Lista de obras - John P. Richard - Dominio Público Uruguay

A Marcus treatment of rate constants for protonation of ring-substituted alpha-methoxystyrenes: intrinsic reaction barriers and the shape of the reaction coordinate

artículo científico publicado en 2007

A Paradigm for Enzyme-Catalyzed Proton Transfer at Carbon: Triosephosphate Isomerase ⬇️

artículo científico publicado el 20 de marzo de 2012

A comparison of the electrophilic reactivities of Zn2+ and acetic acid as catalysts of enolization: imperatives for enzymatic catalysis of proton transfer at carbon

artículo científico publicado en 2004

A minimalist approach to understanding the efficiency of mononuclear Zn(ii) complexes as catalysts of cleavage of an RNA analog

article

A reevaluation of the origin of the rate acceleration for enzyme-catalyzed hydride transfer

artículo científico publicado en 2017

A role for flexible loops in enzyme catalysis

scientific article published on 13 October 2010

A simple method to determine kinetic deuterium isotope effects provides evidence that proton transfer to carbon proceeds over and not through the reaction barrier

artículo científico publicado en 2007

A substrate in pieces: allosteric activation of glycerol 3-phosphate dehydrogenase (NAD+) by phosphite dianion

artículo científico publicado en 2008

A transition state analog for phosphate diester cleavage catalyzed by a small enzyme-like metal ion complex

artículo científico publicado en 2007

Activation of R235A mutant orotidine 5'-monophosphate decarboxylase by the guanidinium cation: effective molarity of the cationic side chain of Arg-235

artículo científico publicado en 2010

Activation of orotidine 5'-monophosphate decarboxylase by phosphite dianion: the whole substrate is the sum of two parts

artículo científico publicado en 2005

Alanine-dependent reactions of 5'-deoxypyridoxal in water

artículo científico publicado en 2008

Altered transition state for the reaction of an RNA model catalyzed by a dinuclear zinc(II) catalyst

artículo científico publicado en 2008

An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organisms

artículo científico publicado en 2009

Binding Energy and Catalysis by d -Xylose Isomerase: Kinetic, Product, and X-ray Crystallographic Analysis of Enzyme-Catalyzed Isomerization of ( R )-Glyceraldehyde

artículo científico publicado en 2011

Bovine serum albumin-catalyzed deprotonation of [1-(13)C]glycolaldehyde: protein reactivity toward deprotonation of the alpha-hydroxy alpha-carbonyl carbon

artículo científico publicado en 2010

Carbon acidity of the alpha-pyridinium carbon of a pyridoxamine analog.

artículo científico publicado en 2005

Catalysis by orotidine 5'-monophosphate decarboxylase: effect of 5-fluoro and 4'-substituents on the decarboxylation of two-part substrates

artículo científico publicado en 2013

Claisen-type addition of glycine to a pyridoxal iminium ion in water

artículo científico publicado en 2006

Claisen-type addition of glycine to pyridoxal in water.

artículo científico publicado en 2004

Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: A Structure-Based Explanation for How the 5′-Phosphate Group Activates the Enzyme

artículo científico publicado en 2012

Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: “Remote” Residues That Stabilize the Active Conformation

artículo científico publicado en 2010

Contribution of phosphate intrinsic binding energy to the enzymatic rate acceleration for triosephosphate isomerase

artículo científico publicado en 2001

Cooperativity between metal ions in the cleavage of phosphate diesters and RNA by dinuclear Zn(II) catalysts

artículo científico publicado en 2003

Covalent catalysis by pyridoxal: evaluation of the effect of the cofactor on the carbon acidity of glycine

artículo científico publicado en 2007

Direct excitation luminescence spectroscopy of Eu(III) complexes of 1,4,7-tris(carbamoylmethyl)-1,4,7,10- tetraazacyclododecane derivatives and kinetic studies of their catalytic cleavage of an RNA analog

artículo científico publicado en 2007

Dissecting the total transition state stabilization provided by amino acid side chains at orotidine 5'-monophosphate decarboxylase: a two-part substrate approach

artículo científico publicado en 2008

Dynamics for Reaction of an Ion Pair in Aqueous Solution: Reactivity of Carboxylate Anions in Bimolecular Carbocation−Nucleophile Addition and Unimolecular Ion Pair Collapse

