Lista de obras - Hiroaki Sakurai - Dominio Público Uruguay

5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases

artículo científico publicado en 2008

A Proteomic Approach for the Diagnosis of 'Oketsu' (blood stasis), a Pathophysiologic Concept of Japanese Traditional (Kampo) Medicine

artículo científico publicado en 2007

A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells

artículo científico publicado en 2006

A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells.

artículo científico publicado en 2013

A newly devised formulation for self-medication enhances interferon-gamma production and proliferation of splenic lymphocytes.

artículo científico publicado en 2005

A novel rabbit immunospot array assay on a chip allows for the rapid generation of rabbit monoclonal antibodies with high affinity

artículo científico publicado en 2012

A phagocytotic inducer from herbal constituent, pentagalloylglucose enhances lipoplex-mediated gene transfection in dendritic cells

artículo científico publicado en 2010

Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861.

artículo científico publicado en 2006

Abyssomicin I, a modified polycyclic polyketide from Streptomyces sp. CHI39.

artículo científico publicado en 2010

Activation of MEK/ERK and PI3K/Akt pathways by fibronectin requires integrin alphav-mediated ADAM activity in hepatocellular carcinoma: a novel functional target for gefitinib

artículo científico publicado en 2006

Activation of NF-kappaB is a novel target of KRAS-induced endometrial carcinogenesis.

artículo científico publicado en 2011

Activation of transcription factor NF-kappa B in experimental glomerulonephritis in rats

artículo científico publicado en 1996

Alternative splicing and gene structure of the transforming growth factor beta-activated kinase 1.

artículo científico publicado en 2000

An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway

artículo científico publicado en 2009

Analysis of chemical properties of edible and medicinal ginger by metabolomics approach

artículo científico publicado en 2015

Anti-enterovirus 71 activities of Melissa officinalis extract and its biologically active constituent rosmarinic acid.

artículo científico publicado en 2017

Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives

artículo científico publicado en 2009

Anti-metastatic and anti-angiogenic activities of a new matrix metalloproteinase inhibitor, TN-6b

artículo científico publicado en 2003

Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice

artículo científico publicado en 2004

Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov.

artículo científico publicado en 2007

Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo

artículo científico publicado en 2017

Artesunate enhances TRAIL-induced apoptosis in human cervical carcinoma cells through inhibition of the NF-κB and PI3K/Akt signaling pathways.

artículo científico publicado en 2011

Bardoxolone-methyl inhibits migration and metabolism in MCF7 cells

artículo científico publicado en 2017

Blockade of transforming growth factor-beta-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade.

artículo científico publicado en 2006

Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells

artículo científico publicado en 2008

Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp.

artículo científico publicado en 2009

Bufotalin sensitizes death receptor-induced apoptosis via Bid- and STAT1-dependent pathways

artículo científico publicado en 2011

CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages.

artículo científico publicado en 2014

Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation

artículo científico publicado en 2012

Catechoserine, a new catecholate-type inhibitor of tumor cell invasion from Streptomyces sp.

artículo científico publicado en 2012

Cell to cell interaction between mesangial cells and macrophages induces the expression of monocyte chemoattractant protein-1 through nuclear factor-kappaB activation

artículo científico publicado en 2000

Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model

artículo científico publicado en 2012

Cochinin B, a novel ribosome-inactivating protein from the seeds of Momordica cochinchinensis

artículo científico publicado en 2007

Constitutive activation of TAK1 by HTLV-1 tax-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-kappaB.

artículo científico publicado en 2007

Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer.

artículo científico publicado en 2015

Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.

artículo científico publicado en 2004

Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 1.

artículo científico publicado en 2009

Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2

scientific journal article

Curcumin inhibits the formation of capillary-like tubes by rat lymphatic endothelial cells

artículo científico publicado en 2007

Cytotoxic cardiac glycosides from the roots of Streptocaulon juventas

artículo científico publicado en 2012

Developmentally and regionally regulated alterations of octamer- and GC-box-binding activities during the postnatal development of mouse cerebellum

artículo científico publicado en 1991

Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.

artículo científico publicado en 2001

Distinct roles of transforming growth factor-beta-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interleukin-9.

artículo científico publicado en 2011

E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity

artículo científico publicado en 2010

Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model

artículo científico publicado en 2011

Enhancement of hyperthermia-induced apoptosis by 5Z-7-oxozeaenol, a TAK1 inhibitor, in A549 cells

artículo científico publicado en 2016

Enhancement of hyperthermia-induced apoptosis by 5Z-7-oxozeaenol, a TAK1 inhibitor, in Molt-4 cells

artículo científico publicado en 2017

Enzymatic and biochemical properties of a novel human serine dehydratase isoform

artículo científico publicado en 2006

Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1.

