Lista de obras - Harley T Kurata - Dominio Público Uruguay

A Conserved Residue Cluster That Governs Kinetics of ATP-dependent Gating of Kir6.2 Potassium Channels

artículo científico publicado en 2015

A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel.

artículo científico publicado en 2013

A structural interpretation of voltage-gated potassium channel inactivation.

artículo científico publicado en 2005

A structure-based computational workflow to predict liability and binding modes of small molecules to hERG

scientific article published on 01 October 2020

Altered state dependence of c-type inactivation in the long and short forms of human Kv1.5.

artículo científico publicado en 2001

An activation gating switch in Kv1.2 is localized to a threonine residue in the S2-S3 linker.

artículo científico publicado en 2007

Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains

artículo científico publicado en 2014

Atom-by-atom engineering of voltage-gated ion channels: magnified insights into function and pharmacology

artículo científico publicado en 2015

Atomic basis for therapeutic activation of neuronal potassium channels

artículo científico publicado en 2015

Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells.

artículo científico publicado en 2013

Complex rectification of Müller cell Kir currents.

artículo científico publicado en 2008

Congenital hyperinsulinism and glucose hypersensitivity in homozygous and heterozygous carriers of Kir6.2 (KCNJ11) mutation V290M mutation: K(ATP) channel inactivation mechanism and clinical management

artículo científico publicado en 2010

Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels

artículo científico publicado en 2020

Decomposition of slide helix contributions to ATP-dependent inhibition of Kir6.2 channels

artículo científico publicado en 2013

Determinants of frequency-dependent regulation of Kv1.2-containing potassium channels

artículo científico publicado en 2015

Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1.

artículo científico publicado en 2008

Emerging complexities of lipid regulation of potassium channels

artículo científico publicado en 2016

Extracellular redox sensitivity of Kv1.2 potassium channels

artículo científico publicado en 2017

Familial neonatal seizures caused by the Kv7.3 selectivity filter mutation T313I

artículo científico publicado en 2020

Forced Gating Motions by a Substituted Titratable Side Chain at the Bundle Crossing of a Potassium Channel ⬇️

artículo científico publicado el 30 de agosto de 2011

Four drug-sensitive subunits are required for maximal effect of a voltage sensor-targeted KCNQ opener

scientific article published on 30 August 2018

Functional and behavioral signatures of Kv7 activator drug subtypes

scientific article published on 11 July 2020

HMR 1098 is not an SUR isotype specific inhibitor of heterologous or sarcolemmal K ATP channels

artículo científico publicado en 2010

Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels

artículo científico publicado en 2013

Inward rectifiers and their regulation by endogenous polyamines

artículo científico publicado en 2014

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting

artículo científico publicado en 2016

Locale and chemistry of spermine binding in the archetypal inward rectifier Kir2.1.

artículo científico publicado en 2010

Molecular mechanisms of chloroquine inhibition of heterologously expressed Kir6.2/SUR2A channels.

artículo científico publicado en 2012

Multiparameter screening reveals a role for Na+ channels in cytokine-induced β-cell death

artículo científico publicado en 2014

NH2-terminal inactivation peptide binding to C-type-inactivated Kv channels

artículo científico publicado en 2004

One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channels.

artículo científico publicado en 2018

PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels

artículo científico publicado en 2017

Paradoxical activation of an inwardly rectifying potassium channel mutant by spermine: "(b)locking" open the bundle crossing gate

artículo científico publicado en 2013

Polyamine block of inwardly rectifying potassium channels

artículo científico publicado en 2011

Polyamine permeation and rectification of Kir4.1 channels

artículo científico publicado en 2007

Pore- and voltage sensor-targeted KCNQ openers have distinct state-dependent actions

artículo científico publicado en 2018

Probing the molecular basis of hERG drug block with unnatural amino acids

artículo científico publicado en 2018

Rapid induction of P/C-type inactivation is the mechanism for acid-induced K+ current inhibition

artículo científico publicado en 2003

Scanning the topography of polyamine blocker binding in an inwardly rectifying potassium channel.