article

Dynamics for Reactions of Ion Pairs in Aqueous Solution: Reactivity of Tosylate Anion Ion Paired with the Highly Destabilized 1-(4-Methylphenyl)-2,2,2-Trifluoroethyl Carbocation

artículo científico publicado en 2010

Effect of an E461G mutation of beta-galactosidase (Escherichia coli, lac Z) on pL rate profiles and solvent deuterium isotope effects

artículo científico publicado en 2001

Enhancement of a Lewis Acid−Base Interaction via Solvation: Ammonia Molecules and the Benzene Radical Cation

artículo científico publicado en 2007

Enzymatic catalysis of proton transfer and decarboxylation reactions ⬇️

artículo científico publicado el 8 de julio de 2011

Enzymatic catalysis of proton transfer at carbon: activation of triosephosphate isomerase by phosphite dianion

artículo científico publicado en 2007

Enzymatic rate enhancements: a review and perspective

artículo científico publicado en 2013

Enzyme Architecture: A Startling Role for Asn270 in Glycerol 3-Phosphate Dehydrogenase-Catalyzed Hydride Transfer

artículo científico publicado en 2016

Enzyme Architecture: Amino Acid Side-Chains That Function To Optimize the Basicity of the Active Site Glutamate of Triosephosphate Isomerase

scholarly article by Xiang Zhai et al published 5 July 2018 in Journal of the American Chemical Society

Enzyme Architecture: Breaking Down the Catalytic Cage that Activates Orotidine 5'-Monophosphate Decarboxylase for Catalysis

scientific article published on 07 December 2018

Enzyme Architecture: Erection of Active Orotidine 5'-Monophosphate Decarboxylase by Substrate-Induced Conformational Changes

artículo científico publicado en 2017

Enzyme Architecture: Modeling the Operation of a Hydrophobic Clamp in Catalysis by Triosephosphate Isomerase

artículo científico publicado en 2017

Enzyme Architecture: Self-Assembly of Enzyme and Substrate Pieces of Glycerol-3-Phosphate Dehydrogenase into a Robust Catalyst of Hydride Transfer

artículo científico publicado en 2016

Enzyme Architecture: The Effect of Replacement and Deletion Mutations of Loop 6 on Catalysis by Triosephosphate Isomerase

artículo científico publicado en 2014

Enzyme Architecture: The Role of a Flexible Loop in Activation of Glycerol-3-phosphate Dehydrogenase for Catalysis of Hydride Transfer

artículo científico publicado en 2018

Enzyme activation through the utilization of intrinsic dianion binding energy.

artículo científico publicado en 2016

Enzyme and coenzyme reaction mechanisms: Editorial overview

artículo científico publicado en 2014

Enzyme architecture: deconstruction of the enzyme-activating phosphodianion interactions of orotidine 5'-monophosphate decarboxylase

artículo científico publicado en 2014

Enzyme architecture: on the importance of being in a protein cage

artículo científico

Enzyme architecture: optimization of transition state stabilization from a cation-phosphodianion pair

artículo científico publicado en 2015

Enzyme architecture: remarkably similar transition states for triosephosphate isomerase-catalyzed reactions of the whole substrate and the substrate in pieces

scientific article published on 06 March 2014

Enzyme architecture: the activating oxydianion binding domain for orotidine 5'-monophophate decarboxylase

artículo científico publicado en 2013

Formation and Mechanism for Reactions of Ring-Substituted Phenonium Ions in Aqueous Solution

artículo científico publicado en 2015

Formation and stability of N-heterocyclic carbenes in water: the carbon acid pKa of imidazolium cations in aqueous solution

artículo científico publicado en 2004

Formation and stability of a vinyl carbanion at the active site of orotidine 5'-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMP

artículo científico publicado en 2008

Formation and stability of carbocations and carbanions in water and intrinsic barriers to their reactions.

artículo científico publicado en 2001

Formation and stability of enolates of acetamide and acetate anion: an Eigen plot for proton transfer at alpha-carbonyl carbon

artículo científico publicado en 2002

Formation and stability of mononuclear and dinuclear Eu(III) complexes and their catalytic reactivity toward cleavage of an RNA analog

artículo científico publicado en 2007

Formation and stability of organic zwitterions The carbon acid pKas of the trimethylsulfonium and tetramethylphosphonium cations in water

Formation and stability of peptide enolates in aqueous solution.