artículo científico publicado en 2008

Ethanolic extract of Thevetia peruviana flowers enhances TNF-α and TRAIL-induced apoptosis of human cervical cancer cells via intrinsic and extrinsic pathways

artículo científico publicado en 2017

Expression patterns of plasma proteins in spontaneously diabetic rats after oral administration of a Kampo medicine, Hachimi-jio-gan, using SELDI ProteinChip platform.

artículo científico publicado en 2005

Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain.

artículo científico publicado en 2016

Fibroblast growth factor-2-induced host stroma reaction during initial tumor growth promotes progression of mouse melanoma via vascular endothelial growth factor A-dependent neovascularization

scientific article published on 14 March 2007

Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation

artículo científico publicado en 1999

Gomisin A enhances tumor necrosis factor-α-induced G1 cell cycle arrest via signal transducer and activator of transcription 1-mediated phosphorylation of retinoblastoma protein.

artículo científico publicado en 2012

Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways

scholarly article by Pornthip Waiwut et al published 28 December 2010 in Molecular and Cellular Biochemistry

Gomisin N enhances TRAIL-induced apoptosis via reactive oxygen species-mediated up-regulation of death receptors 4 and 5

artículo científico publicado en 2011

Helicobacter pylori Induces Serine Phosphorylation of EGFR via Novel TAK1-p38 Activation Pathway in an HB-EGF-Independent Manner

artículo científico publicado en 2015

Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells

artículo científico publicado en 2008

High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer

artículo científico publicado en 2007

Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways

artículo científico publicado en 2009

IKKbeta phosphorylates p65 at S468 in transactivaton domain 2.

artículo científico publicado en 2005

Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1.

artículo científico publicado en 2011

Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling

artículo científico publicado en 2003

Identification of TNF-alpha-responsive NF-kappaB p65-binding element in the distal promoter of the mouse serine protease inhibitor SerpinE2.

artículo científico publicado en 2006

Identification of a predictive biomarker for the beneficial effect of a Kampo (Japanese traditional) medicine keishibukuryogan in rheumatoid arthritis patients

artículo científico publicado en 2007

IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain

artículo científico publicado en 1999

Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model

artículo científico publicado en 2015

Inducible capillary formation in lymphatic endothelial cells by blocking lipid phosphate phosphatase-3 activity.

artículo científico publicado en 2009

Inhibition of p38 mitogen-activated protein kinase potentiates the apoptotic effect of berberine/tumor necrosis factor-related apoptosis-inducing ligand combination therapy

artículo científico publicado en 2015

Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation.

artículo científico publicado en 2014

Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells

artículo científico publicado en 2004

Inverse correlation between Thr-669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation

artículo científico publicado en 2013

Iodine-catalyzed etherification of morroniside

artículo científico publicado en 2009

Juzentaihoto, a Kampo medicine, enhances IL-12 production by modulating Toll-like receptor 4 signaling pathways in murine peritoneal exudate macrophages

artículo científico publicado en 2005

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation

artículo científico publicado en 2017

MAPK regulation and caspase activation are required in DMNQ S-52 induced apoptosis in Lewis lung carcinoma cells

artículo científico publicado en 2006

Massive T-lymphocyte infiltration into the host stroma is essential for fibroblast growth factor-2-promoted growth and metastasis of mammary tumors via neovascular stability.

artículo científico publicado en 2008

Mesenchymal-transitioned cancer cells instigate the invasion of epithelial cancer cells through secretion of WNT3 and WNT5B.

artículo científico publicado en 2014

Modulation of activation-induced cytidine deaminase by curcumin in Helicobacter pylori-infected gastric epithelial cells.

artículo científico publicado en 2009

Negative feedback regulation of ErbB4 tyrosine kinase activity by ERK-mediated non-canonical phosphorylation

scientific article published on 01 May 2019

Non-canonical Activation of Receptor Tyrosine Kinases in Cancer Progression

artículo científico publicado en 2017

Novel inhibitor for fibroblast growth factor receptor tyrosine kinase

scientific article published on 26 June 2007

P38 pathway as a key downstream signal of connective tissue growth factor to regulate metastatic potential in non-small-cell lung cancer

artículo científico publicado en 2016

PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1

artículo científico publicado en 2005

Pharmaceutical evaluation of liquorice before and after roasting in mice

artículo científico publicado en 2004

Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways

artículo científico publicado en 2007

Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses

artículo científico publicado en 2003

Prevention of intrahepatic metastasis by curcumin in an orthotopic implantation model

artículo científico publicado en 2003

Procyanidin C1 from Cinnamomi Cortex inhibits TGF-β-induced epithelial-to-mesenchymal transition in the A549 lung cancer cell line.

artículo científico publicado en 2013

Proteomic identification of haptoglobin as a stroke plasma biomarker in spontaneously hypertensive stroke-prone rats

artículo científico publicado en 2008

RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer

artículo científico publicado en 2014

RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4.