artículo científico publicado en 2013

Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus

artículo científico publicado en 2009

Separation of P/C- and U-type inactivation pathways in Kv1.5 potassium channels

artículo científico publicado en 2005

Sequence determinants of subtype-specific actions of KCNQ channel openers

artículo científico publicado en 2016

Slc7a5 alters Kvβ-mediated regulation of Kv1.2.

scientific article published on 01 July 2020

Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations

artículo científico publicado en 2018

The polyamine binding site in inward rectifier K+ channels.

artículo científico publicado en 2006

Use-dependent activation of neuronal Kv1.2 channel complexes.

artículo científico publicado en 2015

Voltage-dependent gating in a "voltage sensor-less" ion channel

artículo científico publicado en 2010

Lista de obras de Harley T Kurata

A Conserved Residue Cluster That Governs Kinetics of ATP-dependent Gating of Kir6.2 Potassium Channels

A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel.

A structural interpretation of voltage-gated potassium channel inactivation.

A structure-based computational workflow to predict liability and binding modes of small molecules to hERG

Altered state dependence of c-type inactivation in the long and short forms of human Kv1.5.

An activation gating switch in Kv1.2 is localized to a threonine residue in the S2-S3 linker.

Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains

Atom-by-atom engineering of voltage-gated ion channels: magnified insights into function and pharmacology

Atomic basis for therapeutic activation of neuronal potassium channels

Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells.

Complex rectification of Müller cell Kir currents.

Congenital hyperinsulinism and glucose hypersensitivity in homozygous and heterozygous carriers of Kir6.2 (KCNJ11) mutation V290M mutation: K(ATP) channel inactivation mechanism and clinical management

Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels

Decomposition of slide helix contributions to ATP-dependent inhibition of Kir6.2 channels

Determinants of frequency-dependent regulation of Kv1.2-containing potassium channels

Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1.

Emerging complexities of lipid regulation of potassium channels

Extracellular redox sensitivity of Kv1.2 potassium channels

Familial neonatal seizures caused by the Kv7.3 selectivity filter mutation T313I

Forced Gating Motions by a Substituted Titratable Side Chain at the Bundle Crossing of a Potassium Channel ⬇️

Four drug-sensitive subunits are required for maximal effect of a voltage sensor-targeted KCNQ opener

Functional and behavioral signatures of Kv7 activator drug subtypes

HMR 1098 is not an SUR isotype specific inhibitor of heterologous or sarcolemmal K ATP channels

Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels

Inward rectifiers and their regulation by endogenous polyamines

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting

Locale and chemistry of spermine binding in the archetypal inward rectifier Kir2.1.

Molecular mechanisms of chloroquine inhibition of heterologously expressed Kir6.2/SUR2A channels.

Multiparameter screening reveals a role for Na+ channels in cytokine-induced β-cell death

NH2-terminal inactivation peptide binding to C-type-inactivated Kv channels

One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channels.

PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels

Paradoxical activation of an inwardly rectifying potassium channel mutant by spermine: "(b)locking" open the bundle crossing gate

Polyamine block of inwardly rectifying potassium channels

Polyamine permeation and rectification of Kir4.1 channels

Pore- and voltage sensor-targeted KCNQ openers have distinct state-dependent actions

Probing the molecular basis of hERG drug block with unnatural amino acids

Rapid induction of P/C-type inactivation is the mechanism for acid-induced K+ current inhibition

Scanning the topography of polyamine blocker binding in an inwardly rectifying potassium channel.

Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus

Separation of P/C- and U-type inactivation pathways in Kv1.5 potassium channels

Sequence determinants of subtype-specific actions of KCNQ channel openers

Slc7a5 alters Kvβ-mediated regulation of Kv1.2.

Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations

The polyamine binding site in inward rectifier K+ channels.

Use-dependent activation of neuronal Kv1.2 channel complexes.

Voltage-dependent gating in a "voltage sensor-less" ion channel