artículo científico publicado en 2002

Formation and stability of the 4-methoxyphenonium ion in aqueous solution

artículo científico publicado en 2011

Formation and stability of the enolates of N-protonated proline methyl ester and proline zwitterion in aqueous solution: a nonenzymatic model for the first step in the racemization of proline catalyzed by proline racemase

artículo científico publicado en 2003

Glycine enolates: the effect of formation of iminium ions to simple ketones on alpha-amino carbon acidity and a comparison with pyridoxal iminium ions

artículo científico publicado en 2008

Glycine enolates: the large effect of iminium ion formation on alpha-amino carbon acidity

artículo científico publicado en 2001

Ground-state, transition-state, and metal-cation effects of the 2-hydroxyl group on beta-D-galactopyranosyl transfer catalyzed by beta-galactosidase (Escherichia coli, lac Z).

artículo científico publicado en 2005

Human Glycerol 3-Phosphate Dehydrogenase: X-ray Crystal Structures That Guide the Interpretation of Mutagenesis Studies

artículo científico publicado en 2019

Hydride Transfer Catalyzed by Glycerol Phosphate Dehydrogenase: Recruitment of an Acidic Amino Acid Side Chain to Rescue a Damaged Enzyme

artículo científico publicado en 2020

Hydrogen bonding and catalysis of solvolysis of 4-methoxybenzyl fluoride

artículo científico publicado en 2002

Hydron transfer catalyzed by triosephosphate isomerase. Products of isomerization of (R)-glyceraldehyde 3-phosphate in D2O.

artículo científico publicado en 2005

Hydron transfer catalyzed by triosephosphate isomerase. Products of isomerization of dihydroxyacetone phosphate in D2O.

artículo científico publicado en 2005

Hydron transfer catalyzed by triosephosphate isomerase. Products of the direct and phosphite-activated isomerization of [1-(13)C]-glycolaldehyde in D(2)O.

scientific article published on June 2009

Isopentenyl diphosphate isomerase catalyzed reactions in D2O: product release limits the rate of this sluggish enzyme-catalyzed reaction

artículo científico publicado en 2012

Keto-enol/enolate equilibria in the N-acetylamino-p-methylacetophenone system. Effect of a beta-nitrogen substituent.

artículo científico publicado en 2001

Ketonization of the remarkably strongly acidic elongated enol generated by flash photolytic decarboxylation of p-benzoylphenylacetic acid in aqueous solution

artículo científico publicado en 2005

Kinetic and thermodynamic barriers to carbon and oxygen alkylation of phenol and phenoxide ion by the 1-(4-methoxyphenyl)ethyl carbocation

artículo científico publicado en 2003

Magnitude and origin of the enhanced basicity of the catalytic glutamate of triosephosphate isomerase

artículo científico publicado en 2013

Mechanism for activation of triosephosphate isomerase by phosphite dianion: the role of a hydrophobic clamp

artículo científico publicado en 2012

Mechanism for activation of triosephosphate isomerase by phosphite dianion: the role of a ligand-driven conformational change

artículo científico publicado en 2011

Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization ,

artículo científico publicado en 2009

Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: effect of solvent viscosity on kinetic constants

artículo científico publicado en 2009

Mechanisms Complex biological processes and their central chemical events

artículo científico publicado en 2003

Mechanistic Imperatives for Deprotonation of Carbon Catalyzed by Triosephosphate Isomerase: Enzyme-Activation by Phosphite Dianion

artículo científico publicado en 2014

OMP decarboxylase: phosphodianion binding energy is used to stabilize a vinyl carbanion intermediate

artículo científico publicado en 2011

On the importance of being zwitterionic: enzymatic catalysis of decarboxylation and deprotonation of cationic carbon

artículo científico publicado en 2004

Origin of Free Energy Barriers of Decarboxylation and the Reverse Process of CO<sub>2</sub> Capture in Dimethylformamide and in Water

artículo científico publicado en 2020

Orotidine 5'-Monophosphate Decarboxylase: Probing the Limits of the Possible for Enzyme Catalysis

artículo científico publicado en 2018

Orotidine 5'-monophosphate decarboxylase: transition state stabilization from remote protein-phosphodianion interactions

artículo científico publicado en 2012

Phosphate binding energy and catalysis by small and large molecules

artículo científico publicado en 2008

Physical and kinetic analysis of the cooperative role of metal ions in catalysis of phosphodiester cleavage by a dinuclear Zn(II) complex

