en 2010

Sunflower trypsin inhibitor-1.

artículo científico publicado en 2004

Synergistic Activity of the Plant Defensin HsAFP1 and Caspofungin against Candida albicans Biofilms and Planktonic Cultures

artículo científico publicado en 2015

Synthesis and structural analysis of the N-terminal domain of the thyroid hormone-binding protein transthyretin

artículo científico publicado en 2002

Synthesis of an analog of the thyroid hormone-binding protein transthyretin via regioselective chemical ligation

artículo científico publicado en 2001

Synthesis of cyclic disulfide-rich peptides

artículo científico publicado en 2013

Synthesis of cyclic penta- and hexapeptides: a general synthetic strategy on DAS resin

scientific article published on 01 April 1994

Synthesis, Racemic X-ray Crystallographic, and Permeability Studies of Bioactive Orbitides from Jatropha Species

article

Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII.

artículo científico publicado en 2003

Targeted Delivery of Cyclotides via Conjugation to a Nanobody

artículo científico publicado en 2018

Testing of insulin hexamer-stabilizing ligands using theoretical binding, microcalorimetry, and nuclear magnetic resonance (NMR) line broadening techniques

artículo científico publicado en 1990

The 1.1 A crystal structure of the neuronal acetylcholine receptor antagonist, alpha-conotoxin PnIA from Conus pennaceus

artículo científico publicado en 1996

The C-terminal propeptide of a plant defensin confers cytoprotective and subcellular targeting functions

artículo científico publicado en 2014

The Chemistry of Cyclotides ⬇️

artículo científico publicado el 19 de mayo de 2011

The Cyclic Cystine Ladder in  -Defensins Is Important for Structure and Stability, but Not Antibacterial Activity

artículo científico publicado en 2013

The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6.

artículo científico publicado en 2018

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

artículo científico publicado en 2010

The N-terminal pro-domain of the kalata B1 cyclotide precursor is intrinsically unstructured

artículo científico publicado en 2016

The Prototypic Cyclotide Kalata B1 Has a Unique Mechanism of Entering Cells

artículo científico publicado en 2015

The Three-dimensional Solution Structure by 1H NMR of a 6-Kda Proteinase Inhibitor Isolated from the Stigma of Nicotiana alata

artículo científico publicado en 1994

The Yariv reagent: behaviour in different solvents and interaction with a gum arabic arabinogalactan-protein

artículo científico publicado en 2014

The absolute structural requirement for a proline in the P3'-position of Bowman-Birk protease inhibitors is surmounted in the minimized SFTI-1 scaffold

artículo científico publicado en 2006

The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity

artículo científico publicado en 2008

The anthelmintic activity of the cyclotides: natural variants with enhanced activity

artículo científico publicado en 2008

The antimicrobial activity of Sub3 is dependent on membrane binding and cell-penetrating ability.

artículo científico publicado en 2013

The biological activity of the prototypic cyclotide kalata b1 is modulated by the formation of multimeric pores

artículo científico publicado en 2009

The chemistry and biology of human relaxin-3.

artículo científico publicado en 2005

The chemistry and biology of theta defensins.

artículo científico publicado en 2014

The conformation of porcine-brain natriuretic peptide by two-dimensional NMR spectroscopy

artículo científico publicado en 1991

The cyclic antimicrobial peptide RTD-1 induces stabilized lipid-peptide domains more efficiently than its open-chain analogue

artículo científico publicado en 2004

The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis.

artículo científico publicado en 2007

The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: A proof-of-concept study using the integrin-binding RGD motif

artículo científico publicado en 2014

The cyclotide family of circular miniproteins: nature's combinatorial peptide template.

artículo científico publicado en 2006

The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides

scientific article published on 01 June 2007

The cystine knot motif in toxins and implications for drug design.

artículo científico publicado en 2001

The discovery and development of a natural combinatorial peptide template: the cyclotides

artículo científico publicado en 2009

The evolution of Momordica cyclic peptides

artículo científico publicado en 2014

The folding of disulfide-rich proteins

artículo científico publicado en 2010

The future of peptide-based drugs

artículo científico publicado en 2013

The insecticidal wasp toxin Γ-Pompilidotoxin is a linear peptide modulating voltage-gated sodium channels

artículo científico publicado en 2020

The interaction with fungal cell wall polysaccharides determines the salt tolerance of antifungal plant defensins

scientific article published on 22 May 2019

The interactions of the N-terminal fusogenic peptide of HIV-1 gp41 with neutral phospholipids

artículo científico publicado en 1999

The plant decapeptide OSIP108 can alleviate mitochondrial dysfunction induced by cisplatin in human cells.

artículo científico publicado en 2014

The radish defensins RsAFP1 and RsAFP2 act synergistically with caspofungin against Candida albicans biofilms

artículo científico publicado en 2016

The role of conserved Glu residue on cyclotide stability and activity: a structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant

artículo científico publicado en 2011

The role of disulfide bonds in structure and activity of chlorotoxin.