artículo científico publicado en 2006

RANKL-induced down-regulation of CX3CR1 via PI3K/Akt signaling pathway suppresses Fractalkine/CX3CL1-induced cellular responses in RAW264.7 cells

artículo científico publicado en 2007

Rakicidin D, an inhibitor of tumor cell invasion from marine-derived Streptomyces sp.

artículo científico publicado en 2010

Rapid attenuation of AP-1 transcriptional factors associated with nitric oxide (NO)-mediated neuronal cell death

artículo científico publicado en 1996

Rational Combination Therapy for Melanoma with Dinaciclib by Targeting BAK-Dependent Cell Death

scientific article published on 19 November 2019

Role of CX3CL1/fractalkine in osteoclast differentiation and bone resorption

artículo científico publicado en 2009

Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments.

artículo científico publicado en 2015

Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer

artículo científico publicado en 2006

Role of tyrosine kinase-independent phosphorylation of EGFR with activating mutation in cisplatin-treated lung cancer cells

artículo científico publicado en 2015

SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice

artículo científico publicado en 2012

Severe pulmonary metastasis in obese and diabetic mice

artículo científico

Stimulation of cultured colon 26 cells with TNF-alpha promotes lung metastasis through the extracellular signal-regulated kinase pathway.

artículo científico publicado en 2005

Suppression of NF-kappa B and AP-1 activation by glucocorticoids in experimental glomerulonephritis in rats: molecular mechanisms of anti-nephritic action

scientific article published on 01 December 1997

Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis

artículo científico publicado en 2014

Synthesis and evaluation of myxochelin analogues as antimetastatic agents

artículo científico publicado en 2009

TAC-101 inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma

artículo científico publicado en 2003

TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation

artículo científico publicado en 2005

TAK1 promotes cell survival by TNFAIP3 and IL-8 dependent and NF-κB independent pathway in HeLa cells exposed to heat stress.

artículo científico publicado en 2013

TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways

artículo científico publicado en 2002

TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling

artículo científico publicado en 2009

TAK1-mediated stress signaling pathways are essential for TNF-alpha-promoted pulmonary metastasis of murine colon cancer cells.

artículo científico publicado en 2006

TAK1-mediated transcriptional activation of CD28-responsive element and AP-1-binding site within the IL-2 promoter in Jurkat T cells

artículo científico publicado en 2005

TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism

artículo científico publicado en 1998

TGF-β-activated kinase 1 promotes cell cycle arrest and cell survival of X-ray irradiated HeLa cells dependent on p21 induction but independent of NF-κB, p38 MAPK and ERK phosphorylations.

artículo científico publicado en 2012

Targeting of TAK1 in inflammatory disorders and cancer ⬇️

artículo científico publicado el 12 de julio de 2012

Telomerase upregulates expression levels of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-8, and granulocyte-macrophage colony-stimulating factor in normal human fibroblasts

artículo científico publicado en 2003

The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway

artículo científico publicado en 2006

The long-term effects of a kampo medicine, juzentaihoto, on maintenance of antibody titer in elderly people after influenza vaccination

artículo científico publicado en 2013

The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment

artículo científico publicado en 2019

Transient suppression of ligand-mediated activation of epidermal growth factor receptor by tumor necrosis factor-alpha through the TAK1-p38 signaling pathway

artículo científico publicado en 2007

Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway

artículo científico publicado en 2003

Tumour-derived fibroblast growth factor-2 exerts lymphangiogenic effects through Akt/mTOR/p70S6kinase pathway in rat lymphatic endothelial cells

scientific article published on 13 June 2007

Tuning of protein kinase circuitry by p38α is vital for epithelial tissue homeostasis.

artículo científico publicado en 2013

Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling

artículo científico publicado en 2009

Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells.

artículo científico publicado en 2005

eNOS and Hsp90 interaction directly correlates with cord formation in human lymphatic endothelial cells

artículo científico publicado en 2011

p38-Mediated phosphorylation of Eps15 endocytic adaptor protein

artículo científico publicado en 2013

Lista de obras de Hiroaki Sakurai

5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases

A Proteomic Approach for the Diagnosis of 'Oketsu' (blood stasis), a Pathophysiologic Concept of Japanese Traditional (Kampo) Medicine

A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells

A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells.

A newly devised formulation for self-medication enhances interferon-gamma production and proliferation of splenic lymphocytes.

A novel rabbit immunospot array assay on a chip allows for the rapid generation of rabbit monoclonal antibodies with high affinity

A phagocytotic inducer from herbal constituent, pentagalloylglucose enhances lipoplex-mediated gene transfection in dendritic cells

Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861.