artículo científico publicado en 2003

Primary Deuterium Kinetic Isotope Effects From Product Yields: Rationale, Implementation, and Interpretation

artículo científico publicado en 2017

Primary Deuterium Kinetic Isotope Effects: A Probe for the Origin of the Rate Acceleration for Hydride Transfer Catalyzed by Glycerol-3-Phosphate Dehydrogenase

artículo científico publicado en 2018

Product deuterium isotope effect for orotidine 5'-monophosphate decarboxylase: evidence for the existence of a short-lived carbanion intermediate

artículo científico publicado en 2007

Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate

artículo científico publicado en 2010

Protein Flexibility and Stiffness Enable Efficient Enzymatic Catalysis

scientific article published on 14 February 2019

Proton transfer at carbon.

artículo científico publicado en 2001

Proton transfer from C-6 of uridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase: formation and stability of a vinyl carbanion intermediate and the effect of a 5-fluoro substituent

artículo científico publicado en 2012

Punching holes in an enzyme

artículo científico publicado en 2009

Pyridoxal 5'-phosphate: electrophilic catalyst extraordinaire

artículo científico publicado en 2009

Rate and Equilibrium Constants for an Enzyme Conformational Change during Catalysis by Orotidine 5'-Monophosphate Decarboxylase

artículo científico publicado en 2015

Rational design of transition-state analogues as potent enzyme inhibitors with therapeutic applications

artículo científico publicado en 2007

Reactions of ion-pair intermediates of solvolysis

artículo científico publicado en 2005

Reflections on the catalytic power of a TIM-barrel.

artículo científico publicado en 2014

Rescue of K12G triosephosphate isomerase by ammonium cations: the reaction of an enzyme in pieces

artículo científico publicado en 2010

Restoring a metabolic pathway

artículo científico publicado en 2008

Role of Ligand-Driven Conformational Changes in Enzyme Catalysis: Modeling the Reactivity of the Catalytic Cage of Triosephosphate Isomerase

artículo científico publicado en 2018

Role of Loop-Clamping Side Chains in Catalysis by Triosephosphate Isomerase

artículo científico publicado en 2015

Role of Lys-12 in catalysis by triosephosphate isomerase: a two-part substrate approach

artículo científico publicado en 2010

Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5'-phosphate decarboxylase-catalyzed reactions

artículo científico publicado en 2013

Role of the Carboxylate in Enzyme-Catalyzed Decarboxylation of Orotidine 5'-Monophosphate: Transition State Stabilization Dominates Over Ground State Destabilization

artículo científico publicado en 2019

Scrambling of Oxygen-18 during the “Borderline” Solvolysis of 1-(3-Nitrophenyl)ethyl Tosylate

scientific article published on 01 September 2004

Slow proton transfer from the hydrogen-labelled carboxylic acid side chain (Glu-165) of triosephosphate isomerase to imidazole buffer in D2O.

artículo científico publicado en 2007

Solvent deuterium isotope effects on phosphodiester cleavage catalyzed by an extraordinarily active Zn(II) complex

artículo científico publicado en 2005

Specificity in transition state binding: the Pauling model revisited

artículo científico

Stereochemical course of a phosphokinase using a chiral [18O]phosphorothioate. Comparison with the transfer of a chiral [16O,17O,18O] phosphoryl group

artículo científico publicado en 1980

Structural mutations that probe the interactions between the catalytic and dianion activation sites of triosephosphate isomerase

artículo científico publicado en 2013

Structure-Function Studies of Hydrophobic Residues That Clamp a Basic Glutamate Side Chain during Catalysis by Triosephosphate Isomerase

artículo científico publicado en 2016

Structure-Reactivity Effects on Intrinsic Primary Kinetic Isotope Effects for Hydride Transfer Catalyzed by Glycerol-3-phosphate Dehydrogenase

artículo científico publicado en 2016

Structure-Reactivity Relationships for β-Galactosidase (Escherichia coli, lac Z): A Second Derivative Effect on β(nuc) for Addition of Alkyl Alcohols to an Oxocarbenium Ion Reaction Intermediate

artículo científico publicado en 2008

Structure-activity studies on the cleavage of an RNA analogue by a potent dinuclear metal ion catalyst: effect of changing the metal ion.

artículo científico publicado en 2004

Structure-reactivity effects on primary deuterium isotope effects on protonation of ring-substituted alpha-methoxystyrenes

artículo científico publicado en 2009

Structure-reactivity relationships for beta-galactosidase (Escherichia coli, lac Z). 3. Evidence that Glu-461 participates in Brønsted acid-base catalysis of beta-D-galactopyranosyl group transfer.