artículo científico publicado en 2014

The role of disulfide bonds in the structure and function of murine epidermal growth factor (mEGF).

artículo científico publicado en 2005

The role of the cyclic peptide backbone in the anti-HIV activity of the cyclotide kalata B1

scientific article published on 01 September 2004

The self-association of the cyclotide kalata B2 in solution is guided by hydrophobic interactions.

artículo científico publicado en 2013

The solution structure of a monocyclic analogue of endothelin [1,15 Aba]-ET-1, determined by 1H NMR spectroscopy

artículo científico publicado en 1994

The structure of a two-disulfide intermediate assists in elucidating the oxidative folding pathway of a cyclic cystine knot protein

artículo científico publicado en 2008

The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1.

artículo científico publicado en 2006

The three-dimensional solution structure of NaD1, a new floral defensin from Nicotiana alata and its application to a homology model of the crop defense protein alfAFP

artículo científico publicado en 2003

The three-dimensional solution structure of mini-M conotoxin BtIIIA reveals a disconnection between disulfide connectivity and peptide fold ⬇️

artículo científico publicado el 22 de febrero de 2013

The three-dimensional structure of the analgesic alpha-conotoxin, RgIA.

artículo científico publicado en 2008

The use of dietary loading of 133Cs as a potassium substitute in NMR studies of tissues

scientific article published on 01 November 1993

The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance

artículo científico publicado en 2012

Thematic minireview series on circular proteins.

artículo científico publicado en 2012

Therapeutic Potential of Conopeptides ⬇️

artículo científico publicado el 1 de junio de 2012

Therapeutic conotoxins: a US patent literature survey

artículo científico

Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: the importance of the cyclic cystine knot.

artículo científico publicado en 2004

Three-dimensional solution structure of alpha-conotoxin MII by NMR spectroscopy: effects of solution environment on helicity

artículo científico publicado en 1998

Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels

artículo científico publicado en 1996

Three-dimensional structure of RTD-1, a cyclic antimicrobial defensin from Rhesus macaque leukocytes

artículo científico publicado en 2001

Thyroid hormone uptake by hepatocytes: structure-activity relationships of phenylanthranilic acids with inhibitory activity

artículo científico publicado en 1993

Tissue-specific expression of head-to-tail cyclized miniproteins in Violaceae and structure determination of the root cyclotide Viola hederacea root cyclotide1.

artículo científico publicado en 2004

Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-Assisted Folding

article

Toward Structure Determination of Disulfide-Rich Peptides Using Chemical Shift-Based Methods

scientific article published on 21 February 2019

Transcriptomic screening for cyclotides and other cysteine-rich proteins in the metallophyte Viola baoshanensis.

artículo científico publicado en 2015

Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins

artículo científico publicado en 2015

Translational diffusion of cyclic peptides measured using pulsed-field gradient NMR.

artículo científico publicado en 2014

Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.

artículo científico publicado en 2016

Twists, knots, and rings in proteins. Structural definition of the cyclotide framework

artículo científico publicado en 2003

Two Blast-independent tools, CyPerl and CyExcel, for harvesting hundreds of novel cyclotides and analogues from plant genomes and protein databases

artículo científico publicado en 2014

Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter

artículo científico publicado en 2001

Two-dimensional nuclear magnetic resonance spectra of selected tricyclic antidepressants

scientific article published on 01 January 1987

Tyrosine-rich conopeptides affect voltage-gated K+ channels

artículo científico publicado en 2008

Ultra-stable peptide scaffolds for protein engineering-synthesis and folding of the circular cystine knotted cyclotide cycloviolacin O2.

artículo científico publicado en 2008

Understanding the Diversity and Distribution of Cyclotides from Plants of Varied Genetic Origin

artículo científico publicado en 2017

Understanding the structure/activity relationships of the iron regulatory peptide hepcidin

artículo científico publicado en 2011

Using the MCoTI-II Cyclotide Scaffold To Design a Stable Cyclic Peptide Antagonist of SET, a Protein Overexpressed in Human Cancer

artículo científico publicado en 2015

Variations in cyclotide expression in viola species

artículo científico publicado en 2004

Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors

artículo científico publicado en 2018

X-ray diffraction studies of fibrils formed from peptide fragments of transthyretin

artículo científico publicado en 1993

α-Conotoxin ImI Incorporating Stable Cystathionine Bridges Maintains Full Potency and Identical Three-Dimensional Structure

artículo científico publicado en 2011

α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors.

artículo científico publicado en 2016

α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors

artículo científico publicado en 2017

αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype.

artículo científico publicado en 2017

θ-Defensins Prevent HIV-1 Env-mediated Fusion by Binding gp41 and Blocking 6-Helix Bundle Formation

artículo científico publicado en 2006

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