Abyssomicin I, a modified polycyclic polyketide from Streptomyces sp. CHI39.

Activation of MEK/ERK and PI3K/Akt pathways by fibronectin requires integrin alphav-mediated ADAM activity in hepatocellular carcinoma: a novel functional target for gefitinib

Activation of NF-kappaB is a novel target of KRAS-induced endometrial carcinogenesis.

Activation of transcription factor NF-kappa B in experimental glomerulonephritis in rats

Alternative splicing and gene structure of the transforming growth factor beta-activated kinase 1.

An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway

Analysis of chemical properties of edible and medicinal ginger by metabolomics approach

Anti-enterovirus 71 activities of Melissa officinalis extract and its biologically active constituent rosmarinic acid.

Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives

Anti-metastatic and anti-angiogenic activities of a new matrix metalloproteinase inhibitor, TN-6b

Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice

Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov.

Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo

Artesunate enhances TRAIL-induced apoptosis in human cervical carcinoma cells through inhibition of the NF-κB and PI3K/Akt signaling pathways.

Bardoxolone-methyl inhibits migration and metabolism in MCF7 cells

Blockade of transforming growth factor-beta-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade.

Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells

Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp.

Bufotalin sensitizes death receptor-induced apoptosis via Bid- and STAT1-dependent pathways

CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages.

Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation

Catechoserine, a new catecholate-type inhibitor of tumor cell invasion from Streptomyces sp.

Cell to cell interaction between mesangial cells and macrophages induces the expression of monocyte chemoattractant protein-1 through nuclear factor-kappaB activation

Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model

Cochinin B, a novel ribosome-inactivating protein from the seeds of Momordica cochinchinensis

Constitutive activation of TAK1 by HTLV-1 tax-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-kappaB.

Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer.

Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.

Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 1.

Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2

Curcumin inhibits the formation of capillary-like tubes by rat lymphatic endothelial cells

Cytotoxic cardiac glycosides from the roots of Streptocaulon juventas

Developmentally and regionally regulated alterations of octamer- and GC-box-binding activities during the postnatal development of mouse cerebellum

Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.

Distinct roles of transforming growth factor-beta-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interleukin-9.

E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity

Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model

Enhancement of hyperthermia-induced apoptosis by 5Z-7-oxozeaenol, a TAK1 inhibitor, in A549 cells

Enhancement of hyperthermia-induced apoptosis by 5Z-7-oxozeaenol, a TAK1 inhibitor, in Molt-4 cells

Enzymatic and biochemical properties of a novel human serine dehydratase isoform

Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1.

Ethanolic extract of Thevetia peruviana flowers enhances TNF-α and TRAIL-induced apoptosis of human cervical cancer cells via intrinsic and extrinsic pathways

Expression patterns of plasma proteins in spontaneously diabetic rats after oral administration of a Kampo medicine, Hachimi-jio-gan, using SELDI ProteinChip platform.

Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain.

Fibroblast growth factor-2-induced host stroma reaction during initial tumor growth promotes progression of mouse melanoma via vascular endothelial growth factor A-dependent neovascularization

Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation

Gomisin A enhances tumor necrosis factor-α-induced G1 cell cycle arrest via signal transducer and activator of transcription 1-mediated phosphorylation of retinoblastoma protein.

Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways

Gomisin N enhances TRAIL-induced apoptosis via reactive oxygen species-mediated up-regulation of death receptors 4 and 5

Helicobacter pylori Induces Serine Phosphorylation of EGFR via Novel TAK1-p38 Activation Pathway in an HB-EGF-Independent Manner

Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells

High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer

Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways

IKKbeta phosphorylates p65 at S468 in transactivaton domain 2.

Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1.

Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling

Identification of TNF-alpha-responsive NF-kappaB p65-binding element in the distal promoter of the mouse serine protease inhibitor SerpinE2.

Identification of a predictive biomarker for the beneficial effect of a Kampo (Japanese traditional) medicine keishibukuryogan in rheumatoid arthritis patients

IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain

Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model

Inducible capillary formation in lymphatic endothelial cells by blocking lipid phosphate phosphatase-3 activity.

Inhibition of p38 mitogen-activated protein kinase potentiates the apoptotic effect of berberine/tumor necrosis factor-related apoptosis-inducing ligand combination therapy

Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation.

Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells

Inverse correlation between Thr-669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation

Iodine-catalyzed etherification of morroniside

Juzentaihoto, a Kampo medicine, enhances IL-12 production by modulating Toll-like receptor 4 signaling pathways in murine peritoneal exudate macrophages

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation

MAPK regulation and caspase activation are required in DMNQ S-52 induced apoptosis in Lewis lung carcinoma cells

Massive T-lymphocyte infiltration into the host stroma is essential for fibroblast growth factor-2-promoted growth and metastasis of mammary tumors via neovascular stability.