artículo científico publicado en 1996

Structure-reactivity relationships for beta-galactosidase (Escherichia coli, lac Z). 4. Mechanism for reaction of nucleophiles with the galactosyl-enzyme intermediates of E461G and E461Q beta-galactosidases.

artículo científico publicado en 1996

Substituent Effects on Carbon Acidity in Aqueous Solution and at Enzyme Active Sites

artículo científico publicado en 2017

Substituent Effects on the Formation and Nucleophile Selectivity of Ring-Substituted Phenonium Ions in Aqueous Solution

artículo científico publicado en 2013

Substituent effects on carbocation stability: the pK(R) for p-quinone methide

artículo científico publicado en 2003

Substituent effects on electrophilic catalysis by the carbonyl group: anatomy of the rate acceleration for PLP-catalyzed deprotonation of glycine.

artículo científico publicado en 2011

Substituent effects on the thermodynamic stability of imines formed from glycine and aromatic aldehydes: implications for the catalytic activity of pyridoxal-5'-phosphate.

artículo científico publicado en 2009

Substrate specificity of an active dinuclear Zn(II) catalyst for cleavage of RNA analogues and a dinucleoside

artículo científico publicado en 2006

Swain-Scott Relationships for Nucleophile Addition to Ring-Substituted Phenonium Ions

artículo científico publicado en 2014

The Enhancement of Enzymatic Rate Accelerations by Brønsted Acid−Base Catalysis ⬇️

artículo científico publicado el 31 de marzo de 1998

The Generation and Reactions of Quinone Methides

scientific article published on January 2011

The Organization of Active Site Side Chains of Glycerol-3-phosphate Dehydrogenase Promotes Efficient Enzyme Catalysis and Rescue of Variant Enzymes

artículo científico publicado en 2020

The PLP cofactor: lessons from studies on model reactions.

artículo científico publicado en 2010

The activating oxydianion binding domain for enzyme-catalyzed proton transfer, hydride transfer, and decarboxylation: specificity and enzyme architecture

artículo científico publicado en 2015

The mandelamide keto-enol system in aqueous solution. Generation of the enol by hydration of phenylcarbamoylcarbene

artículo científico publicado en 2003

The role of ligand-gated conformational changes in enzyme catalysis

scientific article published on 01 October 2019

The stereochemical course of thiophosphoryl group transfer catalyzed by adenosine kinase

artículo científico publicado en 1980

Theoretical analysis of kinetic isotope effects on proton transfer reactions between substituted alpha-methoxystyrenes and substituted acetic acids

scientific article published on October 2009

Uncovering the Role of Key Active-Site Side Chains in Catalysis: An Extended Brønsted Relationship for Substrate Deprotonation Catalyzed by Wild-Type and Variants of Triosephosphate Isomerase

artículo científico publicado en 2019

What is the stabilizing interaction with nucleophilic solvents in the transition state for solvolysis of tertiary derivatives: nucleophilic solvent participation or nucleophilic solvation?

artículo científico

When does an intermediate become a transition state? Degenerate isomerization without competing racemization during solvolysis of (S)-1-(3-nitrophenyl)ethyl tosylate

artículo científico publicado en 2006

Wildtype and engineered monomeric triosephosphate isomerase from Trypanosoma brucei: partitioning of reaction intermediates in D2O and activation by phosphite dianion

artículo científico publicado en 2011

[14] Stereochemistry of selected phosphotransferases and nucleotidyltransferases

artículo científico publicado en 1982

Lista de obras de John P. Richard

A Marcus treatment of rate constants for protonation of ring-substituted alpha-methoxystyrenes: intrinsic reaction barriers and the shape of the reaction coordinate

A Paradigm for Enzyme-Catalyzed Proton Transfer at Carbon: Triosephosphate Isomerase ⬇️

A comparison of the electrophilic reactivities of Zn2+ and acetic acid as catalysts of enolization: imperatives for enzymatic catalysis of proton transfer at carbon

A minimalist approach to understanding the efficiency of mononuclear Zn(ii) complexes as catalysts of cleavage of an RNA analog

A reevaluation of the origin of the rate acceleration for enzyme-catalyzed hydride transfer

A role for flexible loops in enzyme catalysis

A simple method to determine kinetic deuterium isotope effects provides evidence that proton transfer to carbon proceeds over and not through the reaction barrier

A substrate in pieces: allosteric activation of glycerol 3-phosphate dehydrogenase (NAD+) by phosphite dianion

A transition state analog for phosphate diester cleavage catalyzed by a small enzyme-like metal ion complex

Activation of R235A mutant orotidine 5'-monophosphate decarboxylase by the guanidinium cation: effective molarity of the cationic side chain of Arg-235

Activation of orotidine 5'-monophosphate decarboxylase by phosphite dianion: the whole substrate is the sum of two parts

Alanine-dependent reactions of 5'-deoxypyridoxal in water

Altered transition state for the reaction of an RNA model catalyzed by a dinuclear zinc(II) catalyst

An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organisms

Binding Energy and Catalysis by d -Xylose Isomerase: Kinetic, Product, and X-ray Crystallographic Analysis of Enzyme-Catalyzed Isomerization of ( R )-Glyceraldehyde

Bovine serum albumin-catalyzed deprotonation of [1-(13)C]glycolaldehyde: protein reactivity toward deprotonation of the alpha-hydroxy alpha-carbonyl carbon

Carbon acidity of the alpha-pyridinium carbon of a pyridoxamine analog.

Catalysis by orotidine 5'-monophosphate decarboxylase: effect of 5-fluoro and 4'-substituents on the decarboxylation of two-part substrates

Claisen-type addition of glycine to a pyridoxal iminium ion in water

Claisen-type addition of glycine to pyridoxal in water.

Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: A Structure-Based Explanation for How the 5′-Phosphate Group Activates the Enzyme

Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: “Remote” Residues That Stabilize the Active Conformation

Contribution of phosphate intrinsic binding energy to the enzymatic rate acceleration for triosephosphate isomerase

Cooperativity between metal ions in the cleavage of phosphate diesters and RNA by dinuclear Zn(II) catalysts

Covalent catalysis by pyridoxal: evaluation of the effect of the cofactor on the carbon acidity of glycine

Direct excitation luminescence spectroscopy of Eu(III) complexes of 1,4,7-tris(carbamoylmethyl)-1,4,7,10- tetraazacyclododecane derivatives and kinetic studies of their catalytic cleavage of an RNA analog

Dissecting the total transition state stabilization provided by amino acid side chains at orotidine 5'-monophosphate decarboxylase: a two-part substrate approach

Dynamics for Reaction of an Ion Pair in Aqueous Solution: Reactivity of Carboxylate Anions in Bimolecular Carbocation−Nucleophile Addition and Unimolecular Ion Pair Collapse

Dynamics for Reactions of Ion Pairs in Aqueous Solution: Reactivity of Tosylate Anion Ion Paired with the Highly Destabilized 1-(4-Methylphenyl)-2,2,2-Trifluoroethyl Carbocation

Effect of an E461G mutation of beta-galactosidase (Escherichia coli, lac Z) on pL rate profiles and solvent deuterium isotope effects

Enhancement of a Lewis Acid−Base Interaction via Solvation: Ammonia Molecules and the Benzene Radical Cation

Enzymatic catalysis of proton transfer and decarboxylation reactions ⬇️

Enzymatic catalysis of proton transfer at carbon: activation of triosephosphate isomerase by phosphite dianion

Enzymatic rate enhancements: a review and perspective

Enzyme Architecture: A Startling Role for Asn270 in Glycerol 3-Phosphate Dehydrogenase-Catalyzed Hydride Transfer

Enzyme Architecture: Amino Acid Side-Chains That Function To Optimize the Basicity of the Active Site Glutamate of Triosephosphate Isomerase

Enzyme Architecture: Breaking Down the Catalytic Cage that Activates Orotidine 5'-Monophosphate Decarboxylase for Catalysis

Enzyme Architecture: Erection of Active Orotidine 5'-Monophosphate Decarboxylase by Substrate-Induced Conformational Changes

Enzyme Architecture: Modeling the Operation of a Hydrophobic Clamp in Catalysis by Triosephosphate Isomerase

Enzyme Architecture: Self-Assembly of Enzyme and Substrate Pieces of Glycerol-3-Phosphate Dehydrogenase into a Robust Catalyst of Hydride Transfer

Enzyme Architecture: The Effect of Replacement and Deletion Mutations of Loop 6 on Catalysis by Triosephosphate Isomerase

Enzyme Architecture: The Role of a Flexible Loop in Activation of Glycerol-3-phosphate Dehydrogenase for Catalysis of Hydride Transfer

Enzyme activation through the utilization of intrinsic dianion binding energy.

Enzyme and coenzyme reaction mechanisms: Editorial overview

Enzyme architecture: deconstruction of the enzyme-activating phosphodianion interactions of orotidine 5'-monophosphate decarboxylase

Enzyme architecture: on the importance of being in a protein cage

Enzyme architecture: optimization of transition state stabilization from a cation-phosphodianion pair

Enzyme architecture: remarkably similar transition states for triosephosphate isomerase-catalyzed reactions of the whole substrate and the substrate in pieces

Enzyme architecture: the activating oxydianion binding domain for orotidine 5'-monophophate decarboxylase

Formation and Mechanism for Reactions of Ring-Substituted Phenonium Ions in Aqueous Solution

Formation and stability of N-heterocyclic carbenes in water: the carbon acid pKa of imidazolium cations in aqueous solution

Formation and stability of a vinyl carbanion at the active site of orotidine 5'-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMP

Formation and stability of carbocations and carbanions in water and intrinsic barriers to their reactions.

Formation and stability of enolates of acetamide and acetate anion: an Eigen plot for proton transfer at alpha-carbonyl carbon

Formation and stability of mononuclear and dinuclear Eu(III) complexes and their catalytic reactivity toward cleavage of an RNA analog

Formation and stability of organic zwitterions The carbon acid pKas of the trimethylsulfonium and tetramethylphosphonium cations in water

Formation and stability of peptide enolates in aqueous solution.

Formation and stability of the 4-methoxyphenonium ion in aqueous solution

Formation and stability of the enolates of N-protonated proline methyl ester and proline zwitterion in aqueous solution: a nonenzymatic model for the first step in the racemization of proline catalyzed by proline racemase

Glycine enolates: the effect of formation of iminium ions to simple ketones on alpha-amino carbon acidity and a comparison with pyridoxal iminium ions

Glycine enolates: the large effect of iminium ion formation on alpha-amino carbon acidity

Ground-state, transition-state, and metal-cation effects of the 2-hydroxyl group on beta-D-galactopyranosyl transfer catalyzed by beta-galactosidase (Escherichia coli, lac Z).

Human Glycerol 3-Phosphate Dehydrogenase: X-ray Crystal Structures That Guide the Interpretation of Mutagenesis Studies

Hydride Transfer Catalyzed by Glycerol Phosphate Dehydrogenase: Recruitment of an Acidic Amino Acid Side Chain to Rescue a Damaged Enzyme

Hydrogen bonding and catalysis of solvolysis of 4-methoxybenzyl fluoride

Hydron transfer catalyzed by triosephosphate isomerase. Products of isomerization of (R)-glyceraldehyde 3-phosphate in D2O.

Hydron transfer catalyzed by triosephosphate isomerase. Products of isomerization of dihydroxyacetone phosphate in D2O.

Hydron transfer catalyzed by triosephosphate isomerase. Products of the direct and phosphite-activated isomerization of [1-(13)C]-glycolaldehyde in D(2)O.

Isopentenyl diphosphate isomerase catalyzed reactions in D2O: product release limits the rate of this sluggish enzyme-catalyzed reaction

Keto-enol/enolate equilibria in the N-acetylamino-p-methylacetophenone system. Effect of a beta-nitrogen substituent.

Ketonization of the remarkably strongly acidic elongated enol generated by flash photolytic decarboxylation of p-benzoylphenylacetic acid in aqueous solution

Kinetic and thermodynamic barriers to carbon and oxygen alkylation of phenol and phenoxide ion by the 1-(4-methoxyphenyl)ethyl carbocation

Magnitude and origin of the enhanced basicity of the catalytic glutamate of triosephosphate isomerase

Mechanism for activation of triosephosphate isomerase by phosphite dianion: the role of a hydrophobic clamp

Mechanism for activation of triosephosphate isomerase by phosphite dianion: the role of a ligand-driven conformational change

Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization ,

Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: effect of solvent viscosity on kinetic constants

Mechanisms Complex biological processes and their central chemical events

Mechanistic Imperatives for Deprotonation of Carbon Catalyzed by Triosephosphate Isomerase: Enzyme-Activation by Phosphite Dianion